117,757 results match your criteria acute respiratory

High-dimensional characterization of post-acute sequalae of COVID-19.

Nature 2021 Apr 22. Epub 2021 Apr 22.

Clinical Epidemiology Center, Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, USA.

The acute clinical manifestations of COVID-19 are well characterized; however, its post-acute sequalae have not been comprehensively described. Here, we use the national healthcare databases of the US Department of Veterans Affairs to systematically and comprehensively identify 6-month incident sequalae including diagnoses, medication use, and laboratory abnormalities in 30-day survivors of COVID-19. We show that beyond the first 30 days of illness, people with COVID-19 exhibit higher risk of death and health resource utilization. Read More

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[Proposal for territorial analysis to face the SARS-CoV-2 pandemic based on the Profile of pneumonia and Influenza in Ecuador 2016-2018].

Aten Primaria 2021 Feb 23;53(5):102021. Epub 2021 Feb 23.

Universidad Central del Ecuador, Facultad de Ciencias Médicas, Quito, Ecuador.

Objective: The present study seeks to analyse sociodemographic determinants related to severe acute respiratory infections (SARI) and calculate the priorization index in the cantons of Ecuador to identify areas probably most vulnerable to COVID-19 transmission.

Design: This descriptive ecological observational study.

Setting: 224 cantons (geographical area) of Ecuador with secondary data sources of hospital information. Read More

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February 2021

Development of ciclesonide analogues that block SARS-CoV-2 RNA replication.

Bioorg Med Chem Lett 2021 Apr 19:128052. Epub 2021 Apr 19.

Division of Organic Chemistry, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki, Kanagawa 210-9501, Japan; Graduate School of Medical Life Science, Yokohama City University, 1-7-29, Yokohama, Kanagawa 230-0045, Japan. Electronic address:

Ciclesonide is an inhaled corticosteroid used to treat asthma and is currently undergoing clinical trials for treatment of coronavirus disease 2019 (COVID-19). An active metabolite of ciclesonide, Cic2, was recently reported to repress severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genomic RNA replication. Herein, we designed and synthesized a few types of ciclesonide analogues. Read More

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Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study.

Lancet Respir Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Cardiovascular and Thoracic Surgery, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France; Sorbonne University, INSERM UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France.

Background: In the Île-de-France region (henceforth termed Greater Paris), extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) was considered early in the COVID-19 pandemic. We report ECMO network organisation and outcomes during the first wave of the pandemic.

Methods: In this multicentre cohort study, we present an analysis of all adult patients with laboratory-confirmed SARS-CoV-2 infection and severe ARDS requiring ECMO who were admitted to 17 Greater Paris intensive care units between March 8 and June 3, 2020. Read More

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Risk of Transmitting Coronavirus Disease 2019 During Nebulizer Treatment: A Systematic Review.

J Aerosol Med Pulm Drug Deliv 2021 Apr 21. Epub 2021 Apr 21.

Durham Veterans Affairs Health Care System, Durham, North Carolina, USA.

There is an urgent need to understand the risk of viral transmission during nebulizer treatment of patients with coronavirus disease 2019 (COVID-19). To assess the risk of transmitting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS, Middle East respiratory syndrome (MERS), and influenza with administration of drugs via nebulizer. We searched multiple electronic databases, including PubMed, China National Knowledge Infrastructure, Wanfang, preprint databases, and clinicaltrials. Read More

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Cough augmentation techniques for people with chronic neuromuscular disorders.

Cochrane Database Syst Rev 2021 Apr 22;4:CD013170. Epub 2021 Apr 22.

Centre for Home Mechanical Ventilation and Specialized Centre for Neuromuscular Diseases, Inkendaal Rehabilitation Hospital, Vlezenbeek, Belgium.

Background: People with neuromuscular disorders may have a weak, ineffective cough predisposing them to respiratory complications. Cough augmentation techniques aim to improve cough effectiveness and mucous clearance, reduce the frequency and duration of respiratory infections requiring hospital admission, and improve quality of life.

Objectives: To determine the efficacy and safety of cough augmentation techniques in adults and children with chronic neuromuscular disorders. Read More

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Comparison of viral load between saliva and nasopharyngeal swabs for SARS-CoV2: the role of days of symptoms onset on diagnosis.

Mem Inst Oswaldo Cruz 2021 16;116:e210018. Epub 2021 Apr 16.

Universidade Federal de São Paulo, Departamento de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brasil.

Background: Coronavirus disease 2019 (COVID-19) is highly infectious causing millions of deaths worldwide. Nasopharyngeal swabs are the primary sample of choice for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus, to decrease the exposure to potentially infected samples through the collection is a key point to reduce the risk of infection in healthcare workers.

Objectives: This study aimed to evaluate the sensitivity and viral load of saliva specimens by days of symptoms onset comparing to nasopharyngeal swabs in subjects with mild symptoms. Read More

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Characterization of pulmonary impairment associated with COVID-19 in patients requiring mechanical ventilation.

Rev Bras Ter Intensiva 2021 Jan-Mar;33(1):75-81

Medical Intensive Care Unit, Hôpital Emile Muller, Groupe Hospitalier de la Région de Mulhouse et Sud-Alsace - Alsace - Mulhouse, France.

Objective: To detect early respiratory and hemodynamic instability to characterize pulmonary impairment in patients with severe COVID-19.

Methods: We retrospectively analyzed data collected from COVID-19 patients suffering from acute respiratory failure requiring intubation and mechanical ventilation. We used transpulmonary thermodilution assessment with a PiCCO™ device. Read More

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Consensus for the management of analgesia, sedation and delirium in adults with COVID-19-associated acute respiratory distress syndrome.

Rev Bras Ter Intensiva 2021 Jan-Mar;33(1):48-67

Hospital Interzonal General de Agudos General San Martín - La Plata, Argentina.

Objective: To propose agile strategies for a comprehensive approach to analgesia, sedation, delirium, early mobility and family engagement for patients with COVID-19-associated acute respiratory distress syndrome, considering the high risk of infection among health workers, the humanitarian treatment that we must provide to patients and the inclusion of patients' families, in a context lacking specific therapeutic strategies against the virus globally available to date and a potential lack of health resources.

Methods: A nonsystematic review of the scientific evidence in the main bibliographic databases was carried out, together with national and international clinical experience and judgment. Finally, a consensus of recommendations was made among the members of the Committee for Analgesia, Sedation and Delirium of the Sociedad Argentina de Terapia Intensiva. Read More

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November 2020

Management of a university ambulatory service: nursing in the coping of the pandemic of COVID-19.

Rev Bras Enferm 2021 14;74Suppl 1(Suppl 1):e20200834. Epub 2021 Apr 14.

Universidade do Estado do Rio de Janeiro. Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: to describe the implementation and management of a restructured nursing service to cope with the COVID-19 pandemic.

Methods: a descriptive study, carried out at Piquet Carneiro Polyclinic, a university ambulatory unit, which became a reference for testing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the city of Rio de Janeiro.

Results: dimensioning of human resources for nursing was carried out; flows for serving users of the unit and for testing SARS-CoV-2; professional training on prevention practices. Read More

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Dysautonomia: A Forgotten Condition - Part 1.

Arq Bras Cardiol 2021 Apr;116(4):814-835

Serviço de Eletrofisiologia do Vitória Apart Hospital, Vitória, ES - Brasil.

Dysautonomia covers a range of clinical conditions with different characteristics and prognoses. They are classified as Reflex Syndromes, Postural Orthostatic Tachycardia Syndrome (POTS), Chronic Fatigue Syndrome, Neurogenic Orthostatic Hypotension (nOH) and Carotid Sinus Hypersensitivity Syndrome. Reflex (vasovagal) syndromes will not be discussed in this article. Read More

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Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review.

PLoS One 2021 22;16(4):e0250196. Epub 2021 Apr 22.

Dornsife School of Public Health, Drexel University, Philadelphia, PA, United States of America.

Introduction: The evidence for vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is not well established. Therefore, the objective of this review is to summarize emerging evidence on the vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2.

Methods: We conducted a systematic search in PubMed, CINAHL, Web of Science, SCOPUS, and CENTRAL. Read More

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SARS-CoV-2 testing strategy: A comparison of restricted and extended strategies in a Swiss outpatient cohort from the community and hospital employees.

PLoS One 2021 22;16(4):e0250021. Epub 2021 Apr 22.

Division of Primary Care, Geneva University Hospitals, Geneva, Switzerland.

Background: Testing is a key measure to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we empirically compared two SARS-CoV-2 testing strategies.

Methods: We used data from a Swiss single-centre, outpatient cohort study (n = 6,331 test results). Read More

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The role of oxygen intake and liver enzyme on the dynamics of damaged hepatocytes: Implications to ischaemic liver injury via a mathematical model.

PLoS One 2021 22;16(4):e0230833. Epub 2021 Apr 22.

PRECESIONheor, Los Angeles, CA, United States of America.

Ischaemic Hepatitis (IH) or Hypoxic Hepatitis (HH) also known as centrilobular liver cell necrosis is an acute liver injury characterized by a rapid increase in serum aminotransferase. The liver injury typically results from different underlying medical conditions such as cardiac failure, respiratory failure and septic shock in which the liver becomes damaged due to deprivation of either blood or oxygen. IH is a potentially lethal condition that is often preventable if diagnosed timely. Read More

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Anesthetic Complications Associated with SARS-CoV-2 in Pediatric Patients.

Anesth Analg 2021 Apr 21. Epub 2021 Apr 21.

Department of Anesthesiology and Pain Management, Division of Pediatric Anesthesia, University of Texas Southwestern, Dallas, TX and Children's Health, Dallas, TX.

Background: Coronavirus disease 19 (COVID-19) is associated with high perioperative morbidity and mortality among adults. The incidence and severity of anesthetic complications in children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. We hypothesized that there would be an increased incidence of intra- and postoperative complications in children with SARS-CoV-2 infection as compared to those with negative testing. Read More

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Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus.

JCI Insight 2021 Apr 22. Epub 2021 Apr 22.

Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, United States of America.

Emerging coronaviruses from zoonotic reservoirs including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been associated with human-to-human transmission and significant morbidity and mortality. Here we study both intradermal (ID) and intramuscular (IM) two-dose delivery regimens of an advanced synthetic DNA vaccine candidate encoding a full-length MERS-CoV Spike (S) protein, which induced potent binding and neutralizing antibodies, as well as cellular immune responses in rhesus macaques. In a MERS-CoV challenge, all immunized rhesus macaques exhibited reduced clinical symptoms, lowered viral lung load, and decreased severity of pathological signs of disease compared to controls. Read More

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Immunomodulatory Extracellular Vesicles: An alternative to cell therapy for COVID-19.

Expert Opin Biol Ther 2021 Apr 22. Epub 2021 Apr 22.

Department of Musculoskeletal Disorders, School of Medicine and Surgery, University of Salerno, Fisciano, Italy.

Introduction: SARS-CoV-2 induces a cytokine storm and can cause inflammation, fibrosis and apoptosis in the lungs, leading to acute respiratory distress syndrome (ARDS). ARDS is the leading reason for the mortality and morbidity the associated to COVID-19, and the cytokine storm is a prominent etiological factor. Mesenchymal stem cell-derived extracellular vesicles are an alternative therapy for management of inflammatory and autoimmune conditions because of their immunosuppressive properties. Read More

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Prescription of antibiotics in the medical care of newly arrived refugees and migrants.

Pharmacoepidemiol Drug Saf 2021 Apr 22. Epub 2021 Apr 22.

Department of General Practice, University Medical Center Würzburg, Würzburg, Germany.

Purpose: Unnecessary and inappropriate use of antibiotics is a widespread problem in primary care. However, current data on the care of refugees and migrants in initial reception centers is pending. This article provides data on prescription frequencies of various antibiotics and associated diagnoses. Read More

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Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology.

Top Curr Chem (Cham) 2021 Apr 22;379(3):23. Epub 2021 Apr 22.

Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China.

Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a pandemic around the world. Currently, specific antiviral drugs to control the epidemic remain deficient. Understanding the details of SARS-CoV-2 structural biology is extremely important for development of antiviral agents that will enable regulation of its life cycle. Read More

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Regional citrate anti-coagulation dose titration: impact on dose of continuous renal replacement therapy.

Clin Exp Nephrol 2021 Apr 22. Epub 2021 Apr 22.

Department of Renal Medicine, Changi General Hospital, 2 Simei Street 3, Singapore, 529889, Singapore.

Background: Regional citrate anti-coagulation (RCA) is the recommended anti-coagulation for continuous renal replacement therapy (CRRT). Citrated replacement fluids provide convenience but may compromise effluent delivery when adjusted to maintain circuit ionised calcium levels (circuit-iCa). This study aims to evaluate the effect of RCA titration on the delivered CRRT effluent dose. Read More

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Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced injury in human tubule epithelial cells by regulating miR-93-5p/TXNIP axis.

Med Microbiol Immunol 2021 Apr 22. Epub 2021 Apr 22.

Department of Respiratory and Critical Care Medicine, The Fourth People's Hospital of Shaanxi Province, No. 512, Xianning East Road, Xincheng District, Xi'an City, 710043, Shanxi Province, China.

Many long non-coding RNAs (lncRNAs) have been found to play crucial roles in sepsis-induced acute kidney injury (AKI), including lncRNA nuclear-enriched abundant transcript 1 (NEAT1). We aimed to further elucidate the functions and molecular mechanism of NEAT1 in sepsis-induced AKI. Sepsis-induced AKI cell model was established by treatment with lipopolysaccharide (LPS) in human tubule epithelial (HK2) cells. Read More

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Acute Ischemic Stroke During the Convalescent Phase of Asymptomatic COVID-2019 Infection in Men.

JAMA Netw Open 2021 Apr 1;4(4):e217498. Epub 2021 Apr 1.

Division of Neurology, Department of Medicine, National University Health System, Singapore.

Importance: Acute ischemic stroke (AIS) is a known neurological complication in patients with respiratory symptoms of COVID-19 infection. However, AIS has not been described as a late sequelae in patients without respiratory symptoms of COVID-19.

Objective: To assess AIS experienced by adults 50 years or younger in the convalescent phase of asymptomatic COVID-19 infection. Read More

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Comparative phylogenetic analysis of SARS-CoV-2 spike protein-possibility effect on virus spillover.

Brief Bioinform 2021 Apr 22. Epub 2021 Apr 22.

Queensland Biosciences Precinct, The University of Queensland, St Lucia 4072, Queensland, Australia.

Coronavirus disease 2019 has developed into a dramatic pandemic with tremendous global impact. The receptor-binding motif (RBM) region of the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), binds to host angiotensin-converting enzyme 2 (ACE2) receptors for infection. As ACE2 receptors are highly conserved within vertebrate species, SARS-CoV-2 can infect significant animal species as well as human populations. Read More

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Nasal cannula or high-flow oxygen for patients with COPD in acute respiratory distress?

Nursing 2021 May;51(5):52-57

At the University of Pittsburgh Medical Center Presbyterian Hospital in Pittsburgh, Pa., Frederick J. Tasota is an RN educator and Terri L. Kress, Tiffany L. Conlin, and Natalie M. Scarmack are advanced clinical education specialists.

Abstract: There may be some confusion regarding the use of supplemental oxygen in patients with chronic obstructive pulmonary disease (COPD) who are experiencing acute respiratory distress. This article addresses a common nursing misconception regarding the use of high-flow oxygen administration via non-rebreather masks instead of low-flow oxygen administration via nasal cannulas in patients with COPD who are in acute respiratory distress, an issue that was investigated in a simulation education exercise and survey of the nursing staff at the authors' facility. Read More

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Short-Term Wearable Sensors for In-Hospital Medical and Surgical Patients: Mixed Methods Analysis of Patient Perspectives.

JMIR Perioper Med 2021 Apr 22;4(1):e18836. Epub 2021 Apr 22.

Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

Background: Continuous vital sign monitoring using wearable sensors may enable early detection of patient deterioration and sepsis.

Objective: This study aimed to explore patient experiences with wearable sensor technology and carry out continuous monitoring through questionnaire and interview studies in an acute hospital setting.

Methods: Patients were recruited for a wearable sensor study and were asked to complete a 9-item questionnaire. Read More

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COVID-19 in pregnancy - characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries.

Acta Obstet Gynecol Scand 2021 Apr 22. Epub 2021 Apr 22.

Depaetment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Introduction: Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and health care systems.

Material And Methods: This study examines pregnant women with COVID-19 in the five Nordic countries. Pregnant women were included if they were admitted to hospital between March 1 and June 30, 2020 and had a positive SARS-CoV-2 PCR test 14 days or fewer prior to the admission. Read More

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Severe acute respiratory syndrome coronavirus 2 and forensic pathology.

Brett E Lockyer

Med Sci Law 2021 Apr 22:258024211009749. Epub 2021 Apr 22.

6698Portsmouth Hospitals University NHS Trust, UK.

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Cerebral hyperperfusion syndrome after intracranial stenting: Case report and systematic review.

Interv Neuroradiol 2021 Apr 22:15910199211011860. Epub 2021 Apr 22.

Department of Neuroradiology, A.O.U. San Giovanni di Dio e Ruggi d'Aragona, 19028University of Salerno, Salerno, Italy.

Background: Cerebral Hyperperfusion Syndrome (CHS) is an uncommon complication observed after intracranial angioplasty or stenting procedures. Given to the increasing use of new devices for intracranial angioplasty and stenting (INCS), in selected patients with high ischemic stroke risk, an equally increasing knowledge of complications related to these procedures is mandatory. a 63-year-old man was diagnosed with an hyperperfusion syndrome after percutaneous angioplasty and stenting for severe symptomatic right internal carotid artery (ICA) siphon stenosis. Read More

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Profound dysregulation of T cell homeostasisand function in patients with severe COVID-19.

Allergy 2021 Apr 21. Epub 2021 Apr 21.

Department of Immunology, University Hospital Zurich (USZ), Zurich, Switzerland.

Background: Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and shows a broad clinical presentation ranging from asymptomatic infection to fatal disease. A very prominentfeature associated with severe COVID-19 is T cell lymphopenia. However, homeostatic and functional properties of T cells are ill-defined in COVID-19. Read More

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Percutaneous cholecystostomy in the treatment of acute calculous cholecystitis in elderly patients with COVID-19 and high comorbidity.

Ulus Travma Acil Cerrahi Derg 2021 May;27(3):296-302

Department of General Surgery, Healts Sciences University, Bakirköy Dr. Sadi Konuk Training and Resarch Hospital, İstanbul-Turkey.

Background: The purpose of the study was to review the efficacy, safety, and outcomes of percutaneous cholecystostomy (PC) in elderly patients with acute calculous cholecystitis (ACC), high comorbidity, and COVID-19.

Methods: The hospital registry data were examined of patients aged >65 years who were diagnosed with ACC and COVID-19 between March 2020 and June 2020 and who underwent PC treatment in the interventional radiology unit.

Results: A total of 18 patients were diagnosed with ACC and COVID-19, then underwent PC. Read More

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