27,951 results match your criteria acute rejection


Lung transplantation in the septuagenarian can be successfully performed though long-term results impacted by diseases of aging.

Clin Transplant 2022 Jan 15:e14593. Epub 2022 Jan 15.

Division of Cardiac Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.

Background: Advanced age is considered a risk factor for lung transplantation (LTX). We sought to evaluate the long-term outcomes of LTX in the septuagenarian.

Methods: LTX recipients in the UNOS transplant registry (May 1, 2005 to June 12, 2020) were stratified into 18-59, 60-69, and > = 70 years of age. Read More

View Article and Full-Text PDF
January 2022

Outcomes after heart transplantation in patients with cardiac sarcoidosis.

ESC Heart Fail 2022 Jan 15. Epub 2022 Jan 15.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Background: The number of patients with sarcoidosis requiring heart transplantation (HT) is increasing. The aim of this study was to evaluate outcomes of isolated HT in patients with sarcoid cardiomyopathy and compare them to recipients with non-ischaemic restrictive or dilated cardiomyopathy.

Methods And Results: Adult HT recipients were identified in the UNOS Registry between 1990 and 2020. Read More

View Article and Full-Text PDF
January 2022

Peripheral blood eosinophilia as a marker of acute cellular rejection in lung transplant recipients.

J Heart Lung Transplant 2021 Dec 22. Epub 2021 Dec 22.

Lung Transplant Program, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Previous studies in solid organ transplantation have shown a relationship between circulating eosinophil (EOS) counts and the presence of acute cellular rejection (ACR). However, the relationship between this potential biomarker and ACR in lung transplant (LTx) patients remains unclear.

Objective: To assess the association between EOS and the presence of acute cellular rejection in lung transplant recipients. Read More

View Article and Full-Text PDF
December 2021

Clinical Outcomes of Everolimus With Reduced-Dose Tacrolimus vs Mycophenolate Mofetil With Standard-Dose Tacrolimus in De Novo ABO-Incompatible Kidney Transplant Recipients: 1-Year Follow-up.

Transplant Proc 2022 Jan 11. Epub 2022 Jan 11.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: One of the major barriers for long-term renal graft survival is considered to be calcineurin inhibitor nephrotoxicity, contributing to chronic graft dysfunction. Thus, recent immunosuppressive strategies are focused on regimens that can reduce or avoid exposure to calcineurin inhibitors. Herein, we carried out a small-scale pilot study to assess whether everolimus (EVR) with reduced-dose tacrolimus (Tac) is an acceptable immunosuppressive regimen for patients with de novo ABO-incompatible kidney transplant compared with mycophenolate mofetil (MMF) with standard-dose Tac. Read More

View Article and Full-Text PDF
January 2022

Long-term outcomes in pediatric patients who underwent living donor liver transplantation for biliary atresia.

Surgery 2022 Jan 10. Epub 2022 Jan 10.

Department of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Shimotsuke City, Tochigi, Japan.

Background: There is no consensus about long-term outcomes in patients with biliary atresia. We retrospectively reviewed the long-term outcomes in pediatric patients who underwent living donor liver transplantation for biliary atresia.

Methods: Between May 2001 and December 2020, 221 (73%) of 302 pediatric patients who underwent living donor liver transplantation had biliary atresia. Read More

View Article and Full-Text PDF
January 2022

Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+T cells.

Int Immunopharmacol 2022 Jan 10;104:108521. Epub 2022 Jan 10.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

CD4+T cell-mediated acute rejection remains a major factor that affects the early survival of transplanted organs post-transplantation. Here, we reveal that nuclear receptor subfamily 4 Group A member 1 (Nr4A1) was upregulated during cardiac allograft rejection and that the increased Nr4A1 was primarily localized in intragraft-infiltrating CD4+T cells. Nr4A1 acts as a transcription factor with an important role in CD4+T cell apoptosis, differentiation and T cell dysfunction, which indicates that Nr4A1 may play a critical role in transplant rejection. Read More

View Article and Full-Text PDF
January 2022

The thiopurine tale: an unexpected journey.

J Crohns Colitis 2022 Jan 12. Epub 2022 Jan 12.

Department of Gastroenterology and Hepatology, AGEM Research Institute, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Exactly 70 years ago mercaptopurine (1951) was discovered by Gertrude Elion as a novel treatment option for acute leukemia. A total of three thiopurines (also thioguanine (1950) and azathioprine (1957)) were developed over time. These immunosuppressive drugs were also successfully introduced a few decades later to prevent rejection of transplanted organs and to treat several autoimmune diseases. Read More

View Article and Full-Text PDF
January 2022

Could plasma based therapies still be considered in selected cases with atypical hemolytic uremic syndrome?

Turk J Pediatr 2021 ;63(6):986-993

Department of Pediatric Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey.

Background: Atypical hemolytic uremic syndrome (aHUS) occurs due to defective regulation of the alternative complement pathway (ACP) on vascular endothelial cells. Plasma based therapy (PT) was the mainstay of the treatment for aHUS for many years until the introduction of therapies targeting blockage of the complement system. The aim of this study was to evaluate patients with aHUS who had been treated with plasma based therapies alone. Read More

View Article and Full-Text PDF
January 2021

RtNet: a deep hybrid neural networks for the identification of acute rejection and chronic allograft nephropathy after renal transplantation using multiparametric MRI.

Nephrol Dial Transplant 2022 Jan 10. Epub 2022 Jan 10.

Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Background: Reliable diagnosis of the cause of renal allograft dysfunction is of clinical importance. The aim of this study is to develop a hybrid deep learning approach for determining acute rejection (AR), chronic allograft nephropathy (CAN) and renal function in kidney-allografted patients by multimodality integration.

Methods: Clinical and MRI data of 252 kidney-allografted patients who underwent post-transplantation MRI between Dec 2014 and Nov 2019 were retrospectively collected. Read More

View Article and Full-Text PDF
January 2022

miR-31, miR-155, and miR-221 expression profiles and their association with graft skin tolerance in a syngeneic vs. allogeneic murine skin transplantation model.

J Burn Care Res 2022 Jan 9. Epub 2022 Jan 9.

Laboratory of Connective Tissue, Centro Nacional de Investigación y Atención a Quemados, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico.

Grafting is the gold standard for the treatment of severe skin burns. Frequently, allogeneic tissue is the only transient option for wound coverage, but their use risks damage to surrounding tissues. MicroRNAs have been associated with acute rejection of different tissues/organs. Read More

View Article and Full-Text PDF
January 2022

'Snapshot' of an annual data from a large South Indian Renal Biopsy Registry.

Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):522-529

Renopath, Center for Renal and Urological Pathology, Chennai, India.

Results from biopsy registries are important to know about the prevalence of renal diseases. In large studies done over several years, significant interobserver variability could have existed. Single-year biopsy registry data are analyzed in this study. Read More

View Article and Full-Text PDF
January 2022

Plasma cell rich acute rejection: Risk factors, treatment and outcomes.

Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):387-397

Department of Pathology, Army Hospital (Research and Referral), New Delhi, India.

Plasma cell-rich rejection is a rare and poorly defined entity. Its treatment is not clearly defined and has universally poor prognosis. More data should be published from various transplant centers around the world to identify the treatment that has the best outcomes and to formulate treatment guidelines for these cases. Read More

View Article and Full-Text PDF
January 2022

Tacrolimus intrapatient variability in BK virus nephropathy and chronic calcineurin toxicity in kidney transplantation.

Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):348-354

Department of General Surgery, Division of Transplantation, Baskent University Ankara Hospital, Ankara, Turkey.

Intrapatient variability (IPV) in tacrolimus has been increasingly acknowledged as a risk factor for poor graft survival after kidney transplantation. Although past studies have mainly accounted for IPV in acute or chronic rejection states as due to underimmunosuppression, this is not yet clear. So far, tacrolimus IPV for BK virus-associated nephropathy (BKVN) and chronic calcineurin inhibitor toxicity (CNIT) has not been investigated. Read More

View Article and Full-Text PDF
January 2022

Higher levels of allograft injury in black patients early after heart transplantation.

J Heart Lung Transplant 2021 Dec 23. Epub 2021 Dec 23.

Genomic Research Alliance for Transplantation (GRAfT), Bethesda, Maryland; Laborarory of Applied Precision Omics (APO), Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; Department of Medicine, Stanford University School of Medicine, Palo Alto, California. Electronic address:

Black patients suffer higher rates of antibody-mediated rejection and have worse long-term graft survival after heart transplantation. Donor-derived cell free DNA (ddcfDNA) is released into the blood following allograft injury. This study analyzed %ddcfDNA in 63 heart transplant recipients categorized by Black and non-Black race, during the first 200 days after transplant. Read More

View Article and Full-Text PDF
December 2021

Sex differences in the likelihood of pre-emptive living donor kidney transplantation, and outcomes after kidney transplantation in children and adolescents.

Pediatr Transplant 2022 Jan 10:e14224. Epub 2022 Jan 10.

Centre for Kidney Disease Research, University of Queensland, Brisbane, Queensland, Australia.

Background: Data on sex-based disparities in children with kidney failure and outcomes after kidney transplantation are relatively sparse. This study examined the association between sex differences and the odds of receiving a pre-emptive living donor kidney transplantation, and post-transplant outcomes in children and adolescents.

Methods: We studied all patients (aged <20 years) who commenced kidney replacement therapy (KRT) between 2002 and 2017 using data from the ANZDATA Registry. Read More

View Article and Full-Text PDF
January 2022

Elevated number of IL-21+ TFH and CD86+CD38+ B cells in blood of renal transplant recipients with AMR under conventional immuno-suppression.

Int J Immunopathol Pharmacol 2022 Jan-Dec;36:20587384211048027

Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, Genetic Diagnosis Center, 117971The First Hospital of Jilin University, Changchun, China.

The objective of this study is to detect the number of different subsets of TFH and B cells in renal transplant recipients (RTR) with antibody-mediated acute rejection (AMR), acute rejection (AR), chronic rejection (CR), or transplant stable (TS). The present study was a prospective study. The numbers of ICOS +, PD-1+ and IL-21+ TFH, CD86+, CD38+, CD27+, and IgD- B cells in 21 patients with end-stage renal disease (ESRD) and post-transplant times were measured by flow cytometry. Read More

View Article and Full-Text PDF
January 2022

Low dose rabbit antithymocyte globulin is non-inferior to higher dose in low-risk pediatric kidney transplant recipients.

Pediatr Nephrol 2022 Jan 10. Epub 2022 Jan 10.

Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, USA.

Background: Currently, there is no consensus among pediatric kidney transplant centers regarding the use and regimen for immunosuppressive induction therapy.

Methods: In this single center, retrospective cohort study, pediatric kidney transplant recipients transplanted between 1 May 2013 and 1 May 2018 with rabbit antithymocyte globulin (rATG) induction were included. We stratified patients based on immunological risk, with high risk defined as those with repeat transplant, preformed donor specific antibody, current panel-reactive antibodies > 20%, 0 antigen match and/or African-American heritage. Read More

View Article and Full-Text PDF
January 2022

A Systematized Review of Professional Employment Following Thoracic Transplantation.

Prog Transplant 2022 Jan 10:15269248211064883. Epub 2022 Jan 10.

Institute of Nursing Science, University of Freiburg, Freiburg, Germany.

Introduction: Acknowledging the evolved landscape in thoracic transplantation, professional employment becomes an important outcome measure to quantify the success of this costly procedure.

Objective: We aimed to assess rates of and characterize factors associated with professional employment in patients following thoracic transplantation, and create an evidence-base on the relationship between professional employment and relevant outcome parameters.

Methods: We systematically searched Medline, Cinahl, and GoogleScholar to identify studies published between 1998 and 2021 reporting on professional employment following heart and lung transplantation. Read More

View Article and Full-Text PDF
January 2022

Complement blockade with eculizumab to treat acute symptomatic humoral rejection after heart transplantation.

Xenotransplantation 2022 Jan 10:e12726. Epub 2022 Jan 10.

Center for Organ Transplantation, Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.

Antibody-mediated rejection (AMR) is a major barrier preventing successful discordant organ xenotransplantation, but it also occurs in allotransplantation due to anti-HLA antibodies. Symptomatic acute AMR is rare after heart allograft but carries a high risk of mortality, especially >1 year after transplant. As complement activation may play a major role in mediating tissue injury in acute AMR, drugs blocking the terminal complement cascade like eculizumab may be useful, particularly since "standards of care" like plasmapheresis are not based on strong evidence. Read More

View Article and Full-Text PDF
January 2022

Textbook surgical outcome in lung transplantation: Analysis of a US national registry.

Clin Transplant 2022 Jan 9:e14588. Epub 2022 Jan 9.

Department of Surgery, Duke University Medical Center, Durham, NC, USA.

Textbook surgical outcome (TO) is a novel composite quality measure in lung transplantation (LTx). Compared to one-year survival metrics, TO may better differentiate center performance, and motivate improvements in care. To understand the feasibility of implementing this metric, we defined TO in LTx using US national data, and evaluated its ability to predict post-transplant outcomes and differentiate center performance. Read More

View Article and Full-Text PDF
January 2022

Rabbit antithymocyte globulin dose and early subclinical and clinical rejections in kidney transplantation.

Clin Transplant 2022 Jan 9:e14582. Epub 2022 Jan 9.

University of Pittsburgh Medical Center, Division of Transplant Nephrology.

Antithymocyte globulin (ATG) is a commonly used induction agent in kidney transplant recipients. However, the optimal dosing has not been well defined. Our protocol aims for a 5-6 mg/kg cumulative dose. Read More

View Article and Full-Text PDF
January 2022

Association of post-transplantation anellovirus viral load with kidney transplant rejection in children.

Pediatr Nephrol 2022 Jan 9. Epub 2022 Jan 9.

Research Laboratory of Infectious Diseases, Shaare Zedek Medical Center, affiliated to the Hadassah - Hebrew University Medical School, 12 Beit Shmuel Street, 91031, Jerusalem, Israel.

Background: Post-transplantation immunosuppressive therapy reduces the risk of graft rejection but raises the risk of infection and malignancy. A biomarker of the level of immunosuppression can be helpful in monitoring immunosuppressive therapy. Inverse correlation between Torque teno virus (TTV) from the Anelloviridae (AV) family load and immune competence was described in previous studies. Read More

View Article and Full-Text PDF
January 2022

Pulmonary Pathology of End-Stage COVID-19 Disease in Explanted Lungs and Outcomes After Lung Transplantation.

Am J Clin Pathol 2022 Jan 6. Epub 2022 Jan 6.

Departments of Pathology, NYU Langone Medical Center, New York University School of Medicine, New York, NY, USA.

Objectives: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may develop end-stage lung disease requiring lung transplantation. We report the clinical course, pulmonary pathology with radiographic correlation, and outcomes after lung transplantation in three patients who developed chronic respiratory failure due to postacute sequelae of SARS-CoV-2 infection.

Methods: A retrospective histologic evaluation of explanted lungs due to coronavirus disease 2019 was performed. Read More

View Article and Full-Text PDF
January 2022

Horses' rejection behaviour towards the presence of Senecio jacobaea L. in hay.

BMC Vet Res 2022 Jan 7;18(1):25. Epub 2022 Jan 7.

Institute of Animal Nutrition, Nutrition Diseases and Dietetics, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany.

Background: Senecio jacobaea contains pyrrolizidine alkaloids that can induce severe hepatic intoxication in horses, either acute when ingested in high amounts or chronic when consumed over a long period. The aim of this study was to determine horses' rejection behaviour towards the presence of Senecio jacobaea in hay when fed ad libitum. We hypothesized that adult horses can sort Senecio jacobaea out of the contaminated hay when hay is fed ad libitum. Read More

View Article and Full-Text PDF
January 2022

Endovenous Iliocaval Revascularization for Transplant Kidney Salvage.

J Endovasc Ther 2022 Jan 7:15266028211068765. Epub 2022 Jan 7.

Department of Thoracovascular Surgery, Ghent University Hospital, Ghent, Belgium.

Purpose: We report the case of a venous iliocaval recanalization to preserve a transplant kidney.

Case Report: A young patient with a nephrotic syndrome caused by focal segmental glomerulosclerosis (FSGS) underwent a robot-assisted living-donor kidney transplant. The postoperative course was uneventful; serum creatinine at discharge was 1. Read More

View Article and Full-Text PDF
January 2022

Viral infections in lung transplantation.

J Thorac Dis 2021 Nov;13(11):6673-6694

Infectious Diseases Service, Lausanne University Hospital, Lausanne, Switzerland.

Viral infections account for up to 30% of all infectious complications in lung transplant recipients, remaining a significant cause of morbidity and even mortality. Impact of viral infections is not only due to the direct effects of viral replication, but also to immunologically-mediated lung injury that may lead to acute rejection and chronic lung allograft dysfunction. This has particularly been seen in infections caused by herpesviruses and respiratory viruses. Read More

View Article and Full-Text PDF
November 2021

Impact of G-CSF Therapy on Leukopenia and Acute Rejection Following Kidney Transplantation.

Int J Organ Transplant Med 2021 ;12(2):1-8

Department of General and Digestive Surgery, Section of Transplant Surgery, Medical Center, Faculty of Medicine, University of Freiburg, Germany.

Background: Leukopenia is a common problem after kidney transplantation. The therapeutic approach typically includes a reduction of the immunosuppressive therapy, which is associated with an increased risk of rejection and allograft loss. Granulocyte colony-stimulating factor (G-CSF) is used as a therapeutic option to raise the leukocyte blood count; however, the effect on acute rejections is controversial. Read More

View Article and Full-Text PDF
January 2021

Long-term Outcomes Following Kidney and Liver Transplant in Recipients With HIV.

JAMA Surg 2022 Jan 5. Epub 2022 Jan 5.

Department of Surgery, University of California, San Francisco.

Importance: Kidney transplant (KT) and liver transplant (LT) in HIV-positive patients have become more widely adopted. Data looking at long-term outcomes of patient and graft survival are lacking.

Objective: To compare the long-term outcomes of KT and LT in HIV-positive recipients with matched HIV-negative recipients. Read More

View Article and Full-Text PDF
January 2022

Containment and therapeutic relationships in acute psychiatric care spaces: the symbolic dimensions of doors.

BMC Psychiatry 2022 01 4;22(1). Epub 2022 Jan 4.

Community Nursing Lab, Department of Nursing, University of Thessaly, Larissa, Greece.

Background: There is an increasing trend of door locking practices in acute psychiatric care. The aim of the present study was to illuminate the symbolic dimensions of doors in Greek mental health nurses' experiences of open and locked working spaces.

Results: A sequential mixed-method designexplored the experiences of nurses working in both open and locked psychiatric acute care units. Read More

View Article and Full-Text PDF
January 2022

Expression of Programmed Cell Death 1 and Helios Genes Correlates With rs872071A>G and rs12203592C>T Single-Nucleotide Polymorphisms of InterferonRegulatory Factor 4 in Patients with T-Cell-Mediated Rejection of Renal Allograft.

Exp Clin Transplant 2022 Jan 3. Epub 2022 Jan 3.

From the Nephrology Research Center, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Acute T-cell-mediated rejection of the renal allograft is a serious posttransplant challenge that requires administration of high-dose immunosuppressive drugs with considerable side effects; therefore, specific targeting of T-cell responses may improve both prevention and treatment of T-cell-mediated rejection. A potential candidate for this purpose is interferon regulatory factor 4 because of its implication in differentiation and function of T cells. Our aim was to evaluate the frequency of the rs872071A>G and rs12203592C>T single-nucleotide polymorphisms of the interferon regulatory factor 4 gene and association of these 2 polymorphisms with the gene expression of programmed cell death 1 and Helios in patients with T-cell-mediated rejection versus stable recipients. Read More

View Article and Full-Text PDF
January 2022