12,867 results match your criteria acute seizures

EEG spindles integrity in critical care adults. Analysis of a randomized trial.

Acta Neurol Scand 2021 Jul 26. Epub 2021 Jul 26.

Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Objectives: Occurrence of EEG spindles has been recently associated with favorable outcome in ICU patients. Available data mostly rely on relatively small patients' samples, particular etiologies, and limited variables ascertainment. We aimed to expand previous findings on a larger dataset, to identify clinical and EEG patterns correlated with spindle occurrence, and explore its prognostic implications. Read More

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MRI combined with early clinical variables are excellent outcome predictors for newborn infants undergoing therapeutic hypothermia after perinatal asphyxia.

EClinicalMedicine 2021 Jun 17;36:100885. Epub 2021 May 17.

Neonatal Neuroscience, Translational Health Sciences, University of Bristol, Bristol, United Kingdom.

Background: Binary prediction-models for outcome [death, cognition, presence and severity of cerebral palsy (CP)], using MRI and early clinical data applicable for individual outcome prediction have not been developed.

Methods: From Dec 1 2006 until Dec 31 2013, we recruited 178 infants into a population-based cohort with moderate or severe hypoxic-ischaemic encephalopathy (HIE) including postnatal collapse (PNC,  = 12) and additional diagnoses ( = 12) using CoolCap/TOBY-trial entry-criteria including depressed amplitude-integrated EEG (aEEG). Early clinical/biochemical variables and MRI scans (median day 8) were obtained in 168 infants. Read More

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"Cerebral venous sinus thrombosis sequel of COVID Encephalitis; a rare presentation".

Iqra Athar

Brain Hemorrhages 2021 Jul 16. Epub 2021 Jul 16.

Department of Neurology, PIMS Hospital, Islamabad, Pakistan.

The SARS Covid-19 pneumonia became a pandemic in 2019 affecting millions worldwide and carried a significant high mortality rate. The common presentation of this novel virus is upper and lower respiratory tract infection. However, its popularity as neuropathogen has increased dramatically. Read More

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ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model.

Neurobiol Dis 2021 Jul 22:105450. Epub 2021 Jul 22.

Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:

Imbalanced neuronal excitability homeostasis is commonly observed in patients with fragile X syndrome (FXS) and the animal model of FXS, the Fmr1 KO. While alterations of neuronal intrinsic excitability and synaptic activity at the steady state in FXS have been suggested to contribute to such a deficit and ultimately the increased susceptibility to seizures in FXS, it remains largely unclear whether and how the homeostatic response of neuronal excitability following extrinsic challenges is disrupted in FXS. Our previous work has shown that the acute response following induction of endoplasmic reticulum (ER) stress can reduce neural activity and seizure susceptibility. Read More

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Paroxysmal sympathetic hyperactivity and the later development of epilepsy in a chemotherapy-associated brain damage.

Brain Dev 2021 Jul 20. Epub 2021 Jul 20.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Chemotherapy in childhood leukemia potentially induces brain lesions and neurological sequelae. Paroxysmal sympathetic hyperactivity (PSH) is known as a treatment-associated complication; however, the full clinical spectra of PSH remain to be elusive.

Case Report: A 5-year-old girl was diagnosed of acute myeloid leukemia (AML) M5. Read More

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Impact of Dysfunctional Feed-Forward Inhibition on Glutamate Decarboxylase Isoforms and γ-Aminobutyric Acid Transporters.

Int J Mol Sci 2021 Jul 20;22(14). Epub 2021 Jul 20.

Department of Anatomy, School of Biomedical Sciences, Brain Health Research Centre, University of Otago, Dunedin 9016, New Zealand.

Absence seizures are associated with generalised synchronous 2.5-4 Hz spike-wave discharges causing brief and sudden alteration of awareness during childhood, which is known as childhood absence epilepsy (CAE). CAE is also associated with impaired learning, psychosocial challenges, and physical danger. Read More

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6-Gingerol, a Major Constituent of Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish.

Int J Mol Sci 2021 Jul 20;22(14). Epub 2021 Jul 20.

Chemical Neuroscience Group, Centre for Molecular Medicine Norway, Faculty of Medicine, University of Oslo, Gaustadalléen 21, 0349 Oslo, Norway.

is one of the most frequently used medicinal herbs in Asia. Using rodent seizure models, it was previously shown that hydroethanolic extract exerts antiseizure activity, but the active constituents responsible for this effect have not been determined. In this paper, we demonstrated that methanolic extract exerts anticonvulsant activity in the pentylenetetrazole (PTZ)-induced hyperlocomotion assay in larval zebrafish. Read More

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Retrosplenial Cortex Contributes to Network Changes during Seizures in the GAERS Absence Epilepsy Rat Model.

Cereb Cortex Commun 2021 23;2(2):tgab023. Epub 2021 Mar 23.

Translational Research Imaging Center, Clinic for Radiology, University Hospital Münster, 48149 Münster, Germany.

Resting state-fMRI was performed to explore brain networks in Genetic Absence Epilepsy Rats from Strasbourg and in nonepileptic controls (NEC) during monitoring of the brain state by simultaneous optical Ca-recordings. Graph theoretical analysis allowed for the identification of acute and chronic network changes and revealed preserved small world topology before and after seizure onset. The most prominent acute change in network organization during seizures was the segregation of cortical regions from the remaining brain. Read More

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Deep Cerebral Venous Thrombosis-A Clinicoradiological Study.

J Neurosci Rural Pract 2021 Jul 16;12(3):560-565. Epub 2021 Jun 16.

Department of Neurology, Ramaiah Medical College, Bengaluru, India.

Stroke is a common neurological emergency. Almost 80% of strokes are due to arterial occlusion. Venous thrombosis comprises less than 1-2% of all strokes. Read More

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Threatening Blindness in a Child With Typical Hemolytic Uremic Syndrome.

Pediatr Neurol 2021 Jun 25;122:35-37. Epub 2021 Jun 25.

Department of Paediatric Neurology, APHM La Timone, Marseille, France. Electronic address:

Background: Hemolytic uremic syndrome (HUS) is the most common cause of acute kidney failure in children younger than five years. Central nervous system involvement occurs in 15% of patients, with clinical manifestations including confusion, coma, seizures, stroke, and cortical blindness. Ocular involvement in children with HUS is rare, but retinal and choroidal hemorrhages as well as ischemic retinopathy due to thrombotic microangiopathic lesions have been documented. Read More

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Influenza-Associated Neurologic Complications in Hospitalized Children.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

Divisions of Neurology, The Children's Hospital of Philadelphia; Departments of Neurology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:

Objectives: To define the incidence and characteristics of influenza-associated neurologic complications in a cohort of children hospitalized at a tertiary care pediatric hospital with laboratory-confirmed influenza, and to identify associated clinical, epidemiologic, and virologic factors.

Study Design: Historical cohort study of children 0.5-18. Read More

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Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.

Acta Neuropathol 2021 Jul 22. Epub 2021 Jul 22.

Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, to date, alterations in iron metabolism in the epileptogenic brain have not been addressed in detail. Iron-related neuropathology and antioxidant metabolic processes were investigated in resected brain tissue from patients with temporal lobe epilepsy and hippocampal sclerosis (TLE-HS), post-mortem brain tissue from patients who died after status epilepticus (SE) as well as brain tissue from the electrically induced SE rat model of TLE. Read More

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Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.

Epilepsia 2021 Jul 21. Epub 2021 Jul 21.

SEIN: Epilepsy Institute in the Netherlands Foundation Heemstede, Heemstede, The Netherlands.

Objective: There have been recommendations to improve therapy discovery for epilepsy by incorporating chronic epilepsy models into the preclinical process, but unpredictable seizures and difficulties in maintaining drug levels over prolonged periods have been obstacles to using these animals. We report new protocols in which drugs are administered through a new chronic gastric tube to rats with higher seizure frequencies to minimize these obstacles.

Methods: Adult rats with spontaneous limbic seizures following an episode of limbic status epilepticus induced by electrical hippocampal stimulation were monitored with long-term video- electroencephalography (EEG). Read More

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Ischemic Lesions in the Brain of a Neonate With SARS-CoV2 Infection.

Pediatr Infect Dis J 2021 Jun 22. Epub 2021 Jun 22.

Hospital Sanatorio de la Trinidad Palermo, Buenos Aires, Argentina.

Aim: To describe a term newborn with acquired severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and multisystem involvement including seizures associated to ischemic lesions in the brain.

Background: Coronavirus disease 2019 (COVID-19) is predominantly a respiratory infection, but it may affect many other systems. Most pediatric COVID-19 cases range from asymptomatic to mild-moderate disease. Read More

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Status Epilepticus in Patients with Anti-NMDAR Encephalitis Requiring Intensive Care: A Follow-Up Study.

Neurocrit Care 2021 Jul 20. Epub 2021 Jul 20.

Department of Neurology, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, 710032, Shaanxi Province, China.

Background: To date, specialized studies focusing on status epilepticus (SE) in anti-N-methyl D-aspartate receptor (anti-NMDAR) encephalitis are limited, and the association between the occurrence of SE and clinical outcome is controversial. This study aims to investigate the differences between patients with critical anti-NMDAR encephalitis with SE and patients who experienced epileptic seizures without SE and to evaluate the long-term disease outcomes of patients with anti-NMDAR encephalitis with SE who were admitted to the neurological intensive care unit (neuro-ICU).

Methods: In this retrospective study based on a prospective registry, patients with anti-NMDAR encephalitis with neuro-ICU admission from 2014 to 2019 were analyzed and divided into two groups based on whether they had SE. Read More

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Organophosphate poisoning at Chris Hani Baragwanath Academic Hospital 2012 - 2015.

Afr J Thorac Crit Care Med 2019 17;25(3). Epub 2019 Sep 17.

Division of Pulmonology, Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Patients with acute organophosphate poisoning are frequently admitted to the Chris Hani Baragwanath Academic Hospital (CHBAH), and yet there is little literature assessing aspects of these admissions.

Objectives: To determine the demographic profile, common clinical and biochemical findings, use of prognostic tools (APACHE II), management and outcome of adult patients admitted to the high care area (HCA) and intensive care unit (ICU) at CHBAH.

Methods: A retrospective data analysis of hospital records for 129 patients admitted to the HCA and ICU at CHBAH for the period 2012 - 2015 was undertaken. Read More

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September 2019

Prevalence and risk factors of seizure in children with acute bacterial meningitis: updating previous evidence using an epidemiological design.

Iran J Child Neurol 2021 ;15(3):47-54

Infection Control &Hand Hygiene Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The current study aimed to investigate the prevalence and risk factors of seizure in acute bacterial meningitis.

Materials & Methods: In the present study, a total of 180 children (age range, 2 months to 14 years) with acute bacterial meningitis, were separated into two groups based on the diagnosis of seizure. The study was conducted in Mashhad (Iran) from 2002 to 2016. Read More

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January 2021

Scopolamine prevents aberrant mossy fiber sprouting and facilitates remission of epilepsy after brain injury.

Neurobiol Dis 2021 Jul 16:105446. Epub 2021 Jul 16.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

Prevention or modification of acquired epilepsy in patients at risk is an urgent, yet unmet, clinical need. Following acute brain insults, there is an increased risk of mesial temporal lobe epilepsy (mTLE), which is often associated with debilitating comorbidities and reduced life expectancy. The latent period between brain injury and the onset of epilepsy may offer a therapeutic window for interfering with epileptogenesis. Read More

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The effect of dexketoprofen trometamol on WAG/Rij rats with absence epilepsy (dexketoprofen in absence epilepsy).

Neurol Res 2021 Jul 18:1-10. Epub 2021 Jul 18.

Department of Physiology, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey.

Aim: Epilepsy is one of the most common neurological diseases. Dexketoprofen (DEX) is a nonselective nonsteroidal anti-inflammatory drug that is used as an analgesic. The present study aimed to assess the efficiency of DEX on WAG/Rij rats by electrophysiologically and behaviorally. Read More

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Case Report: Coexistence of Anti-AMPA Receptor Encephalitis and Positive Biomarkers of Alzheimer's Disease.

Front Neurol 2021 2;12:673347. Epub 2021 Jul 2.

Institute of Neuropsychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is a rare autoimmune disease that is characterized by acute cognitive impairment, mental symptoms, and seizures. The high comorbidity rate between anti-AMPA receptor (AMPAR) encephalitis and other somatic diseases, such as malignancy, has revealed the possibility of potential copathogenesis. However, there have not yet been reports about anti-AMPAR encephalitis with concomitant cerebrospinal fluid (CSF) biomarkers consistent with Alzheimer disease (AD). Read More

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Posterior Reversible Encephalopathy Syndrome: A Review of the Literature.

Intern Med 2021 Jul 17. Epub 2021 Jul 17.

Department of Eat-loss Medicine, Graduate School of Medicine, The University of Tokyo, Japan.

Posterior reversible encephalopathy syndrome (PRES) is a group of clinical syndromes typically characterized by bilateral reversible vasogenic edema of the subcortical white matter in the parieto-occipital region on neuroimaging that causes a wide variety of acute or subacute neurological symptoms, including headache, mental status alteration, seizures, and visual dysfunction. PRES is classically suspected in patients with severe hypertension, renal failure, autoimmune disorders, eclampsia, or immunosuppressant medications. Frequent neurological evaluations and neuroimaging examinations by computed tomography or magnetic resonance imaging are required for both the diagnosis and assessment of the condition. Read More

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Clinical effects and outcomes of perampanel overdoses reported to U.S. poison centers.

Clin Toxicol (Phila) 2021 Jul 19:1-4. Epub 2021 Jul 19.

Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, MD, USA.

Introduction: Perampanel is indicated for partial onset seizures in children and adults. The mechanism is unique among antiepileptic agents as it inhibits glutamate activity on AMPA receptors. Currently, there are few published case reports describing overdose. Read More

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A follow-up study of patients with COVID-19 presenting with seizures.

Epilepsy Behav 2021 Jul 2;122:108207. Epub 2021 Jul 2.

Burn & Wound Healing Research Center, Department of Microbiology, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: We performed a follow-up study of patients with COVID-19 presenting with seizures.

Methods: All consecutive patients with seizures, who were referred to Namazee Hospital, Shiraz, Iran, with a diagnosis of COVID-19, from 10 August 2020 until 20 October 2020 were included in this longitudinal study. The clinical data were collected by the admitting physician. Read More

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Pediatric auto-immune encephalitis.

Curr Probl Pediatr Adolesc Health Care 2021 Jul 13:101031. Epub 2021 Jul 13.

Dayton Children Hospital, Wright State University Boonshoft School of Medicine, 1 Children Plaza, Dayton Ohio 45404. Electronic address:

Pediatric Auto-Immune Encephalitis (PAE) is a neuro-inflammatory disorder with a varied presentation. The discovery of the Anti NMDA receptor and other antibodies as the causative agents of PAE, has led to an increased need for guidelines for diagnosis and management of these disorders. PAE remains a challenging group of disorders due to their varying presentations and etiology with a prolonged clinical course. Read More

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Cefepime-Induced Delirium.

Cureus 2021 Jun 7;13(6):e15505. Epub 2021 Jun 7.

Internal Medicine, St. Vincent Charity Medical Center, Cleveland, USA.

Cefepime is a fourth-generation cephalosporin usually reserved to treat severe infections or those caused by multi-resistant microorganisms. Neurotoxicity is attributed to its ability to cross the blood-brain barrier and produce gamma-aminobutyric acid antagonism. Neurological symptoms may range from mild somnolence to seizures and coma. Read More

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Anti-NMDA receptor encephalitis and overlapping demyelinating disorder in a 20-year old female with borderline personality disorder: proposal of a diagnostic and therapeutic algorithm for autoimmune encephalitis in psychiatric patients "case report".

BMC Psychiatry 2021 Jul 15;21(1):355. Epub 2021 Jul 15.

Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany.

Background: Anti-NMDA receptor encephalitis (NMDAR-E) is an autoimmune encephalitis (AE) mainly affecting young females. It typically presents with isolated psychiatric symptoms (e.g. Read More

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Cardiac effects of rapid intravenous loading of lacosamide in patients with epilepsy.

Epilepsy Res 2021 Jul 7;176:106710. Epub 2021 Jul 7.

Department of Neurology, Konkuk University School of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Lacosamide (LCM) is a new antiseizure medication, and intravenous (IV) loading of LCM is recently used against status epilepticus. IV loading of LCM is usually well-tolerated; however, there are concerns about LCM-induced serious adverse cardiac events. This study was aimed at investigating whether rapid IV loading of LCM is associated with adverse cardiac or hemodynamic events in cases of epilepsy emergencies in real-world settings. Read More

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Neurological Outcome According to the Site of Cannulation in Septic Children Supported by Venoarterial Extracorporeal Membrane Oxygenation.

ASAIO J 2021 Jul 15. Epub 2021 Jul 15.

From the Pediatric Intensive Care Unit Pediatric Cardiac Surgery Unit, University Hospital, Nantes, France Division of Cardiothoracic Surgery, University of Utah Health, Salt Lake City, Uttah Extracorporeal Life Support Organization (ELSO), Ann Arbor, Michigan.

The impact of cervical cannulation on neurologic outcome has not been yet studied among children receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) in the context of severe sepsis or septic shock. A retrospective cohort study was performed using the extracorporeal life support organization (ELSO) registry. A total of 559 children weighing less than 20 kg with a primary or secondary diagnosis of severe sepsis, septic shock or toxic shock syndrome were included between January 1, 2010, and December 31, 2019. Read More

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Neurological manifestations of paediatric acute COVID infections: A single centre experience.

J Trop Pediatr 2021 Jul 12. Epub 2021 Jul 12.

Department of Pediatrics, Division of Neonatal Critical Care, Health Sciences University Kanuni Training and Research Hospital, Trabzon, Türkiye, 61000.

Background: Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, while serious complications may occur in conjunction with both acute infection and neurological symptoms, which have been predominantly reported in adults. The neurological complications in these patients vary based on patient age and underlying comorbidities. Data on clinical features, particularly neurological features, and prognostic factors in children and adolescents are limited. Read More

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Cardiology perspective on seizure-related bradyarrhythmias and SUDEP: A survey study.

Epilepsy Behav 2021 Jul 9;122:108188. Epub 2021 Jul 9.

Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, United States.

Objective: To determine cardiologist knowledge of and experience with seizure-related bradyarrhythmias and sudden unexpected death in epilepsy (SUDEP).

Background: Autonomic changes related to acute seizures are common and can occur during the ictal or postictal period. Two concerning changes in these periods are significant bradycardia and asystole. Read More

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