202,923 results match your criteria acute cardiac


Fight or Flight: The Effect of Heart Rate Reactivity on Acute Stress-Induced Food Intake.

Physiol Behav 2022 Jan 12:113704. Epub 2022 Jan 12.

Medical Psychology & Medical Sociology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.

The ´fight-or-flight-reaction´ describes the suppression of all irrelevant functions like food intake during the acute stress response. However, heart rate reactivity and food intake under acute stress has not been investigated. Therefore, the aim of this study was to investigate the effect of high and low heart rate reactivity on food intake following an acute laboratory stress paradigm in individuals with healthy weight. Read More

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January 2022

Identifying patterns of acute kidney injury after cardiac surgery offers opportunity to target treatment strategies.

Ann Thorac Surg 2022 Jan 12. Epub 2022 Jan 12.

University of Texas Health Science Center- San Antonio, Division of Thoracic Surgery, 7703 Floyd Curl Drive, MC 7841, San Antonio, TX 78229. Electronic address:

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January 2022

Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study.

Lancet Haematol 2022 Jan 12. Epub 2022 Jan 12.

Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands.

Background: Melphalan flufenamide (melflufen), an alkylating peptide-drug conjugate, plus dexamethasone showed clinical activity and manageable safety in the phase 2 HORIZON study. We aimed to determine whether melflufen plus dexamethasone would provide a progression-free survival benefit compared with pomalidomide plus dexamethasone in patients with previously treated multiple myeloma.

Methods: In this randomised, open-label, head-to-head, phase 3 study (OCEAN), adult patients (aged ≥18 years) were recruited from 108 university hospitals, specialist hospitals, and community-based centres in 21 countries across Europe, North America, and Asia. Read More

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January 2022

Early life stress and autonomic response to acute mental stress in individuals with coronary heart disease.

J Trauma Stress 2022 Jan 15. Epub 2022 Jan 15.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Early life stress (ELS) has been associated with an increased risk of cardiovascular disease. We examined whether ELS was associated with autonomic function and stress reactivity among individuals with coronary heart disease (CHD). We included patients with stable CHD from two parallel studies, the Mental Stress Ischemia Prognosis Study (MIPS) and the Myocardial Infarction and Mental Stress Study 2 (MIMS2), and assessed ELS using the Early Trauma Inventory-Self-Report-Short Form. Read More

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January 2022

Lung transplantation in the septuagenarian can be successfully performed though long-term results impacted by diseases of aging.

Clin Transplant 2022 Jan 15:e14593. Epub 2022 Jan 15.

Division of Cardiac Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.

Background: Advanced age is considered a risk factor for lung transplantation (LTX). We sought to evaluate the long-term outcomes of LTX in the septuagenarian.

Methods: LTX recipients in the UNOS transplant registry (May 1, 2005 to June 12, 2020) were stratified into 18-59, 60-69, and > = 70 years of age. Read More

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January 2022

Helicopter emergency medical service for patients with acute coronary syndrome: selection validity and impact on clinical outcomes.

Heart Vessels 2022 Jan 15. Epub 2022 Jan 15.

Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.

Helicopter emergency medical service (HEMS) has the potential to improve prognosis for acute coronary syndrome (ACS). However, adequacy and effectiveness of HEMS have not been fully evaluated. A total of 862 ACS patients transferred by emergency medical services were divided into two groups: patients transferred by HEMS (n = 171) or by ground ambulance (GA; n = 691). Read More

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January 2022

Ticagrelor versus clopidogrel in patients with acute coronary syndrome undergoing complex percutaneous coronary intervention.

Catheter Cardiovasc Interv 2022 Jan 15. Epub 2022 Jan 15.

Department of Cardiology, The General Hospital of Northern Theater Command, Shenyang, China.

Objectives: To evaluate the effectiveness and safety of ticagrelor versus clopidogrel in patients with acute coronary syndromes (ACS) undergoing complex percutaneous coronary intervention (PCI).

Background: It remains inconclusive whether ticagrelor is superior to clopidogrel in ACS patients undergoing complex PCI in real-world practice.

Methods: Based on an all-comers PCI registry, we compared the long-term effectiveness and safety between ticagrelor and clopidogrel in ACS patients undergoing complex PCI, defined as PCI procedures for complex lesions including bifurcation, chronic total occlusion, ostial, tortuous, calcific, diffused, thrombus-containing, and restenotic lesions. Read More

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January 2022

Outcomes after heart transplantation in patients with cardiac sarcoidosis.

ESC Heart Fail 2022 Jan 15. Epub 2022 Jan 15.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Background: The number of patients with sarcoidosis requiring heart transplantation (HT) is increasing. The aim of this study was to evaluate outcomes of isolated HT in patients with sarcoid cardiomyopathy and compare them to recipients with non-ischaemic restrictive or dilated cardiomyopathy.

Methods And Results: Adult HT recipients were identified in the UNOS Registry between 1990 and 2020. Read More

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January 2022

Impact of prior sternotomy on survival and allograft function after heart transplantation: A single center matched analysis.

J Card Surg 2022 Jan 14. Epub 2022 Jan 14.

Division of Cardiac Surgery IRCCS Azienda Ospedaliero-Universitaria di Bologna, St. Orsola Policlinic-Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Background: Orthotopic heart transplantation (OHT) remains the gold standard for the treatment of end-stage heart failure. The number of patients who have had at least one prior sternotomy while awaiting transplantation has increased over the years reaching 50% in the last ISHLT registry report. We analysed our institutional transplant activity focusing on prior-sternotomy setting to identify the real burden of this preoperative variable and its potential consequences. Read More

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January 2022

Post-sequelae symptoms and comorbidities after COVID-19.

J Med Virol 2022 Jan 14. Epub 2022 Jan 14.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Background: The frequency, severity, and forms of symptoms months after coronavirus 2019 (COVID-19) are poorly understood, especially in community settings.

Objective: To characterize symptoms months after community-based COVID-19.

Design: Retrospective cohort analysis. Read More

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January 2022

Multisystem inflammatory syndrome in neonates (MIS-N) associated with SARS-CoV2 infection: a case series.

Eur J Pediatr 2022 Jan 14. Epub 2022 Jan 14.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Multisystem inflammatory syndrome in neonates (MIS-N) is hypothesised to be caused either following transplacental transfer of SARS-CoV2 antibodies or antibodies developed in the neonate after infection with SARS-CoV-2. In this paper, we aim to discuss the clinical manifestations, laboratory features, and management of neonates diagnosed with MIS-N. We collated information from five participating hospitals in western India. Read More

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January 2022

Machine learning prediction model of acute kidney injury after percutaneous coronary intervention.

Sci Rep 2022 Jan 14;12(1):749. Epub 2022 Jan 14.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Acute kidney injury (AKI) after percutaneous coronary intervention (PCI) is associated with a significant risk of morbidity and mortality. The traditional risk model provided by the National Cardiovascular Data Registry (NCDR) is useful for predicting the preprocedural risk of AKI, although the scoring system requires a number of clinical contents. We sought to examine whether machine learning (ML) techniques could predict AKI with fewer NCDR-AKI risk model variables within a comparable PCI database in Japan. Read More

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January 2022

Emergent repair of acute type A aortic dissection from transcatheter aortic valve replacement.

Can J Cardiol 2022 Jan 11. Epub 2022 Jan 11.

Division of Cardiac Surgery,Yale School of Medicine, New Haven, CT. Electronic address:

Acute type A aortic dissection(TAAD) is a rare,but life-threatening complication of transcatheter aortic valve replacement(TAVR).While surgical repair is the standard treatment for managing TAAD,TAVR patients represent a unique population due to contraindications to open procedures.We report the case of a 90-year-old woman who had an iatrogenic TAAD following TAVR and underwent high-risk surgical repair. Read More

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January 2022

Adverse childhood experiences (ACEs) relate to blunted cardiovascular and cortisol reactivity to acute laboratory stress: A systematic review and meta-analysis.

Neurosci Biobehav Rev 2022 Jan 11;134:104530. Epub 2022 Jan 11.

Department of Psychology and Neuroscience, Baylor University, Waco, TX, United States.

Adverse childhood experiences (ACEs) are associated with poor future mental and physical health. Altered biological reactivity to mental stress may be a possible mechanism linking ACEs to poor health. However, it is not clear if ACEs relate to blunted or exaggerated stress reactivity. Read More

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January 2022

Procedural, Short-Term, and Intermediate-Term Outcomes in Propensity-Matched Patients With Severe Mitral Valve Regurgitation Undergoing Urgent Versus Elective MitraClip Percutaneous Mitral Valve Repair.

J Cardiothorac Vasc Anesth 2021 Dec 16. Epub 2021 Dec 16.

Veterans Affairs Boston Healthcare System, Department of Anesthesia, Critical Care and Pain Medicine, and Tufts University School of Medicine, Boston, MA.

Objective: The study authors sought to compare outcomes in patients with severe mitral valve regurgitation (MR) undergoing urgent, as compared to elective, mitral valve repair employing MitraClip. They hypothesized that, compared to elective cases, MitraClip procedures performed for urgent indications would be associated with increased intraoperative and postoperative complications but have similar long-term outcomes.

Design: A retrospective chart review with 3:1 propensity score matching of elective-to-urgent cases. Read More

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December 2021

Peripheral blood eosinophilia as a marker of acute cellular rejection in lung transplant recipients.

J Heart Lung Transplant 2021 Dec 22. Epub 2021 Dec 22.

Lung Transplant Program, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Previous studies in solid organ transplantation have shown a relationship between circulating eosinophil (EOS) counts and the presence of acute cellular rejection (ACR). However, the relationship between this potential biomarker and ACR in lung transplant (LTx) patients remains unclear.

Objective: To assess the association between EOS and the presence of acute cellular rejection in lung transplant recipients. Read More

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December 2021

A Validated Model to Identify Patients With Low Likelihood of High-Risk Coronary Artery Disease Anatomy.

Am J Cardiol 2022 Jan 11. Epub 2022 Jan 11.

Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio; Center for Value-Based Care Research, Cleveland Clinic, Cleveland, Ohio. Electronic address:

In stable coronary artery disease (CAD), revascularization improves outcomes only for patients with high-risk coronary anatomy (HRCA). We sought to derive and validate a prediction model, incorporating clinical and exercise stress test characteristics, to identify patients with HRCA. We conducted a retrospective analysis of patients undergoing exercise stress testing at Cleveland Clinic (2005 to 2014), followed by invasive coronary angiography within 3 months. Read More

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January 2022

Impact of Race/Ethnicity on Long Term Outcomes After Percutaneous Coronary Intervention with Drug-Eluting Stents.

Am J Cardiol 2022 Jan 11. Epub 2022 Jan 11.

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City, New York. Electronic address:

Cardiovascular disease constitutes the leading cause of mortality worldwide, irrespective of race/ethnicity. Previous studies have shown that minority patients with acute coronary syndrome have distinct clinical, anatomic, and socioeconomic characteristics which may affect clinical outcomes. We included patients who underwent percutaneous coronary intervention with drug-eluting stents for ST-segment elevation myocardial infarction (STEMI), non-STEMI, or unstable angina in a single center. Read More

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January 2022

Development and validation of a coding framework to identify severe acute toxicity from systemic anti-cancer therapy using hospital administrative data.

Cancer Epidemiol 2022 Jan 11;77:102096. Epub 2022 Jan 11.

Department of Oncology, Guy's and St. Thomas' NHS Foundation Trust, London, UK. Electronic address:

Background: The capture of toxicities from systemic anti-cancer therapy (SACT) in real-world data will complement results from clinical trials. The aim of this study was to develop and validate a comprehensive coding framework to identify severe acute toxicity in hospital administrative data.

Methods: A coding framework was developed to identify diagnostic codes representing severe acute toxicity in hospital administrative data. Read More

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January 2022

COVID-19-associated acute kidney injury patients treated with renal replacement therapy in the intensive care unit: A multicenter study in São Paulo, Brazil.

PLoS One 2022 14;17(1):e0261958. Epub 2022 Jan 14.

Nephrology Division, University of São Paulo Medical School, São Paulo, Brazil.

Introduction: Multicenter studies involving patients with acute kidney injury (AKI) associated with the disease caused by the new coronavirus (COVID-19) and treated with renal replacement therapy (RRT) in developing countries are scarce. The objectives of this study were to evaluate the demographic profile, clinical picture, risk factors for mortality, and outcomes of critically ill patients with AKI requiring dialysis (AKI-RRT) and with COVID-19 in the megalopolis of São Paulo, Brazil.

Methods: This multicenter, retrospective, observational study was conducted in the intensive care units of 13 public and private hospitals in the metropolitan region of the municipality of São Paulo. Read More

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January 2022

The impact of cardiopulmonary exercise-derived scoring on prediction of cardio-cerebral outcome in hypertrophic cardiomyopathy.

PLoS One 2022 14;17(1):e0259638. Epub 2022 Jan 14.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Sudden cardiac death (SCD) and stroke-related events accompanied by atrial fibrillation (AF) can affect morbidity and mortality in hypertrophic cardiomyopathy (HCM). This study sought to evaluate a scoring system predicting cardio-cerebral events in HCM patients using cardiopulmonary exercise testing (CPET).

Methods: We investigated the role of a previous prediction model based on CPET, the HYPertrophic Exercise-derived Risk score for Heart Failure-related events (HyperHF), which is derived from peak circulatory power ventilatory efficiency and left atrial diameter (LAD), for predicting a composite of SCD-related (SCD, serious ventricular arrhythmia, death from cardiac cause, heart failure admission) and stroke-related (new-onset AF, acute stroke) events. Read More

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January 2022

Polypharmacy and Clinical Outcomes in Hospitalized Patients With Acute Decompensated Heart Failure.

J Cardiovasc Nurs 2022 Jan 14. Epub 2022 Jan 14.

Neiko Ozasa, MD, PhD Assistant Professor, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Takao Kato, MD, PhD Assistant Professor, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Takeshi Morimoto, MD, MPH Professor, Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan. Hidenori Yaku, MD, PhD Visiting Professor, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Erika Yamamoto, MD, PhD Assistant Professor, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Yasutaka Inuzuka, MD, PhD Assistant Manager, Shiga General Hospital, Moriyama, Japan. Yodo Tamaki, MD, PhD Manager, Tenri Hospital, Tenri, Japan. Takeshi Kitai, MD, PhD Head Doctor, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan. Koichi Washida, MSN Graduate Student, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Yuta Seko, MD Graduate Student, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Yusuke Yoshikawa, MD Graduate Student, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Yukihito Sato, MD, PhD Chief Manager, Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan. Hirohiko Motoki, MD, PhD Associate Professor, Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan. Koichiro Kuwahara, MD, PhD Professor, Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan. Takeshi Kimura, MD, PhD Professor, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: Polypharmacy is a common problem among patients with acute decompensated heart failure (ADHF) who often have multiple comorbidities.

Objective: The aim of this study was to define the number of medications at hospital discharge and whether it is associated with clinical outcomes at 1 year.

Methods: We evaluated the number of medications in 2578 patients with ADHF who were ambulatory at hospital discharge in the Kyoto Congestive Heart Failure Registry and compared 1-year outcomes in 4 groups categorized by quartiles of the number of medications (quartile 1, ≤ 5; quartile 2, 6-8; quartile 3, 9-11; and quartile 4, ≥ 12). Read More

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January 2022

Arterial Atherosclerosis: Vascular Surgery Interventions.

Am Fam Physician 2022 Jan;105(1):65-72

East Carolina University and East Carolina Heart Institute, Greenville, NC, USA.

Atherosclerotic vascular disease is a leading cause of death worldwide. Atherosclerotic stenosis of the internal carotid or intracranial arteries causes up to 15% of strokes. Peripheral artery disease affects up to one in five people in the United States who are 60 years and older and nearly one-half of those who are 85 years and older. Read More

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January 2022

Early Neuromuscular Blockade in Moderate-to-Severe Pediatric Acute Respiratory Distress Syndrome.

Crit Care Med 2022 Jan 6. Epub 2022 Jan 6.

Department of Family and Community Health, School of Nursing, University of Pennsylvania, Philadelphia, PA.

Objectives: The use of neuromuscular blocking agents (NMBAs) in pediatric acute respiratory distress syndrome (PARDS) is common but unsupported by efficacy data. We sought to compare the outcomes between patients with moderate-to-severe PARDS receiving continuous NMBA during the first 48 hours of endotracheal intubation (early NMBA) and those without.

Design: Secondary analysis of data from the Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) clinical trial, a pediatric multicenter cluster randomized trial of sedation. Read More

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January 2022

IDENTIFYING THE EFFECTS OF SUPPLEMENTAL OXYGEN ADMINISTRATION ON THE HEALTH OUTCOMES OF PATIENTS PRESENTING WITH ACUTE CORONARY SYNDROME AND OXYGEN SATURATION >93% - A SYSTEMATIC REVIEW.

Contemp Nurse 2022 Jan 14:1-34. Epub 2022 Jan 14.

School of Nursing, Midwifery & Paramedicine, Australian Catholic University, Rm 17- 33 Berry St, North Sydney, NSW, 2060. Email: Phone: +61 2 97392829.

Objectives: Oxygen was commonly used in the early management of patients presenting with Acute Coronary Syndrome (ACS) regardless of their oxygen saturation. Inappropriate administration of supplemental oxygen could potentially result in adverse patient health outcomes.

Aim: To identify the effects of supplemental oxygen administration on the health outcomes of patients presenting with ACS and oxygen saturations >93%. Read More

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January 2022

Comparison of Clinical and Radiologic Findings Between Perforated and Non-Perforated Choledochal Cysts in Children.

Korean J Radiol 2022 Jan 4. Epub 2022 Jan 4.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objective: To compare the clinical and radiologic findings between perforated and non-perforated choledochal cysts in children.

Materials And Methods: Fourteen patients (mean age ± standard deviation, 1.7 ± 1. Read More

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January 2022

The Stockholm CREAtinine Measurements (SCREAM) project: Fostering improvements in chronic kidney disease care.

J Intern Med 2022 Jan 13. Epub 2022 Jan 13.

Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

SCREAM (Stockholm CREAtinine Measurements project) was initiated in 2010 in collaboration with the healthcare provider of Stockholm County healthcare to quantify potential medication errors, estimate the burden of chronic kidney disease (CKD) and to illustrate the value of incorporating measures of kidney function into the medical decision process. Because most patients are unaware of their CKD and diagnoses are seldom issued, SCREAM took advantage of the commonness of serum/plasma creatinine testing, which can be used to estimate the glomerular filtration rate (eGFR) and classify the stage of CKD severity. SCREAM is periodically updated, and at present contains healthcare information of all residents in Stockholm region during 2006-2019 (about 3 million people), enriched with a broad range of laboratory measurements for those in whom creatinine or albuminuria has been measured (about 1. Read More

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January 2022

The Role of ECG in the Diagnosis and Risk Stratification of Acute Coronary Syndromes: an Old but Indispensable Tool.

Curr Cardiol Rep 2022 Jan 13. Epub 2022 Jan 13.

Heart Center, Faculty of Medicine and Health Technology, Tampere University Hospital, Tampere University, Tampere, Finland.

Purpose Of Review: Since its inception in 1902 by Willem Einthoven, the electrocardiogram (ECG) has fundamentally undergone minimal technological advances. Nevertheless, its clinical utility is critical, and it remains an essential tool to diagnose, risk stratify, and guide reperfusion and invasive strategies in patients with suspected acute coronary syndromes. ECG reading can be demanding, with many healthcare professionals lacking the necessary expertise to accurately interpret them. Read More

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January 2022

Pediatric Patients Undergoing a Fontan Operation or with a High RACHS-1 Score Require Monitoring for Chronic Kidney Disease in Early Childhood.

Pediatr Cardiol 2022 Jan 13. Epub 2022 Jan 13.

Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.

Although the number of pediatric patients with long-term survival following cardiac surgery is increasing, concerns regarding chronic kidney disease (CKD) after surgery are growing. We examined the frequency of and risk factors for pediatric CKD development in patients with congenital heart disease (CHD) at least 2 years after cardiac surgery. This was a cross-sectional study of 147 patients who underwent open-heart surgery for CHD at Kagoshima University Hospital from April 2010 to March 2017. Read More

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January 2022