Genomics 2021 Sep 14. Epub 2021 Sep 14.
Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Southwest Medical University, Luzhou 646000, China. Electronic address:
As a key component of gene regulation, transcription factors (TFs) play an important role in a number of biological processes. To fully understand the underlying mechanism of TF-mediated gene regulation, it is therefore critical to accurately identify TF binding sites and predict their affinities. Recently, deep learning (DL) algorithms have achieved promising results in the prediction of DNA-TF binding, however, various deep learning architectures have not been systematically compared, and the relative merit of each architecture remains unclear. Read More