655,946 results match your criteria activity data


Can a ToF-PET photon attenuation reconstruction test stopping power estimations in proton therapy? a phantom study.

Phys Med Biol 2021 Sep 17. Epub 2021 Sep 17.

WPE, University Hospital Essen, Essen, GERMANY.

Objective: The aim of the phantom study was to validate and to improve the computed tomography (CT) images used for the dose computation in proton therapy. It was tested, if the joint reconstruction of activity and attenuation images of time-of-flight PET (ToF-PET) scans could improve the estimation of the proton stopping power.

Approach: The attenuation images, i. Read More

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September 2021

Bicentric validation of the navigated transcranial magnetic stimulation motor risk stratification model.

J Neurosurg 2021 Sep 17:1-13. Epub 2021 Sep 17.

1Department of Neurosurgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin.

Objective: The authors sought to validate the navigated transcranial magnetic stimulation (nTMS)-based risk stratification model. The postoperative motor outcome in glioma surgery may be preoperatively predicted based on data derived by nTMS. The tumor-to-tract distance (TTD) and the interhemispheric resting motor threshold (RMT) ratio (as a surrogate parameter for cortical excitability) emerged as major factors related to a new postoperative deficit. Read More

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September 2021

Identification of grape H3K4 genes and their expression profiles during grape fruit ripening and postharvest ROS treatment.

Genomics 2021 Sep 14. Epub 2021 Sep 14.

College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, PR China; Henan Engineering Technology Research Center of Quality Regulation of Horticultural Plants, Luoyang 471023, PR China. Electronic address:

Fruit development is modified by different types of epigenetics. Histone methylation is an important way of epigenetic modification. Eight genes related to H3K4 methyltransferase, named VvH3K4s, were identified and isolated from the grape genome based on conserved domain analysis, which could be divided into 3 categories by the phylogenetic relationship. Read More

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September 2021

Evaluation of deep learning approaches for modeling transcription factor sequence specificity.

Genomics 2021 Sep 14. Epub 2021 Sep 14.

Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Southwest Medical University, Luzhou 646000, China. Electronic address:

As a key component of gene regulation, transcription factors (TFs) play an important role in a number of biological processes. To fully understand the underlying mechanism of TF-mediated gene regulation, it is therefore critical to accurately identify TF binding sites and predict their affinities. Recently, deep learning (DL) algorithms have achieved promising results in the prediction of DNA-TF binding, however, various deep learning architectures have not been systematically compared, and the relative merit of each architecture remains unclear. Read More

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September 2021

Experimental and mathematical modeling approaches for biocatalytic post-consumer poly(ethylene terephthalate) hydrolysis.

J Biotechnol 2021 Sep 14. Epub 2021 Sep 14.

Chemistry Institute, Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil; Federal Institute of Education, Science and Technology of Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil. Electronic address:

The environmental impact arising from poly(ethylene terephthalate) (PET) waste is notable worldwide. Enzymatic PET hydrolysis can provide chemicals that serve as intermediates for value-added product synthesis and savings in the resources. In the present work, some reaction parameters were evaluated on the hydrolysis of post-consumer PET (PC-PET) using a cutinase from Humicola insolens (HiC). Read More

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September 2021

Acalabrutinib, venetoclax, and obinutuzumab as frontline treatment for chronic lymphocytic leukaemia: a single-arm, open-label, phase 2 study.

Lancet Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Background: Both continuous therapy with acalabrutinib and fixed-duration therapy with venetoclax-obinutuzumab are effective for previously untreated chronic lymphocytic leukaemia. We hypothesised that frontline time-limited, minimal residual disease (MRD)-guided triplet therapy with acalabrutinib, venetoclax, and obinutuzumab would induce deep (ie, more patients with undetectable MRD) and durable remissions.

Methods: In this open-label, single-arm, investigator-sponsored, phase 2 study, patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma were recruited from two academic hospitals in Boston, MA, USA. Read More

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September 2021

Complete Genome Sequence of the Biocontrol Yeast Papiliotrema terrestris Strain LS28.

G3 (Bethesda) 2021 Sep 17. Epub 2021 Sep 17.

Department of Agricultural, Environmental and Food Sciences, University of Molise, via Francesco de Sanctis, 86100 Campobasso, Italy.

Papiliotrema terrestris strain LS28 is a biocontrol agent (BCA) selected for its antagonistic activity against several plant pathogens both in the field and postharvest. The availability of a genome sequencing sets the foundation for the identification of the genetic mechanisms of its antagonistic activity. The genome size is 21. Read More

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September 2021

The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro.

PLoS One 2021 17;16(9):e0257705. Epub 2021 Sep 17.

Division of Environmental Pathology, Department of Oral Science, Kanagawa Dental University, Yokosuka, Kanagawa, Japan.

SARS-CoV-2 enters host cells when the viral spike protein is cleaved by transmembrane protease serine 2 (TMPRSS2) after binding to the host angiotensin-converting enzyme 2 (ACE2). Since ACE2 and TMPRSS2 are expressed in the tongue and gingival mucosa, the oral cavity is a potential entry point for SARS-CoV-2. This study evaluated the inhibitory effects of general ingredients of toothpastes and mouthwashes on the spike protein-ACE2 interaction and the TMPRSS2 protease activity using an in vitro assay. Read More

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September 2021

Pupillary fluctuation amplitude before target presentation reflects short-term vigilance level in Psychomotor Vigilance Tasks.

PLoS One 2021 17;16(9):e0256953. Epub 2021 Sep 17.

Department of Intelligence Science and Technology, Graduate School of Informatics, Kyoto University, Kyoto, Kyoto, Japan.

Our daily activities require vigilance. Therefore, it is useful to externally monitor and predict our vigilance level using a straightforward method. It is known that the vigilance level is linked to pupillary fluctuations via Locus Coeruleus and Norepinephrine (LC-NE) system. Read More

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September 2021

Adaptation supports short-term memory in a visual change detection task.

PLoS Comput Biol 2021 Sep 17;17(9):e1009246. Epub 2021 Sep 17.

Allen Institute for Brain Science, Seattle, Washington, United States of America.

The maintenance of short-term memories is critical for survival in a dynamically changing world. Previous studies suggest that this memory can be stored in the form of persistent neural activity or using a synaptic mechanism, such as with short-term plasticity. Here, we compare the predictions of these two mechanisms to neural and behavioral measurements in a visual change detection task. Read More

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September 2021

Self-Care Capacity and Its Relationship to Age, Disability, and Perceived Well-Being in Medicare Beneficiaries.

Nurs Res 2021 Sep 15. Epub 2021 Sep 15.

University of Delaware, School of Nursing, Newark, DE University of Delaware, Department of Behavioral Health and Nutrition, Newark, DE Northern Kentucky University, Department of Psychological Science, Highland Heights, KY College of Nursing and Health Innovation, University of Texas at Arlington.

Background: Self-care is a multicomponent set of capacities that influence beliefs about health and well-being.

Objectives: We examined the relationship between self-care capacity, age, and disability status with two perceptions of well-being in a cohort of Medicare beneficiaries.

Methods: The current study is part of a multisite research project to determine factors associated with cross-sectional and longitudinal morbidity and mortality trajectories observed in Medicare beneficiaries. Read More

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September 2021

Sufficient conditions for effective psychological treatment of chronic pain: a qualitative comparative analysis.

Pain 2021 Oct;162(10):2472-2485

Research Department of Clinical, Educational & Health Psychology, University College London, London, United Kingdom.

Abstract: Chronic pain (CP) is the leading cause of years lived with disability globally. Treatment within Western medicine is often multicomponent; the psychological element of treatment varies, yet the optimal conditions for effective reduction of pain-related outcomes remain unclear. This study used qualitative comparative analysis, a relatively new form of evidence synthesis in the field based on set theory to ascertain configurations of intervention components and processes of psychological treatment of chronic pain in adults that lead to more effective interventions. Read More

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October 2021

Silencing of a Pseudo-nitzschia arenysensis lipoxygenase transcript leads to reduced oxylipin production and impaired growth.

New Phytol 2021 Sep 17. Epub 2021 Sep 17.

Stazione Zoologica Anton Dohrn, Villa Comunale 1, Naples, 80121, Italy.

Because of their importance as chemical mediators, the presence of a rich and varied family of lipoxygenase (LOX) products, collectively named oxylipins, has been deeply investigated in diatoms and the involvement of these products in important processes such as bloom regulation has been postulated. Nevertheless, little information is available on the enzymes and pathways operating in these protists. Exploiting transcriptome data, we identified and characterized a LOX gene, PaLOX, in Pseudo-nitzschia arenysensis, a marine diatom known to produce different species of oxylipins by stereo- and regio-selective oxidation of eicosapentaenoic acid (EPA) at C12 and C15. Read More

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September 2021

Patient perspectives on digital patient reported outcomes in routine care of inflammatory bowel disease.

J Patient Rep Outcomes 2021 Sep 17;5(1):92. Epub 2021 Sep 17.

School of Health and Social Development, Deakin University, Geelong, Australia.

Background: Digital patient reported outcomes are used increasingly in daily care and treatment of inflammatory bowel disease. Their purpose includes increased focus on patient wellbeing, reduction in avoidable follow-up consultations and increased patient self-management. However, implementation issues occur and studies indicate patients may have concerns, particularly regarding having fewer face-to-face consultations. Read More

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September 2021

Non-invasive neurally adjusted ventilatory assist in preterm infants with RDS: effect of changing NAVA levels.

Eur J Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Neonatology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.

We aimed to examine the effect of changing levels of support (NAVA level) during non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants with respiratory distress syndrome (RDS) on electrical diaphragm activity. This is a prospective, single-centre, interventional, exploratory study in a convenience sample. Clinically stable preterm infants supported with NIV-NAVA for RDS were eligible. Read More

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September 2021

Epidemiological shift of glucose-6-phosphate dehydrogenase mutations in northern Italy in the last 15 years.

Ann Hematol 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine and Medical Specialties, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive hemolytic anemia caused by mutations in G6PD gene. The distribution and frequency of genetic variants differ depending on ethnicity and geographical areas. Because of new migrations different variants are now present in Europe. Read More

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September 2021

Cancer Risk After Radioactive Iodine Treatment for Hyperthyroidism: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 Sep 1;4(9):e2125072. Epub 2021 Sep 1.

Department of Preventive Medicine, Korea University College of Medicine, Seoul, Republic of Korea.

Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health.

Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism.

Data Sources: The Medline and Cochrane Library electronic databases, using the Medical Subject Headings terms and text keywords, and Embase, using Emtree, were screened up to October 2020. Read More

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September 2021

Over a century since ephedrine discovery: an updated revisit to its pharmacological aspects, functionality and toxicity in comparison to its herbal extracts.

Food Funct 2021 Sep 17. Epub 2021 Sep 17.

Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, P.B. 11562, Cairo, Egypt.

Ephedrine, a sympathomimetic amine that exhibits several adrenaline actions, is a plant alkaloid that is a common ingredient in several cold, asthma and narcolepsy treatment preparations, and in obesity management and sport medicine. Its principal action mechanism relies on its direct adrenergic actions as well as indirect role that involves the release of epinephrine and norepinephrine, thus increasing the activity of epinephrine and norepinephrine at the postsynaptic α and β receptors. Nevertheless, its serious side effects, including stroke, heart attack, drug abuse and interactions, have never been comprehensively reviewed. Read More

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September 2021

Healthy Lifestyle Behaviors: Nursing Considerations for Social Determinants of Health.

Clin J Oncol Nurs 2021 Oct;25(5):42-48

University of North Carolina at Chapel Hill.

Background: Nurses develop meaningful and deep connections with patients, making them particularly skilled to consider how social determinants of health (SDOH) affect patients. SDOH include one's neighborhood and built environment, health and health care, social and community context, education, and economic stability. Consideration of SDOH, in addition to individual factors, allows nurses to better support patient engagement in health behaviors. Read More

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October 2021

Gambling behaviors during COVID-19: a narrative review.

J Addict Dis 2021 Sep 17:1-9. Epub 2021 Sep 17.

Texas Tech University Health Sciences Center, Lubbock, TX, USA.

The COVID-19 pandemic has ushered the world into unforeseen circumstances, prompting the authorities to impose restrictions and cut back various events including many gambling avenues. Professional sports have been postponed, land casinos are closed, and social distancing has shut home games down. The present narrative overview has addressed the following changes in gambling behavior since the start of the pandemic: - a) Change in the number of gamblers and intensity of gambling b) differences among various types of gambling modalities (land-based, horse betting, casino, online). Read More

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September 2021

Structural and functional analysis of broad pH and thermal stable protease from URM 4622.

Prep Biochem Biotechnol 2021 Sep 17:1-12. Epub 2021 Sep 17.

Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, PE, Brazil.

This study aimed to better characterize a recently purified stable extracellular alkaline peptidase produced by (URM 4622) through fluorescence spectroscopy, far-UV circular dichroism, kinetic and thermodynamic models to understand its' structure-activity and denaturation. Fluorescence data showed that changing pH leads to tryptophan residues exposure to more hydrophilic environments at optimum activity pH 9.0 and 10. Read More

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September 2021

UV-Vis Spectra-Activated Droplet Sorting for Label-Free Chemical Identification and Collection of Droplets.

Anal Chem 2021 Sep 17. Epub 2021 Sep 17.

Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.

We introduce the UV-vis spectra-activated droplet sorter (UVADS) for high-throughput label-free chemical identification and enzyme screening. In contrast to previous absorbance-based droplet sorters that relied on single-wavelength absorbance in the visible range, our platform collects full UV-vis spectra from 200 to 1050 nm at up to 2100 spectra per second. Our custom-built open-source software application, "SpectraSorter," enables real-time data processing, analysis, visualization, and selection of droplets for sorting with any set of UV-vis spectral features. Read More

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September 2021

Functional diversity loss and change in nocturnal behavior of mammals under anthropogenic disturbance.

Conserv Biol 2021 Sep 17. Epub 2021 Sep 17.

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

In the Anthropocene epoch, understanding the impacts of anthropogenic influence on biodiversity and behavior of vulnerable wildlife communities is increasingly relevant to effective conservation. However, comparative studies aimed at disentangling the concurrent effect of different types of human disturbance on multifaceted biodiversity and on activity patterns of mammals are surprisingly rare. We applied a multi-region community model to separately estimate the effects of cumulative human modification (settlement, agriculture, and transportation etc. Read More

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September 2021

Allied health led post-operative hand clinic: Evaluation of an alternative model of care.

Aust Occup Ther J 2021 Sep 17. Epub 2021 Sep 17.

Hand Therapy Clinic, Cairns Hospital Orthopaedic Department, Cairns and Hinterland Hospital and Health Service, Cairns, Queensland, Australia.

Introduction: To assist with the increasing orthopaedic workload, an allied health led hand therapy clinic was established to manage people having routine hand surgeries. The aim of this study was to evaluate patient and doctor satisfaction and safety of this alternative service delivery model.

Methods: Prospective multimethod design evaluation was undertaken by occupational therapists and physiotherapists working in the field of hand therapy. Read More

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September 2021

Botulinum Toxin A in the Management of a Gummy Smile: A Clinical Controlled Preliminary Study.

Aesthet Surg J 2021 Sep 17. Epub 2021 Sep 17.

Ibirapuera University, São Paulo, Brazil.

Background: Botulinum toxin-A (BTX-A) is recent technique to treat gummy smile.

Objectives: This randomized controlled preliminary clinical trial evaluated BTX-A on excessive gingiva display (EGD) reduction, muscle activity, and patient satisfaction at 2, 8, 12, 16, 21, and 25 weeks.

Methods: Group 1(G1): 4 points of BTX-A application (2U/point) for relaxation of the levatorlabii superioris alaeque nasi (LLSAN) and levatorlabiisuperioris (LLS) muscles; Group 2(G2): Two points of BTX-A (2U/point) for relaxation of the LLSAN muscle. Read More

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September 2021

Expression profiles of tyrosine metabolic pathway genes and functional analysis of DOPA decarboxylase in puparium tanning of Bactrocera dorsalis (Hendel).

Pest Manag Sci 2021 Sep 16. Epub 2021 Sep 16.

Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, 400715, China.

Background: Tanning is an important physiological process that play the critical roles in affecting cuticle pigmentation and sclerotization. Previous studies have showed that insect cuticle tanning was closely associated with tyrosine metabolism pathway that consisted of a series of enzymes.

Results: In this study, a total of 24 tyrosine metabolism pathway genes were identified in the oriental fruit fly Bactrocera dorsalis (Hendel) genome. Read More

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September 2021

Phenology and flowering overlap drive specialisation in plant-pollinator networks.

Ecol Lett 2021 Sep 17. Epub 2021 Sep 17.

Department of Environmental Science and Policy, University of California-Davis, Davis, California, USA.

Variation in dietary specialisation stems from fundamental interactions between species and their environment. Consequently, understanding the drivers of this variation is key to understanding ecological and evolutionary processes. Dietary specialisation in wild bees has received attention due to their close mutualistic dependence on plants, and because both groups are threatened by biodiversity loss. Read More

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September 2021

Decreased dynamin-related protein 1-related mitophagy induces myocardial apoptosis in the aging heart.

Acta Biochim Biophys Sin (Shanghai) 2021 Sep 17. Epub 2021 Sep 17.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.

An increase in cardiomyocyte apoptosis is the main contributor to the observed high morbidity of cardiac disease during aging. Mitochondria play important roles in cardiac apoptosis, and dynamin-related protein 1 (Drp1) is the critical factor that participates in mitochondrial fission and induces mitophagy to maintain mitochondria quality. However, whether Drp1 is involved in the increase of apoptosis in aging heart remains unclear. Read More

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September 2021

Anti-inflammatory topical medication - new developments in the treatment of atopic dermatitis.

Allergol Select 2021 27;5:260-264. Epub 2021 Aug 27.

Institute for Applied Dermatopharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Atopic dermatitis is a chronic inflammatory disease that arises from polygenic disposition, a dysfunction of the physicochemical epithelial barrier, a cutaneous dysbiosis, and a faulty neurosensory activity and shows a highly individual acuity due to epigenetic factors. An essential component of therapeutic management is the application of anti-inflammatory topical medication. Currently, topical glucocorticoids and topical calcineurin inhibitors are routinely used in reactive and proactive therapy. Read More

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Does Losing 5-7% of Prediabetic Body Weight from a Diabetes Prevention Program decrease Cardiovascular Risks?

Spartan Med Res J 2021 30;6(2):27627. Epub 2021 Aug 30.

Beaumont Farmington Hills.

Introduction: According to the Centers for Disease Control and Prevention (CDC), one-third of adults have prediabetes (i.e., at risk for developing type 2 diabetes), a leading risk factor for cardiovascular disease. Read More

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