Crit Care Med 2021 Sep 16. Epub 2021 Sep 16.
Pathophysiology of Injury-Induced Immunosuppression (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, Immunology Laboratory & Anesthesia and Critical Care Medicine Department, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France. BIOASTER, Lyon, France. Sanofi Pasteur, Marcy l'Etoile, France. GSK, GSK Medicines Research Centre, Stevenage, United Kingdom. Laboratoire de Biochimie (LBC), ESPCI Paris, PSL Université, CNRS UMR8231, Paris, France.
Objectives: The host response plays a central role in the pathophysiology of sepsis and severe injuries. So far, no study has comprehensively described the overtime changes of the injury-induced immune profile in a large cohort of critically ill patients with different etiologies.
Design: Prospective observational cohort study. Read More