1,387,762 results match your criteria acute timepoints


Increase in SARS-CoV-2 infected biomedical waste among low middle-income countries: environmental sustainability and impact with health implications.

J Basic Clin Physiol Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Department of Anatomical Sciences, School of Medicine and Allied Health Sciences, University of the Gambia, Serekunda, The Gambia.

Studies have shown that severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) is a highly infectious disease, with global deaths rising to about 360,438 as of 28 May 2020. Different countries have used various approaches such as lockdown, social distancing, maintenance of personal hygiene, and increased establishment of testing and isolation centers to manage the pandemic. Poor biomedical waste (BMW) management, treatment, and disposal techniques, especially SARS-CoV-2 infected BMW, may threaten the environmental and public health in most developing countries and, by extension, impact the economic status of individuals and the nation at large. Read More

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Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.

Br J Clin Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Centre for Human Drug Research, Leiden, the Netherlands.

Introduction: Whereas intravenous administration of TLR4 ligand lipopolysaccharide (LPS) to human volunteers is frequently used in clinical pharmacology studies, systemic use of LPS has practical limitations. We aimed to characterize the intradermal LPS response in healthy volunteers, and as such qualify the method as local inflammation model for clinical pharmacology studies.

Methods: 18 healthy male volunteers received two or four intradermal 10 ng LPS injections and one saline injection on the forearms. Read More

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Combined Central Retinal Arterial and Venous Occlusions due to Leukemic Infiltration.

Retin Cases Brief Rep 2021 Sep 19. Epub 2021 Sep 19.

Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium Department of Pathology, Antwerp University Hospital, Edegem, Belgium Department of Radiology, Antwerp University Hospital, Edegem, Belgium Faculty of Health Sciences, University of Antwerp, Edegem, Belgium Name and address for correspondence: Vincent M. De La Porte, M.D. E-mail: Telephone: +32 3 821 4428, Address: Department of Ophthalmology, Antwerp University Hospital, 2650 Edegem, Belgium.

Purpose: To report combined central arterial and venous occlusions secondary to bilateral leukemic interfascicular optic nerve infiltration in a 56-year-old man. This was the sole presentation of a relapse in T/Myeloid mixed-phenotype acute leukemia after 5 months of remission.

Methods: Case report with clinical photography. Read More

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September 2021

Accelerated Progression of Diabetic Retinopathy in a Patient with Acquired Lipodystrophy Following Hematopoietic Stem Cell Transplantation.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan.

Purpose: To report a case of bilateral proliferative diabetic retinopathy and lipemia retinalis in a patient with acquired lipodystrophy.

Methods: A retrospective case report.

Results: A 23-year-old woman with a diagnosis of acquired lipodystrophy was referred for ophthalmic evaluation. Read More

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Anemia in Pregnancy: ACOG Practice Bulletin, Number 233.

Authors:

Obstet Gynecol 2021 Aug;138(2):e55-e64

Anemia, the most common hematologic abnormality, is a reduction in the concentration of erythrocytes or hemoglobin in blood. The two most common causes of anemia in pregnancy and the puerperium are iron deficiency and acute blood loss. Iron requirements increase during pregnancy, and a failure to maintain sufficient levels of iron may result in adverse maternal-fetal consequences. Read More

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Anemia in Pregnancy: ACOG Practice Bulletin Summary, Number 233.

Authors:

Obstet Gynecol 2021 Aug;138(2):317-319

Anemia, the most common hematologic abnormality, is a reduction in the concentration of erythrocytes or hemoglobin in blood. The two most common causes of anemia in pregnancy and the puerperium are iron deficiency and acute blood loss. Iron requirements increase during pregnancy, and a failure to maintain sufficient levels of iron may result in adverse maternal-fetal consequences. Read More

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Acute Fatty Liver of Pregnancy.

Obstet Gynecol 2021 Aug;138(2):307

Hepatology Department, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France.

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A perspective on hospital-acquired (nosocomial) infection control of COVID-19: usefulness of spatial separation between wards and airborne isolation unit.

J Breath Res 2021 Jul 22. Epub 2021 Jul 22.

Emergency Medicine and Critical Care, Saitama Medical Center, 1981 Kamoda, Kawagoe, Saitama, 350-8550, JAPAN.

The coronavirus disease 2019 (COVID-19) pandemic has imposed a considerable burden on hospitals and healthcare workers (HCWs) worldwide, increasing the risk of outbreaks and nosocomial transmission to "non-COVID-19" patients, who represent the highest-risk population in terms of mortality, and HCWs. Since HCWs are at the interface between hospitals on the one hand and the community on the other, they are potential reservoirs, carriers, or victims of severe acute respiratory syndrome coronavirus 2 cross-transmission. In addition, there has been a paradigm shift in the management of viral respiratory outbreaks, such as the widespread testing of patients and HCWs, including asymptomatic individuals. Read More

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Clinical sympathy - A mixed method study of the relationship between the clinical nurse educator and the graduate nurse.

Nurse Educ Pract 2021 Jul 14;55:103150. Epub 2021 Jul 14.

School of Medicine, University of Notre Dame Australia, Henry Street, Fremantle 6160, Western Australia, Australia.

Aim/objective: This paper sought to investigate the influence of the supernumerary clinical nurse educator role on the newly qualified graduate nurses' professional development and successful transition to competent and confident practitioners in the acute care hospital environment.

Background: The novice nurses learning in the inpatient clinical environment is affected by increasing patient acuity, complex conditions and organisational expectations. The supernumerary clinical nurse educator is uniquely positioned to prioritise these nurses' education through protected and available time to support adaption in the workplace culture and retention in the organisation. Read More

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The usefulness of postmortem computed tomography angiography for subdural hematoma caused by rupture of the cortical artery: A report of two autopsy cases and a literature review.

Leg Med (Tokyo) 2021 Jul 12;53:101941. Epub 2021 Jul 12.

Division of Legal Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Center of Cause of Death Investigation, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Acute subdural hematoma (SDH) occurs following severe head trauma with brain contusion or rupture of bridging veins. Conversely, SDH caused by rupture of a cortical artery without trauma or with minor trauma is also possible. Although over 150 cases of the latter SDH have been reported, they were predominantly diagnosed only during surgery, and therefore, no adequate histological evaluation has been performed. Read More

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Acute autoimmune-like hepatitis with atypical anti-mitochondrial antibody after mRNA COVID-19 vaccination: A novel clinical entity?

J Autoimmun 2021 Jul 15;123:102706. Epub 2021 Jul 15.

Epatocentro Ticino, Via Soldino 5, 6900, Lugano, Switzerland; King's College London Faculty of Life Sciences & Medicine, Institute of Liver Studies, MowatLabs, London, UK; Faculty of Biomedical Sciences, Università Della Svizzera Italiana, 6900, Lugano, Switzerland. Electronic address:

Autoimmune phenomena and clinically apparent autoimmune diseases, including autoimmune hepatitis, are increasingly been reported not only after natural infection with the SARS-CoV-2 virus, but also after vaccination against it. We report the case of a 63-year old man without a history of autoimmunity or SARS-CoV-2 natural infection who experienced acute severe autoimmune-like hepatitis seven days after the first dose of the mRNA-1273 SARS-CoV-2 vaccine. Liver histology showed inflammatory portal infiltrate with interface hepatitis, lobular and centrilobular inflammation with centrilobular necrosis, in absence of fibrosis and steatosis. Read More

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Threatening Blindness in a Child With Typical Hemolytic Uremic Syndrome.

Pediatr Neurol 2021 Jun 25;122:35-37. Epub 2021 Jun 25.

Department of Paediatric Neurology, APHM La Timone, Marseille, France. Electronic address:

Background: Hemolytic uremic syndrome (HUS) is the most common cause of acute kidney failure in children younger than five years. Central nervous system involvement occurs in 15% of patients, with clinical manifestations including confusion, coma, seizures, stroke, and cortical blindness. Ocular involvement in children with HUS is rare, but retinal and choroidal hemorrhages as well as ischemic retinopathy due to thrombotic microangiopathic lesions have been documented. Read More

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Effect of Guo Qing Yi Tang combined with Western medicine cluster therapy on acute pancreatitis.

Am J Emerg Med 2021 Jul 8;50:66-70. Epub 2021 Jul 8.

Department of Critical Care Medicine, Jinjiang Hospital of Traditional Chinese Medicine, Jinjiang 362200, Fujian province, People's Republic of China.

Background: This study evaluated the effect of Guo Qing Yi Tang (GQYT) combined with Western medicine cluster therapy on acute pancreatitis (AP).

Methods: A total of 138 AP patients were recruited and divided into the observation group (68 patients) and control group (70 patients). The control group was treated with cluster therapy alone, while the observation group was treated with trans-jejunum feeding of GQYT combined with cluster therapy. Read More

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Facing stress: No effect of acute stress at encoding or retrieval on face recognition memory.

Acta Psychol (Amst) 2021 Jul 19;219:103376. Epub 2021 Jul 19.

Department of Clinical Psychological Science, Maastricht University, Maastricht, Netherlands.

Eyewitnesses may experience stress during a crime and when attempting to identify the perpetrator subsequently. Laboratory studies can provide insight into how acute stress at encoding and retrieval affects memory performance. However, previous findings exploring this issue have been mixed. Read More

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Endoscopic Endonasal Approach for Giant Pituitary Adenoma Occupying The Entire Third Ventricle: Surgical Results and A Review of Literature.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurosurgery , Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India - 695011. Electronic address:

Background: Pituitary macroadenomas, occasionally, disrupt the sellar diaphragm and extend directly to the third ventricle causing hydrocephalus.

Objective: We present the results of a single stage extended endoscopic approach for managing giant pituitary adenomas occupying the entire third ventricle.

Methods: A retrospective study of all giant pituitary adenomas, occupying the entire third ventricle, operated via the endoscopic endonasal approach between January 2016 and December 2020 was performed. Read More

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Penicillin allergy label increases risk of worse clinical outcomes in COVID-19.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

Division of Gastroenterology and Hepatology, Pennsylvania State University College of Medicine, Hershey, PA, USA.

Background: Coronavirus disease-2019 (COVID-19) ranges from asymptomatic to severe. Several co-morbidities are associated with worse clinical outcomes. Antibiotic use is common in COVID-19 and penicillin (PCN) allergy can impact antibiotic choice and may influence COVID-19 outcomes. Read More

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Enteric adenovirus epidemiology from historical fecal samples in Brazil (1998-2005): Pre-rotavirus vaccine era.

Infect Genet Evol 2021 Jul 19:105007. Epub 2021 Jul 19.

Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, Sao Paulo, Brazil. Electronic address:

Human adenovirus (HAdV) is recognized as frequent cause of acute gastroenteritis and enteric viruses can be preserved in frozen stored feces for long periods of times. The purpose of the present study was to investigate enteric HAdV genotypic diversity in archival fecal specimens stored from 1998 to 2005 in order to understand the natural history of HAdV in diarrheal patients in Brazil before rotavirus vaccine introduction. A total of 3346 specimens were tested for HAdV using conventional PCR. Read More

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Wu-Zi-Yan-Zong-Wan protects mouse blood-testis barrier from Tripterygium wilfordii Hook. f. multiglycoside-induced disruption by regulating proinflammatory cytokines.

J Ethnopharmacol 2021 Jul 19:114440. Epub 2021 Jul 19.

Department of Gynecology, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China. Electronic address:

Ethnopharmacological Relevance: Wu-Zi-Yan-Zong-Wan (WZYZW) is a classical traditonal Chinese herbal formula and a Chinese patent medicine used to treat male infertility. However, the chemical components of WZYZW and its mechanism are not yet fully clarified.

Aim Of The Study: The purpose of this study is to observe the effect and underlying mechanism of WZYZW on ameliorating blood-testis barrier (BTB) dysfunction in mice with spermatogenic dysfunction induced by administration of Tripterygium wilfordii Hook. Read More

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Automated read-across workflow for predicting acute oral toxicity: I. The decision scheme in the QSAR Toolbox.

Regul Toxicol Pharmacol 2021 Jul 19:105015. Epub 2021 Jul 19.

Laboratory of Mathematical Chemistry, Prof. As. Zlatarov University, Bourgas, Bulgaria. Electronic address:

A decision-scheme outlining the steps for identifying the appropriate chemical category and subsequently appropriate tested source analog(s) for data gap filling of a target chemical by read-across is described. The primary features used in the grouping of the target chemical with source analogs within a database of 10,039 discrete organic substances include reactivity mechanisms associated with protein interactions and specific-acute-oral-toxicity-related mechanisms (e.g. Read More

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Design and evaluation of GLP-1 receptor G-protein biased agonist with prolonged efficacy on diabetes.

Life Sci 2021 Jul 19:119844. Epub 2021 Jul 19.

Peking University Third Hospital, Beijing 100191, PR China. Electronic address:

Aim: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as potent drug development target for treating diabetes and obesity. Here, we designed and evaluated novel long-acting GLP-1R G protein biased agonist with potent clinical application.

Main Methods: GLP-1R G-protein biased sequences were screened via a high-throughput autocrine-based strategy and then fused to Exendin (9-39). Read More

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Acute gene expression changes in the mouse hippocampus following a combined Gulf War toxicant exposure.

Life Sci 2021 Jul 19:119845. Epub 2021 Jul 19.

Laboratory of Molecular Biology, VA New Jersey Health Care System, Research & Development (Mailstop 15), Bldg. 16, Rm. 16-176, 385 Tremont Ave, East Orange, NJ 07018, United States of America; Rutgers School of Graduate Studies, Newark, NJ 07103, United States of America; Laboratory of Molecular Biology, Bay Pines VA Healthcare System, Research and Development, 151, Bldg. 22, Rm. 123, 10000 Bay Pines Blvd, Bay Pines, FL 33744, United States of America; Pharmacology, Physiology, and Neuroscience, Rutgers-New Jersey Medical School, Newark, NJ 07103, United States of America. Electronic address:

Aims: Approximately 30% of the nearly 700,000 Veterans who were deployed to the Gulf War from 1990 to 1991 have reported experiencing a variety of symptoms including difficulties with learning and memory, depression and anxiety, and increased incidence of neurodegenerative diseases. Combined toxicant exposure to acetylcholinesterase (AChE) inhibitors has been studied extensively as a likely risk factor. In this study, we modeled Gulf War exposure in male C57Bl/6J mice with simultaneous administration of three chemicals implicated as exposure hazards for Gulf War Veterans: pyridostigmine bromide, the anti-sarin prophylactic; chlorpyrifos, an organophosphate insecticide; and the repellant N,N-diethyl-m-toluamide (DEET). Read More

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Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD.

Am J Kidney Dis 2021 Jul 19. Epub 2021 Jul 19.

University of Maryland School of Medicine, Department of Medicine.

Rationale & Objective: The utility of conventional upper reference limits (URL) for N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population.

Study Design: Observational study. Read More

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Influenza-Associated Neurologic Complications in Hospitalized Children.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

Divisions of Neurology, The Children's Hospital of Philadelphia; Departments of Neurology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:

Objectives: To define the incidence and characteristics of influenza-associated neurologic complications in a cohort of children hospitalized at a tertiary care pediatric hospital with laboratory-confirmed influenza, and to identify associated clinical, epidemiologic, and virologic factors.

Study Design: Historical cohort study of children 0.5-18. Read More

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Microbial production, molecular modification, and practical application of l-Asparaginase: A review.

Int J Biol Macromol 2021 Jul 19. Epub 2021 Jul 19.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China.

L-Asparaginase (L-ASNase, EC 3.5.1. Read More

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Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis.

Cell Stem Cell 2021 Jul 12. Epub 2021 Jul 12.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medicine, University of Toronto, ON, Canada; Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, ON, Canada. Electronic address:

Current treatments for acute myeloid leukemia (AML) are often ineffective in eliminating leukemic stem cells (LSCs), which perpetuate the disease. Here, we performed a metabolic drug screen to identify LSC-specific vulnerabilities and found that nicotinamide phosphoribosyltransferase (NAMPT) inhibitors selectively killed LSCs, while sparing normal hematopoietic stem and progenitor cells. Treatment with KPT-9274, a NAMPT inhibitor, suppressed the conversion of saturated fatty acids to monounsaturated fatty acids, a reaction catalyzed by the stearoyl-CoA desaturase (SCD) enzyme, resulting in apoptosis of AML cells. Read More

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Proteome plasticity in response to persistent environmental change.

Mol Cell 2021 Jul 13. Epub 2021 Jul 13.

Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA; USC Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave., Los Angeles, CA 90191, USA. Electronic address:

Temperature is a variable component of the environment, and all organisms must deal with or adapt to temperature change. Acute temperature change activates cellular stress responses, resulting in refolding or removal of damaged proteins. However, how organisms adapt to long-term temperature change remains largely unexplored. Read More

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Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2.

J Control Release 2021 Jul 19. Epub 2021 Jul 19.

Institute of Inorganic Chemistry, Department of Chemistry, , University of Cologne, Greinstraße 6, 50939 Cologne, Germany.

The coronavirus disease-19 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has taken the world by surprise. To date, a worldwide approved treatment remains lacking and hence in the context of rapid viral spread and the growing need for rapid action, drug repurposing has emerged as one of the frontline strategies in the battle against SARS-CoV2. Repurposed drugs currently being evaluated against COVID-19 either tackle the replication and spread of SARS-CoV2 or they aim at controlling hyper-inflammation and the rampaged immune response in severe disease. Read More

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Parapneumonic Effusions are characterized by elevated levels of Neutrophil Extracellular Traps (NETs).

Chest 2021 Jul 19. Epub 2021 Jul 19.

School of Medicine and Public Health, Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, The University of Newcastle, NSW, Australia and Hunter Medical Research Institute, Newcastle, NSW, Australia.

Background: Neutrophil Extracellular Traps (NETs) are increasingly implicated in acute and chronic conditions involving multiple organ systems.

Research Question: Are NETs concentrations higher in parapneumonic effusions compared to effusions of other etiologies and does this reflect the inflammatory nature of these effusions?

Study Design And Methods: Patients (N=101) presenting to hospital with undifferentiated pleural effusion for investigation had pleural fluid classified based on cytology, biochemical, microbiological characteristics, and clinical judgement. Concentrations of NETs markers (extracellular DNA, citrullinated histone H3 (citH3)), neutrophil (α-defensins) and inflammation (Interleukin-1β (IL-1β)) related proteins were quantified by ELISA. Read More

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Covid-19 and Risk of Venous Thromboembolism in Ethnically Diverse Populations.

Chest 2021 Jul 19. Epub 2021 Jul 19.

Department of Medicine, University of California, San Francisco, San Francisco, CA USA.

Background: Limited existing data suggest the novel coronavirus disease 2019 (Covid-19) may increase risk for venous thromboembolism (VTE) but information from large, ethnically diverse populations with appropriate controls are lacking.

Research Question: Does the rate of VTE among adults hospitalized with Covid-19 differ from matched hospitalized controls without Covid-19?

Study Design And Methods: We conducted a retrospective study among hospitalized adults with laboratory-confirmed Covid-19 and hospitalized adults without evidence of Covid-19 matched on age, gender, race/ethnicity, acute illness severity, and month of hospitalization between February-August 2020 from two integrated healthcare delivery systems with 36 hospitals. Outcomes included VTE (deep venous thrombosis or pulmonary embolism ascertained using diagnosis codes combined with validated natural language processing algorithms applied to electronic health records) and death from any cause at 30 days. Read More

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Using optogenetics to link myosin patterns to contractile cell behaviors during convergent extension.

Biophys J 2021 Jul 19. Epub 2021 Jul 19.

Department of Mechanical Engineering, Columbia University, New York, New York, 10027, USA. Electronic address:

Distinct patterns of actomyosin contractility are often associated with particular epithelial tissue shape changes during development. For example, a planar polarized pattern of myosin II localization regulated by Rho1 signaling during Drosophila body axis elongation is thought to drive cell behaviors that contribute to convergent extension. However, it is not well understood how specific aspects of a myosin pattern influence the multiple cell behaviors-including cell intercalation, cell shape changes, and apical cell area fluctuations-that simultaneously occur during morphogenesis. Read More

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