30,842 results match your criteria acute anterior

Ultrasound-based evaluation revealed reliable postoperative knee stability after combined acute ACL and MCL injuries.

J Exp Orthop 2021 Sep 15;8(1):76. Epub 2021 Sep 15.

Department for Orthopedic Sports Medicine, Technical University Munich, Ismaningerstrasse 22, 81675, Munich, Germany.

Purpose: Anterior cruciate ligament (ACL) injuries are often combined with lesions of the medial collateral ligament (MCL). The aim of this study was to evaluate treatment outcome of combined acute ACL and MCL lesions using functional US and clinical examination.

Methods: Patients aged > 18 years undergoing primary ACL reconstruction with concomitant operative (group 1) or non-operative treatment of the MCL (group 2) between 2014 and 2019 were included after a minimum follow-up of 12 months. Read More

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September 2021

Exercise intervention decreases acute and late doxorubicin-induced cardiotoxicity.

Cancer Med 2021 Sep 15. Epub 2021 Sep 15.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Doxorubicin (Dox) is one of the most effective chemotherapy agents used to treat adolescent and young adult sarcoma patients. Unfortunately, Dox causes cardiotoxicities that compromise long-term survival. We investigated whether exercise prevented cardiotoxicity and increased survival following myocardial infarction. Read More

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September 2021

White Matter Hyperintensity Burden and Collateral Circulation in Large Vessel Occlusion Stroke.

Stroke 2021 Sep 14:STROKEAHA120031736. Epub 2021 Sep 14.

Department of Neuroradiology, Hôpital Gui de Chauliac, Montpellier University Medical Center, Montpellier, France. (I.D., M.A., R.A., F.C., C.D., P.-H.L., C.R., G.G., A.B., V.C.).

Background And Purpose: White matter hyperintensity (WMH), a marker of chronic cerebral small vessel disease, might impact the recruitment of leptomeningeal collaterals. We aimed to assess whether the WMH burden is associated with collateral circulation in patients treated by endovascular thrombectomy for anterior circulation acute ischemic stroke.

Methods: Consecutive acute ischemic stroke due to anterior circulation large vessel occlusion and treated with endovascular thrombectomy from January 2015 to December 2017 were included. Read More

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September 2021

Outcomes between in-hospital stroke and community-onset stroke after thrombectomy: Propensity-score matching analysis.

Interv Neuroradiol 2021 Sep 13:15910199211030769. Epub 2021 Sep 13.

Department of Interventional Radiology, 74734The First Affiliated Hospital with Nanjing Medical University, China.

Background: The benefit of endovascular thrombectomy for patients with in-hospital stroke remains unclear. Thus, the aim of this study was to compare the endovascular thrombectomy outcomes between in-hospital stroke and community-onset stroke among patients with acute ischemic stroke.

Methods: From January 2015 to July 2019, 362 consecutive patients with acute ischemic stroke with large vessel occlusion in the anterior circulation received endovascular thrombectomy in our centre. Read More

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September 2021

Inhibition of the lncRNA DANCR attenuates cardiomyocyte injury induced by oxygen-glucose deprivation via the miR-19a-3p/MAPK1 axis.

Acta Biochim Biophys Sin (Shanghai) 2021 Sep 13. Epub 2021 Sep 13.

Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

Long noncoding RNAs (lncRNAs) have been considered as crucial regulators of acute myocardial infarction (AMI). In this study, to analyze the effect of differentiation antagonizing nonprotein coding RNA (DANCR) of lncRNA on cardiomyocyte damage in AMI, cardiomyocyte injury was induced by oxygen-glucose deprivation (OGD). Cell counting kit-8 (CCK-8) assay and flow cytometry were used to assess cell viability and apoptosis, respectively. Read More

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September 2021

Peripheral Lymphadenopathy in Children: Cytomorphological Spectrum and Interesting Diagnoses.

Turk Patoloji Derg 2021 May 12. Epub 2021 May 12.

Department of Pathology, Chacha Nehru Bal Chikitsalaya, DELHI, INDIA.

Objective: Peripheral lymphadenopathy is a common complaint in the pediatric outpatient department. Fine needle aspiration cytology is the first investigation of choice with a high sensitivity for diagnosis but cytology may be challenging in some cases. The study was planned to study the cytomorphological spectrum and discuss a few interesting cases. Read More

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Anterior Shoulder Dislocation Complicated by Hill-Sachs Lesion.

Cureus 2021 Aug 5;13(8):e16925. Epub 2021 Aug 5.

Emergency Medicine, Ocala Regional Medical Center, Ocala, USA.

We present the case of a 60-year-old woman with a Hill-Sachs lesion caused by an anterior shoulder dislocation (SD) as a result of her falling on her left shoulder at a local restaurant. While the diagnosis of an anterior SD is commonplace, the involvement of a Hill-Sachs lesion can complicate the treatment needed to manage the SD. Crucial aspects of treatment include performing closed reduction followed by acute immobilization in a timely manner and prompt consultation with orthopedic surgery. Read More

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Radiologically Occult Lung Cancer Curatively Treated with High-Dose Rate Endobronchial Brachytherapy.

J Clin Imaging Sci 2021 23;11:45. Epub 2021 Aug 23.

Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York, United States.

Most patients diagnosed with early-stage non-small cell lung cancer (NSCLC) can be easily cured with surgery or stereotactic body radiotherapy (SBRT). Modalities such as photodynamic therapy, cryotherapy, or laser therapy only offer temporary palliation. A 79-year-old gentleman with early-stage NSCLC who underwent a left lower lobe lobectomy in 2009 presented to us again in 2010 with hemoptysis. Read More

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De Winter's pattern: an uncommon but very important electrocardiographic sign in the prompt recognition of spontaneous occlusive coronary artery dissection in young patients with chest pain (a case report).

Pan Afr Med J 2021 8;39:112. Epub 2021 Jun 8.

Forensic Medicine Research Center, Birjand, Iran.

Chest pain is a clinical symptom for immediate consultation, and electrocardiogram (ECG) is a valuable diagnostic tool for use in the emergency room. Although the ST- elevation myocardial infarction (STEMI) requires urgent management, there are other ECG high-risk findings which are associated with adverse outcomes or imminent acute myocardial infarction (AMI). This is a case of STEMI equivalent pattern such as de Winter. Read More

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Effects of Anterior Borderzone Angle Grading on Predicting the 90-Day Prognosis After Recanalization of Acute Middle Cerebral Artery Occlusion.

Front Neurol 2021 26;12:700732. Epub 2021 Aug 26.

Department of Neurology, Fujian Provincial Hospital, Shengli Clinical College of Fujian Medical University, Fuzhou, China.

This work explores collateral circulation metrics, such as the anterior borderzone angle grading (ABZA-grading), as a predictor of the prognosis in patients with acute middle cerebral artery occlusion (MCAO) following endovascular treatment (EVT). Clinical data from 108 patients with acute MCAO, treated by EVT, were retrospectively analyzed. In patients with MCAO, ABZA is the angle between the median line of the sagittal sinus and the borderzone of the pial arterioles of ACA and MCA, and the ABZA/23. Read More

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IV-Thrombolysis in Ischemic Stroke With Unknown Time of Onset-Safety and Outcomes in Posterior vs. Anterior Circulation Stroke.

Front Neurol 2021 27;12:692067. Epub 2021 Aug 27.

Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nuremberg (FAU), Erlangen, Germany.

rt-PA for ischemic stroke in the unknown or extended time window beyond the first 4. 5 h after symptom onset is safe and effective for certain patients after selection by multimodal neuroimaging. However, the evidence for this approach comes mainly from patients with anterior circulation stroke (ACS), while the data on posterior circulation stroke (PCS) are scarce. Read More

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Cortical Venous Changes on Susceptibility-Weighted Imaging Predict the Cerebral Collateral Circulation as Confirmed by Digital Subtraction Angiography.

Front Neurol 2021 27;12:691430. Epub 2021 Aug 27.

Department of Radiology, Affiliated Dongguan Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, China.

Asymmetrical cortical vein sign (ACVS) shown on susceptibility-weighted imaging (SWI) can reflect regional hypoperfusion. We investigated if ACVS could predict the cerebral collateral circulation (CC) as assessed by digital subtraction angiography (DSA) in acute ischemic stroke patients with ipsilateral severe stenosis/occlusion of the anterior circulation. Clinical data and imaging data of 62 acute ischemic stroke patients with ipsilateral severe stenosis or occlusion of the anterior circulation confirmed by DSA were collected retrospectively. Read More

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Downregulation of miR-23b by transcription factor c-Myc alleviates ischemic brain injury by upregulating Nrf2.

Int J Biol Sci 2021 26;17(13):3659-3671. Epub 2021 Aug 26.

Jilin University, Changchun 130000, P. R. China.

Ischemic brain injury (IBI) is a common acute cerebral vessel disease that occurs secondary to blockage in arteries, mainly characterized by insufficient blood supply to the brain. The transcription factor c-Myc in IBI continues to be implicated in numerous studies. This study was conducted with emphasis placed on the underlying mechanism of c-Myc in IBI. Read More

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Managing Perioperative Pain After Anterior Cruciate Ligament (ACL) Reconstruction: Perspectives from a Sports Medicine Surgeon.

Open Access J Sports Med 2021 4;12:129-138. Epub 2021 Sep 4.

USC Epstein Family Center for Sports Medicine at Keck Medicine of USC, Los Angeles, CA, USA.

Anterior cruciate ligament reconstructions (ACLR) are a relatively common procedure in orthopedic sports medicine with an estimated 130,000 arthroscopic operations performed annually. Most procedures are carried out on an outpatient basis, and though success rates of ACLR are as high as 95%, pain remains the most common postoperative complication delaying patient discharge, and thereby increasing the costs associated with patient care. Despite the success and relative frequency of ACLR surgery, optimal and widely accepted strategies and regimens for controlling perioperative pain are not well established. Read More

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September 2021

Inflammatory Factors as Potential Markers of Early Neurological Deterioration in Acute Ischemic Stroke Patients Receiving Endovascular Therapy - The AISRNA Study.

J Inflamm Res 2021 2;14:4399-4407. Epub 2021 Sep 2.

Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, People's Republic of China.

Background And Purpose: This study aimed to explore several peripheral blood-based markers related to the inflammatory response in a total of 210 patients with acute ischemic stroke (AIS) caused by large artery occlusion in the anterior circulation who received endovascular therapy (EVT) from an observational study of clinical significance of circulating non-coding RNA in acute ischemic stroke (AISRNA).

Methods: We collected baseline characteristics of 210 AIS patients participating in an observational acute stroke cohort: the AISRNA study. The following inflammatory factors were measured in these participants: interleukin-2 [IL-2], IL-4, IL-6, IL-10, tumor necrosis factor-α [TNF-α], and interferon-γ [IFN-γ]. Read More

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September 2021

Isolated thalamic stroke - analysis of clinical characteristics and asymmetry of lesion distribution in a retrospective cohort study.

Neurol Res Pract 2021 Sep 13;3(1):49. Epub 2021 Sep 13.

Institute of Neuroradiology, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany.

Background: More patients with left-hemispheric than right-hemispheric strokes are admitted to hospitals. This is due to the easier recognition of cortical symptoms of the dominant-hemisphere. The thalamus constitutes a "micro-model" of the brain cortex with structure-function relationships known to be asymmetric, especially for language, memory, and visuo-spatial neurocognitive functions. Read More

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September 2021

Human urinary kallidinogenase in acute ischemic stroke: A single-arm, multicenter, phase IV study (RESK study).

CNS Neurosci Ther 2021 Sep 12. Epub 2021 Sep 12.

Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Aims: Human urinary kallidinogenase (HUK) has shown favorable efficacies in acute ischemic stroke (AIS) treatment. We sought confirmation of the safety and efficacy of HUK for AIS in a large population.

Methods: RESK study enrolled patients with AIS of anterior circulation to receive HUK infusion. Read More

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September 2021

Higher sensitivity with the lever sign test for diagnosis of anterior cruciate ligament rupture in the emergency department.

Arch Orthop Trauma Surg 2021 Sep 12. Epub 2021 Sep 12.

Cliniques Universitaires Saint-Luc, Service d'Orthopédie et de Traumatologie de L'appareil Locomoteur, Université Catholique de Louvain (UCLouvain), Avenue Hippocrate 10, 1200, Brussels, Belgium.

Introduction: The objective of this study was to assess the diagnostic value of the "lever sign test" to diagnose ACL rupture and to compare this test to the two most commonly used, the Lachman and anterior drawer test.

Method: This prospective study was performed in the ED of the Cliniques Universitaires Saint-Luc (Brussels, Belgium) from March 2017 to May 2019. 52 patients were included undergoing knee trauma, within 8 days, with an initial radiograph excluding a fracture (except Segond fracture or tibial spine fracture). Read More

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September 2021

Hydration for prevention of kidney injury after primary coronary intervention for acute myocardial infarction: a randomised clinical trial.

Heart 2021 Sep 11. Epub 2021 Sep 11.

Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, The Affiliated Guangdong Provincial People's Hospital of South China University of Technology, Guangzhou, Guangdong, China

Objective: To evaluate the efficacy of aggressive hydration compared with general hydration for contrast-induced acute kidney injury (CI-AKI) prevention among patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI).

Methods: The Aggressive hydraTion in patients with STEMI undergoing pPCI to prevenT Contrast-Induced Acute Kidney Injury study is an open-label, randomised controlled study at 15 teaching hospitals in China. A total of 560 adult patients were randomly assigned (1:1) to receive aggressive hydration or general hydration treatment. Read More

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September 2021

Optogenetic Stimulation of the Anterior Cingulate Cortex Modulates the Pain Processing in Neuropathic Pain: A Review.

J Mol Neurosci 2021 Sep 10. Epub 2021 Sep 10.

Department of Neurosurgery, Chungbuk National University Hospital, Cheongju, Republic of Korea.

Neuropathic pain is characterized by hypersensitivity, hyperalgesia, and allodynia, which is caused by damage to the somatosensory nervous system. It substantially impairs the quality of life. The management of neuropathic pain is challenging and should comprise alternative therapies. Read More

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September 2021

Combined ACL and Segond Repair in Combined Acute Proximal ACL Tears and Segond Fracture.

Arthrosc Tech 2021 Sep 23;10(9):e2151-e2156. Epub 2021 Aug 23.

University of Rome "Sapienza", Sant'Andrea Hospital, Rome, Italy.

A renewed interest in anterior cruciate ligament preservation has been noted using arthroscopic primary repair in patients with proximal tears, but the main concern remained the control of the rotational instability. Segond fracture occurs in less than 10% of cases of acute anterolateral instability, but it can result in continued rotation instability. The aim of this study is to describe the surgical technique to acutely repair both the anterior cruciate ligament and Segond fracture in the acute setting. Read More

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September 2021

Stent Retriever Thrombectomy for Anterior vs. Posterior Circulation Ischemic Stroke: Analysis of the STRATIS Registry.

Front Neurol 2021 23;12:706130. Epub 2021 Aug 23.

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

The benefits of mechanical thrombectomy (MT) in vertebrobasilar artery occlusions have not been well-studied. We compared clinical, procedural, and safety outcomes of MT for posterior circulation (PC) vs. anterior circulation (AC) occlusions among patients in the STRATIS registry. Read More

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Mechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials.

EuroIntervention 2021 Sep 10. Epub 2021 Sep 10.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Background: Retrievable stents and aspiration catheters have been developed to provide more effective arterial recanalisation in acute ischaemic stroke.

Aims: The aim of this analysis was to test the effect of mechanical thrombectomy on mortality and long-term neurological outcome in patients presenting with acute large-vessel anterior circulation ischaemic stroke.

Methods: A structured search identified randomised controlled trials of thrombectomy (using a retrievable stent or aspiration catheter) versus control on a background of medical therapy which included intravenous thrombolysis if appropriate. Read More

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September 2021

Immune Cells Invade the Collateral Circulation during Human Stroke: Prospective Replication and Extension.

Int J Mol Sci 2021 Aug 25;22(17). Epub 2021 Aug 25.

Department of Neuroradiology, University Hospital of Würzburg, 97080 Würzburg, Germany.

It remains unclear if principal components of the local cerebral stroke immune response can be reliably and reproducibly observed in patients with acute large-vessel-occlusion (LVO) stroke. We prospectively studied a large independent cohort of = 318 consecutive LVO stroke patients undergoing mechanical thrombectomy during which cerebral blood samples from within the occluded anterior circulation and systemic control samples from the ipsilateral cervical internal carotid artery were obtained. An extensive protocol was applied to homogenize the patient cohort and to standardize the procedural steps of endovascular sample collection, sample processing, and laboratory analyses. Read More

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Prognostic factors for tibiofemoral and patellofemoral osteoarthritis 32-37 years after anterior cruciate ligament injury managed with early surgical repair or rehabilitation alone.

Osteoarthritis Cartilage 2021 Sep 6. Epub 2021 Sep 6.

Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine, Unit of Physiotherapy; SE-581 83 Linköping, Sweden. Electronic address:

Objective: Explore prognostic factors for tibiofemoral (TFJ) and patellofemoral (PFJ) radiographic osteoarthritis (ROA) and 'symptoms plus ROA' (SOA), 32-37 years following anterior cruciate ligament (ACL) injury.

Design: Exploratory analysis, longitudinal cohort.

Methods: In 1980-1985, 251 patients aged 15-40 years with acute ACL rupture were allocated to early augmented or non-augmented repair (5±4 days post-injury) plus rehabilitation, or rehabilitation alone. Read More

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September 2021