Life Sci 2021 Jul 19:119845. Epub 2021 Jul 19.
Laboratory of Molecular Biology, VA New Jersey Health Care System, Research & Development (Mailstop 15), Bldg. 16, Rm. 16-176, 385 Tremont Ave, East Orange, NJ 07018, United States of America; Rutgers School of Graduate Studies, Newark, NJ 07103, United States of America; Laboratory of Molecular Biology, Bay Pines VA Healthcare System, Research and Development, 151, Bldg. 22, Rm. 123, 10000 Bay Pines Blvd, Bay Pines, FL 33744, United States of America; Pharmacology, Physiology, and Neuroscience, Rutgers-New Jersey Medical School, Newark, NJ 07103, United States of America. Electronic address:
Aims: Approximately 30% of the nearly 700,000 Veterans who were deployed to the Gulf War from 1990 to 1991 have reported experiencing a variety of symptoms including difficulties with learning and memory, depression and anxiety, and increased incidence of neurodegenerative diseases. Combined toxicant exposure to acetylcholinesterase (AChE) inhibitors has been studied extensively as a likely risk factor. In this study, we modeled Gulf War exposure in male C57Bl/6J mice with simultaneous administration of three chemicals implicated as exposure hazards for Gulf War Veterans: pyridostigmine bromide, the anti-sarin prophylactic; chlorpyrifos, an organophosphate insecticide; and the repellant N,N-diethyl-m-toluamide (DEET). Read More