291,048 results match your criteria activity presence

Impact of pharmacist involvement on medication safety in interprofessional transfer of care activity.

N Z Med J 2021 Jul 30;134(1539):9-20. Epub 2021 Jul 30.

Associate Dean Medical Education, University of Otago, Christchurch, Specialist Respiratory Physician, Canterbury District Health Board.

Aim: Any transition of patient care is a high-risk time for communication error. This paper explores whether the presence of a pharmacist as part of an interprofessional group provides additional benefit and safety in transitions of care.

Method: Six pharmacy interns and newly qualified pharmacists joined participants from seven other health professional training programmes to take part in an interprofessional education activity. Read More

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Gender Differences in Personal and Situational Risk Factors for Traumatic Brain Injury Among Older Adults.

J Head Trauma Rehabil 2021 Jul 26. Epub 2021 Jul 26.

Department of Emergency Medicine, Taipei Medical University Hospital, Taipei, Taiwan, ROC (Dr Yu); Institute of Injury Prevention and Control, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan, ROC (Drs Yu and Lin); and Department of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan, ROC (Dr Hwang).

Objective: To investigate differences between older men and women in Taiwan in personal and situational risk factors for sustaining a traumatic brain injury (TBI) versus soft-tissue injury (STI) due to a fall.

Design: Matched case-control study.

Participants And Settings: Cases were defined as patients with a primary diagnosis of TBI due to a fall and were identified from those 60 years or older who visited the emergency department (ED) of 3 university-affiliated hospitals in 2015. Read More

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Nicotine-like discriminative and aversive effects of two α4β2-selective nicotine agonists, ispronicline and metanicotine.

Gail Winger

Behav Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

Department of Pharmacology, University of Texas Health, San Antonio, Texas, USA.

An attempt to determine the receptor selective nature of some of nicotine's behavioral effects was undertaken through the evaluation of the ability of two nicotinic α4β2*-selective receptor agonists to produce nicotine-like effects and modify rates of responding in a discrimination assay and in an aversive stimulus assay. A group of eight rats was trained to discriminate the presence of 1 mg/kg nicotine base. Another group of 4-6 rats was trained to report the aversive effects of nicotine by selecting a lever that produced one food pellet over a second lever that produced two food pellets and an intravenous injection of nicotine. Read More

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Infusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: Chemical, toxicological and bioactivities characterization.

J Ethnopharmacol 2021 Jul 25:114455. Epub 2021 Jul 25.

REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, 228 4050-313 Porto, Portugal.

Ethnopharmacological Relevance: Salvia chudaei Batt. & Trab. from Algeria is traditionally used to relieve several dysfunctions, including inflammatory and pain-related situations. Read More

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Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.

PLoS Biol 2021 Jul 28;19(7):e3001355. Epub 2021 Jul 28.

Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America.

Sensing and response to environmental cues, such as pH and chloride (Cl-), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have identified compounds that dysregulate Mtb response to high Cl- levels, with a subset of the hits also inhibiting Mtb growth in host macrophages. Structure-activity relationship studies on the hit compound "C6," or 2-(4-((2-(ethylthio)pyrimidin-5-yl)methyl)piperazin-1-yl)benzo[d]oxazole, demonstrated a correlation between compound perturbation of Mtb Cl- response and inhibition of bacterial growth in macrophages. Read More

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Evaluating the antibacterial effect of synthesized herbal toothpastes and their efficacy for dentine tubule occlusion: Scanning electron microscopy and energy-dispersive X-ray spectroscopy analysis.

Microsc Res Tech 2021 Jul 28. Epub 2021 Jul 28.

Department of Microbiology and Virology, Kerman University of Medical Sciences, Kerman, Iran.

The tubule occlusion of two newly developed herbal toothpastes was examined. They were prepared based on the mixture of pomegranate peel and Equisetum arvense extracts with strontium acetate. The antimicrobial activity of pomegranate peel and E. Read More

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A novel DNA biosensor for the ultrasensitive detection of DNA methyltransferase activity based on a high-density "hot spot" SERS substrate and rolling circle amplification strategy.

Analyst 2021 Jul 28. Epub 2021 Jul 28.

Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225001, P. R. China. and Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, P. R. China and Jiangsu Key Laboratory of Experimental & Translational Noncoding RNA Research, Medical College, Yangzhou University, Yangzhou, China.

Herein, we proposed a novel biosensor based on a high-density "hot spot" [email protected] array substrate and rolling circle amplification (RCA) strategy for the ultrasensitive detection of CpG methyltransferase (M.SssI) activity. In the presence of M. Read More

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IFITM proteins that restrict the early stages of respiratory virus infection do not influence late-stage replication.

J Virol 2021 Jul 28:JVI0083721. Epub 2021 Jul 28.

Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Victoria 3000, Australia.

Interferon-induced transmembrane (IFITM) proteins inhibit a broad range of enveloped viruses by blocking entry into host cells. We used an inducible overexpression system to investigate if IFITM1, IFITM2 and IFITM3 could modulate early and/or late stages of influenza A virus (IAV) or parainfluenza virus (PIV)-3 infection in human A549 airway epithelial cells. IAV and PIV-3 represent respiratory viruses which utilise distinct cellular entry pathways. Read More

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Sexuality of Female Spina Bifida Patients: Predictors of a Satisfactory Sexual Function.

Rev Bras Ginecol Obstet 2021 Jun 27;43(6):467-473. Epub 2021 Jul 27.

Postgraduate Program in Health Sciences: Gynecology and Obstetrics, Universidade Federal do Rio Grande do Sul, RS, Brazil.

Objective:  To assess the sexual function of women with spina bifida (SB), and to verify the factors that influence their sexual function.

Methods:  A cross-sectional study in which a validated female-specific questionnaire was applied to 140 SB female patients from four different cities (Porto Alegre, Brazil; and Barcelona, Madrid, and Málaga, Spain) between 2019 and 2020. The questionnaires collected data on the clinical characteristics of SB, and female sexual function was assessed using the 6-item version of the Female Sexual Function Index (FSFI-6) validated to Portuguese and Spanish. Read More

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Dynamics of Germination Behaviour, Protein Secondary Structure, Technofunctional Properties, Antinutrients, Antioxidant Capacity and Mineral Elements in Germinated Dhaincha.

Food Technol Biotechnol 2021 Jun;59(2):238-250

Department of Food Science and Technology, Punjab Agricultural University, Ludhiana-141004 (Punjab), India.

Research Background: Dhaincha () is a forage legume primarily used for green manuring and animal feed. Good nutritional profile of dhaincha makes it a potential alternative legume in human nutrition. However, the presence of high amount of antinutrients poses a problem in its utilisation for food applications. Read More

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Antioxidant and Cytotoxic Effects and Identification of Bioactive Proteins Using Shotgun Proteomic Analysis.

Food Technol Biotechnol 2021 Jun;59(2):201-208

Medicinal Mushroom Research Group, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Research Background: a highly valued medicinal fungus, is close to extinction due to overexploitation. Successful cultivation of fruiting body (OCS02®) shows that the cultivar has a promising nutritional value and numerous bioactive compounds. Antioxidant and antiproliferative properties and biologically active proteins of the OCS02® are investigated for possible development into nutraceuticals. Read More

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Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands.

Sci Rep 2021 Jul 27;11(1):15231. Epub 2021 Jul 27.

Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein Campus Kiel, Arnold-Heller-Str. 3, Building U30, 24105, Kiel, Germany.

Human Vγ9Vδ2 T cells recognize pyrophosphates produced by microbes and transformed cells and play a role in anti-infective immunity and tumor surveillance. Toll-like receptors (TLR) are pattern recognition receptors in innate immune cells which sense microbial structures including nucleic acids. Given that γδ T cells are in clinical development for application in cellular cancer immunotherapy and TLR ligands have potent adjuvant activity, we investigated the co-stimulatory role of selected TLR ligands in γδ T-cell activation. Read More

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Feature Availability Comparison in Free and Paid Versions of Popular Smartphone Weight Management Applications.

J Nutr Educ Behav 2021 Jul 24. Epub 2021 Jul 24.

Department of Human Ecology, Rutgers University, New Brunswick, NJ.

Objective: Characterize capabilities of nutrition applications (apps) for weight management and associations between features, ratings, and app installations.

Design: Calorie tracking apps with weight management as a primary outcome were selected from the Apple App Store and Google Play Store using keywords "diet" and "weight loss."

Methods: Reviewers assessed free and upgraded versions of nutrition apps (n = 15) for features within 4 categories: (1) dietary intake, (2) anthropometrics, (3) physical activity, and (4) behavior change strategies. Read More

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Comparison of mass spectrometry data and bioinformatics predictions to assess the bona fide localization of proteins identified in cell wall proteomics studies.

Plant Sci 2021 Sep 18;310:110979. Epub 2021 Jun 18.

Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, Auzeville Tolosane, France. Electronic address:

Plant cell walls have complex architectures made of polysaccharides among which cellulose, hemicelluloses, pectins and cell wall proteins (CWPs). Some CWPs are anchored in the plasma membrane through a glycosylphosphatidylinositol (GPI)-anchor. The secretion pathway is the classical route to reach the extracellular space. Read More

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September 2021

Computational study of DMPC liposomes loaded with the N-(2-Hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) and determination of its antiproliferative activity in NIH-3T3 cells.

J Biomol Struct Dyn 2021 Jul 27:1-12. Epub 2021 Jul 27.

Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica (Laboratory for the Design and Development of New Drugs and Biotechnological Innovation) SEPI-ESM Instituto Politécnico Nacional, Ciudad de México, Mexico.

-(2-Hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) is a valproic acid (VPA) derivative that has shown promising antiproliferative effects in different cancer cell lines, such as A204, HeLa, and MDA-MB-231. However, its low water solubility could reduce its therapeutic effectiveness. To solve this problem, in this work, we incorporated HO-AAVPA into dimyristoyl-phosphatidylcholine (DMPC) liposomes in the presence or absence of cholesterol (CHOL). Read More

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How do patients spend their time in stroke rehabilitation units in England? The REVIHR study.

Disabil Rehabil 2021 Aug 6;43(16):2312-2319. Epub 2019 Dec 6.

Division of Rehabilitation, Ageing and Wellbeing, School of Medicine, University of Nottingham, Nottingham, UK.

Aim: To examine how patients spend their time in stroke rehabilitation units in England.

Methods: We recruited 144 patients within a month after stroke from four stroke rehabilitation units and observed their activity type, interactions and location. Each participant was observed for 1 min every 10-minutes, for a total of 20 h, over three consecutive days. Read More

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Impact of Epstein-Barr virus infection on inflammatory bowel disease (IBD) clinical outcomes.

Rev Esp Enferm Dig 2021 Jul 28. Epub 2021 Jul 28.

UCG Aparato Digestivo, Hospital Universitario Virgen del Rocío. .

Objective: To evaluate the role of Epstein-Barr virus (EBV) on the intestinal mucosa in the evolution of inflammatory bowel disease (IBD), to investigate the risk factors for EBV infection and the frequency of EBV-associated lymphoproliferative disorders in IBD patients.

Methods: Intestinal biopsies of IBD patients with available EBV status determined by Epstein-Barr-encoding RNA (EBER) in situ hybridization were searched in the Pathology Database of our center. Clinical information, including phenotypic characteristics of IBD, previous treatments, diagnosis of lymphoma, and patient outcome, were reviewed for all cases. Read More

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Dynamic modeling of the activated sludge microbial growth and activity under exposure to heavy metals.

Bioresour Technol 2021 Jul 21;339:125623. Epub 2021 Jul 21.

Wroclaw University of Science and Technology, Faculty of Chemistry, Department of Micro, Nano, and Bioprocess Engineering, Norwida 4/6, 50-373 Wrocław, Poland.

The presence of heavy metals in the environment can lead to ecological and health problems. The evolution of biological systems, such as activated sludge, exposed to heavy metals is still underexplored. Therefore, this study sought to develop a model of microorganism activity and growth in activated sludge and used it to investigate the toxicity of five metals: Cu, Cd, Ni, Zn, and Ag. Read More

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Optimization of thermostable proteases production under agro-wastes solid-state fermentation by a new thermophilic Mycothermus thermophilus isolated from a hydrothermal spring Hammam Debagh, Algeria.

Chemosphere 2021 Jul 8;286(Pt 1):131479. Epub 2021 Jul 8.

Laboratoire de Mycologie, de Biotechnologie et de l'Activité Microbienne (LaMyBAM), Département de Biologie Appliquée, Université des Frères Mentouri, Constantine 1, BP, 325 Route de Aïn El Bey, Constantine 25017, Algeria.

The present work investigates for the first time the presence and isolation of the thermophilic fungi from hydrothermal spring situated at the locality of Guelma, in the Northeast of Algeria. The production of the thermostable proteases and the optimization of culture conditions under agro-wastes solid-state fermentation to achieve optimal production capacity were explored. A statistical experimental approach consisting of two designs was used to determine the optimum culture conditions and to attain the greatest enzyme production. Read More

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A hypothetical adhesin protein induces anti-biofilm antibodies against multi-drug resistant Acinetobacter baumannii.

Microb Pathog 2021 Jul 24:105112. Epub 2021 Jul 24.

Center of Technological Development, Biotechnology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil; Department of Microbiology and Parasitology, Biology Institute, Federal University of Pelotas, Pelotas, RS, Brazil. Electronic address:

The increase in multidrug-resistant (MDR) Acinetobacter baumannii strains in hospital environments has generated great concern around the world. Biofilm is one of the forms of bacterial adaptation that is increasingly leading to antimicrobial resistance and therapeutic failure. The search for alternative therapeutic strategies, especially non-antibiotic-based, is urgently needed. Read More

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Effect of extracts and isolated compounds derived from Retama monosperma (L.) Boiss. on anti-aging gene expression in human keratinocytes.

J Ethnopharmacol 2021 Jul 24:114451. Epub 2021 Jul 24.

Laboratory of Bioorganic Chemistry, Faculty of Sciences, University Chouaïb Doukkali, Jabran Khalil Jabran Avenue, PO Box: 299, El Jadida, 24000, Morocco. Electronic address:

Ethnopharmacological Relevance: Retama monosperma is used currently in Moroccan folk medicine to treat skin cicatrization; but the mechanism involved still not well known. The wound healing and skin regeneration can be obtained by the activation of SIRT1 and SIRT3 genes and the sirtuin proteins expression, which delay cellular senescence. Especially, SIRT1 the most studied gene, lead to fast skin restauration and cicatrization. Read More

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Phormidepistatin from the Cyanobacterium UIC 10484: Assessing the Phylogenetic Distribution of the Statine Pharmacophore.

J Nat Prod 2021 Jul 27. Epub 2021 Jul 27.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.

A new linear lipopeptide, phormidepistatin (), containing an epi-statine amino acid was isolated from cf. sp. strain UIC 10484. Read More

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Radiosynthesis and in silico bioevaluation of I-Sulfasalazine as a highly selective radiotracer for imaging of ulcerative colitis.

Chem Biol Drug Des 2021 Jul 27. Epub 2021 Jul 27.

Department of Pharmaceutical Chemistry, Ahram Canadian University, Giza-12511, Egypt.

This study demonstrated the tracking of ulcerative colitis, which is considered a stressful immune disease. Although there are many ways to test for this disease including dependence on gases, dyes, and painful anal endoscopy, these treatment modalities have many disadvantages. Hence, it is the utmost need of time to discover new methods to detect this chronic immune disease and to avoid the defects of traditional methodologies. Read More

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Carbon dioxide capture enhanced by pre-adsorption of water and methanol in UiO-66.

Chemistry 2021 Jul 27. Epub 2021 Jul 27.

TU/e: Technische Universiteit Eindhoven, Applied Physics, Groene Loper 3, 5612 AE, Eindhoven, NETHERLANDS.

The rapidly rising level of carbon dioxide in the atmosphere resulting from human activity is one of the greatest environmental problems facing our civilization today. Most technologies are not yet sufficiently developed to move existing infrastructure to cleaner alternatives. Therefore, techniques for capturing carbon dioxide from emission sources may play a key role at the moment. Read More

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Ruthenium(II) Complex-based G-quadruplex DNA Selective Luminescent 'Light-up' Probe for RNase H Activity Detection.

Chembiochem 2021 Jul 27. Epub 2021 Jul 27.

North-Eastern Hill University, Biotechnology and bioinformatics, INDIA.

A bis -heteroleptic ruthenium(II) complex, 1[PF6]2 of benzothiazole amide substituted 2,2'-bipyridine ligand (bmbbipy) has been synthesized for the selective detection of G-quadruplex (GQ) DNA and luminescence assay based RNase H activity monitoring. Compound 1[PF6]2 exhibited aggregation caused quenching (ACQ) property in water. The aggregate formation was supported by DLS, UV-vis, and 1 H NMR spectroscopy, and the morphology of aggregated particles was witnessed by SEM and TEM. Read More

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MoS nanosheets/silver nanoparticles anchored onto textile fabric as "dip catalyst" for synergistic p-nitrophenol hydrogenation.

Environ Sci Pollut Res Int 2021 Jul 27. Epub 2021 Jul 27.

Laboratory of Applied Organic Chemistry, Faculty of Science and Techniques, Sidi Mohamed Ben Abdellah University, 2202, Fes, Morocco.

Attaining a synergistic merge between the performance of homogenous catalysts and the recyclability of heterogeneous catalysts remains until now a concerning issue. The main challenge is to design efficient, low-cost catalyst with outstanding reusability, facile recovery, and ease of retrieval and monitoring between the reuses. Despite the vast efforts in the development of silver nanoparticle-based catalyst for the reaction of hydrogenation of 4-nitrophenol, the aforementioned criteria are infrequently found in a chosen system. Read More

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Calmodulin Antagonist W-7 Enhances Intermediate Conductance Ca- Sensitive Basolateral Potassium Channel (IK) Activity in Human Colonic Crypts.

J Membr Biol 2021 Jul 27. Epub 2021 Jul 27.

Leeds Institute of Medical Research at St James, St James University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

Intermediate conductance potassium (IK) channels are exquisitively Ca sensitive, intracellular Ca regulating channel activity by complexing with calmodulin (CaM), which is bound to the cytosolic carboxyl tail. Although CaM antagonists might be expected to decrease IK channel activity, the effect of W-7 in human T lymphocytes are conflicting. We therefore evaluated the effect of W-7 on basolateral IK channels in human colonic crypt cells. Read More

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Application of nano-graphene oxide as nontoxic disinfectant against alpha and betacoronaviruses.

Vet Med Sci 2021 Jul 27. Epub 2021 Jul 27.

Adult Stem, Cell Research Center and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.

New viruses are continuously emerging and recently there have been many great concerns on severe acute respiratory syndrome coronavirus (SARS-CoV-2). Nanographene oxide (nanoGO) has received much attention and is widely investigated to be utilised in therapy for infectious diseases by viruses. Thus, antiviral activity of nanoGO was evaluated using the porcine epidemic diarrhoea virus (PEDV), bovine coronavirus (BCoV), and SARS-CoV-2, which are all Alpha- and Beta-coronavirus. Read More

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An engineered microfluidic blood-brain barrier model to evaluate the anti-metastatic activity of β-boswellic acid.

Biotechnol J 2021 Jul 27:e2100044. Epub 2021 Jul 27.

Laboratory for Stem Cell & Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman.

Background: The development of anti-cancer drugs with the ability to inhibit brain metastasis through the blood-brain barrier (BBB) is substantially limited due to the lack of reliable in vitro models.

Main Methods: In this study, the Geltrex™-based Transwell and microfluidic BBB models were applied to screen the effect of β-boswellic acid (β-BA) on the metastasis of MDA-MB-231 cells through the BBB in static and dynamic conditions, respectively.

Major Results: The toxicity assay revealed that β-BA deteriorates MDA-MB-231 cells, while β-BA had no detectable toxic effects on human umbilical vein endothelial cells (HUVECs) and astrocytes. Read More

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Improvement of Fucosylated Oligosaccharides Synthesis by α-L-Fucosidase from Thermotoga maritima in Water-Organic Cosolvent Reaction System.

Appl Biochem Biotechnol 2021 Jul 26. Epub 2021 Jul 26.

Departamento de Biotecnología, Universidad Autónoma Metropolitana, Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, 09340, Mexico City, Mexico.

The effects of water activity (a), pH, and temperature on transglycosylation activity of α-L-fucosidase from Thermotoga maritima in the synthesis of fucosylated oligosaccharides were evaluated using different water-organic cosolvent reaction systems. The optimum conditions of transglycosylation reaction were the pH range between 7 and 10 and temperature 90-95 °C. The addition of organic cosolvent decreased α-L-fucosidase transglycosylation activity in the following order: acetone > dimethyl sulfoxide (DMSO) > acetonitrile (0. Read More

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