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A retrospective evaluation of the value of COVID-19 screening and testing in patients with cancer: Aiming at a moving target.

J Infect Public Health 2021 May 26;14(7):949-953. Epub 2021 May 26.

Department of Oncology, King Abdulaziz Medical City, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia.

Background: Diagnosis of COVID-19 infection in cancer patients is critical to co-manage their underlying disease and infection appropriately. Our study aimed at evaluating the sensitivity and specificity of screening patients with cancer for COVID-19 infection.

Methods: All oncology patients receiving care at Department of Oncology at King Abdulaziz Medical City in Riyadh were screened using the acute respiratory infection (ARI) survey. Read More

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Morbidity and Mortality Trends of Pancreatitis: An Observational Study.

Surg Infect (Larchmt) 2021 Jun 15. Epub 2021 Jun 15.

Department of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Pancreatitis accounts for more than $2.5 billion of healthcare costs and remains the most common gastrointestinal (GI) admission. Few contemporary studies have assessed temporal trends of incidence, complications, management, and outcomes for acute pancreatitis in hospitalized patients at the national level. Read More

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Aripiprazole Lauroxil 2-Month Formulation With 1-Day Initiation for Acute Schizophrenia: ALPINE Exploratory Efficacy and Patient-Reported Outcomes.

CNS Spectr 2021 Apr;26(2):171-172

Alkermes, Inc., Waltham, MA, USA.

Objective: The randomized, controlled, phase 3b ALPINE study evaluated efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) initiated with a 1-day regimen during hospitalization for an acute exacerbation of schizophrenia; paliperidone palmitate (PP) was included as an active control. The primary efficacy outcome, within-group change from baseline in PANSS total score at 4 weeks, was previously reported. Here we report additional exploratory PANSS subscale endpoints and patient-reported outcomes (PROs). Read More

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Hospital utilization rates for influenza and RSV: a novel approach and critical assessment.

Popul Health Metr 2021 Jun 14;19(1):31. Epub 2021 Jun 14.

Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA.

Background: Influenza and respiratory syncytial virus (RSV) contribute significantly to the burden of acute lower respiratory infection (ALRI) inpatient care, but heterogeneous coding practices and availability of inpatient data make it difficult to estimate global hospital utilization for either disease based on coded diagnoses alone.

Methods: This study estimates rates of influenza and RSV hospitalization by calculating the proportion of ALRI due to influenza and RSV and applying this proportion to inpatient admissions with ALRI coded as primary diagnosis. Proportions of ALRI attributed to influenza and RSV were extracted from a meta-analysis of 360 total sources describing inpatient hospital admissions which were input to a Bayesian mixed effects model over age with random effects over location. Read More

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[Difference on prevalence and trends of conventional risk factors for ASCVD between young Chinese and American adults with first acute myocardial infarction].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):580-585

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

This study aimed to compare the prevalence and trends of conventional risk factors for atherosclerotic cardiovascular disease(ASCVD) between young Chinese and American adults with first acute myocardial infarction. This was a retrospective cohort analysis. Hospitalized yang adults (aged from 18 to 44 years old) with first acute myocardial infarction(AMI) from January 2007 through December 2017 were identified from Beijing Anzhen hospital medical record system. Read More

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[Inpatient Psychiatric Treatment in the Corona-crisis by Psychologists and Psychiatrists in Home-office and in the Clinic].

Fortschr Neurol Psychiatr 2021 Jun 14. Epub 2021 Jun 14.

Psychiatrie und Psychotherapie, LMU Klinikum der Universität München Medizinische Klinik und Poliklinik IV, München, Germany.

Since the emergence of the new coronavirus (COVID-19) pandemic in March 2020, many people in Germany have become ill. This meant a challenge for the care of mentally ill hospitalized patients. There was a social shut-down in Bavaria with a decrease in social contacts. Read More

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Timing of Coronary Artery Bypass Grafting in Acute Coronary Syndrome: A National Analysis.

Ann Thorac Surg 2021 Jun 11. Epub 2021 Jun 11.

Cardiovascular Outcomes Research Laboratories, Division of Cardiac Surgery, Department of Surgery, University of California, Los Angeles, Los Angeles, California. Electronic address:

Background: Timing of surgical revascularization for acute coronary syndrome (ACS) remains debated. We assessed the impact of timing to CABG on mortality and resource utilization in a national cohort.

Methods: Adults admitted for ACS in the 2009-2018 National Inpatient Sample were grouped by time from coronary angiography to CABG (Δt): 0, 1-3, 4-7, and >7 days. Read More

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Outcomes of COVID-19 in Patients With Cancer: A Closer Look at Pre-Emptive Routine Screening Strategies.

JCO Oncol Pract 2021 Jun 14:OP2100177. Epub 2021 Jun 14.

Division of Medical Oncology, Mayo Clinic, Rochester, MN.

Purpose: The benefit of routine pre-emptive screening for severe acute respiratory syndrome coronavirus 2 infections in patients with cancer before cancer-directed therapies is unclear. Herein, we characterize the outcomes of a cohort of patients with cancer who were diagnosed with COVID-19 by routine screening (RS) in comparison with those diagnosed on the basis of clinical suspicion or exposure history (nonroutine screening [NRS]).

Methods: A multisite prospective observational study was conducted at three major and five satellite campuses of the Mayo Clinic Cancer Center between March 18 and July 31, 2020. Read More

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Improvements in Hope, Engagement and Functioning Following a Recovery-Focused Sub-Acute Inpatient Intervention: a Six-Month Evaluation.

Psychiatr Q 2021 Jun 14. Epub 2021 Jun 14.

Hunter New England Mental Health Service, PO Box 833, Newcastle, NSW, 2300, Australia.

Few studies have examined the post-discharge benefits associated with recover-oriented programs delivered in inpatient and sub-acute mental health settings. The aim of this study was to evaluate the medium-term outcomes of a 6-week sub-acute inpatient intervention program for 27 service users with a diagnosis of serious mental illness (mean age = 33.22 years, 70. Read More

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Risk factors for a second nonsimultaneous hip fracture in a prospective cohort study.

Arch Orthop Trauma Surg 2021 Jun 14. Epub 2021 Jun 14.

Musculoskeletal Research Unit, IMIM-Parc Salut Mar, CIBERFES, Universitat Autonoma de Barcelona, Doctor Aiguader 88, 20, 08003, Barcelona, Spain.

Introduction: The risk factors for a second nonsimultaneous hip fracture are unclear, and in general, it is empirically assumed that they are similar to those associated with the first hip fracture. We aimed to determine the incidence of a second hip fracture and define the characteristics of the patients sustaining the event in a prospective cohort study in a Spanish population.

Materials And Methods: We conducted a multicentric, prospective cohort study in a representative sample of 45 hospitals from 15 autonomic regions in Spain. Read More

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Performance of Emergency Heart Failure Mortality Risk Grade in the Emergency Department.

West J Emerg Med 2021 Apr 8;22(3):672-677. Epub 2021 Apr 8.

Northwell Health, Long Island Jewish Medical Center, Department of Emergency Medicine, New Hyde Park, New York.

Introduction: The purpose of this study was to validate and assess the performance of the Emergency Heart Failure Mortality Risk Grade (EHMRG) to predict seven-day mortality in US patients presenting to the emergency department (ED) with acute congestive heart failure (CHF) exacerbation.

Methods: We performed a retrospective chart review on patients presenting to the ED with acute CHF exacerbation between January 2014-January 2016 across eight EDs in New York. We identified patients using codes from the International Classification of Diseases, 9th and 10 Revisions, or who were diagnosed with CHF in the ED. Read More

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Psychometric properties of a patient-reported outcome set in acute stroke patients.

Brain Behav 2021 Jun 14. Epub 2021 Jun 14.

Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objectives: Impairments after stroke may affect multiple domains of health-related quality of life (HRQoL). Patient-reported outcome measures (PROMs) have proven valuable in measuring patients' well-being. We examine the psychometric properties of a standard set of PROMs assessing global health, anxiety, and depression, and functioning in a German health care setting. Read More

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Examining the impact of Diabetes Inpatient Specialist Nursing in acute trusts in London.

J Adv Nurs 2021 Jun 14. Epub 2021 Jun 14.

Department of Health and Social Care, London South Bank University, London, UK.

Aims: To examine if the introduction of Diabetes Inpatient Specialist Nurses impacted on length of stay and rates of readmission.

Design: Knowledge discovery through data mining as part of a larger realist evaluation of the role.

Methods: Data from January 2017 to January 2019 was extracted and examined. Read More

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Case-Based Curriculum for Pediatric Residents in Diabetes Fundamentals.

MedEdPORTAL 2021 05 27;17:11157. Epub 2021 May 27.

Assistant Professor, Department of Pediatrics, Section of Diabetes and Endocrinology and Section of Nutrition, Baylor College of Medicine and Texas Children's Hospital.

Introduction: Pediatricians are at the front line to diagnose new-onset diabetes and treat acute diabetes complications in children. Pediatric residents need a strong foundation in recognizing and managing pediatric diabetes, imposing a demand for a structured, comprehensive pediatric-specific diabetes curriculum.

Methods: This three-module case-based curriculum focused on diabetes fundamentals relevant to pediatricians in the outpatient and inpatient settings. Read More

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Sterile Leukocytosis Predicts Hemorrhagic Transformation in Arterial Ischemic Stroke: A National Inpatient Sample Study.

Cureus 2021 May 11;13(5):e14973. Epub 2021 May 11.

Neurological Surgery, Albert Einstein College of Medicine, Bronx, USA.

Objective: Hemorrhage transformation (HT) is a known complication of arterial ischemic stroke (AIS). In addition, it is known that the increase of proinflammatory immune cells in the brain tissue after AIS predict worse outcomes. However, it is not clear whether inflammation due to preceding or post-stroke infections affect outcomes and moreover, if systemic inflammatory markers could be useful as a clinical prediction tool for HT post-stroke. Read More

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Prevalence and Treatment Characteristics of Spastic Hypertonia on First-time Admission to Acute Inpatient Rehabilitation.

Am J Phys Med Rehabil 2021 Jun 12. Epub 2021 Jun 12.

Department of Physical Medicine & Rehabilitation, McGovern Medical School at UTHealth, Houston, Texas. Department of Physical Medicine & Rehabilitation, Penn State Health, Hershey, Pennsylvania. Department of Physical Medicine & Rehabilitation, UTHealth San Antonio, San Antonio, Texas.

Objective: Report the prevalence of spasticity and treatment patterns during first-time admission to inpatient rehabilitation following acute stroke, traumatic brain injury (TBI), and spinal cord injury (SCI).

Design: Retrospective cohort.

Methods: Review of 285 adult patients consecutively admitted to inpatient rehabilitation. Read More

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An Analysis of Traumatic Ankle Fracture Patients: Does Income Status Influence Access to Acute Orthopaedic Surgical Care?

J Health Care Poor Underserved 2021 ;32(2):1059-1068

Purpose: To evaluate if income status affects the timing of presentation to orthopaedic care, surgical treatment, or continuity of care following a closed ankle fracture.

Methods: Th is retrospective study identified 434 patients with closed ankle fractures treated with operative fixation from 2014 to 2016. Median income data were extracted using the patients' ZIP codes and data from the U. Read More

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January 2021

Feasibility and early experience of a novel multidisciplinary alcohol-associated liver disease clinic.

J Subst Abuse Treat 2021 Apr 9;130:108396. Epub 2021 Apr 9.

Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, United States of America.

Background: Alcohol cessation improves mortality in alcohol-associated liver disease (ALD), but access to treatment is limited. To address this gap, implementation and early feasibility and outcomes of a multidisciplinary ALD clinic are described.

Methods: The clinic comprised a hepatologist, psychiatrist, psychologist, nurse, and social worker. Read More

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Acupuncture as an adjunctive treatment for pain in hospitalized children with sickle cell disease.

J Pain Symptom Manage 2021 Jun 9. Epub 2021 Jun 9.

Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington DC; Division of Hematology, Center for Cancer and Blood Disorders, Children's National Hospital, Washington DC. Electronic address:

Context: Acute episodes of pain associated with sickle cell disease (SCD) account for over 100,000 hospitalizations and expenses of nearly 1 billion dollars annually in the United States. New treatment approaches are needed as the current opioid based therapy is often inadequate in controlling pain, resulting in prolonged inpatient stays and high rates of readmission.

Objectives: To evaluate acceptability of acupuncture as an adjunctive therapy and explore the impact of acupuncture on pain related outcomes in a population of youth with SCD hospitalized for management of acute pain. Read More

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Discharge Disposition and Clinical Outcomes After Spine Surgery.

Am J Med Qual 2021 Jun 10. Epub 2021 Jun 10.

Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA.

Objective: Spinal decompression with or without fusion is one of the most commonly performed procedures in spine surgery. However, there is limited evidence on the effect of discharge environment on outcomes after surgery. The purpose of this study is to identify the effects of discharge disposition setting on clinical outcomes after spine surgery. Read More

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Pediatric Ocular Injury Due to Hand Sanitizer Exposure An Emerging Hazard.

Pediatr Emerg Care 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer Pediatric Emergency Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.

Objectives: The objective of this study was to describe the incidence and severity of ocular exposure to alcohol-based hand rub (ABHR) in children presenting to a tertiary medical center during the severe acute respiratory syndrome coronavirus 2 pandemic.

Methods: A retrospective single-center observational study conducted from February 21, 2020, to October 11, 2020. Subjects 10 years or younger who presented with ABHR-induced ocular injury were included. Read More

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Acute Appendicitis: Trends in Surgical Treatment.

Dtsch Arztebl Int 2021 Apr;118(14):244-249

Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of MunichMünchner Studienzentrum, Klinikum rechts der Isar, School of Medicine,Technical University ofMunichDepartment of Health Care Management, Institute of Technology and Management, TechnischeUniversität Berlin.

Background: Appendectomy is the gold standard for treatment of acute appendicitis. However, recent studies favor primary antibiotic therapy. The aim of this observational study was to explore changes in the numbers of operations for acute appendicitis in the period 2010-2017, paying special attention to disease severity. Read More

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[Evidence on the effects of crisis resolution teams, home treatment and assertive outreach for people with mental disorders in Germany, Austria and Switzerland - a systematic review].

Nervenarzt 2021 Jun 10. Epub 2021 Jun 10.

Kliniken für Psychiatrie, Psychotherapie und Psychosomatik, Vivantes Klinikum Am Urban und Vivantes Klinikum im Friedrichshain - Akademische Lehrkrankenhäuser Charité-Universitätsmedizin Berlin, Dieffenbachstr. 1, 10967, Berlin, Deutschland.

Background: Based on international randomized controlled trials (RCT) the German Association for Psychiatry, Psychotherapy and Psychosomatics (DGPPN) recommends acute treatment in the domestic environment (AHU) and intensive outreach treatment (IAB) with the highest level of evidence; however, due to large differences in national healthcare systems the transference of results from international studies to the healthcare systems in Germany, Austria and Switzerland could be limited.

Objective: Evaluation of studies on outreach psychiatric treatment forms in Germany, Austria and Switzerland and discussion of the results in the light of international evidence.

Material And Methods: A systematic literature search for clinical trials on outreach community treatment from Germany, Austria and Switzerland was conducted in the PubMed database. Read More

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Real-world antibiotic use in treating acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in China: Evidence from the ACURE study.

Front Pharmacol 2021 25;12:649884. Epub 2021 May 25.

Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

The evidence for real-world antibiotic use in treating acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is insufficient. This study aimed to investigate real-world antibiotic use in the management of AECOPD in China. All hospitalized AECOPD patients from the acute exacerbation of chronic obstructive pulmonary disease inpatient registry (ACURE) study conducted at 163 sites between January 2018 and December 2019 were screened according to the eligible criteria. Read More

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The Association with COPD Readmission Rate and Access to Medical Institutions in Elderly Patients.

Int J Chron Obstruct Pulmon Dis 2021 3;16:1599-1606. Epub 2021 Jun 3.

Department of Health Policy & Management, Kangwon National University, Chuncheon, South Korea.

Purpose: Up to 20% of patients with chronic obstructive pulmonary disease (COPD) require re-admission within 30 days of discharge after hospitalization for acute exacerbations of the disease. These re-admissions can increase morbidity and the economic burden of COPD. Reducing re-admissions has become a policy target in many developed countries. Read More

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What is the burden of osteomyelitis in Germany? An analysis of inpatient data from 2008 through 2018.

BMC Infect Dis 2021 Jun 10;21(1):550. Epub 2021 Jun 10.

Department for Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Background: The epidemiology of osteomyelitis in Germany is unknown, which makes it difficult to estimate future demands. Therefore, we aimed to analyse how the numbers of cases have developed over the last decade as a function of osteomyelitis subtype, age group, gender, and anatomical localization.

Methods: Osteomyelitis rates were quantified based on annual ICD-10 diagnosis codes from German medical institutions between 2008 through 2018, provided by the Federal Statistical Office of Germany (Destatis). Read More

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Corona Virus Disease-19 serology, inflammatory markers, hospitalizations, case finding, and aging.

PLoS One 2021 10;16(6):e0252818. Epub 2021 Jun 10.

Research Division, Diazyme Laboratories, Inc., Poway, California, United States of America.

Most deaths from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection occur in older subjects. We assessed the utility of serum inflammatory markers interleukin-6 (IL-6), C reactive protein (CRP), and ferritin (Roche, Indianapolis, IN), and SARS-CoV-2 immunoglobulin G (IgG), immunoglobulin M (IgM), and neutralizing antibodies (Diazyme, Poway, CA). In controls, non-hospitalized subjects, and hospitalized subjects assessed for SARS-CoV-2 RNA (n = 278), median IgG levels in arbitrary units (AU)/mL were 0. Read More

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Incidence and Risk Factors of In-Hospital Prosthesis-Related Complications Following Total Knee Arthroplasty: A Retrospective Nationwide Inpatient Sample Database Study.

Orthop Surg 2021 Jun 9. Epub 2021 Jun 9.

Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: To examine the incidence and risk factors of in-hospital prosthesis-related complications (PRCs) following total knee arthroplasty (TKA) using a large-scale national database.

Methods: A retrospective database analysis was performed based on Nationwide Inpatient Sample (NIS) from 2005-2014. Patients who underwent TKA were included. Read More

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Chronic, acute and acute-on-chronic pain prevalence in a tertiary care hospital setting.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3848-3858

Pain Medicine Unit, Department of Neuroscience, Azienda Socio-Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Objective: The aim of the study was to develop appropriate pain therapy and prevention plans; pain needs to be understood in terms of prevalence and associated predictor factors in hospital and primary care. The purpose of our research was to assess the prevalence of chronic, acute, and acute-on-chronic pain, and ascertain the effects of several factors on the likelihood of pain in an Italian Tertiary Care Hospital.

Patients And Methods: This is a prevalence study in which the primary outcome was the prevalence rate of chronic pain inpatients. Read More

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A Role to Alleviate Burnout and Maintain Quality of Care.

J Adv Pract Oncol 2021 Mar 1;12(2):203-208. Epub 2021 Mar 1.

University of Colorado Medicine, Aurora, Colorado.

Health care in acute care settings has become increasingly complex and stressful with rapidly evolving treatment options, a growing aging population with multiple comorbidities, and expectations to deliver high-quality care with less resources to curb rising costs. Numerous studies have documented the ever-growing problem of burnout in health-care providers working in acute care settings and increased provider interruptions leading to medical errors. From 2018 to 2019, a new advanced practice provider (APP) role was tested on a 36-bed inpatient bone marrow transplant unit at the University of Colorado to address these issues. Read More

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