213,523 results match your criteria activity enhanced

Effects of dietary nicotinic acid supplementation on meat quality, carcass characteristics, lipid metabolism, and tibia parameters of Wulong geese.

Poult Sci 2021 Aug 14;100(11):101430. Epub 2021 Aug 14.

College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China. Electronic address:

The purpose of this study was to evaluate the effects of nicotinic acid (NA) supplementation on the meat quality, carcass characteristics, lipid metabolism, and tibia parameters in Wulong geese. A total of 360 twenty-nine-day-old Wulong geese were randomly divided into 6 treatments, and each treatment included 6 pens with 10 birds per pen. Birds were fed a basal diet supplemented with 0, 20, 40, 60, 80, or 100 mg/kg NA for 12 wk. Read More

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Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging.

Cell Rep 2021 Sep;36(11):109689

The Garvan Institute of Medical Research, St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.

Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Förster resonance energy transfer (FRET) biosensor mouse coupled with in vivo photoswitching to track intratumoral movement, we help guide treatment scheduling in a live breast cancer setting to impair metastatic progression. We uncover altered Rac1 activity at the center versus invasive border of tumors and demonstrate enhanced Rac1 activity of cells in close proximity to live tumor vasculature using optical window imaging. Read More

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September 2021

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy.

Cell Stem Cell 2021 Sep 9. Epub 2021 Sep 9.

University of Minnesota, Department of Medicine, Minneapolis, MN 55455, USA. Electronic address:

Select subsets of immune effector cells have the greatest propensity to mediate antitumor responses. However, procuring these subsets is challenging, and cell-based immunotherapy is hampered by limited effector-cell persistence and lack of on-demand availability. To address these limitations, we generated a triple-gene-edited induced pluripotent stem cell (iPSC). Read More

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September 2021

Soluble CD127 potentiates IL-7 activity in vivo in healthy mice.

Immun Inflamm Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: Soluble forms of cytokine receptors can be involved in the endogenous regulation of cytokine activity. Soluble interleukin 7 receptor α (sCD127) naturally binds IL-7, therefore there is interest in its potential application as an immunotherapeutic agent to regulate IL-7. With the hypothesis that sCD127 enhances IL-7 activity, thus promoting T-cell proliferation in vivo, we sought to assess the effect of sCD127, IL-7 or IL-7 + sCD127 treatment on CD4 and CD8 T-cells in the blood and spleen of mice. Read More

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September 2021

Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway.

Am J Physiol Regul Integr Comp Physiol 2021 Sep 15. Epub 2021 Sep 15.

Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, United States.

Maternal e-cigarette (e-cig) exposure is a pressing perinatal health concern. Emerging evidence reveals its potential adverse impacts on brain development in offspring, yet the underlying mechanisms are poorly understood. The present study tested the hypothesis that fetal e-cig exposure induces an aberrant DNA methylation profiles in the developing brain, leading to alteration of autophagic flux signaling and programming of a sensitive phenotype to neonatal hypoxic-ischemic encephalopathy (HIE). Read More

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September 2021

Expansion of Human iNKT Cells Ex Vivo.

Methods Mol Biol 2021 ;2388:123-129

Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China.

Invariant natural killer T (iNKT) cells are credited with antitumor activity by preclinical studies and clinical trials. Efficient expansion of iNKT cells ex vivo is essential for their translational usage. The culturing procedure described here provides an optimized method for ex vivo expansion of iNKT cells using recombinant human IL-15 (rhIL-15) and recombinant human IL-12 (rhIL-12), which results in cell products with enhanced cytokine secretion and cytotoxicity while maintaining the purity and viability of iNKT cells. Read More

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January 2021

A simple method for decellularizing a cell-derived matrix for bone cell cultivation and differentiation.

J Mater Sci Mater Med 2021 Sep 15;32(9):124. Epub 2021 Sep 15.

Department of Trauma and Reconstructive Surgery, BG Trauma Center Tübingen, Siegfried Weller Institute for Trauma Research, Eberhard Karls University Tübingen, 72076, Tübingen, Germany.

The extracellular matrix regulates cell survival, proliferation, and differentiation. In vitro two-dimensional cell experiments are typically performed on a plastic plate or a substrate of a single extracellular matrix constituent such as collagen or calcium phosphate. As these approaches do not include extracellular matrix proteins or growth factors, they fail to mimic a complex cell microenvironment. Read More

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September 2021

Enzyme-responsive micellar JQ1 induces enhanced BET protein inhibition and immunotherapy of malignant tumors.

Biomater Sci 2021 Sep 15. Epub 2021 Sep 15.

Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.

Bromodomain and extra-terminal (BET) proteins are attractive targets for treating various malignancies including melanoma. The inhibition of BET bromodomains, with JQ1, is found to downregulate the expression of both c-MYC oncoprotein and programmed cell death ligand 1 (PD-L1), which play a crucial role in tumor growth and the immunosuppressive tumor microenvironment, respectively. The BET bromodomain inhibitors like JQ1 though exhibiting high selectivity and affinity show usually low bioavailability and efficacy due to fast clearance and inferior uptake by tumor cells. Read More

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September 2021

Ethyl Acetate Fraction of (L.) Medic Flowers Exerts Inhibitory Effects Against Oxidative Stress in HO-Induced HepG2 Cells and D-Galactose-Induced Aging Mice.

J Med Food 2021 Sep;24(9):997-1009

College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang, China.

Oxidative stress has been demonstrated to be associated with numerous aging-related diseases. Ethyl acetate fraction of (L.) Medic (EA) had been reported to possess strong radical-scavenging activity due to its rich content of flavonoids. Read More

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September 2021

Constructing Porous Carbon Electrocatalysts from Cobalt Complex-Decorated Micelles of Mesoporous Silica for Oxygen Reduction/Evolution Reaction.

Inorg Chem 2021 Sep 15. Epub 2021 Sep 15.

School of Materials Science and Engineering, College of Science, China University of Petroleum (East China), Qingdao 266580, P. R. China.

The construction of a porous carbon structure with a high specific surface area is conducive to enhanced electrocatalytic activity due to the accessibility of active sites and improvement of the mass transfer. Herein, we explored the possibility of using micelles of mesoporous silica (MCM-48) as the carbon source to generate porous carbon under the confinement of MCM-48 channels. The complexes formed by Co and 4,4'-bipyridine were in situ incorporated into the micelles to derive Co-related active sites (Co-N, Co, and CoO) for catalyzing the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). Read More

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September 2021

Biochar amendment rapidly shifts microbial community structure with enhanced thermophilic digestion activity.

Bioresour Technol 2021 Sep 1;341:125864. Epub 2021 Sep 1.

UBC Bioreactor Technology Group, School of Engineering, University of British Columbia, Kelowna, British Columbia V1V 1V7, Canada. Electronic address:

Effects of powdered (<0.075 mm) biochar on thermophilic anaerobic digestion were investigated with biochemical methane potential (BMP) assays. The assays had substrate to inoculum ratios (SIR) of 2. Read More

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September 2021

Humification process and mechanisms investigated by Fenton-like reaction and laccase functional expression during composting.

Bioresour Technol 2021 Sep 8;341:125906. Epub 2021 Sep 8.

School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, PR China. Electronic address:

This study aims to explore the impacts of the Fenton-like reaction on hydrogen peroxide, hydroxyl radicals, humic substance (HS) formation, laccase activity and microbial communities during composting to optimize composting performances. The results indicated that the activity of laccase in the presence of the Fenton-like reaction (HC) (35.92 U/g) was significantly higher than that in the control (CP) (29. Read More

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September 2021

Sewage denitrification performance and sludge properties variation with the addition of liquid from perishable organic anaerobic fermentation.

Bioresour Technol 2021 Aug 21;341:125821. Epub 2021 Aug 21.

The State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, 1515 North Zhongshan Rd. (No. 2), Shanghai 200092, China. Electronic address:

The organics in the classified wet waste were deficiently utilized while sewage denitrification requires abundant carbon sources. Herein, the fermentation of perishable organic waste (POW) and the denitrification process with obtained liquid were investigated. The most volatile fatty acids (VFAs) production was realized with the fermentation liquid of food waste (FL-FW). Read More

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Facial fabricated biocompatible homogeneous biocarriers involving biochar to enhance denitrification performance in an anoxic moving bed biofilm reactor.

Bioresour Technol 2021 Sep 1;341:125866. Epub 2021 Sep 1.

Joint Research Centre for Protective Infrastructure Technology and Environmental Green Bioprocess, Department of Environmental and Municipal Engineering, Tianjin Chengjian University, Tianjin 300384, China.

Biochar prepared from pineapple peel was facially combined with polyurethane sponges for the first time to form homogeneous biocompatible biocarriers, which can enhance denitrification performance in an anoxic MBBR. The experiments showed that a higher NO-N removal efficiency (96.24 ± 1. Read More

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September 2021

Toxicity of isoprocarb to earthworms (Eisenia fetida): Oxidative stress, neurotoxicity, biochemical responses and detoxification mechanisms.

Environ Pollut 2021 Aug 28;290:118038. Epub 2021 Aug 28.

Eco-environmental Protection Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China; Agricultural Environment and Farmland Conservation Experiment Station of Ministry Agriculture, Shanghai, 201403, China.

Isoprocarb (IPC) is a conventional carbamate with high insecticidal activity, however, generalized use of it may cause soil contamination and adversely implicate non-target biota. Following OECD standardized toxicological protocols, the toxic effects of IPC on Eisenia fetida at lethal and sublethal concentrations were examined to elucidate its toxic modes of action as well as biochemical and detoxification responses of E. fetida. Read More

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Bimetallic FeNi nanoparticles immobilized by biomass-derived hierarchically porous carbon for efficient removal of Cr(VI) from aqueous solution.

J Hazard Mater 2021 Sep 4;423(Pt A):127098. Epub 2021 Sep 4.

School of Environmental Science and Engineering, Yancheng Institute of Technology, Yancheng 224051, PR China. Electronic address:

Nano zero-valent iron (nZVI) is an effective material for Cr(VI) treatment, however excessive agglomeration and surface oxidation limit its application. Herein, straw derived hierarchically porous carbon supported FeNi bimetallic nanoparticles ([email protected]) was prepared for effective removal of Cr(VI) from water. FeNi nanoparticles were successfully loaded onto HPC with good dispersibility, and HPC caused an increase in specific surface area of FeNi nanoparticles. Read More

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September 2021

Salicylic acid induces tolerance of Vitisriparia×V.labrusca to chilling stress by altered photosynthetic, antioxidant mechanisms and expression of cold stress responsive genes.

Plant Signal Behav 2021 Sep 15:1973711. Epub 2021 Sep 15.

Key Laboratory of Arid Land Crop Science of Gansu Province, College of Life Science and Technology,Gansu Agricultural University,Lanzhou,China.

The yield and quality of wine grapes are severely persecuted by low-temperaturestresses. Salicylic acid (SA) assists plants in coping with abiotic stresses such as drought, heavy metal toxicity, and osmotic stress. The objective of this study was to evaluate the effect of foliar spraying of different concentrations of SA on the mitigation of cold damage in grapes, which is useful for the cultivation of wine grapes. Read More

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September 2021

Polymyxin B-Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy.

Adv Healthc Mater 2021 Sep 14:e2101465. Epub 2021 Sep 14.

School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.

Repurposing old antibiotics into more effective and safer formulations is an emergent approach to tackle the growing threat of antimicrobial resistance. Herein, a peptide hydrogel is reported for the localized and sustained release of polymyxin B (PMB), a decade-old antibiotic with increasing clinical utility for treating multidrug-resistant Gram-negative bacterial infections. The hydrogel is assembled by additing PMB solution into a rationally designed peptide amphiphile (PA) solution and its mechanical properties can be adjusted through the addition of counterions, envisioning its application in diverse infection scenarios. Read More

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September 2021

Atomic cation-vacancy engineering of NiFe-layered double hydroxides for improved activity and stability towards the oxygen evolution reaction.

Angew Chem Int Ed Engl 2021 Sep 14. Epub 2021 Sep 14.

The University of Auckland, School of Chemical Sciences, 23 Symonds Street, 1142, Auckland, NEW ZEALAND.

NiFe-layered double hydroxides (NiFe-LDH) are among the most active catalysts developed to date for the oxygen evolution reaction (OER) in alkaline media, though their long-term OER stability remains unsatisfactory. Herein, we reveal that the stability degradation of NiFe-LDH catalysts during alkaline OER results from a decreased number of active sites and undesirable phase segregation to form NiOOH and FeOOH, with metal dissolution underpinning both of these deactivation mechanisms. Further, we demonstrate that the introduction of cation-vacancies in the basal plane of NiFe LDH is an effective approach for achieving both high catalyst activity and stability during OER. Read More

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September 2021

Effect of different doses of the catecholamine epinephrine on antioxidant responses of larvae of the flesh fly Sarcophaga dux.

Environ Sci Pollut Res Int 2021 Sep 14. Epub 2021 Sep 14.

University of Rennes, CNRS, ECOBIO [(Ecosystèmes, biodiversité, évolution)] - UMR 6553, 263 Avenue du Gal Leclerc, 74205, F 35000, 35042, Rennes, CS, France.

The production and use of pharmaceutical products have increased over the past decades, and several are considered potential or proved hazardous wastes. When contaminating the environment, they can severely impact biodiversity. The catecholamine epinephrine (adrenaline) is no exception. Read More

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September 2021

Mechanical properties of Na-montmorillonite-modified EICP-treated silty sand.

Environ Sci Pollut Res Int 2021 Sep 14. Epub 2021 Sep 14.

Central Plains Development Research Institute, Henan University, Kaifeng, 475004, People's Republic of China.

The effects of Na-montmorillonite (Na-Mt) content and curing age on enzyme-induced carbonate precipitation (EICP)-treated soil were studied. First, the effects of Na-Mt addition on the urease activity, Ca precipitation rate, and pH of the solution were analyzed through tube tests. Then, Na-Mt-modified EICP was used to reinforce silty sand in the Yellow River flooding area in China. Read More

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September 2021

Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production.

iScience 2021 Sep 24;24(9):103022. Epub 2021 Aug 24.

Research Institute, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan.

Cellular senescence acts as a potent tumor-suppression mechanism in mammals; however, it also promotes tumor progression in a non-cell-autonomous manner. We provided insights into the mechanism underlying senescence-dependent metastatic cancer development. The elimination of senescent cells suppressed the lung metastasis of melanoma cells. Read More

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September 2021

Norepinephrine modulates wakefulness via α1 adrenoceptors in paraventricular thalamic nucleus.

iScience 2021 Sep 21;24(9):103015. Epub 2021 Aug 21.

Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 Xin Song Jiang Road, Shanghai 201620, China.

Norepinephrine (NE) neurons in the locus coeruleus (LC) play key roles in modulating sleep and wakefulness. Recent studies have revealed that the paraventricular thalamic nucleus (PVT) is a critical wakefulness-controlling nucleus in mice. However, the effects of NE on PVT neurons remain largely unknown. Read More

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September 2021

Magnetic systems for cancer immunotherapy.

Acta Pharm Sin B 2021 Aug 30;11(8):2172-2196. Epub 2021 Apr 30.

Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO 80303, USA.

Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies. Immune cell modulation through the administration of drugs, proteins, and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive tumors. Magnetic systems offer several advantages for improving the performance of immunotherapies, including increased spatiotemporal control over transport, release, and dosing of immunomodulatory drugs within the body, resulting in reduced off-target effects and improved efficacy. Read More

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Indoleamine 2,3-Dioxygenase in Hematopoietic Stem Cell-Derived Cells Suppresses Rhinovirus-Induced Neutrophilic Airway Inflammation by Regulating Th1- and Th17-Type Responses.

Immune Netw 2021 Aug 17;21(4):e26. Epub 2021 Aug 17.

College of Veterinary Medicine and Bio-Safety Research Institute, Jeonbuk National University, Iksan 54596, Korea.

Asthma exacerbations are a major cause of intractable morbidity, increases in health care costs, and a greater progressive loss of lung function. Asthma exacerbations are most commonly triggered by respiratory viral infections, particularly with human rhinovirus (hRV). Respiratory viral infections are believed to affect the expression of indoleamine 2,3-dioxygenase (IDO), a limiting enzyme in tryptophan catabolism, which is presumed to alter asthmatic airway inflammation. Read More

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Plasmon-enabled N photofixation on partially reduced TiC MXene.

Chem Sci 2021 Aug 20;12(33):11213-11224. Epub 2021 Jul 20.

Department of Physics, The Chinese University of Hong Kong Shatin Hong Kong SAR China

Benefiting from the superior conductivity, rich surface chemistry and tunable bandgap, TiC MXene has become a frontier cocatalyst material for boosting the efficiency of semiconductor photocatalysts. It has been theoretically predicted to be an ideal material for N fixation. However, the realization of N photofixation with TiC as a host photocatalyst has so far remained experimentally challenging. Read More

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Elucidating the anticancer activities of guanidinium-functionalized amphiphilic random copolymers by varying the structure and composition in the hydrophobic monomer.

Theranostics 2021 21;11(18):8977-8992. Epub 2021 Aug 21.

Institute of Bioengineering and Bioimaging, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.

Use of traditional anticancer chemotherapeutics has been hindered by the multifactorial nature of multi-drug resistance (MDR) development and metastasis. Recently, cationic polycarbonates were reported as novel unconventional anticancer agents that mitigated MDR and inhibited metastasis. The aim of this study is to explore structure-anticancer activity relationship. Read More

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Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin.

Theranostics 2021 11;11(18):8797-8812. Epub 2021 Aug 11.

Sir Run run Hospital, Nanjing Medical University, Nanjing, China.

Neprilysin (NEP) is a major endogenous catabolic enzyme of amyloid β (Aβ). Previous studies have suggested that increasing NEP expression in animal models of Alzheimer's disease had an ameliorative effect. However, the underlying signaling pathway that regulates NEP expression remains unclear. Read More

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An "eat me" combinatory nano-formulation for systemic immunotherapy of solid tumors.

Theranostics 2021 11;11(18):8738-8754. Epub 2021 Aug 11.

Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom.

Tumor immunogenic cell death (ICD), induced by certain chemotherapeutic drugs such as doxorubicin (Dox), is a form of apoptosis potentiating a protective immune response. One of the hallmarks of ICD is the translocation of calreticulin to the cell surface acting as an 'eat me' signal. This manuscript describes the development of a stable nucleic acid-lipid particles (SNALPs) formulation for the simultaneous delivery of ICD inducing drug (Dox) with small interfering RNA (siRNA) knocking down CD47 (siCD47), the dominant 'don't eat me' marker, for synergistic enhancement of ICD. Read More

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Effects of fruit and bark alcoholic extracts, alone and in combination, on scopolamine-induced memory impairment in mice.

Res Pharm Sci 2021 Oct 19;16(5):474-481. Epub 2021 Aug 19.

Department of Pharmacology and Toxicology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.

Background And Purpose: Alzheimer's disease is a progressive brain disorder that is thought to be triggered disruption of cholinergic neurons and enhanced oxidative stress. Therefore, antioxidant phytochemicals with the ability to fortify cholinergic function should help in preventing the progress of the disease. This study aimed at evaluating the combinational effects of two popular herbs one with anticholinesterase activity namely and the other with antioxidant capacity, . Read More

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October 2021