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Cardiovascular risk and mortality prediction in patients suspected of sleep apnea: a model based on an artificial intelligence system.

Physiol Meas 2021 Sep 27. Epub 2021 Sep 27.

ESEO, Angers, FRANCE.

Objective: Cardiovascular disease (CVD) is one of the leading causes of death worldwide. There are many CVD risk estimators but very few take into account sleep features. Moreover, they are rarely tested on patients investigated for obstructive sleep apnea (OSA). Read More

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September 2021

Differing Visual Behavior Between Inexperienced and Experienced Critical Care Nurses While Using a Closed-Loop Ventilation System-A Prospective Observational Study.

Front Med (Lausanne) 2021 8;8:681321. Epub 2021 Sep 8.

Institute of Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland.

Closed-loop ventilation modes are increasingly being used in intensive care units to ensure more automaticity. Little is known about the visual behavior of health professionals using these ventilation modes. The aim of this study was to analyze gaze patterns of intensive care nurses while ventilating a patient in the closed-loop mode with Intellivent adaptive support ventilation® (I-ASV) and to compare inexperienced with experienced nurses. Read More

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September 2021

Industrial applications of cold-adapted enzymes: challenges, innovations and future perspective.

3 Biotech 2021 Oct 6;11(10):426. Epub 2021 Sep 6.

Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Post Box No. 06, Palampur, Himachal Pradesh 176 061 India.

Extreme cold environments are potential reservoirs of microorganisms producing unique and novel enzymes in response to environmental stress conditions. Such cold-adapted enzymes prove to be valuable tools in industrial biotechnology to meet the increasing demand for efficient biocatalysts. The inherent properties like high catalytic activity at low temperature, high specific activity and low activation energy make the cold-adapted enzymes well suited for application in various industries. Read More

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October 2021

Construction of Interferon-Gamma-Related Gene Signature to Characterize the Immune-Inflamed Phenotype of Glioblastoma and Predict Prognosis, Efficacy of Immunotherapy and Radiotherapy.

Front Immunol 2021 10;12:729359. Epub 2021 Sep 10.

Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Interferon-gamma (IFNG) has profound impacts on tumor-immune interaction and is of great clinical significance for multiple cancers. Exploring the role of IFNG in glioblastoma (GBM) may optimize the current treatment paradigm of this disease. Here, multi-dimensional data of 429 GBM samples were collected. Read More

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September 2021

Facilitating Adaptive Emotion Processing and Somatic Reappraisal Sustained Mindful Interoceptive Attention.

Front Psychol 2021 8;12:578827. Epub 2021 Sep 8.

Osher Center for Integrative Medicine, Neuroscape Center, Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, United States.

Emotions are by nature embodied, as the brain has evolved to quickly assess the emotional significance of stimuli and output signals to the body's viscera and periphery to aid adaptive responses. Emotions involve both implicit bodily and explicit narrative processes, and patients may experience transdiagnostic distress when bodily signals are not attended to and holistically integrated with explicit narratives about experience. Similarly, therapists may be trained in more implicit body-based approaches (i. Read More

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September 2021

Reproductive consequences of material use in avian nest construction.

Behav Processes 2021 Sep 22:104507. Epub 2021 Sep 22.

School of Biology, University of St Andrews, St Andrews, United Kingdom; Department of Psychology, University of Alberta, Edmonton, Canada.

Birds' nests represent a rich behavioural 'fingerprint', comprising several important decisions-not the least of which is the selection of appropriate material. Material selection in nest-building birds is thought to reflect, in part, builder-birds' use of the 'best' material-in terms of physical properties (e.g. Read More

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September 2021

Regulation of prophage induction and lysogenization by phage communication systems.

Curr Biol 2021 Sep 22. Epub 2021 Sep 22.

CEFE, CNRS, Univ Montpellier, EPHE, IRD, Univ Paul Valéry Montpellier 3, Montpellier, France. Electronic address:

Many viruses cause both lytic infections, where they release viral particles, and dormant infections, where they await future opportunities to reactivate. The benefits of each transmission mode depend on the density of susceptible hosts in the environment. Some viruses infecting bacteria use molecular signaling to respond plastically to changes in host availability. Read More

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September 2021

Prognostic and therapeutic TILs of cervical cancer-Current advances and future perspectives.

Mol Ther Oncolytics 2021 Sep 21;22:410-430. Epub 2021 Jul 21.

Gillion ITM Research Institute, Guangzhou Hongkeyuan, Guangzhou, China.

Cervical cancer is a top lethal cancer for women worldwide. Although screening and vaccination programs are available in many countries, resulting in the decline of new cases, this is not true for developing countries where there are many new cases and related deaths. Cancer immunotherapy through adaptive cell therapy (ACT) has been applied in clinics, but now much attention is focused on autogenic tumor-infiltrating lymphocyte (TIL)-based therapy, which has shown more specificity and better ability to inhibit tumor growth. Read More

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September 2021

Revelation of candidate genes and molecular mechanism of reproductive seasonality in female rohu (Labeo rohita Ham.) by RNA sequencing.

BMC Genomics 2021 Sep 22;22(1):685. Epub 2021 Sep 22.

Centre for Agricultural Bioinformatics, ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.

Background: Carp fish, rohu (Labeo rohita Ham.) is important freshwater aquaculture species of South-East Asia having seasonal reproductive rhythm. There is no holistic study at transcriptome level revealing key candidate genes involved in such circannual rhythm regulated by biological clock genes (BCGs). Read More

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September 2021

Development and prospective validation of a spatial dose pattern based model predicting acute pulmonary toxicity in patients treated with volumetric arc-therapy for locally advanced lung cancer.

Radiother Oncol 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiation Oncology, University Hospital, Brest, France; LaTIM UMR 1101 INSERM, University Brest, Brest, France.

Introduction: (Chemo)-radiotherapy is the standard treatment for patients with locally advanced lung cancer (LALC) not accessible to surgery. Despite strict application of dose constraints, acute toxicities such as acute pulmonary toxicity (APT) remain frequent, and may impact treatment's compliance and patients' quality of life. Previously, on a population treated with intensity-modulated photon therapy or passive scattering proton therapy, spatial dose patterns associated with APT were identified in the lower lungs, especially in the posterior right lung. Read More

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September 2021

Can TKA outcomes be predicted with computational simulation? Generation of a patient specific planning tool.

Knee 2021 Sep 17;33:38-48. Epub 2021 Sep 17.

360MedCare, Sydney 2073, Australia.

Background: Computer simulations of knee movement allow Total Knee Arthroplasty (TKA) dynamic outcomes to be studied. This study aims to build a model predicting patient reported outcome from a simulation of post-operative TKA joint dynamics.

Methods: Landmark localisation was performed on 239 segmented pre-operative computerized tomography (CT) scans to capture patient specific soft tissue attachments. Read More

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September 2021

Cantil - a new organ or a morphological oddity?

New Phytol 2021 Sep 19. Epub 2021 Sep 19.

School of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram (IISER TVM), Maruthamala PO, Vithura Thiruvananthapuram, Kerala, 695551, India.

Cantil is reported as a newfound organ specific to the model plant Arabidopsis thaliana that is prominent only in short-day grown wild-type accessions or long-day grown genetic mutants with delayed vegetative to reproductive transition. Here, we show that cantils (previously known as nubbins) arise as one of the many phenotypic consequences of aneuploidy resulting from chromosome dosage imbalances in Arabidopsis polyaneuploids despite normal reproductive transition in long-day photoperiods. Without a demonstrated function or adaptive significance, we view cantils as a morphological oddity rather than a separate organ, and as a manifestation of physiological perturbations triggered by genetic and environmental factors. Read More

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September 2021

Pediatric hemispherectomy outcome: Adaptive functioning, intelligence, and memory.

Epilepsy Behav 2021 Sep 16;124:108298. Epub 2021 Sep 16.

Neurosciences, Seattle Children's Hospital, United States; Center for Integrated Brain Research, Seattle Children's Hospital, United States; Department of Neurology, University of Washington School of Medicine, United States; Division of Pediatric Neurology, Seattle Children's Hospital, United States.

Objective: Our purpose was to characterize neuropsychological evaluation (NP) outcome following functional hemispherectomy in a large, representative cohort of pediatric patients.

Methods: We evaluated seizure and NP outcomes and medical variables for all post-hemispherectomy patients from Seattle Children's Hospital epilepsy surgery program between 1996 and 2020. Neuropsychological evaluation outcome tests used were not available on all patients due to the diversity of patient ages and competency that is typical of a representative pediatric cohort; all patients had at least an adaptive functioning or intelligence measure, and a subgroup had memory testing. Read More

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September 2021

Adaptive Hierarchical Dual Consistency for Semi-Supervised Left Atrium Segmentation on Cross-Domain Data.

IEEE Trans Med Imaging 2021 Sep 17;PP. Epub 2021 Sep 17.

Semi-supervised learning provides great significance in left atrium (LA) segmentation model learning with insufficient labelled data. Generalising semi-supervised learning to cross-domain data is of high importance to further improve model robustness. However, the widely existing distribution difference and sample mismatch between different data domains hinder the generalisation of semi-supervised learning. Read More

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September 2021

The evolutionary and physiological significance of the Hif pathway in teleost fishes.

J Exp Biol 2021 Sep 17;224(18). Epub 2021 Sep 17.

Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, Canada, K1N 6N5.

The hypoxia-inducible factor (HIF) pathway is a key regulator of cellular O2 homeostasis and an important orchestrator of the physiological responses to hypoxia (low O2) in vertebrates. Fish can be exposed to significant and frequent changes in environmental O2, and increases in Hif-α (the hypoxia-sensitive subunit of the transcription factor Hif) have been documented in a number of species as a result of a decrease in O2. Here, we discuss the impact of the Hif pathway on the hypoxic response and the contribution to hypoxia tolerance, particularly in fishes of the cyprinid lineage, which includes the zebrafish (Danio rerio). Read More

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September 2021

Optimization Research on Deep Learning and Temporal Segmentation Algorithm of Video Shot in Basketball Games.

Comput Intell Neurosci 2021 6;2021:4674140. Epub 2021 Sep 6.

Arba Minch University, Arba Minch, Ethiopia.

The analysis of the video shot in basketball games and the edge detection of the video shot are the most active and rapid development topics in the field of multimedia research in the world. Video shots' temporal segmentation is based on video image frame extraction. It is the precondition for video application. Read More

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September 2021

Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19.

Eur J Med Res 2021 Sep 16;26(1):107. Epub 2021 Sep 16.

Medical Faculty, University of Dusseldorf, Dusseldorf, Germany.

Background: COVID-19, the pandemic disease caused by infection with SARS-CoV-2, may take highly variable clinical courses, ranging from symptom-free and pauci-symptomatic to fatal disease. The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients' adaptive immune responses without progression to severe disease with patients' Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, and the presence or absence of near-loss-of-function delta 32 deletion mutant of the C-C chemokine receptor type 5 (CCR5).

Patient And Methods: An exploratory observational study including 157 adult COVID-19 convalescent patients was performed with a median follow-up of 250 days. Read More

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September 2021

Abdominal synthetic CT reconstruction with intensity projection prior for MRI-only adaptive radiotherapy.

Phys Med Biol 2021 Sep 16. Epub 2021 Sep 16.

Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, UNITED STATES.

Objective: Owing to the superior soft tissue contrast of MRI, MRI-guided adaptive radiotherapy (ART) is well-suited to managing interfractional changes in anatomy. An MRI-only workflow is desirable, but producing synthetic CT (sCT) data through paired data-driven deep learning (DL) for abdominal dose calculations remains a challenge due to the highly variable presence of intestinal gas. We present the preliminary dosimetric evaluation of our novel approach to sCT reconstruction that is well suited to handling intestinal gas in abdominal MRI-only ART. Read More

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September 2021

Initial analysis of the dosimetric benefit and clinical resource cost of CBCT-based online adaptive radiotherapy for patients with cancers of the cervix or rectum.

J Appl Clin Med Phys 2021 Sep 16. Epub 2021 Sep 16.

Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Purpose: This provides a benchmark of dosimetric benefit and clinical cost of cone-beam CT-based online adaptive radiotherapy (ART) technology for cervical and rectal cancer patients.

Methods: An emulator of a CBCT-based online ART system was used to simulate more than 300 treatments for 13 cervical and 15 rectal cancer patients. CBCT images were used to generate adaptive replans. Read More

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September 2021

Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial.

JAMA Oncol 2021 Sep 16. Epub 2021 Sep 16.

Medical Oncology, Swedish Cancer Institute, Seattle, Washington.

Importance: Residual cancer burden (RCB) distributions may improve the interpretation of efficacy in neoadjuvant breast cancer trials.

Objective: To compare RCB distributions between randomized control and investigational treatments within subtypes of breast cancer and explore the relationship with survival.

Design, Setting, And Participants: The I-SPY2 is a multicenter, platform adaptive, randomized clinical trial in the US that compares, by subtype, investigational agents in combination with chemotherapy vs chemotherapy alone in adult women with stage 2/3 breast cancer at high risk of early recurrence. Read More

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September 2021

Screening and evaluation of the role of immune genes of brain metastasis in lung adenocarcinoma progression based on the TCGA and GEO databases.

J Thorac Dis 2021 Aug;13(8):5016-5034

Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Background: Brain metastasis was one of the factors leading to the poor long-term prognosis of patients with lung adenocarcinoma (LUAD).

Methods: The expression levels of immune genes in LUAD and LUAD brain metastases tissues were analyzed in GSE161116 dataset using the GEO2R, and the levels of differential immune genes in normal lung and LUAD tissues were verified. The biological functions and signaling mechanisms of the differential immune genes were explored via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis. Read More

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Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas.

Front Neurol 2021 30;12:638851. Epub 2021 Aug 30.

Department of Neurosurgery, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Prolactinomas have been reported for the failure of cognitive functions. However, the electrophysiological mechanisms of attention processing in prolactinomas remain unclear. In a visual mission, we monitored the scalp electroencephalography (EEG) of the participants. Read More

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Perspectives on emerging pressures and their integrated impact on large river systems: An insight from the Yellow River basin.

J Environ Manage 2021 Nov 3;298:113423. Epub 2021 Sep 3.

River Research Institute, Department of Hydraulic Engineering, Tsinghua University, Beijing, PR China. Electronic address:

The Yellow River, with a developmental and historical significance to China, is now facing several emerging pressures, which are degrading the river status and creating challenges for high-quality development in the basin. Numerous studies on such emerging pressures, present scattered outcomes, and trigger uncertainties and deficient assumptions on the river's problems. This review integrated such scattered information and investigated the emerging pressures, their drivers and integrated impacts at the basin level. Read More

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November 2021

Evolutionary ecology of climacteric and non-climacteric fruits.

Biol Lett 2021 09 15;17(9):20210352. Epub 2021 Sep 15.

Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.

Fleshy fruits can be divided between climacteric (CL, showing a typical rise in respiration and ethylene production with ripening after harvest) and non-climacteric (NC, showing no rise). However, despite the importance of the CL/NC traits in horticulture and the fruit industry, the evolutionary significance of the distinction remains untested. In this study, we tested the hypothesis that NC fruits, which ripen only on the plant, are adapted to tree dispersers (feeding in the tree), and CL fruits, which ripen after falling from the plant, are adapted to ground dispersers. Read More

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September 2021

Somatostatin Interneurons of the Insula Mediate QR2 Dependent Novel Taste Memory Enhancement.

eNeuro 2021 Sep 13. Epub 2021 Sep 13.

Sagol Department of Neuroscience, University of Haifa, 199 Aba Khoushy Ave., Mount Carmel, Haifa, 3498838, Israel

Forming long term memories is crucial for adaptive behavior and survival in changing environments. The molecular consolidation processes which underlie the formation of these long term memories are dependent on protein synthesis in excitatory and SST expressing neurons. A centrally important, parallel process to this involves the removal of the memory constraint quinone reductase 2 (QR2), which has been recently shown to enhance memory consolidation for novel experiences in the cortex and hippocampus, via redox modulation. Read More

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September 2021

Multimodal analysis of electroencephalographic and electrooculographic signals.

Comput Biol Med 2021 Aug 27;137:104809. Epub 2021 Aug 27.

Department of Computer Science, Faculty of Computers and Information, Mansoura University, 35511, Egypt. Electronic address:

Electrooculography (EOG) is a method to concurrently obtain electrophysiological signals accompanying an Electroencephalography (EEG), where both methods have a common cerebral pattern and imply a similar medical significance. The most common electrophysiological signal source is EOG that contaminated the EEG signal and thereby decreases the accuracy of measurement and the predicated signal strength. In this study, we introduce a method to improve the correction efficiency for EOG artifacts (EOAs) on raw EEG recordings: We retrieve cerebral information from three EEG signals with high system performance and accuracy by applying feature engineering and a novel machine-learning (ML) procedure. Read More

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Probabilistic Model-based Learning Control of a Soft Pneumatic Glove for Hand Rehabilitation.

IEEE Trans Biomed Eng 2021 Sep 13;PP. Epub 2021 Sep 13.

Objective: Stroke survivors are usually unable to perform activities of daily living (ADL) independently due to loss of hand functions. Soft pneumatic gloves provide a promising assistance approach for stroke survivors to conduct ADL tasks. However, few studies have explored effective control strategies for the 'human-soft robot' integrated system due to challenges in the nonlinearities of soft robots and uncertainties of human intentions. Read More

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September 2021

Crop genetic erosion: understanding and responding to loss of crop diversity.

New Phytol 2021 Sep 13. Epub 2021 Sep 13.

Federal Office for Agriculture and Food (BLE), Information and Coordination Centre for Biological Diversity (IBV), Deichmanns Aue 29, 53179, Bonn, Germany.

Crop diversity underpins the productivity, resilience, and adaptive capacity of agriculture. Loss of this diversity, termed crop genetic erosion, is therefore concerning. While alarms regarding evident declines in crop diversity have been raised for over a century, the magnitude, trajectory, drivers, and significance of these losses remain insufficiently understood. Read More

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September 2021

Role of Immune Cell-Specific Hypermethylation Signatures in Classification and Risk Stratification of Breast Cancer.

Front Med (Lausanne) 2021 26;8:674338. Epub 2021 Aug 26.

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China.

Epigenetic regulation, including DNA methylation, plays a major role in shaping the identity and function of immune cells. Innate and adaptive immune cells recruited into tumor tissues contribute to the formation of the tumor immune microenvironment (TIME), which is closely involved in tumor progression in breast cancer (BC). However, the specific methylation signatures of immune cells have not been thoroughly investigated yet. Read More

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Vision-correcting holographic display: evaluation of aberration correcting hologram.

Biomed Opt Express 2021 Aug 22;12(8):5179-5195. Epub 2021 Jul 22.

School of Electrical and Computer Engineering, Seoul National University, Gwanak-gu Gwanak-ro 1, Seoul 08826, Republic of Korea.

Vision-correcting displays are key to achieving physical and physiological comforts to the users with refractive errors. Among such displays are holographic displays, which can provide a high-resolution vision-adaptive solution with complex wavefront modulation. However, none of the existing hologram rendering techniques have considered the optical properties of the human eye nor evaluated the significance of vision correction. Read More

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