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Effects of Ultrashort Wave Therapy on Inflammation and Macrophage Polarization after Acute Lung Injury in Rats.

Bioelectromagnetics 2021 Jun 15. Epub 2021 Jun 15.

Rehabilitation Medicine Center, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of China.

Acute lung injury (ALI) features dysregulated pulmonary inflammation. Ultrashort waves (USWs) exert anti-inflammatory effects but no studies have evaluated their activity in ALI. Herein, we used an in vivo lipopolysaccharide (LPS)-induced ALI model to investigate whether the anti-inflammatory activity of USWs is mediated by altering the polarization of M1 to M2 macrophages. Read More

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Investigation of indole functionalized pyrazoles and oxadiazoles as anti-inflammatory agents: Synthesis, in-vivo, in-vitro and in-silico analysis.

Bioorg Chem 2021 Jun 8;114:105068. Epub 2021 Jun 8.

Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, Ferozpur G.T. Road MOGA-142001, Punjab, India. Electronic address:

There are several potential side and adverse effects are found to be associated with the anti-inflammatory drugs in clinical practice. The long-term use of these clinical agents highly unsafe. It encouraged the development of novel heterocyclic compounds with potential anti-inflammatory activity and low to no toxicity. Read More

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Morphometric properties of immature reticulocytes in health and during acute lymphoblastic and acute myeloid leukemia.

Tissue Cell 2021 Jun 10;71:101578. Epub 2021 Jun 10.

Department of Biology, Faculty of Biology and Chemistry, Belgorod State University, 85 Pobeda St., Belgorod, 308015, Russia. Electronic address:

Despite significant advances, many changes occurring in the tumor microenvironment during acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) remain unclear. The surface of immature reticulocytes was examined by atomic force microscopy (AFM) to determine specific changes during the development of ALL and AML. In patients with ALL the surface area of reticulocytes increased by 18. Read More

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Mesenchyme homeobox 1 mediated-promotion of osteoblastic differentiation is negatively regulated by mir-3064-5p.

Differentiation 2021 Jun 10;120:19-27. Epub 2021 Jun 10.

Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao, 266000, Shandong, China. Electronic address:

Human mesenchymal stem cells (hMSCs) are multipotent cells that can be differentiated into different cell types including osteoblasts. Herein we aimed to assess the regulation of transcription factor mesenchyme homeobox 1 (Meox1) in the osteogenic differentiation of hMSCs and to determine the microRNA which targets on Meox1. Total RNA was extracted from the isolated ligamentum flavum tissue samples and cultured hMSCs, and the expression of Meox1 was assessed by RT-PCR and Western blot assays. Read More

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Niujiaodihuang Detoxify Decoction inhibits ferroptosis by enhancing glutathione synthesis in acute liver failure models.

J Ethnopharmacol 2021 Jun 12:114305. Epub 2021 Jun 12.

School of Pharmacy,Guangdong Medical University,Dongguan 524023,China. Electronic address:

Ethnopharmacological Relevance: Niujiaodihuang Detoxify Decoction (NDD) is an integrated traditional Chinese medicine prescription that has been used as a therapeutic agent for the treatment of acute liver failure (ALF). However, the mechanisms underlying its action remain unclear.

Aim Of The Study: To determine the protective effect of NDD on D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced ALF and explore the underlying mechanisms. Read More

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Time-Driven Activity-Based Costing for Cataract Surgery in Canada: The Case of the Kensington Eye Institute.

Healthc Policy 2021 May;16(4):97-108

Director, Health System Strategy, Medtronic ULC, Brampton, ON.

Time-driven activity-based costing (TDABC) has received considerable attention globally as a way to measure value in healthcare systems. This study aimed to apply TDABC for cataract surgery at the Kensington Eye Institute (KEI). During a field evaluation, a detailed process map was created for cataract surgery at KEI. Read More

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Effect of a Probiotic Supplement Containing Lactobacillus Acidophilus and Bifidobacterium Animalis Lactis on Urine Oxalate in Calcium Stone Formers with Hyperoxaluria: A Randomized, Placebo-controlled, Double-blind and In-vitro Trial.

Urol J 2021 Jun 15. Epub 2021 Jun 15.

Assistant Professor, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.

Purpose: To determine the effect of a probiotic supplement containing native Lactobacillus acidophilus (L. acidophilus) and Bifidobacterium animalis lactis (B. lactis) on 24-hour urine oxalate in recurrent calcium stone formers with hyperoxaluria. Read More

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Internet Interest in Colon Cancer Following the Death of Chadwick Boseman: Infoveillance Study.

J Med Internet Res 2021 Jun 15;23(6):e27052. Epub 2021 Jun 15.

Beedie School of Business, Simon Fraser University, Vancouver, BC, Canada.

Background: Compared with White Americans, Black Americans have higher colon cancer mortality rates but lower up-to-date screening rates. Chadwick Boseman was a prominent Black American actor who died of colon cancer on August 28, 2020. As announcements of celebrity diagnoses often result in increased awareness, Boseman's death may have resulted in greater interest in colon cancer on the internet, particularly among Black Americans. Read More

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Protective role of physical activity patterns prior to COVID-19 confinement with the severity/duration of respiratory pathologies consistent with COVID-19 symptoms in Spanish populations.

Res Sports Med 2021 Jun 15:1-12. Epub 2021 Jun 15.

Department of Didactics of Corporal Expression, University of Jaen, Spain.

The main purpose of the present study was to determine the association of physical activity (PA) patterns prior to COVID-19 confinement with severe respiratory distress consistent with COVID-19 symptoms. Participants were recruited by sending a survey through various social network channels via the snowball method. A voluntary sample of 420 individuals consisting of 199 men and 221 women from the Spanish national territory participated in this study. Read More

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Circadian characteristics of the rest-activity rhythm, executive function, and glucose fluctuations in young adults with type 1 diabetes.

Chronobiol Int 2021 Jun 15:1-11. Epub 2021 Jun 15.

Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA.

Circadian alignment is an important element in individual health, and one behavioral marker, rest-activity rhythm, could influence self-management in young adults with type 1 diabetes (T1D). Little is known about the rest-activity rhythms, executive function, and glycemia among young adults with type 1 diabetes (T1D). The purpose of this study was to evaluate parametric and nonparametric circadian characteristics of the rest-activity rhythm and the associations between these variables, sleep-wake behavior, executive function, and glycemia among young adults with T1D. Read More

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Sleep timing and consistency are associated with the standardised test performance of Icelandic adolescents.

J Sleep Res 2021 Jun 14:e13422. Epub 2021 Jun 14.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.

Sleep has been shown to affect cognitive function in laboratory studies; however, its association to the academic performance of adolescents has largely been demonstrated using self-reported measures. Studies with objective measures of both sleep and academic performance are limited. The aim of the present study was to determine whether the free-living sleep quantity, quality, and timing of 15-year-old adolescents measured with wrist actiography are associated with their scores on national standardised examinations as an objective measure of academic achievement. Read More

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X-chromosome inactivation patterns in females with Fabry disease examined by both ultra-deep RNA sequencing and methylation-dependent assay.

Clin Exp Nephrol 2021 Jun 14. Epub 2021 Jun 14.

Department of Nephrology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Fabry disease is an X-linked inherited lysosomal storage disorder caused by mutations in the gene encoding α-galactosidase A. Males are usually severely affected, while females have a wide range of disease severity. This variability has been assumed to be derived from organ-dependent skewed X-chromosome inactivation (XCI) patterns in each female patient. Read More

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Temporal patterns of physical activity in successful weight loss maintainers.

Int J Obes (Lond) 2021 Jun 14. Epub 2021 Jun 14.

Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Background/objectives: Individuals successful at weight loss maintenance engage in high amounts of physical activity (PA). Understanding how and when weight loss maintainers accumulate PA within a day and across the week may inform PA promotion strategies and recommendations for weight management.

Methods: We compared patterns of PA in a cohort of weight loss maintainers (WLM, n = 28, maintaining ≥13. Read More

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Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury.

Sci Rep 2021 Jun 14;11(1):12468. Epub 2021 Jun 14.

Department of Biophysics, Faculty of Medicine, Altinbas University, Bakirkoy, Istanbul, Turkey.

Traumatic brain injury (TBI) is the main cause of disability and mortality in individuals under the age of 45 years. Elucidation of the molecular and structural alterations in brain tissue due to TBI is crucial to understand secondary and long-term effects after traumatic brain injury, and to develop and apply the correct therapies. In the current study, the molecular effects of TBI were investigated in rat brain at 24 h and 1 month after the injury to determine acute and chronic effects, respectively by Fourier transform infrared imaging. Read More

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Surgery school-who, what, when, and how: results of a national survey of multidisciplinary teams delivering group preoperative education.

Perioper Med (Lond) 2021 Jun 15;10(1):20. Epub 2021 Jun 15.

Manchester University NHS Foundation Trust, Manchester, UK.

Background: Group education is increasing in popularity as a means of preparing patients for surgery. In recent years, these 'surgery schools' have evolved from primarily informing patients of what to expect before and after surgery, to providing support and encouragement for patients to 'prehabilitate' prior to surgery, through improving physical fitness, nutrition and emotional wellbeing.

Method: A survey aimed at clinicians delivering surgery schools was employed to capture a national overview of activity to establish research and practice priorities in this area. Read More

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Who should I involve in my research and why? Patients, carers or the public?

Res Involv Engagem 2021 Jun 14;7(1):41. Epub 2021 Jun 14.

NCRI Consumer Forum, Sarcoma Patients Euronet, Shropshire, UK.

Patient and public involvement in research helps to make it more relevant and useful to the end-users. Involvement influences the design, delivery and dissemination of research, ultimately leading to better services, treatments and care. Researchers are therefore keen to involve patients, carers and public in their work, but are sometimes uncertain about who to involve. Read More

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The Brain in Motion II Study: study protocol for a randomized controlled trial of an aerobic exercise intervention for older adults at increased risk of dementia.

Trials 2021 Jun 14;22(1):394. Epub 2021 Jun 14.

Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.

Background: There remains no effective intervention capable of reversing most cases of dementia. Current research is focused on prevention by addressing risk factors that are shared between cardiovascular disease and dementia (e.g. Read More

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Oxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation.

Am J Respir Cell Mol Biol 2021 Jun 14. Epub 2021 Jun 14.

University of North Carolina, Pediatrics, Chapel Hill, North Carolina, United States;

Ozone (O) is a prevalent air pollutant causing lung inflammation. Previous studies demonstrate that O oxidizes lipids, such as cholesterol, in the airway to produce oxysterols, such as secosterol-A (SecoA), which are electrophiles capable of forming covalent linkages preferentially with lysine residues and consequently modify protein function. The breadth of proteins modified by this oxysterol as well as the biological consequences in the lung are unknown. Read More

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DNA binding ability and cytotoxicity, cell cycle arrest and apoptosis inducing properties of a benzochromene derivative against K562 human leukemia cells.

Nucleosides Nucleotides Nucleic Acids 2021 Jun 15:1-22. Epub 2021 Jun 15.

Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

Chromene and its derivatives are generally spread in nature. Heterocylic-based compounds like chromenes have displayed pharmacological activities. Chromene derivatives are critical due to some biological features such as anticancer activity. Read More

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Impact of smoking on sleep macro- and microstructure.

Sleep Med 2021 May 28;84:86-92. Epub 2021 May 28.

Department of Medicine, Service of Pulmonary Medicine, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland; Center for Investigation and Research in Sleep (CIRS), Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.

Objectives: Existing data suggest that smoking may be associated with sleep disturbances. This study aimed to determine the association between smoking and both subjective and objective sleep quality.

Methods: Cross-sectional analysis of sleep characteristics in 3233 participants from the population-based CoLaus-HypnoLaus cohort (52. Read More

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Estimation of unattached and aerosol-attached activities of airborne short-lived radon progeny in indoor environments.

J Environ Radioact 2021 Jun 11;237:106665. Epub 2021 Jun 11.

Laboratory of Material Physics and Subatomic, Department of Physics, Faculty of Sciences, Ibn Toufail University, Kenitra, 14000, Morocco.

Inhalation of the airborne short-lived radon progeny is regarded as the most crucial way of internal exposure to the natural radiation dose delivered to the human lung. In this respect, this study aims to determine the unattached and aerosol-attached activities of radon progeny and to estimate some important physical parameters employed to assess the radiological impact of this radiation on humans. For this purpose, radioactive aerosol samples collected on polycarbonate membrane filters to measure total alpha activity by passive alpha dosimetric technique using CR-39 detectors in sixteen different locations including some houses and workplaces in El Jadida city, in Morocco. Read More

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Imidazole antifungal drug clotrimazole alters the behavior, brain acetylcholinesterase and oxidative stress biomarkers in African catfish Clarias gariepinus (Burchell 1822).

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jun 11:109108. Epub 2021 Jun 11.

Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Nigeria. Electronic address:

This study was carried out to determine the effect of clotrimazole (CTZ), an imidazole fungicide on behavior, brain acetylcholinesterase, lipid peroxidation and oxidative stress parameters in Clarias gariepinus juveniles. Fish were acutely exposed to five nominal concentrations of CTZ and control to assess the behavioral effects on fish. To determine the effects on brain acetylcholinesterase, lipid peroxidation and oxidative stress parameters, fish were exposed to three sub-lethal concentrations vis 7. Read More

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Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex.

Brain Stimul 2021 Jun 11. Epub 2021 Jun 11.

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Over the past decade, the number of experimental and clinical studies using theta-burst-stimulation (TBS) protocols of transcranial magnetic stimulation (TMS) to modulate brain activity has risen substantially. The use of TBS is motivated by the assumption that these protocols can reliably and lastingly modulate cortical excitability despite their short duration and low number of stimuli. However, this assumption, and thus the experimental validity of studies using TBS, is challenged by recent work showing large inter- and intra-subject variability in response to TBS protocols. Read More

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Pulseless electrical activity vs. asystole in adult in-hospital cardiac arrest: Predictors and outcomes.

Resuscitation 2021 Jun 11. Epub 2021 Jun 11.

Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Denmark. Electronic address:

Aim: This observational cohort study aimed to identify factors associated with pulseless electrical activity (PEA) and asystole in in-hospital cardiac arrest (IHCA) patients and to determine whether differences in outcome based on the initial rhythm were explained by patient- and cardiac arrest characteristics.

Methods: Adults with IHCA from 2017 to 2018 were included from the Danish IHCA Registry (DANARREST). Additional data came from population-based registries. Read More

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Cell type hierarchy reconstruction via reconciliation of multi-resolution cluster tree.

Nucleic Acids Res 2021 Jun 14. Epub 2021 Jun 14.

Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

A wealth of clustering algorithms are available for single-cell RNA sequencing (scRNA-seq) data to enable the identification of functionally distinct subpopulations that each possess a different pattern of gene expression activity. Implementation of these methods requires a choice of resolution parameter to determine the number of clusters, and critical judgment from the researchers is required to determine the desired resolution. This supervised process takes significant time and effort. Read More

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3DMol-Net: Learn 3D Molecular Representation using Adaptive Graph Convolutional Network Based on Rotation Invariance.

IEEE J Biomed Health Inform 2021 Jun 14;PP. Epub 2021 Jun 14.

Studying the deep learning-based molecular representation has great significance on predicting molecular property, promoted the development of drug screening and new drug discovery, and improving human well-being for avoiding illnesses. It is essential to learn the characterization of drug for various downstream tasks, such as molecular property prediction. In particular, the 3D structure features of molecules play an important role in biochemical function and activity prediction. Read More

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Determination of risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus in a Palestinian Diabetes Study.

Curr Med Res Opin 2021 Jun 14. Epub 2021 Jun 14.

Department of Nursing, Faculty of Applied Medical Sciences, Al-Azhar University of Gaza (AUG), Gaza City 00970, State of Palestine.

Objective: to determine the risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus.

Methods: A total of 164 hypertensive patients with type 2 diabetes patients aged 38 to 60 years were selected from 7 primary healthcare centers in Gaza city, Palestine. Interview questionnaire were employed to collect data related to age, gender, smoking habits, and physical activity pattern. Read More

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Patterns of discordance of physical functioning in older persons; different associations for apathy and depression? Results from the NESDO-study.

Aging Ment Health 2021 Jun 14:1-9. Epub 2021 Jun 14.

Department of Epidemiology & Biostatistics, Medical Faculty Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objectives: Discordance between self-reported functional limitations and performance-based physical functioning may have a negative impact in functional independence in older adults. We longitudinally examined baseline apathy- and depressive symptomatology as associates of discordance.

Method: 469 participants from the multi-site cohort study NESDO were included. Read More

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Molecular and cell biological analysis of SwrB in .

J Bacteriol 2021 Jun 14:JB0022721. Epub 2021 Jun 14.

1Department of Biology, Indiana University, Bloomington IN 47408.

Type III secretion systems (T3SS) are elaborate nanomachines that form the core of the bacterial flagellum and injectisome of pathogens. The machines not only secrete proteins like virulence factors but also secrete the structural components for their own assembly. Moreover, proper construction requires complex regulation to ensure that the parts are roughly secreted in the order in which they are assembled. Read More

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Association between dietary protein intake and change in grip strength over time among adults of advanced age: Life and Living in Advanced Age: A Cohort Study in New Zealand (LiLACS NZ).

Australas J Ageing 2021 Jun 14. Epub 2021 Jun 14.

Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Objective: To determine the association between dietary protein intake and change in grip strength (GS) over time among Māori and non-Māori of advanced age.

Methods: Protein intake was estimated from 2×24h multiple pass recall (MPR) in 554 participants, and GS was measured yearly over five years. Anthropometric, physical activity and health data were collected. Read More

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