362,739 results match your criteria acute stroke

Comparison of patterns of infarction in TB and cryptococcal meningitis.

Trans R Soc Trop Med Hyg 2021 May 7. Epub 2021 May 7.

Department of Internal Medicine, All India Institute of Medical Sciences, Raipur, 492099, India.

Background: To compare the frequency and patterns of stroke, the specificity of tubercular zone (TBZ) infarction and its effect on outcomes in TB (TBM) and cryptococcal meningitis (CM).

Methods: This retrospective study was conducted at two tertiary centres in India from May 2018 to July 2020. Sixty-one patients with TBM and 22 with CM were included. Read More

View Article and Full-Text PDF

New challenges in vascular biology and medicine: from unravelling the mechanisms of neointima formation to the prevention of amputations and of ischaemic stroke.

Filippo Crea

Eur Heart J 2021 May;42(18):1715-1719

Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

View Article and Full-Text PDF

Cost-effectiveness of endovascular thrombectomy in patients with low Alberta Stroke Program Early CT Scores (< 6) at presentation.

J Neurosurg 2021 May 7:1-11. Epub 2021 May 7.

Departments of1Radiology and Biomedical Imaging and.

Objective: The utility of endovascular thrombectomy (EVT) in patients with acute ischemic stroke, large vessel occlusion (LVO), and low Alberta Stroke Program Early CT Scores (ASPECTS) remains uncertain. The objective of this study was to determine the health outcomes and cost-effectiveness of EVT versus medical management in patients with ASPECTS < 6.

Methods: A decision-analytical study was performed with Markov modeling to estimate the lifetime quality-adjusted life-years (QALYs) and associated costs of EVT-treated patients compared to medical management. Read More

View Article and Full-Text PDF

Distinct Clinical and Radiographic Phenotypes in Pediatric Patients With Moyamoya.

Pediatr Neurol 2021 Apr 2;120:18-26. Epub 2021 Apr 2.

Division of Neurology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Given the expanding evidence of clinico-radiological differences between moyamoya disease (MMD) and moyamoya syndrome (MMS), we compared the clinical and radiographic features of childhood MMD and MMS to identify predictors of ischemic event recurrence.

Methods: We reviewed a pediatric moyamoya cohort followed between 2003 and 2019. Clinical and radiographic characteristics at diagnosis and follow-up were abstracted. Read More

View Article and Full-Text PDF

Potential of dual-layer spectral CT for the differentiation between hemorrhage and iodinated contrast medium in the brain after endovascular treatment of ischemic stroke patients.

Clin Imaging 2021 Apr 29;79:158-164. Epub 2021 Apr 29.

Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany.

Background: One possible complication after mechanical thrombectomy is hemorrhage. In conventional CT it is often difficult to differ between extravasation of iodinated contrast medium and blood. This differentiation, however, is essential for treatments with anticoagulants and antiplatelets. Read More

View Article and Full-Text PDF

Evolutionary algorithms and decision trees for predicting poor outcome after endovascular treatment for acute ischemic stroke.

Comput Biol Med 2021 Apr 21;133:104414. Epub 2021 Apr 21.

Department of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Despite the large overall beneficial effects of endovascular treatment in patients with acute ischemic stroke, severe disability or death still occurs in almost one-third of patients. These patients, who might not benefit from treatment, have been previously identified with traditional logistic regression models, which may oversimplify relations between characteristics and outcome, or machine learning techniques, which may be difficult to interpret. We developed and evaluated a novel evolutionary algorithm for fuzzy decision trees to accurately identify patients with poor outcome after endovascular treatment, which was defined as having a modified Rankin Scale score (mRS) higher or equal to 5. Read More

View Article and Full-Text PDF

Smart glasses evaluation during the COVID-19 pandemic: First-use on Neurointerventional procedures.

Clin Neurol Neurosurg 2021 Apr 19;205:106655. Epub 2021 Apr 19.

Interventional Neuroradiology, Clinical Hospital Center "Sisters of Mercy", Zagreb, Croatia.

The COVID-19 pandemic is rapidly transforming the healthcare system, with telemedicine, or virtual health, being one of the key drivers of the change. Smart glasses have recently been introduced to the public and have generated interest with healthcare professionals as demonstrated by their early adoption in clinics and hospitals. Observing procedures is essential for young interventionalist-in-training, but sometimes it is difficult for them to be able to get the volume of exposure to procedures that they need. Read More

View Article and Full-Text PDF

Effect modification of the association between diurnal temperature range and hospitalisations for ischaemic stroke by temperature in Hefei, China.

Public Health 2021 May 4;194:208-215. Epub 2021 May 4.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, China. Electronic address:

Objectives: Diurnal temperature range (DTR) is an important indicator of global climate change. Many epidemiological studies have reported the associations between high DTR and human health. This study investigated the association between DTR and hospitalisations for ischaemic stroke in Hefei, China. Read More

View Article and Full-Text PDF

Neurovascular-modulation: A review of primary vascular responses to transcranial electrical stimulation as a mechanism of action.

Brain Stimul 2021 May 4. Epub 2021 May 4.

Department of Biomedical Engineering, The City College of New York (CCNY), New York, NY, USA.

Background: The ubiquitous vascular response to transcranial electrical stimulation (tES) has been attributed to the secondary effect of neuronal activity forming the classic neurovascular coupling. However, the current density delivered transcranially concentrates in: A) the cerebrospinal fluid of subarachnoid space where cerebral vasculature resides after reaching the dural and pial surfaces and B) across the blood-brain-barrier after reaching the brain parenchyma. Therefore, it is anticipated that tES has a primary vascular influence. Read More

View Article and Full-Text PDF

Central and Peripheral Arterial Diseases in Chronic Kidney Disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2021 May 4. Epub 2021 May 4.

Department of Cardiology I: Coronary and Peripheral Vascular Disease, Heart Failure, Münster University Hospital, Münster, Germany. Electronic address:

Chronic kidney disease (CKD) affects about 10% of all populations worldwide, with about 2 million people requiring dialysis. Although patients with CKD are at high risk of cardiovascular disease (CVD) and events, they are often underrepresented or excluded in clinical trials, leading to important knowledge gaps about how to treat these patients. KDIGO (Kidney Disease: Improving Global Outcomes) convened the fourth Clinical Controversies Conference on the Heart, Kidney and Vasculature in Dublin, Ireland, in February 2020, entitled "Central and Peripheral Arterial Diseases in Chronic Kidney Disease. Read More

View Article and Full-Text PDF

Work-life conflict and cardiovascular health: 5-year follow-up of the Gutenberg Health Study.

PLoS One 2021 7;16(5):e0251260. Epub 2021 May 7.

Institute and Policlinic of Occupational and Social Medicine (IPAS), Faculty of Medicine Carl Gustav Carus, TU Dresden, Germany.

Introduction: Work-life conflicts (WLC) may impact health, but few studies prospectively consider the impact of WLC on objective outcomes such as cardiovascular disease. Using data from the Gutenberg Health Study (GHS), we examined if WLC at baseline was associated with an increased five-year incidence of cardiovascular events (myocardial infarct, stroke, atrial fibrillation, peripheral artery disease, coronary artery disease, chronic heart failure, sudden cardiac death). We also considered if WLC was associated with incident hypertension and arterial stiffness and if the effects of WLC on cardiovascular health differ for men and women. Read More

View Article and Full-Text PDF

An exploration of goal-setting practices in Queensland rehabilitation services.

Disabil Rehabil 2021 May 7:1-11. Epub 2021 May 7.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia.

Background: Goals are vital in rehabilitation; however, how goal-setting occurs varies widely in clinical practice. This study aims to review goal-setting practices across the rehabilitation continuum within varied case mix services in Queensland, Australia.

Method: A descriptive multisite qualitative case study with medical record audits and interviews of adult rehabilitation clients was used to evaluate four propositions across three inpatient and two community rehabilitation services. Read More

View Article and Full-Text PDF

Olive Oil Intake and Cardiovascular Disease Prevention: "Seek and You Shall Find".

Curr Cardiol Rep 2021 May 7;23(6):64. Epub 2021 May 7.

Lipid and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital, University of Cordoba, Avda. Menendez Pidal, s/n., 14004, Cordoba, Spain.

Purpose Of Review: The present narrative review focuses on the up-to-date clinical data on the correlations between olive oil consumption and cardiovascular (CV) diseases (i.e., CHD, stroke, and peripheral artery disease). Read More

View Article and Full-Text PDF

Impact of Early Blood Pressure Lowering in Patients Presenting with Acute Ischemic Stroke.

Curr Cardiol Rep 2021 May 7;23(6):63. Epub 2021 May 7.

Department of Neurology, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.

Purpose Of Review: In this review article we will discuss the acute hypertensive response in the context of acute ischemic stroke and present the latest evidence-based concepts of the significance and management of the hemodynamic response in acute ischemic stroke.

Recent Findings: Acute hypertensive response is considered a common hemodynamic physiologic response in the early setting of an acute ischemic stroke. The significance of the acute hypertensive response is not entirely well understood. Read More

View Article and Full-Text PDF

Functional motor phenotypes: to lump or to split?

J Neurol 2021 May 7. Epub 2021 May 7.

IRCCS Mondino Foundation, Pavia, Italy.

Introduction: Functional motor disorders (FMDs) are usually categorized according to the predominant phenomenology; however, it is unclear whether this phenotypic classification mirrors the underlying pathophysiologic mechanisms.

Objective: To compare the characteristics of patients with different FMDs phenotypes and without co-morbid neurological disorders, aiming to answer the question of whether they represent different expressions of the same disorder or reflect distinct entities.

Methods: Consecutive outpatients with a clinically definite diagnosis of FMDs were included in the Italian registry of functional motor disorders (IRFMD), a multicenter data collection platform gathering several clinical and demographic variables. Read More

View Article and Full-Text PDF

In patients with multi-vessel coronary artery diseases, does hybrid revascularization provide similar outcomes to conventional coronary artery bypass grafting?

Interact Cardiovasc Thorac Surg 2021 May 7. Epub 2021 May 7.

Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK.

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: In [patients with multivessel coronary artery diseases (CAD)] is [hybrid revascularization (HCR)] equal to [coronary artery bypass grafting (CABG)] in regard to [mortality, myocardial infarction, stroke and target vessel revascularization (TVR)]? Three-hundred and fifty-five papers were found using the reported search, of which 8 represented the best evidence to answer the question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Read More

View Article and Full-Text PDF

Healthcare Quality Assessments: No Guarantees of Same Outcomes for Different Socioeconomic Stroke Patients.

Int J Qual Health Care 2021 May 7. Epub 2021 May 7.

Health Insurance Review & Assessment Service, Wonju, Korea.

Background: Health care quality assessment is being conducted in many countries. However, although improving health equity is one of the major objectives of medical quality assessment, it is not clear whether different socioeconomic statuses shows the same health outcomes even in the same medical quality hospitals. No study has directly compared the health outcomes of different socioeconomic status in the same hospitals nationwide. Read More

View Article and Full-Text PDF

Colchicine and the heart.

Eur Heart J 2021 May 7. Epub 2021 May 7.

GenesisCare, 3/140 Mounts Bay Rd, Perth, Western Australia, Australia.

Colchicine is a unique, sophisticated anti-inflammatory agent that has been used for decades for the prevention of acute inflammatory flares in gout and familial Mediterranean fever. In recent years, clinical trials have demonstrated its potential in a range of cardiovascular (CV) conditions. Colchicine is avidly taken up by leucocytes, and its ability to bind to tubulin and interfere with microtubular function affects the expression of cytokines and interleukins, and the ability of neutrophils to marginate, ingress, aggregate, express superoxide, release neutrophil extracellular traps, and interact with platelets. Read More

View Article and Full-Text PDF

Content validity of the Brief and Comprehensive ICF Core Sets for common disabling conditions in a developing country.

Int J Rehabil Res 2021 Jun;44(2):159-165

Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine.

The International Classification of Functioning, Disability and Health (ICF) features associated tools, the Brief and Comprehensive ICF Core Sets. These are designed to be universally applicable, but have limited evidence of content validity (i.e. Read More

View Article and Full-Text PDF

Anesthetic Management for Endovascular Treatment of Stroke in Patients With Coronavirus Disease 2019: A Case Series.

A A Pract 2021 May 7;15(5):e01458. Epub 2021 May 7.

From the Department of Anesthesiology, Columbia University Medical Center, NewYork-Presbyterian Hospital, New York, New York.

A significant number of patients with coronavirus disease 2019 develop strokes with large vessel obstructions that may require endovascular treatment for revascularization. Our series focuses on periprocedural issues and the anesthetic management of these patients. We analyzed medical records of 5 patients with positive reverse transcription polymerase chain reaction tests for severe acute respiratory syndrome coronavirus 2 during their hospitalization who underwent endovascular treatment at our hospital between March and mid-June 2020. Read More

View Article and Full-Text PDF

fMRI-based detection of alertness predicts behavioral response variability.

Elife 2021 May 7;10. Epub 2021 May 7.

Department of Biomedical Engineering, Vanderbilt University, Nashville, United States.

Levels of alertness are closely linked with human behavior and cognition. However, while functional magnetic resonance imaging (fMRI) allows for investigating whole-brain dynamics during behavior and task engagement, concurrent measures of alertness (such as EEG or pupillometry) are often unavailable. Here, we extract a continuous, time-resolved marker of alertness from fMRI data alone. Read More

View Article and Full-Text PDF

Integrating visual search, eye movement training and reversing prism exposure in the treatment of Balint-Holmes syndrome: a single case report.

Top Stroke Rehabil 2021 May 7:1-6. Epub 2021 May 7.

Department of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.

For the first time, we administered reversing prism exposure to treat optic ataxia in a single patient with Balint-Holmes Syndrome (BHS), who also underwent specific trainings for simultanagnosia and ocular apraxia. By an introduction and withdrawal experimental design, we observed that the active treatment periods improved patient's visuospatial defects and functional autonomy. We thus provided a proof of principle supporting the use of reversing prism exposure in optic ataxia within an integrated and personalized rehabilitative approach for BHS. Read More

View Article and Full-Text PDF

Increased risk of stroke among patients with inflammatory bowel disease: A PRISMA-compliant meta-analysis.

Yao Chen Xiang Wang

Brain Behav 2021 May 7:e02159. Epub 2021 May 7.

Department of Ultrasound, The Third Affiliated Hospital of Chongqing Medical University (Gener Hospital), Chongqing, China.

Background: Previous studies on the association between inflammatory bowel disease (IBD) and stroke showed conflicting results.

Methods: Articles published before July 2020 were searched in databases (PubMed, Web of Science, Medline, EMBASE, and Google Scholar). We computed all multivariate odds ratios (ORs) or relative risks (RRs) and 95% confidence intervals (CI) by using STATA 12. Read More

View Article and Full-Text PDF

Conscious sedation compared to general anesthesia for intracranial mechanical thrombectomy: A meta-analysis.

Brain Behav 2021 May 7:e02161. Epub 2021 May 7.

Department of Anesthesiology, The Fourth Hospital of Shijiazhuang, Shijiazhuang, China.

Introduction: Endovascular therapy is the standard of care for severe acute ischemic stroke caused by large-vessel occlusion in the anterior circulation, but there is a debate on the optimal anesthetic approach during this therapy. Meta-analyses of observational studies suggest that general anesthesia increases disability and death compared with conscious sedation However, their results are conflicting. This meta-analysis study was performed to assess the relationship between the effects of general anesthesia compared to conscious sedation during endovascular therapy for acute ischemic stroke. Read More

View Article and Full-Text PDF

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource.

Mov Disord 2021 May 7. Epub 2021 May 7.

Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, Maryland, USA.

Background: Whole-genome sequencing data are available from several large studies across a variety of diseases and traits. However, massive storage and computation resources are required to use these data, and to achieve sufficient power for discoveries, harmonization of multiple cohorts is critical.

Objectives: The Accelerating Medicines Partnership Parkinson's Disease program has developed a research platform for Parkinson's disease (PD) that integrates the storage and analysis of whole-genome sequencing data, RNA expression data, and clinical data, harmonized across multiple cohort studies. Read More

View Article and Full-Text PDF

Risk factors for recurrence of atrial fibrillation.

Anatol J Cardiol 2021 May;25(5):338-345

First Department of Internal Medicine, Medical University Varna; Varna-Bulgaria.

Objective: Atrial fibrillation (AF) is a progressive disease, associated with increased risk of mortality, stroke, heart failure, and worsens quality of life. There is a high incidence of AF recurrence despite the treatment. The aim of the study was to assess the time to recurrence of AF after sinus rhythm restoration with electrical or pharmacological cardioversion and to identify the risk factors. Read More

View Article and Full-Text PDF

Acute lacunar infarct in an obese adolescent with obstructive sleep apnea.

J Clin Sleep Med 2021 May 7. Epub 2021 May 7.

Sleep Disorders Center, Neurological Institute, Cleveland Clinic.

Abstract: Obstructive sleep apnea (OSA) is associated with an increased risk of acute ischemic cerebrovascular accidents in adults. However, this association has not been well established in the pediatric population. We report a case of acute right internal capsule lacunar infarct manifesting as left-sided hemiplegia in an adolescent with severe obesity. Read More

View Article and Full-Text PDF

Cardiovascular disease and meaning in life: A systematic literature review and conceptual model.

Joel Vos

Palliat Support Care 2021 May 7:1-10. Epub 2021 May 7.

Metanoia Institute, Ealing, London, UK.

Objectives: Previous studies have shown that psychological stress and mental health problems increase the risk for cardiovascular disease (CVD) events, such as heart attack or stroke. Furthermore, after CVD events, the majority of patients report large stress. However, psychological treatments have only modest effects in CVD patients. Read More

View Article and Full-Text PDF

Acute upper limb ischemia as a complication of tunneled hemodialysis catheter placement via the right internal jugular vein.

Ahmet Can Topcu

J Vasc Access 2021 May 7:11297298211015041. Epub 2021 May 7.

Department of Cardiovascular Surgery, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey.

Arterial injury during internal jugular vein cannulation can cause devastating complications such as stroke, hematoma, hemothorax, pseudoaneurysm, AV fistula, or even death. Acute upper limb ischemia caused by inadvertent arterial puncture during internal jugular vein cannulation has been rarely reported. The present report describes the case of a patient who experienced right upper limb ischemia caused by subclavian artery thrombosis developed during attempted placement of a tunneled hemodialysis catheter via the right internal jugular vein. Read More

View Article and Full-Text PDF

How well do we understand pulsatility in the context of modern ventricular assist devices?

Int J Artif Organs 2021 May 7:3913988211012707. Epub 2021 May 7.

St Vincent's Hospital (Sydney), Darlinghurst, NSW, Australia.

Background: Modern ventricular assist devices (VADs) use a continuous flow design. It has been suggested that a lack of pulsatility contributes to a range of adverse outcomes including pump thrombus, gastrointestinal bleeding and stroke. To better assess the role of pulsatility in these adverse events, we first require a clear definition of 'pulsatility' in the setting of a severely impaired ventricle and a modern continuous flow VAD. Read More

View Article and Full-Text PDF