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J Pharmacol Exp Ther 2022 Jul 2. Epub 2022 Jul 2.

Discipline of Pharmacology, Sydney Pharmacy School, The University of Sydney, Australia

Aberrations in spinal glycinergic signalling are a feature of pain chronification. Normalising these changes by inhibiting glycine transporter-2 (GlyT2) is a promising treatment strategy. However, existing GlyT2 inhibitors e. Read More

J Pharmacol Exp Ther 2022 Jul 2. Epub 2022 Jul 2.

Department of Medicine, Surgery and Dentistry, University of Salerno, Italy

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to be a global challenge due to resulting morbidity and mortality. Cardiovascular (CV) involvement is a crucial complication in COVID-19, and no strategies are available to prevent or specifically address CV events in COVID patients. The identification of molecular partners contributing to CV manifestations in COVID-19 patients is crucial for providing early biomarkers, prognostic predictors and new therapeutic targets. Read More

Adv Cancer Res 2022 20;155:167-214. Epub 2022 Apr 20.

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Pauley Heart Center, Richmond, VA, United States. Electronic address:

The quest of defeating cancer and improving prognosis in survivors has generated remarkable strides forward in research and have advanced the development of new antineoplastic therapies. These achievements, combined with rapid screening and early detection, have considerably extended the life expectancy of patients surviving multiple types of malignancies. Consequently, chemotherapy-related toxicity in several organ systems, especially the cardiovascular system, has surfaced as one of the leading causes of morbidity and mortality among cancer survivors. Read More

Neurologia (Engl Ed) 2022 Jul-Aug;37(6):466-479. Epub 2020 Aug 20.

Servicio de Neurología, Hospital Universitario Marqués de Valdecilla (IDIVAL), Universidad de Cantabria, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Santander, Spain. Electronic address:

Introduction: Guillain-Barré syndrome (GBS) is an acute-onset, immune-mediated disease of the peripheral nervous system. It may be classified into 2 main subtypes: demyelinating (AIDP) and axonal (AMAN). This study aims to analyse the mechanisms of axonal damage in the early stages of GBS (within 10 days of onset). Read More

N Biotechnol 2022 Jun 29. Epub 2022 Jun 29.

Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.

Aiming to accommodate the unmet need for easily accessible biomarkers with a focus on biological differences between haematological diseases, the diagnostic value of plasma proteins in acute leukaemias and lymphomas was investigated. A multiplex proximity extension assay (PEA) was used to analyze 183 proteins in diagnostic plasma samples from 251 acute leukaemia and lymphoma patients and compared with samples from 60 healthy controls. Multivariate modelling using partial least square discriminant analysis revealed highly significant differences between distinct disease subgroups and controls. Read More

Ann Allergy Asthma Immunol 2022 Jun 29. Epub 2022 Jun 29.

Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Background: Asthma hospitalizations declined rapidly in many parts of the world, including Canada, in the 1990s and early 2000s.

Objective: Has the declining trend of asthma hospitalizations persisted in recent years in Canada?

Methods: Using the Canadian comprehensive nationwide hospitalization data (2002-2017), we identified hospital admissions with the main International Classification of Diseases codes for asthma. We analyzed sex-specific age-standardized trends in annual hospitalization rates among pediatric (<19 years) and adult (19+ years) patients. Read More

J Ethnopharmacol 2022 Jun 29:115513. Epub 2022 Jun 29.

State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. Electronic address:

Ethnopharmacological Relevance: Pneumonia is common and frequently-occurred disease caused by pathogens which predisposes to lung parenchymal inflammation leading pulmonary dysfunction. To prevent and alleviate the symptoms of pneumonia, Qinggan Yin formula (QGY) was composed based on clinical experience and four classical traditional Chinese medicine prescriptions which frequently applied to treat infectious diseases.

Aim Of The Study: Traditional Chinese medicine is a complex mixture and it is difficult to distinguish the effective component molecules. Read More

Brain Res Bull 2022 Jun 29. Epub 2022 Jun 29.

College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, 300071 Tianjin, PR China. Electronic address:

Depression has several negative effects on emotion as well as learning and memory abilities. Previous studies showed that depression could exacerbate inflammation, which in turn further aggravated depression. Deferoxamine (DFO) is a chelating agent binding iron and aluminium, and is clinically applied to treat acute ion poisoning and hemochromatosis. Read More

Resuscitation 2022 Jun 29. Epub 2022 Jun 29.

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.

Aims: To evaluate, in UK acute hospitals, the early implementation of Recommended Summary Plan for Emergency Care and Treatment (ReSPECT), which embeds cardiopulmonary resuscitation (CPR) recommendations within wider emergency treatment plans To understand for whom and how the process was being used and the quality of form completion.

Methods: A retrospective observational study evaluating emergency care and treatment planning approaches used in acute UK hospitals (2015-2019), and in six English hospital trusts the extent of ReSPECT use, patient characteristics and completion quality in a sample 3000 patient case notes.

Results: The use of stand-alone Do Not Attempt Cardiopulmonary Resuscitation forms fell from 133/186 hospitals in 2015 to 64/186 in 2019 (a 38% absolute reduction). Read More

Acta Biomater 2022 Jun 29. Epub 2022 Jun 29.

Department of Biomedical Engineering, University of California, Davis, CA 95616, USA. Electronic address:

Rapid joint clearance of small molecule drugs is the major limitation of current clinical approaches to osteoarthritis and its subtypes, including post-traumatic osteoarthritis (PTOA). Particulate systems such as nano/microtechnology could provide a potential avenue for improved joint retention of small molecule drugs. One drug of interest for PTOA treatment is flavopiridol, which inhibits cyclin-dependent kinase 9 (CDK9). Read More

Sci Total Environ 2022 Jun 29:156962. Epub 2022 Jun 29.

Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan. Electronic address:

Climate changes, such as extreme temperature shifts, can have a direct and significant impact on animals living in the ocean system. Ectothermic animals may undergo concerted metabolic shifts in response to ambient temperature changes. The physiological and molecular adaptations in cephalopods during their early life stages are largely unknown due to the challenge of rearing them outside of a natural marine environment. Read More

Sci Total Environ 2022 Jun 29:157048. Epub 2022 Jun 29.

Department of Environment and Geography, University of York, Heslington, York YO10 5NG, UK; Syngenta Crop Protection AG, Basel, Switzerland.

The assessment of chemical mixture toxicity is one of the major challenges in ecotoxicology. Chemicals can interact, leading to more or less effects than expected, commonly named synergism and antagonism respectively. The classic ad hoc approach for the assessment of mixture effects is based on dose-response curves at a single time point, and is limited to identifying a mixture interaction but cannot provide predictions for untested exposure durations, nor for scenarios where exposure varies in time. Read More

Sci Total Environ 2022 Jun 29:157032. Epub 2022 Jun 29.

Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

We investigated how natural dissolved organic matter (DOM) of the Rio Negro (Amazon) affects acute copper (Cu) toxicity to local fish: the cardinal tetra (Paracheirodon axelrodi) and the dwarf cichlid (Apistogramma agassizii). It is established that Cu2+ complexation with DOM decreases Cu bioavailability (and thus toxicity) to aquatic organisms, as conceptualized by the Biotic Ligand Model (BLM). However, we also know that Rio Negro's DOM can interact with fish gills and have a beneficial effect on Na + homeostasis, the main target of acute Cu toxicity in freshwater animals. Read More

Sci Total Environ 2022 Jun 29:157046. Epub 2022 Jun 29.

KU Leuven, Department of Public Health and Primary Care, Centre for Environment and Health, Herestraat 49 box 952, 3000 Leuven, Belgium. Electronic address:

Rationale: Exercise-induced bronchoconstriction (EIB) is defined as acute narrowing of the airways during or immediately after exercise. EIB has a high prevalence in elite swimmers probably due to the high ventilation rate and exposure to the chlorine by-products. It is still puzzling which pathophysiological mechanisms drive EIB. Read More

Sci Total Environ 2022 Jun 29:157006. Epub 2022 Jun 29.

Department of Chemical Engineering, McGill University, 3610 Rue University, Montréal, QC H3A 0C5, Canada. Electronic address:

This research evaluates photocatalytic ozonation for removing 5 PFAS (PFOA/PFHxS/PFBS/6:2 FTS/GenX) from water using a WO/TiO catalyst under UVA-visible radiation. Four catalysts of varying WO content (0/1/3/5 wt%) were synthesized by sol-gel and characterized by XRD, TEM, STEM-EDS, HAADF-STEM, adsorption/desorption N isotherms, and DRS-UV-vis. 5 wt% WO/TiO was the optimal composition based on physicochemical properties and photocatalytic activity tests with methylene blue. Read More

Ann Epidemiol 2022 Jun 29. Epub 2022 Jun 29.

Sharp HealthCare.

Importance: Patient age, comorbidity burden, and disease severity at presentation are the major factors associated with surviving COVID-19. Hospital-level factors including ICU occupancy may confer additional risk to individual patients, particularly at times of maximal stress on healthcare systems. The interaction of patient- and hospital-level factors over time during pandemic disease remains an area of active exploration. Read More

Behav Brain Res 2022 Jun 29:113982. Epub 2022 Jun 29.

Departamento de Psicologia, Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento, Centro de Ciências Humanas, Letras e Artes, Universidade Federal da Paraíba. Electronic address:

Episodic-like memory (ELM) consists in the capacity of nonhuman animals to remember 'where' and 'when' a specific episode occurred ('what'). Previous studies have showed that Wistar rats can form an ELM, but not after a 24h retention delay. On the other hand, it has been demonstrated that caffeine can improve episodic memory consolidation in humans. Read More

Environ Toxicol Pharmacol 2022 Jun 29:103917. Epub 2022 Jun 29.

Shandong Dongyuan New Material Technology Co., Ltd, Dongying, 257300, Shandong, China.

A previous acute toxicity study of binary mixtures showed that the combined toxicity can be predicted with the parameter k∙EC. To systematically investigate the ability of k∙EC to predict the chronic combined toxicity of binary mixtures, the toxicity of six contaminants and five binary mixtures was determined by long-term microplate toxicity analysis (L-MTA) using Aliivibrio fischeri as the test organism. The independent action model (IA) and the relative model deviation ratio (rMDR) were employed to determine the relationship between the Δ(k∙EC)% and rMDR. Read More

J Control Release 2022 Jun 29. Epub 2022 Jun 29.

Institute of Nephrology, Zhong Da Hospital, Nanjing, China. Electronic address:

With the ever-increasing burden of kidney disease, the need for developing new therapeutics to manage this disease has never been greater. Extracellular vesicles (EVs) are natural membranous nanoparticles present in virtually all organisms. Given their excellent delivery capacity in the body, EVs have emerged as a frontier technology for drug delivery and have the potential to usher in a new era of nanomedicine for kidney disease. Read More

Kidney Int 2022 Jun 29. Epub 2022 Jun 29.

The University of Arizona R. Ken Coit College of Pharmacy, Skaggs Pharmaceutical Sciences Center, 1703 E. Mabel St. 85721, Tucson, AZ. USA; The University of Arizona College of Medicine, 501 N Campbell Ave. 85724, Tucson, AZ. USA; The University of Arizona, BIO5 Institute, 1657 E Helen St. 85719, Tucson, AZ. USA; Southern Arizona VA Health Care System, USA. Electronic address:

The β adrenergic receptor agonist, formoterol, is an inducer of mitochondrial biogenesis and restorer of mitochondrial and kidney function in acute and chronic models of kidney injury. Unfortunately, systemic administration of formoterol has the potential for adverse cardiovascular effects, increased heart rate, and decreased blood pressure. To minimize these effects, we developed biodegradable and biocompatible polymeric nanoparticles containing formoterol that target the kidney, thereby decreasing the effective dose, and lessen cardiovascular effects while restoring kidney function after injury. Read More

Acta Trop 2022 Jun 29:106581. Epub 2022 Jun 29.

Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Campus Universitário, Morro do Cruzeiro - Ouro Preto, Minas Gerais, Brasil.

In recent decades, the oral infection of Trypanosoma cruzi has gathered increased attention due to frequent outbreaks that can lead to more severe clinical signs than those usually found in the areas of vector transmission. This study addresses the main routes of infection using metacyclic trypomastigotes (MT) and blood trypomastigotes (BT). Herein, BALB/c mice were infected with the Colombian (TcI) strain via intraperitoneal (IP), oral, intragastric (IG), ocular (OC) and cutaneous (CT) routes with 10 culture-derived MT or BT. Read More

Brain Res 2022 Jun 29:147996. Epub 2022 Jun 29.

Dept Psychiatry at BIDMC, Harvard Medical School, USA. Electronic address:

Respiratory rhythm plays an important role in cognitive functions in rodents, as well as in humans. Respiratory related oscillation (RRO), generated in the olfactory bulb (OB), is an extrinsic rhythm imposed on brain networks. In rats, RRO can couple with intrinsic brain oscillations at theta frequency during sniffing and in the delta range outside of such episodes. Read More

Cell Mol Gastroenterol Hepatol 2022 Jun 29. Epub 2022 Jun 29.

Surgical Research Laboratory and Section of Hepatobiliary Surgery and Liver Transplantation Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

Lancet Haematol 2022 Jun 29. Epub 2022 Jun 29.

Department of Angiology, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland.

Background: COVID-19 is a viral prothrombotic respiratory infection. Heparins exert antithrombotic and anti-inflammatory effects, and might have antiviral properties. We aimed to investigate whether thromboprophylaxis with enoxaparin would prevent untoward hospitalisation and death in symptomatic, but clinically stable outpatients with COVID-19. Read More

Lancet 2022 Jun 28. Epub 2022 Jun 28.

Second Department of Neurology, National and Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.

Lancet 2022 Jun 28. Epub 2022 Jun 28.

Centre de recherche du CHUS, Centre intégré Universitaire de Santé et des Services Sociaux de l'Estrie, Sherbrooke, QC, Canada.

Background: Intravenous thrombolysis with alteplase bolus followed by infusion is a global standard of care for patients with acute ischaemic stroke. We aimed to determine whether tenecteplase given as a single bolus might increase reperfusion compared with this standard of care.

Methods: In this multicentre, open-label, parallel-group, registry-linked, randomised, controlled trial (AcT), patients were enrolled from 22 primary and comprehensive stroke centres across Canada. Read More

Lancet Psychiatry 2022 Jun 29. Epub 2022 Jun 29.

Department of Research, Arkin, Amsterdam, Netherlands; Vrije Universiteit Department Clinical Psychology, Amsterdam, The Netherlands.

Background: Although de-institutionalisation has been underway for decades, admission to hospital followed by low-intensity outpatient care remains the usual treatment for patients with an acute psychiatric crisis. Intensive home treatment has been developed for patients in a severe psychiatric crisis as an alternative to inpatient care. This study aimed to evaluate the potential of intensive home treatment to reduce bed-days and its clinical effectiveness compared with treatment as usual. Read More

Aquat Toxicol 2022 Jun 25;249:106233. Epub 2022 Jun 25.

Department of Physical and Environmental Sciences and Environmental NMR Centre, University of Toronto Scarborough, Ontario, Canada. Electronic address:

As urbanization and the global population increases, pollutants associated with municipal wastewater such as pharmaceuticals are becoming more prevalent in aquatic environments. Acetaminophen (paracetamol) is a widely used drug worldwide and one of the most frequently detected pharmaceuticals in freshwater ecosystems. This study investigated the impact of acetaminophen on the metabolite profile of Daphnia magna at two life stages; and used these metabolomic findings to hypothesize a potential impact at a higher organismal level which was subsequently tested experimentally. Read More

J Infect Public Health 2022 Jun 24;15(8):845-852. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Ministry of National Health Affairs, Riyadh, Saudi Arabia.

Introduction: COVID-19 infection in pregnancy ranges from asymptomatic infection to severe disease. However, the maternal and pregnancy outcomes are primarily favorable. Acute Respiratory Illness (ARI) score is a Visual Triage Checklist for Acute Respiratory symptoms created by the ministry of health of Saudi Arabia to screen the patient for acute respiratory infection with MERS-CoV. Read More

Biosens Bioelectron 2022 Jun 21;214:114494. Epub 2022 Jun 21.

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. Electronic address:

Dry chemistry-based fluorescence or colorimetric immunosensors have been widely applied for point-of-care testing (POCT). However, dry chemistry-based electrochemiluminescence (ECL) immunosensors have not been reported for real sample-to-answer detection. Herein, a dry chemistry-based sample-to-answer, ultrasensitive closed bipolar electrode-ECL (CBP-ECL) immunosensor based on lateral flow assay has been firstly designed for POCT of Cardiac Troponin I (cTnI). Read More