Pharmaceutics 2021 Jul 27;13(8). Epub 2021 Jul 27.
Center for Convergence Bioceramic Materials, Convergence R&D Division, Korea Institute of Ceramic Engineering and Technology, 202, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju 28160, Korea.
Cancer, which is a leading cause of death, contributes significantly to reducing life expectancy worldwide. Even though paclitaxel (PTX) is known as one of the main anticancer drugs, it has several limitations, including low solubility in aqueous solutions, a limited dosage range, an insufficient release amount, and patient resistance. To overcome these limitations, we suggest the development of PTX-loaded thermosponge nanoparticles ([email protected]), which result in improved anticancer effects, via a simple nanoprecipitation method, which allows the preparation of [email protected] with hydrophobic interactions without any chemical conjugation. Read More