23,685 results match your criteria activity circular

New antibacterial chromone from a marine sponge-associated fungus Aspergillus sp. LS57.

Fitoterapia 2021 Jul 30:105004. Epub 2021 Jul 30.

Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, China. Electronic address:

Chemical investigation for the secondary metabolite of marine-derived fungus Aspergillus sp. LS57 resulted in the isolation of one new chromone named aspergilluone A (1) containing a chromone skeleton fused with an unusual hydrogenation cyclopentanoid ring, along with three known compounds 2-4. The structure of 1 was elucidated by 1D and 2D nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analyses. Read More

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Profiling Analysis of Circular RNA and mRNA in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis ILAE Type 1.

Cell Mol Neurobiol 2021 Aug 2. Epub 2021 Aug 2.

Department of Neurosurgery, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, Heilongjiang, China.

Hippocampal sclerosis (HS) is the most common surgical pathology associated with temporal lobe epilepsy (TLE). However, the cause of TLE with or without HS remains unknown. Our current study aimed to illustrate the essential molecular mechanism that is potentially involved in the pathogenesis of TLE-HS and to shed light on the transcriptional changes associated with hippocampal sclerosis. Read More

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Multiple structural rearrangements mediated by high-plasticity regions in Atg3 are key for efficient conjugation of Atg8 to PE during autophagy.

Autophagy 2021 Jul 31:1-4. Epub 2021 Jul 31.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

The Atg3 protein is highly homologous from yeast to human. Atg3 functions as an E2-like enzyme promoting conjugation of Atg8-family proteins to phosphatidylethanolamine (PE), a lipid molecule embedded in the growing phagophore membrane during stress-induced autophagy. Over the last decade, Atg3 became one of the most explored autophagy proteins, resulting in observations that provided specific insights into the structural mechanisms of its function. Read More

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The Digestive Diverticula in the Carnivorous Nudibranch, , Do Not Contain Photosynthetic Symbionts.

Integr Org Biol 2021 21;3(1):obab015. Epub 2021 May 21.

Department of Biology and Health Science, New England College, Henniker, NH 03242, USA.

A number of nudibranchs, including and , harbor symbiotic photosynthetic zooxanthellae. spends most of its adult life on seagrass or kelp, capturing planktonic organisms in the water column with a large, tentacle-lined oral hood that brings food to its mouth. also has an extensive network of digestive diverticula, located just beneath its translucent integument, that are typically filled with pigmented material likely derived from ingested food. Read More

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Brevibacillin 2V Exerts Its Bactericidal Activity Binding to Lipid II and Permeabilizing Cellular Membranes.

Front Microbiol 2021 16;12:694847. Epub 2021 Jul 16.

Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, Netherlands.

Lipo-tridecapeptides, a class of bacterial non-ribosomally produced peptides, show strong antimicrobial activity against Gram-positive pathogens, including antibiotic-resistant and spp. However, many of these lipo-tridecapeptides have shown high hemolytic activity and cytotoxicity, which has limited their potential to be developed into antibiotics. Recently, we reported a novel antimicrobial lipo-tridecapeptide, brevibacillin 2V, which showed no hemolytic activity against human red blood cells at a high concentration of 128 mg/L, opposite to other brevibacillins and lipo-tridecapeptides. Read More

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Iridoid glycosides and lignans from the fruits of Gardenia jasminoides Eills.

Phytochemistry 2021 Jul 28;190:112893. Epub 2021 Jul 28.

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, PR China; Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of PR China, Zhengzhou, 450046, PR China. Electronic address:

Four previously undescribed iridoid glycosides, including two bis-iridoid glycosides, and three undescribed lignans, together with 16 known analogues, were isolated from the fruits of Gardenia jasminoides Eills. Their structures were elucidated on basis of spectroscopic methods, and the absolute configurations of three of the unknown compounds were determined by interpretation of their electronic circular dichroic (ECD) and [α] [Formula: see text] data. The α-glucosidase inhibitory effects of the isolated compounds were evaluated and all the compounds exhibited slightly inhibitory activity with the values of IC greater than 50 μM. Read More

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The role of enteric inhibitory neurons in intestinal motility.

Auton Neurosci 2021 Jul 17;235:102854. Epub 2021 Jul 17.

College of Medicine and Public Health, Department of Human Physiology, Flinders University, Bedford Park, South Australia 5042, Australia.

The enteric nervous system controls much of the mixing and propulsion of nutrients along the digestive tract. Enteric neural circuits involve intrinsic sensory neurons, interneurons and motor neurons. While the role of the excitatory motor neurons is well established, the role of the enteric inhibitory motor neurons (IMNs) is less clear. Read More

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Transformation of fish waste protein to Hermetia illucens protein improves the efficacy of poultry by-products in the culture of juvenile barramundi, Lates calcarifer.

Sci Total Environ 2021 Jul 15;796:149045. Epub 2021 Jul 15.

School of Molecular and Life Sciences, Curtin University, 1 Turner Avenue, Bentley, WA 6102, Australia.

Promoting a circular economy via the transformation of food waste into alternative and high-value protein sources for aquaculture diets is a novel approach to developing alternative raw materials to fishmeal (FM). This approach can reduce the ecological impact on the aquatic environment and simultaneously can provide an option for sustainable food waste management. In this context, we report a 56-day trial of feeding barramundi, Lates calcarifer on four iso‑nitrogenous and iso-lipidic diets where the control (0PBM-0HI) was a FM-based diet and the other test diets replaced FM protein with mixtures of a poultry by-product meal (PBM) and a full-fat Hermetia illucens (HI) larvae meal reared on fish waste: the test diets were 85% PBM + 15% HI (85PBM-15HI), 80% PBM + 20% HI (80PBM-20HI) and 75% PBM + 25% HI (75PBM-25HI). Read More

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Knockdown of circ‑PVT1 inhibits the progression of lung adenocarcinoma and enhances the sensitivity to cisplatin via the miR‑429/FOXK1 signaling axis.

Mol Med Rep 2021 Oct 30;24(4). Epub 2021 Jul 30.

Department of Oncology, The Affiliated Hospital of Nantong University, Dongtai, Jiangsu 224200, P.R. China.

Lung cancer is one of the most prevalent cancers in China, and its incidence and morbidity remain high due to various independent factors. Lung adenocarcinoma (ADC) is the most common type of non‑small cell lung carcinoma. Circular RNA plasmacytoma variant translocation 1 (circ‑PVT1) plays an oncogenic role in various types of cancer, but the specific role of circ‑PVT1 in lung ADC has not yet been reported. Read More

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October 2021

CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression.

Junfen Xu Weiguo Lu

Aging (Albany NY) 2021 Jul 29;13(undefined). Epub 2021 Jul 29.

Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China.

To identify circular RNAs (circRNAs) with tumor suppressor activity against cervical adenocarcinoma, we compared the circRNA levels of cervical adenocarcinoma and normal cervical tissues. We found that circSPIDR was dramatically downregulated in cervical adenocarcinoma tissues. In cervical adenocarcinoma cells, overexpression of circSPIDR reduced cell viability, inhibited colony formation and promoted apoptosis, whereas knockdown of circSPIDR exerted the opposite effects. Read More

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Bioformulation development via valorizing silica-rich spent mushroom substrate with Trichoderma asperellum for plant nutrient and disease management.

J Environ Manage 2021 Jul 26;297:113278. Epub 2021 Jul 26.

Centre for Rural Development & Technology, Indian Institute of Technology (IIT), New Delhi, 110016, India. Electronic address:

The present investigation was performed to valorize paddy straw (PS) based silica (Si) rich Spent Mushroom Substrate (SMS) of Pleurotus ostreatus for Plant Nutrient and Disease Management in wilt (caused by F. oxysporum f. sp. Read More

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Arteannoides U-Z: Six undescribed sesquiterpenoids with anti-inflammatory activities from the aerial parts of Artemisia annua (Qinghao).

Fitoterapia 2021 Jul 26:105002. Epub 2021 Jul 26.

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China. Electronic address:

Four previously unreported sesquiterpenoid diasteromers, arteannoides U-X (1-4), together with one new norsesquiterpenoid 5 (arteannoide Y) and one undescribed rearranged cadinene sesquiterpenoid 6 (arteannoide Z) were obtained from the dried aerial parts of Artemisia annua (Qinghao). Notably, arteannoides U-X (1-4) are four stereoisomers that possess the same molecules and the same planar connectivity, but differ from each other in configuration at a certain stereocenter. Their accurate structures were unambiguously identified and distinguished by extensive spectroscopic analyses, NMR calculations with DP4+ analysis, electronic circular dichroism (ECD) calculations and X-ray diffraction analyses. Read More

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Tyrosine -GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model Glycopeptides.

ACS Chem Neurosci 2021 Jul 29. Epub 2021 Jul 29.

Department of Chemistry and Biochemistry, Charles E, Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, United States.

The amyloid-β precursor protein (APP) undergoes proteolytic cleavage by α-, β-, and γ-secretases, to determine its fate in Alzheimer's disease (AD) pathogenesis. Recent findings suggest a possible role of -glycosylation in APP's proteolytic processing. Therefore, we synthesized native and Swedish-double-mutated APP (glyco)peptides with Tyr--GalNAc. Read More

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α-Synuclein conformations followed by vibrational optical activity. Simulation and understanding of the spectra.

Phys Chem Chem Phys 2021 Jul 29. Epub 2021 Jul 29.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, 16610 Prague, Czech Republic.

α-Synuclein is a neuronal protein which adopts multiple conformations. These can be conveniently studied by the spectroscopy of vibrational optical activity (VOA). However, the interpretation of VOA spectra based on quantum-chemical simulations is difficult. Read More

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Chiroptical anisotropy of crystals and molecules.

Chem Commun (Camb) 2021 Jul 29. Epub 2021 Jul 29.

Department of Chemistry and Molecular Design Institute, New York University, New York City, NY 10003, USA.

Optical activity, a foundational part of chemistry, is not restricted to chiral molecules although generations have been instructed otherwise. A more inclusive view of optical activity is valuable because it clarifies structure-property relationships however, this view only comes into focus in measurements of oriented molecules, commonly found in crystals. Unfortunately, measurements of optical rotatory dispersion or circular dichroism in anisotropic single crystals have challenged scientists for more than two centuries. Read More

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Cyclotides Isolated From Violet Plants of Cameroon Are Inhibitors of Human Prolyl Oligopeptidase.

Front Pharmacol 2021 12;12:707596. Epub 2021 Jul 12.

Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Traditional medicine and the use of herbal remedies are well established in the African health care system. For instance, Violaceae plants are used for antimicrobial or anti-inflammatory applications in folk medicine. This study describes the phytochemical analysis and bioactivity screening of four species of the violet Allexis found in Cameroon. Read More

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Anillin propels myosin-independent constriction of actin rings.

Nat Commun 2021 07 28;12(1):4595. Epub 2021 Jul 28.

Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Prague West, Czechia.

Constriction of the cytokinetic ring, a circular structure of actin filaments, is an essential step during cell division. Mechanical forces driving the constriction are attributed to myosin motor proteins, which slide actin filaments along each other. However, in multiple organisms, ring constriction has been reported to be myosin independent. Read More

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Exploring factors affecting individual GPS-based activity space and how researcher-defined food environments represent activity space, exposure and use of food outlets.

Int J Health Geogr 2021 Jul 28;20(1):34. Epub 2021 Jul 28.

Leeds Beckett University, Leeds, LS6 3QS, UK.

Background: Obesity remains one of the most challenging public health issues of our modern time. Despite the face validity of claims for influence, studies on the causes of obesity have reported the influence of the food environment to be inconsistent. This inconsistency has been attributed to the variability of measures used by researchers to represent the food environments-Researcher-Defined Food Environments (RDFE) like circular, street-network buffers, and others. Read More

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The pacemaker of snake heart is localized near the sinoatrial valve.

J Exp Biol 2021 Jul 28. Epub 2021 Jul 28.

Section of Zoophysiology, Institute of Biology, University of Aarhus, Aarhus, Denmark.

To provide the first description of the exact location of primary pacemaker of the squamate heart, we used sharp microelectrode impalements and optical mapping of isolated sinus venosus preparations from Burmese pythons. We located the dominant pacemaker site at the base of the right leaflet of the sinoatrial valve (SAV), but latent pacemakers were also identified in a circular region around the SAV. Acetylcholine (10-5M) or noradrenaline (10-6M) induced shifts of the leading pacemaker site to other points near the SAV. Read More

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Low-intensity ultrasound enhances the antimicrobial activity of neutral peptide TGH2 against Escherichia coli.

Ultrason Sonochem 2021 Jul 20;77:105676. Epub 2021 Jul 20.

College of Food and Biological Engineering, Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Jimei University, 43 Yindou Road, Xiamen, Fujian 361021, China. Electronic address:

In recent years, foodborne diseases caused by Escherichia coli are a major threat to the food industry and consumers. Antimicrobial peptides (AMPs) and ultrasound both have good inhibitory effects on E. coli. Read More

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Structural exploration of Y-domain reveals its essentiality in HEV pathogenesis.

Protein Expr Purif 2021 Jul 24:105947. Epub 2021 Jul 24.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India. Electronic address:

Hepatitis E virus (HEV) is a major causative agent of hepatitis E infections across the globe. Although the essentiality of HEV nonstructural polyprotein (pORF1) putative Y-domain (Yd) has been established in viral pathogenesis, its structural-functional role remains elusive. The current research discusses the novel exploration on Yd protein expression, purification, biophysical characterization and structure-based docking analysis. Read More

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Vibrational circular dichroism of D-amino acid-containing peptide NdWFamide in the crystal form.

Chirality 2021 Jul 27. Epub 2021 Jul 27.

Graduate School of Engineering Science, Yokohama National University, Yokohama, Japan.

Microcrystals of l-Asn-d-Trp-l-Phe-NH (NdWFamide), a tripeptide derived from Aplysia kurodai that exhibits invertebrate cardiac activity, were evaluated by vibrational circular dichroism (VCD). The chirality of the tryptophan residue at the second position in NdWFamide was associated with the conformation and biological characteristics. The VCD spectrum of NdWFamide was a mirror image of its enantiomer; however, it was significantly different from that of its diastereomer, NWFamide, which is its precursor. Read More

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CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3.

J Clin Lab Anal 2021 Jul 27:e23865. Epub 2021 Jul 27.

Department of Thoracic Surgery, Cixi People's Hospital, Cixi City, China.

Background: Lung cancer is the most commonly diagnosed cancer and leading cause of cancer death, with 80%-85% of non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) have been shown to be promising early diagnostic and therapeutic molecular biomarkers for NSCLC. However, biological role and regulatory mechanism of circRNA WHSC1 (circWHSC1) in NSCLC are unknown. Read More

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Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA Virus.

mBio 2021 Jul 27:e0076321. Epub 2021 Jul 27.

Department of Chemistry and Biochemistry, The City College of New Yorkgrid.254250.4, New York, New York, USA.

Circular Rep-encoding single-stranded DNA (CRESS-DNA) viruses infect members from all three domains of life (, , and ). The replicase (Rep) from these viruses is responsible for initiating rolling circle replication (RCR) of their genomes. Rep is a multifunctional enzyme responsible for nicking and ligating ssDNA and unwinding double-stranded DNA (dsDNA). Read More

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α-Glucosidase inhibition action of major flavonoids identified from Hypericum attenuatum Choisy and their synergistic effects.

Chem Biodivers 2021 Jul 26. Epub 2021 Jul 26.

Tianjin University of Science and Technology, College of Biotechnology, No. 9, the 13th Road, Economic and Technological Development Zone, Tianjin, CHINA.

Hypericum attenuatum Choisy is a traditional Chinese herbal plant with multiple therapeutic effects. In this study, bioactivity-guided fractionation of Hypericum attenuatum Choisy extracts afforded three major flavonoids (including astragalin, guaijaverin and quercetin), which possessed α-glucosidase inhibitory activity with IC 50 values of 33.90 ± 0. Read More

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Seasonal variation in the diel activity of a dung beetle assemblage.

PeerJ 2021 12;9:e11786. Epub 2021 Jul 12.

Department of Biogeography and Global Change, Museo Nacional de Ciencias Naturales (C.S.I.C.), Madrid, Spain.

The seasonal and diel variations of dung beetle species were studied in an Iberian mid-mountain locality to examine the interaction between these two temporal rhythms. We assume that a seasonal variation in the diel activity would support the notion that both rhythms may assist in achieving a quick and flexible response when the climatic conditions change. Data coming from 4,104 pitfall traps placed during 15 sampling periods and totalling 30 daily sampling cycles were analysed using circular statistics and General Linear Models. Read More

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Indole-Terpenoids With Anti-inflammatory Activities From sp. HFF16 Associated With the Rhizosphere Soil of Decne.

Front Microbiol 2021 9;12:710364. Epub 2021 Jul 9.

State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agriculture University, Tai'an, China.

Four new indole-terpenoids named encindolene A, 18--methyl-encindolene A, encindolene B, and encindolene C, as well as three known analogs , were isolated from the fungus sp. HFF16 from the rhizosphere soil of Decne. The structures of compounds including absolute configurations were elucidated by spectroscopic data and electronic circular dichroism (ECD) analysis. Read More

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Utilization of Nanotechnology to Improve the Application and Bioavailability of Phytochemicals Derived from Waste Streams.

J Agric Food Chem 2021 Jul 26. Epub 2021 Jul 26.

Department of Food Engineering, Faculty of Engineering, Yeditepe University, Istanbul 34755, Turkey.

Phytochemicals are relatively small molecular species found in edible plants that may exhibit a diverse range of techno- and biofunctional attributes. In particular, there has been great interest in the identification, isolation, and utilization of dietary phytochemicals that can be used as natural pigments, antioxidants, or antimicrobials or that may improve human health and wellbeing by preventing chronic diseases, such as cardiovascular diseases, diabetes, obesity, and cancer. Relatively high levels of these phytochemicals are often present in the waste streams produced by the food and agriculture industry, such as the peels, stems, roots, or leaves of plants, that are normally discarded or turned into animal foods. Read More

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Targeted muscle effort distribution with exercise robots: Trajectory and resistance effects.

Med Eng Phys 2021 Aug 3;94:70-79. Epub 2021 Jul 3.

Mechanical Engineering Department, Cleveland State University, Cleveland, OH 44115, USA.

The objective of this work is to relate muscle effort distributions to the trajectory and resistance settings of a robotic exercise and rehabilitation machine. Muscular effort distribution, representing the participation of each muscle in the training activity, was measured with electromyography sensors (EMG) and defined as the individual activation divided by the total muscle group activation. A four degrees-of-freedom robot and its impedance control system are used to create advanced exercise protocols whereby the user is asked to follow a path against the machine's neutral path and resistance. Read More

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Multipurpose peptides: the venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities.

Biochem Pharmacol 2021 Jul 21:114693. Epub 2021 Jul 21.

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, St Lucia, QLD 4072, Australia. Electronic address:

In the face of increasing drug resistance, the development of new anthelmintics is critical for controlling nematodes that parasitise livestock. Although hymenopteran venom toxins have attracted attention for applications in agriculture and medicine, few studies have explored their potential as anthelmintics. Here we assessed hymenopteran venoms as a possible source of new anthelmintic compounds by screening a panel of ten hymenopteran venoms against Haemonchus contortus, a major pathogenic nematode of ruminants. Read More

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