J Biol Chem 2021 Jun 18:100893. Epub 2021 Jun 18.
The Frick Center for Heart Failure and Arrhythmia, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, OH, USA; Department of Internal Medicine, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein β-spectrin as an important step in CF activation and cardiac fibrosis. Further, loss of β-spectrin was found to depend on Ca/calmodulin-dependent kinase II (CaMKII). Read More