8,593 results match your criteria acute ocular

Bioinformatics and survival analysis of glia maturation factor-γ in pan-cancers.

BMC Cancer 2021 Apr 17;21(1):423. Epub 2021 Apr 17.

Central Laboratory, the Fifth People's Hospital of Shanghai, Fudan University, Shanghai, 200240, China.

Background: Glia maturation factor-γ (GMFG) is reported to inhibit the actin nucleation through binding to the actin-related protein-2/3 complex (Arp2/3). Considering the main function of GMFG in actin remodeling, which is vital for immune response, angiogenesis, cell division and motility, GMFG is supposed to have important roles in tumor development, while up to now, only two studies described the role of GMFG in cancers. By investigating the clinical values of GMFG using The Cancer Genome Atlas (TCGA) data and the functional mechanisms of GMFG through analyses of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichments, this study was aimed to better understand the impact of GMFG in pan-cancers and to draw more attentions for the future research of GMFG. Read More

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A Review of Filamentary Keratitis.

Surv Ophthalmol 2021 Apr 13. Epub 2021 Apr 13.

Department of Ophthalmology, Long School of Medicine, University of Texas Health San Antonio, San Antonio, Texas. Electronic address:

Filamentary keratitis (FK) is characterized by presence of filaments on the corneal surface that are often associated with symptoms of foreign body sensation, irritation, and eye pain. FK is associated with a variety of ocular and systemic conditions, most notably dry eye disease. These filaments are composed primarily of epithelium, mucus, and cellular debris; however, their pathogenesis remains an area of debate. Read More

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Subpalpebral Antibiotic Lavage as Safe, Emergent, and Cost-Effective Management of Acute Infectious Keratitis Related to Contact Lens Overwear: Case Report and Literature Review.

Cornea 2021 Apr 14. Epub 2021 Apr 14.

Faculty of Medicine, University of New South Wales, Sydney, Australia; Royal North Shore Hospital, Sydney, Australia; and Department of Ophthalmology, Prince of Wales Hospital, Sydney, Australia.

Purpose: The aim of this study is to describe the technique of subpalpebral antibiotic lavage (SAL), which is a highly therapeutic, efficient, and cost-effective method for managing severe bacterial keratitis.

Methods: This case report describes a 26-year-old woman with severe bacterial keratitis in the right eye due to contact lens overwear, with progressive corneal thinning, a hypopyon, impending perforation, and marked visual loss to perception of light despite treatment with intensive topical antibiotics. This was managed with SAL that involves the insertion of a cannula transcutaneously into the upper conjunctival fornix to provide continuous antibiotic irrigation of the ocular surface. Read More

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Eye amputation following lifitegrast treatment for ocular graft-versus-host disease: First case report.

J Fr Ophtalmol 2021 Apr 12. Epub 2021 Apr 12.

Ophthalmology department, University Hospital of Nice, 30, voie Romaine, 06000 Nice, France. Electronic address:

Graft-versus-host disease (GVHD) is a common complication in patients undergoing allogeneic stem cell transplantation for acute myeloblastic leukemia that could be very difficult to treat. Lifitegrast 5% (Xiidra@, Novartis), a new immunosuppressive eye drop, was recently approved by the FDA for the treatment of severe dry eye and is currently under review by the European Medicines Agency. In France, lifitegrast has been approved by the French authorities for temporary use in refractory dry eye syndrome resistant to tear substitutes and topical cyclosporine. Read More

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Bedside video-oculographic evaluation of eye movements in acute supratentorial stroke patients: A potential biomarker for hemispatial neglect.

J Neurol Sci 2021 Apr 9;425:117442. Epub 2021 Apr 9.

Department of Neurology, Yokohama Brain and Spine Center, Yokohama, Japan. Electronic address:

Background And Purpose: The presence of hemispatial neglect adversely affects functional outcomes in stroke patients; consequently, it warrants early targeted rehabilitative intervention. Nevertheless, hemispatial neglect in the acute phase of stroke has often been underdiagnosed. In this study, we aimed to detect hemispatial neglect at the bedside in acute stroke patients by measuring eye movements using video-oculography (VOG). Read More

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Acute strabismus in neurological emergencies of childhood: A retrospective, single-centre study.

Eur J Paediatr Neurol 2021 Apr 2;32:80-85. Epub 2021 Apr 2.

Pediatric Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Electronic address:

Objectives: Acute strabismus (AS) is the most common ocular motility disorder in children. In the emergency setting evaluation, the primary concern is to exclude a potentially dangerous underlying condition, requiring immediate intervention. Our first aim was to describe the epidemiology, clinical features, and underlying causes of AS in a cohort of children presenting to the emergency department (ED). Read More

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Acute Onset Variable and Progressive Trochlear Nerve Palsy and Ophthalmoparesis Secondary to Bilateral Carotid Cavernous Fistula.

J Binocul Vis Ocul Motil 2021 Apr 15:1-5. Epub 2021 Apr 15.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.

: To describe a patient who presented with right unilateral white-eyed posteriorly-draining carotid-cavernous fistulas (CCF) causing an isolated, acute-onset trochlear nerve palsy with atypical progression to a contralateral left red-eyed anteriorly-draining CCF associated with orbital congestion.: A 74-year-old female presented with an acute onset incomitant right hypertropia consistent with the clinical diagnosis of a superior oblique palsy. Initial workup including MRI was normal. Read More

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Bilateral Acute Anterior Uveitis and Corneal Punctate Epitheliopathy in Children Diagnosed with Multisystem Inflammatory Syndrome Secondary to COVID-19.

Ocul Immunol Inflamm 2021 Apr 15:1-5. Epub 2021 Apr 15.

Department of Pediatric Infectious Diseases, Health Sciences University, Dr. Sami Ulus Education and Research Hospital, Ankara, Turkey.

: To report bilateral anterior uveitis and corneal punctate epitheliopathy in children with multisystem inflammatory syndrome (MIS-C) secondary to coronavirus disease (COVID-19).: Five patients who were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies and diagnosed with MIS-C were evaluated. Ophthalmologic examinations were performed in order to reveal ocular findings in MIS-C disease. Read More

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Exploring the role of macular thickness as a potential early biomarker of neurodegeneration in acute schizophrenia.

Int Ophthalmol 2021 Apr 15. Epub 2021 Apr 15.

Department of Psychiatry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (SBV) Deemed To Be University, Puducherry, India.

Objective: The retina has been investigated as a gateway to assess the neurodegenerative changes in the brain. Schizophrenia is also conceptualized as a neurodegenerative disorder like Alzheimer's and Parkinson's disease. The current literature suggests reduced retinal nerve fibre layer (RNFL) thickness and macular thickness (MT), as a marker of neurodegeneration, in patient suffering from chronic schizophrenia. Read More

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Allergic Rhinitis Therapy Decisions During a Routine Consultation: A Multicenter, Cross-Sectional Survey.

J Asthma Allergy 2021 7;14:335-345. Epub 2021 Apr 7.

Global Medical Affairs, MEDA Pharma GmbH & Co. KG (A Mylan Company), Bad Homburg, Germany.

Background: Allergic rhinitis (AR) is characterized by nasal and ocular symptoms, and substantially impacts the quality of life. Therapy selection for patients with AR depends on several factors, including symptom severity, age, patient preference, patient adherence, and cost.

Methods: The purpose of this multicenter, noninterventional, cross-sectional survey was to evaluate current therapy decisions in routine clinical practice for patients with symptomatic AR, and to determine how these decisions are linked to experiences with previous treatments and current symptom severity as assessed by aVAS. Read More

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Association of retinal detachment with age 50 years or younger at onset in patients with acute retinal necrosis.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 12. Epub 2021 Apr 12.

Inflammatory Eye Disease Clinic, Dr. Luis Sanchez Bulnes" Hospital, Asociación para Evitar la Ceguera en México (APEC), Mexico City, CDMX, Mexico.

Background: Due to the guarded prognosis of acute retinal necrosis (ARN), it is relevant to develop a strategy to early categorize those patients in a higher risk of worse outcomes. The purpose of this study is to describe clinical features and predictive factors for retinal detachment (RD) in patients with ARN.

Methods: Retrospective observational case series of 34 adult patients (38 eyes) with ARN examined between January 2005 and July 2015 in the National Eye Institute (Bethesda, USA), the Department of Ophthalmology, University of Chile (Santiago, Chile), and APEC (CDMX, Mexico). Read More

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Orbital infarction syndrome following hyaluronic acid filler rhinoplasty.

Luai Eldweik

Am J Ophthalmol Case Rep 2021 Jun 18;22:101063. Epub 2021 Mar 18.

Eye Institute, Cleveland Clinic Abu Dhabi, C7-257 Swing Wing, Al Maryah Island, Abu Dhabi, 112412, United Arab Emirates.

Purpose: Over the last decade, injectable soft tissue fillers have become an essential part of facial plastic surgery practice. We report here a tragic complication of hyaluronic acid filler injection in a young healthy woman, management offered, and the outcome.

Observations: A 32-year-old woman developed unilateral acute blindness, orbital pain, total ophthalmoplegia, and anterior and posterior segment ischemia immediately following hyaluronic acid injection. Read More

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Polluted Air Exposure Compromises Corneal Immunity and Exacerbates Inflammation in Acute Herpes Simplex Keratitis.

Front Immunol 2021 25;12:618597. Epub 2021 Feb 25.

Laboratorio Traslacional de Inmunopatología y Oftalmología, Departamento de Patología, Facultad de Medicina, Universidad de Buenos Aires, Cuidad Autónoma de Buenos Aires, Argentina.

Air pollution is a serious environmental issue worldwide in developing countries' megacities, affecting the population's health, including the ocular surface, by predisposing or exacerbating other ocular diseases. Herpes simplex keratitis (HSK) is caused by the herpes simplex virus type 1 (HSV-1). The primary or recurring infection in the ocular site causes progressive corneal scarring that may result in visual impairment. Read More

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February 2021

GLOS and HARM in patients with transient neurovascular symptoms with and without ischemic infarction.

J Neuroradiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.

Background And Purpose: Gadolinium leakage in ocular structures (GLOS) on fluid attenuated inversion recovery images (FLAIR) is a novel imaging marker in acute ischemic stroke and other neurological disorders.

Methods: In patients with transient neurovascular symptoms who underwent repeated MRI with intravenous contrast agent administration, the presence of acute ischemic lesions on diffusion-weighted images (DWI) as well as the frequency and pattern of blood-brain barrier and blood-retina barrier impairment as demonstrated by the hyperintense acute reperfusion marker (HARM) and GLOS respectively on postcontrast FLAIR were evaluated.

Results: Overall 28 patients with transient neurovascular symptoms (median age 70. Read More

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Acute Bilateral Neuroretinitis and Panuveitis in A Patient with Coronavirus Disease 2019: A Case Report.

Ocul Immunol Inflamm 2021 Apr 8:1-4. Epub 2021 Apr 8.

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

: Herein, we report a case of bilateral neuroretinitis and panuveitis in a patient recovered from coronavirus disease 2019 (COVID-19).: A 37-year-old male patient with a history of recovered COVID-19, which was confirmed with nasopharyngeal reverse transcriptase polymerase chain reaction (RT-PCR) for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), about one-month ago was referred with one-week history of bilateral severe vision loss. Visual acuity was counting fingers, and bilateral retinitis and panuveitis were revealed in ocular examination. Read More

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What can visual caregivers expect with patients treated for SARS-CoV-2? An analysis of ongoing clinical trials and ocular side effects.

Eur J Ophthalmol 2020 Oct 8:1120672120958323. Epub 2020 Oct 8.

Department of Community Nursing, Preventive Medicine and Public Health and History of Science, Public Health Research Group, University of Alicante, Spain.

Within the COVID-19 pandemic context, the WHO has proposed a list of medicines to treat patients with severe acute respiratory syndrome (SARS-CoV-2). An analysis of their ocular side effects was performed. Only chloroquine and hydroxychloroquine were found to have an ocular impact in the medium and long-term. Read More

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October 2020

Corneal Biomechanical Changes Caused by Acute Elevation of IOP in Eyes with and without Glaucoma.

Optom Vis Sci 2021 04;98(4):367-373

Eye Associates of New Mexico, Albuquerque, New Mexico.

Significance: Although corneal biomechanical parameters are well linked with glaucoma, their clinical utility has not yet been fully elucidated. This study was designed to provide unique evidence about the dynamic nature of corneal biomechanical parameters and their potential prognostic ability for glaucoma.

Purpose: This study aimed to evaluate the effect of acute intraocular pressure (IOP) elevation on corneal hysteresis (CH) and corneal resistance factor (CRF) and the associations of these biomechanical parameters with glaucomatous disease. Read More

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SARS-CoV-2 Not Detectable in Ocular Specimens of a Patient with a Past Infection.

Ocul Immunol Inflamm 2021 Apr 7:1-3. Epub 2021 Apr 7.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.

: To present a a case study that aims to investigate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the ocular tissue samples of a patient previously infected with COVID-19 and determine its transmissibility.: Case Report: In this case study, SARS-CoV-2 was not detected in the vitreous and uveal tissue samples by RT-PCR for detection of three gene targets in a patient with a past COVID-19 infection 15 days prior to presention with a globe rupture.: Our findings suggest that patients with long-term existence of SARS-CoV-2 at low detectable levels may not have active intraocular viral shedding. Read More

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Ocular Adverse Events following Yellow Fever Vaccination: A Case Series.

Ocul Immunol Inflamm 2021 Apr 7:1-5. Epub 2021 Apr 7.

Department of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

: To describe four cases of ocular adverse events resembling intraocular inflammatory and non-inflammatory conditions following yellow fever vaccination (YFV) during a recent yellow fever (YF) outbreak in Brazil.: Charts of patients diagnosed with ocular adverse events after YFV between January 2017 and January 2019 at two tertiary referral centers in Brazil.: Four patients (two adults and two children) are reported. Read More

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Current opinion in neurological manifestations of SARS-CoV-2 infection.

Curr Opin Toxicol 2021 Mar 29. Epub 2021 Mar 29.

Gazi University, Faculty of Medicine, Department of General Surgery, Ankara, Turkey.

Neurological symptoms occur in approximately one third of hospitalized patients with coronavirus disease 2019 (COVID-19). Among these symptoms, hypoxic encephalopathy develops in one-fifth of severe cases, while ischemic strokes due to thrombotic complications are common in one-third of COVID-19 intensive care patients. Brain involvement of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is eventuated by several routes, including hematogenous spread, trans-synaptic entry through infected neurons, olfactory nerve, ocular epithelium, vascular endothelium and impaired blood-brain barrier. Read More

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Wegener's granulomatosis with orbital involvement: case report and literature review.

Rom J Ophthalmol 2021 Jan-Mar;65(1):93-97

Emergency Eye Hospital, Bucharest, Romania.

To describe the chronology and the extent of orbital involvement in a case of granulomatosis with polyangiitis. Descriptive case report and literature review. A 45-year-old patient, formerly diagnosed with granulomatosis with polyangiitis due to otorhinolaryngologic manifestations, pulmonary lesions, renal impairment, left knee arthritis and high blood levels of antineutrophil cytoplasmic antibodies, addressed the Ophthalmology Department in November 2020, having the following complaints: left eye mild retro-orbital discomfort, proptosis and epiphora. Read More

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Branch Retinal Vein Occlusion in a COVID-19 Positive Patient.

Cureus 2021 Feb 27;13(2):e13586. Epub 2021 Feb 27.

Ophthalmology, University of Florida, Gainesville, USA.

Retinal vein occlusions (RVOs), including central retinal vein occlusions (CRVOs) and branch retinal vein occlusions (BRVOs), are a common cause of morbidity in elderly patients. We present the case of a healthy 74-year-old female patient who initially presented with blurry vision in her left eye in the setting of a symptomatic COVID-19 infection. She was diagnosed with a branch retinal vein occlusion that did not immediately require treatment. Read More

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February 2021

Prognosis after acute unilateral vestibulopathy: Usefulness of the suppression head impulse paradigm (SHIMP).

J Vestib Res 2021 Mar 29. Epub 2021 Mar 29.

Department of Surgical Pathology, Medical, Molecular and Critical Area, ENT Section, Pisa University Hospital, Pisa, Italy.

Objectives: This cross-sectional study aims to describe the features of the suppression head impulse paradigm (SHIMP) in acute unilateral vestibulopathy (AUV) and to define its role in predicting the recovery of patients.

Methods: Thirty patients diagnosed with AUV were retrospectively analyzed. The dizziness handicap inventory score and video head impulse test parameters performed 4-8 weeks from the AUV onset constituted the main outcome measures. Read More

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"Eye" Don't See: An Analysis of Visual Symptom Reporting by Stroke Survivors from a Large Epidemiology Study.

J Stroke Cerebrovasc Dis 2021 Apr 1;30(6):105759. Epub 2021 Apr 1.

Department of Health Services Research, University of Liverpool, Waterhouse Building Block B, 2nd floor, 1-5 Brownlow Street, Liverpool L69 3GL, United Kingdom. Electronic address:

Aim: The purpose was to explore the reported symptoms of post-stroke visual impairment from a large multi-centre prospective epidemiology study.

Methods: Visual assessment, including a case history, visual acuity, ocular alignment, ocular motility, visual fields, visual inattention and visual perception, was attempted for all stroke admissions to three acute stroke units.

Results: Of 1500 stroke admissions, 1204 received a visual assessment, of which 867 had one or more visual impairments. Read More

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Vocal cord paralysis secondary to vincristine treatment in children - A case series of seven children and literature review.

Clin Otolaryngol 2021 Apr 3. Epub 2021 Apr 3.

Department of ENT, Sheffield Children's NHS Foundation Trust.

Vincristine is a vinca alkaloid chemotherapy agent used in the treatment haematological malignancies including acute lymphoblastic leukaemia (ALL) and some lymphomas. Common toxicity includes neuropathy which can be peripheral, autonomic or less commonly central . Vincristine remains an essential chemotherapy agent in modern ALL protocols . Read More

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Acute vestibulopathy with simultaneous bilateral involvement of the vestibulo-ocular reflex limited to the low-frequency range.

Auris Nasus Larynx 2021 Mar 30. Epub 2021 Mar 30.

Department of Otolaryngology-Head and Neck Surgery, Nagoya City University Graduate School of Medical Science, 1 Kawaumi Mizuho-Ku, Nagoya, Aichi, 467-8601, Japan.

We report a novel type of idiopathic bilateral vestibulopathy with acute simultaneous involvement of the vestibulo-ocular reflex limited to the low-frequency range. A 64-year-old female presented with dizziness, oscillopsia, and difficulty walking. She did not experience rotatory vertigo and did not show any nystagmus. Read More

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Treatment Strategy in Human Ocular Toxoplasmosis: Why Antibiotics Have Failed.

J Clin Med 2021 Mar 5;10(5). Epub 2021 Mar 5.

Department of Ophthalmology, Campus Virchow, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Charité, 13353 Berlin, Germany.

Background: There is currently no clear evidence of the effectiveness of antibiotic therapy in acute ocular toxoplasmosis (OT), but its effect as a secondary prophylaxis is undisputed. The majority of uveitis specialists advocate treatment. This meta-analytic review aims to critically analyze determinants of treatment success and to update current treatment strategies for OT in order to explain this discrepancy. Read More

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Imbalance in the Levels of Angiogenic Factors in Patients with Acute and Chronic Central Serous Chorioretinopathy.

J Clin Med 2021 Mar 5;10(5). Epub 2021 Mar 5.

Molecular Biology and Clinical Genetics Unit, Department of Internal Medicine, Jagiellonian University Medical College Faculty of Medicine, 31-066 Krakow, Poland.

Background: The pathogenesis of central serous chorioretinopathy (CSC) remains a subject of intensive research. We aimed to determine correlations between plasma levels of selected angiogenic factors and different forms of CSC.

Methods: Eighty patients were enrolled in the study including 30 with a chronic form of CSC, 30 with acute CSC, and 20 controls. Read More

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SARS-CoV-2 Infection and Antibody Response in a Symptomatic Cat from Italy with Intestinal B-Cell Lymphoma.

Viruses 2021 03 23;13(3). Epub 2021 Mar 23.

Clinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.

Since the coronavirus disease (COVID-19) pandemic was first identified in early 2020, rare cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in pet cats have been reported worldwide. Some reports of cats with SARS-CoV-2 showed self-limiting respiratory or gastrointestinal disease after suspected human-to-feline transmission via close contact with humans with SARS-CoV-2. In the present study, we investigated a cat with SARS-CoV-2 that was presented to a private animal clinic in Northern Italy in May 2020 in a weak clinical condition due to an underlying intestinal B-cell lymphoma. Read More

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Characteristics and Detection Rate of SARS-CoV-2 in Alternative Sites and Specimens Pertaining to Dental Practice: An Evidence Summary.

J Clin Med 2021 Mar 10;10(6). Epub 2021 Mar 10.

Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, 801 S Paulina St, Chicago, IL 60612, USA.

Knowledge about the detection potential and detection rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in various body fluids and sites is important for dentists since they, directly or indirectly, deal with many of these fluids/sites in their daily practices. In this study, we attempt to review the latest evidence and meta-analysis studies regarding the detection rate of SARS-CoV-2 in different body specimens and sites as well as the characteristics of these sample. The presence/detection of SARS-CoV-2 viral biomolecules (nucleic acid, antigens, antibody) in different clinical specimens depends greatly on the specimen type and timing of collection. Read More

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