ACS Omega 2021 Jun 4;6(23):15486-15498. Epub 2021 Jun 4.
Southwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706, United States.
A total of 12 new cycloartane- and lanostane-type triterpenoids including 16-deoxyargentatin A (), 16-deoxyisoargentatin A (), 7-oxoisoargentatin A (), 24--argentatin H (), 24---anisoylargentatin C (), 24---cinnamoylargentatin C (), 16-dehydroargentatin C (), 16,17(20)-didehydroargentatin C (), isoargentatin C (), isoargentatin H (), 3--quisquagenin (), and isoquisquagenin () together with 10 known triterpenoids (-) were isolated from the resin of AZ-2 obtained as a byproduct of Bridgestone guayule rubber production. The structures of new triterpenoids - and argentatin H (), which has previously been characterized as its diacetate (), were elucidated by extensive analysis of their spectroscopic data and chemical conversions, and the known compounds - were identified by comparison of their spectroscopic data with those reported. Of these, , , and exhibited weak cytotoxic activity for several cancer cell lines. Read More