3,249,304 results match your criteria activity

Preparation and Photocatalytic Activity of Hexagonal Plate-like ZnO Particles Using Anionic Surfactants.

J Oleo Sci 2022 May 18. Epub 2022 May 18.

Faculty of engineering, Chiba Institute of Technology.

Hexagonal plate-like ZnO particles with a high degree of c-face orientation have been synthesized using hydrothermal method in the presence of various anionic surfactants bearing different hydrocarbon chains. The c-face of the ZnO particles increased upon increasing the surfactant alkyl chain length. The photocatalytic activity of the as-obtained hexagonal plate-like ZnO particles was evaluated using the degradation of methylene blue (MB). Read More

View Article and Full-Text PDF

Calcium carbonate supplementation causes motor dysfunction.

Exp Anim 2022 May 17. Epub 2022 May 17.

College of Environmental Technology, Muroran Institute of Technology.

We previously showed that a diet containing calcium carbonate causes impairments in spatial and recognition memory in mice. In this study, we investigated the effects of calcium carbonate supplementation on motor function. Motor function was determined using different tests that have been used to analyze different aspects of Parkinsonism. Read More

View Article and Full-Text PDF

Calcium phosphate-adsorbable and acid-degradable carboxylated polyrotaxane consisting of β-cyclodextrins suppresses osteoclast resorptive activity.

Dent Mater J 2022 May 19. Epub 2022 May 19.

Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University.

Recently, the potential of β-cyclodextrin-thread acid-degradable polyrotaxane (AdPRX) has been emphasized as a therapeutic agent for cholesterol-related metabolic disorders. In this study, we investigated whether carboxymethyl carbamate-modified AdPRX (CMC-AdPRX) can be used for adsorption to calcium phosphate to treat bone diseases. We first synthesized CMC-AdPRX and used it to coat the calcium phosphate plate. Read More

View Article and Full-Text PDF

Glomerular Exostosin as a Subtype and Activity Marker of Class V Lupus Nephritis.

Clin J Am Soc Nephrol 2022 May 18. Epub 2022 May 18.

W Hu, The First School of Clinical Medicine, Southern Medical University, Jinling Hospital National Clinical Research Center of Kidney Diseases, Nanjing, China

There have been only several studies on the correlation between glomerular exostosin expression and membranous lupus nephritis. In this study, we validate the previous findings in Chinese patients with class V lupus nephritis. 165 class V cases and varying numbers of control cases were included. Read More

View Article and Full-Text PDF

What is a biocrust? A refined, contemporary definition for a broadening research community.

Biol Rev Camb Philos Soc 2022 May 18. Epub 2022 May 18.

School of Forestry, Northern Arizona University, 200 E. Pine Knoll Drive, Box 15018, Flagstaff, AZ, 86011, USA.

Studies of biological soil crusts (biocrusts) have proliferated over the last few decades. The biocrust literature has broadened, with more studies assessing and describing the function of a variety of biocrust communities in a broad range of biomes and habitats and across a large spectrum of disciplines, and also by the incorporation of biocrusts into global perspectives and biogeochemical models. As the number of biocrust researchers increases, along with the scope of soil communities defined as 'biocrust', it is worth asking whether we all share a clear, universal, and fully articulated definition of what constitutes a biocrust. Read More

View Article and Full-Text PDF

Sex differences and rehabilitation needs after hospital discharge for COVID-19: an Italian cross-sectional study.

BMJ Open 2022 May 18;12(5):e055308. Epub 2022 May 18.

Department of Medical and Sugical Sciences;University of Modena e Reggio, Bachelor' degree in OT, Modena e Reggio Emilia, Italy.

Objectives: COVID-19 can result in persistent symptoms leaving potential rehabilitation needs unmet. This study aims to describe persistent symptoms and health status of individuals hospitalised for COVID-19 according to the International Classification of Functioning, Disability and Health domains of impairments, limitations in activity, and participation restrictions.

Design: Cross-sectional study consisting in a telephone interview 3 months after hospital discharge. Read More

View Article and Full-Text PDF

Xe MRI ventilation defects in ever-hospitalised and never-hospitalised people with post-acute COVID-19 syndrome.

BMJ Open Respir Res 2022 May;9(1)

Robarts Research Institute, Western University, London, Ontario, Canada

Background: Patients often report persistent symptoms beyond the acute infectious phase of COVID-19. Hyperpolarised Xe MRI provides a way to directly measure airway functional abnormalities; the clinical relevance of Xe MRI ventilation defects in ever-hospitalised and never-hospitalised patients who had COVID-19 has not been ascertained. It remains unclear if persistent symptoms beyond the infectious phase are related to small airways disease and ventilation heterogeneity. Read More

View Article and Full-Text PDF

Effects of dietary vitamin E and fat supplementation in growing-finishing swine fed to a heavy slaughter weight of 150 kg: II. Tissue fatty acid profile, vitamin E concentrations and antioxidant capacity of plasma and tissue.

J Anim Sci 2022 May 18. Epub 2022 May 18.

University of Kentucky, Lexington, KY, USA.

The study aimed to assess the effects of vitamin E (VE) supplementation and fat source on fatty acid (FA) composition, VE concentrations, and antioxidant capacity in plasma and tissues of pigs fed to a heavy slaughter weight (150 kg). A total of 64 pigs (32 barrows, 32 gilts; 28.41 ± 0. Read More

View Article and Full-Text PDF

Effects of Low-Frequency Whole-Body Vibration on Muscle Activation, Fatigue, and Oxygen Consumption in Healthy Young Adults: A Single-Group Repeated-Measures Controlled Trial.

J Sport Rehabil 2022 May 16:1-9. Epub 2022 May 16.

Department of Physical Medicine and Rehabilitation, Jeonbuk National University Medical School, Jeonju,Korea.

Context: Whole-body vibration (WBV) training improves muscle strength and balance. Few studies have focused on the effects of WBV frequencies below 30 Hz. We aimed to investigate the effect of low-frequency WBV training on muscle activity, fatigue recovery, and oxygen consumption (VO2). Read More

View Article and Full-Text PDF

Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens.

ACS Chem Biol 2022 May 18. Epub 2022 May 18.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada.

With resistance to current agricultural fungicides rising, a great need has emerged for new antifungals with unexploited targets. In response, we report a novel series of diazaborines with potent activity against representative fungal plant pathogens. To identify their mode of action, we selected for resistant isolates using the model fungus . Read More

View Article and Full-Text PDF

Working memory and reward increase the accuracy of animal location encoding in the medial prefrontal cortex.

Cereb Cortex 2022 May 19. Epub 2022 May 19.

Section on Synapse Development Plasticity, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, United States.

The ability to perceive spatial environments and locate oneself during navigation is crucial for the survival of animals. Mounting evidence suggests a role of the medial prefrontal cortex (mPFC) in spatially related behaviors. However, the properties of mPFC spatial encoding and how it is influenced by animal behavior are poorly defined. Read More

View Article and Full-Text PDF

Domestic physical activity and new-onset hypertension: A nationwide cohort study in China.

Am J Med 2022 May 15. Epub 2022 May 15.

Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory; Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou, China; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Institute of Biomedicine, Anhui Medical University, Hefei 230032, China. Electronic address:

Background: The association between domestic physical activity and the risk of hypertension remains uncertain. We aimed to evaluate the prospective relation of domestic physical activity and new-onset hypertension among Chinese males and females.

Methods: A total of 9254 adults who were free of hypertension at baseline were enrolled from the China Health and Nutrition Survey (CHNS). Read More

View Article and Full-Text PDF

Characterization of aspartyl aminopeptidase from Schistosoma japonicum.

Acta Trop 2022 May 15:106519. Epub 2022 May 15.

National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention (Chinese Center for Tropical Diseases Research); National Health Commission of the People's Republic of China (NHC) Key Laboratory of Parasite and Vector Biology; World Health Organization (WHO) Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China.. Electronic address:

The tegument of schistosomes is the interface between the worm and the host environment. Some molecules distributed on the tegument participate in host-parasite interactions. Aspartyl aminopeptidase (AAP), identified on the tegument of Schistosoma japonicum (S. Read More

View Article and Full-Text PDF

Performance of gravity-driven membrane systems for algal water treatment: Effects of temperature and membrane properties.

Sci Total Environ 2022 May 15:155963. Epub 2022 May 15.

Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information Technology, Harbin Institute of Technology, China.

Gravity-driven membrane (GDM) systems are promising for algal water treatment. However, the algae-bacteria interaction in the biofilm on the membrane, which is highly dependent on temperature and membrane properties, is still unclear. Therefore, this study investigated the effect of temperature on the performance of GDM systems during the filtration of algae-rich water for 50 days using two types of membranes. Read More

View Article and Full-Text PDF

A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on.

Metabolism 2022 May 15:155217. Epub 2022 May 15.

Department of Medicine, Boston VA Healthcare system and Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Slosberg-Landay SL-419, Boston, MA 02215, USA. Electronic address:

The WHO just released in May 2022 a report on the state of the obesity pandemic in Europe, stating that 60% of citizens in the area of Europe are either overweight or obese, and highlighting the implications of the obesity pandemic, especially as it interacts with the COVID pandemic to create a twin pandemic, to increase morbidity and mortality. Obesity is a complex disease which has reached pandemic dimensions. The worldwide prevalence of obesity has nearly tripled since 1975, mainly due to the adoption of a progressively more sedentary lifestyle and the consumption of less healthy diets. Read More

View Article and Full-Text PDF

Frequency-specific medial septal nucleus deep brain stimulation improves spatial memory in MK-801-treated male rats.

Neurobiol Dis 2022 May 15:105756. Epub 2022 May 15.

Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90033, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, USA. Electronic address:

Background: Few treatments exist for the cognitive symptoms of schizophrenia. Pharmacological agents resulting in glutamate N-methyl-d-aspartate (NMDA) receptor hypofunction, such as MK-801, mimic many of these symptoms and disrupt neural activity. Recent evidence suggests that deep brain stimulation (DBS) of the medial septal nucleus (MSN) can modulate medial prefrontal cortex (mPFC) and hippocampal activity and improve spatial memory. Read More

View Article and Full-Text PDF

An analog of [d-Trp]CJ-15,208 exhibits kappa opioid receptor antagonism following oral administration and prevents stress-induced reinstatement of extinguished morphine conditioned place preference.

Pharmacol Biochem Behav 2022 May 15:173405. Epub 2022 May 15.

Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, United States of America. Electronic address:

Opioid use disorder (OUD) relapse rates are discouragingly high, underscoring the need for new treatment options. The macrocyclic tetrapeptide natural product CJ-15,208 and its stereoisomer [d-Trp]CJ-15,208 demonstrate kappa opioid receptor (KOR) antagonist activity upon oral administration which prevent stress-induced reinstatement of cocaine-seeking behavior. In order to further explore the structure-activity relationships and expand the potential therapeutic applications of KOR antagonism for the treatment of OUD, we screened a series of 24 analogs of [d-Trp]CJ-15,208 with the goal of enhancing KOR antagonist activity. Read More

View Article and Full-Text PDF

Structural characterization of polysaccharides from Geranium sanguineum L. and their immunomodulatory effects in response to inflammatory agents.

J Ethnopharmacol 2022 May 15:115390. Epub 2022 May 15.

Department of Biotechnology, University of Food Technologies, 26 Maritza Blvd., 4002, Plovdiv, Bulgaria. Electronic address:

Ethnopharmacological Relevance: Geranium sanguineum L. is used for treatment of inflammations, anemia, malignant diseases of the blood-forming organs, diarrhea, respiratory infections, etc. Only flavonoids in root extracts have been elucidated as immunostimulating and anti-inflammatory compounds, and polysaccharides in the herb have not been examined. Read More

View Article and Full-Text PDF

(±)-Hyperpyran A: Terpenoid-based bicyclic dihydropyran enantiomers with hypoglycemic activity from Hypericum perforatum (St. John's wort).

Fitoterapia 2022 May 15:105221. Epub 2022 May 15.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China. Electronic address:

(±)-Hyperpyran A (1a/1b), a pair of new terpenoid-based bicyclic dihydropyran enantiomers, were isolated from the aerial parts of Hypericum perforatum (St. John's wort). Their structures and absolute configurations were elucidated by NMR spectroscopic analyses, ECD comparison, and X-ray crystal diffraction. Read More

View Article and Full-Text PDF

Synthesis of macromolecular Astragalus polysaccharide-nano selenium complex and the inhibitory effects on HepG2 cells.

Int J Biol Macromol 2022 May 15. Epub 2022 May 15.

College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address:

In the present study, the previously obtained macromolecuar-weight Astragalus polysaccharide (average molecular weight of 1.61 × 10 Da) was used as a stabilizer and dispersing agent for nano-composites preparation by modifying selenium nanoparticles, and then the anti-hepatoma activity on HepG2 cells was investigated as well. Results showed that the nano-composites were obtained under polysaccharide concentration of 2 mg/mL and selenium/polysaccharide mass ratio of 1:15, and exhibited symmetrical spheroid with an average diameter of 62. Read More

View Article and Full-Text PDF

Direct Z-scheme mediated SmVO/UiO-66-NH heterojunction nanocomposite for the degradation of antibiotic tetracycline hydrochloride molecules under sunlight.

Chemosphere 2022 May 15:134861. Epub 2022 May 15.

Department of Chemical Engineering, Laval University, 1065 Avenue de la Médecine, Quebec, QC G1V0A6, Canada. Electronic address:

The use of tetracycline hydrochloride (TCH) for veterinary, human therapy, and agriculture has risen in the past few decades, making it to become one of the most exploited antibiotics. However, TCH residue in the environment is causing issues related to the evolution of antibiotic-resistant bacteria. To address such a problem, photodegradation offers a potential solution to decompose these pollutants in wastewater and thereby mitigates negative environmental impacts. Read More

View Article and Full-Text PDF

Waste coal cinder catalyst enhanced electrocatalytic oxidation and persulfate advanced oxidation for the degradation of sulfadiazine.

Chemosphere 2022 May 15:134880. Epub 2022 May 15.

College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China. Electronic address:

Waste coal cinder, a kind of waste cinder discharged from coal combustion of thermal power plants, industrial and civil boilers, and other equipment, was rich in metal oxides with catalytic activity. In this work, waste coal cinder was used to enhance electrochemical coupling peroxymonosulfate (PMS) advanced oxidation degradation of sulfadiazine (SD). The surface morphology, elemental composition, and electrocatalytic activity of waste coal cinder were characterized by various characterization instruments. Read More

View Article and Full-Text PDF

Perceptual enhancement and suppression correlate with V1 neural activity during active sensing.

Curr Biol 2022 May 12. Epub 2022 May 12.

Department of Neuroscience, Brown University, Providence, RI, USA. Electronic address:

Perception in multiple sensory modalities is an active process that involves exploratory behaviors. In humans and other primates, vision results from sensory sampling guided by saccadic eye movements. Saccades are known to modulate visual perception, and a corollary discharge signal associated with saccades appears to establish a sense of visual stability. Read More

View Article and Full-Text PDF

Mpe1 senses the binding of pre-mRNA and controls 3' end processing by CPF.

Mol Cell 2022 May 11. Epub 2022 May 11.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

Most eukaryotic messenger RNAs (mRNAs) are processed at their 3' end by the cleavage and polyadenylation specificity factor (CPF/CPSF). CPF mediates the endonucleolytic cleavage of the pre-mRNA and addition of a polyadenosine (poly(A)) tail, which together define the 3' end of the mature transcript. The activation of CPF is highly regulated to maintain the fidelity of RNA processing. Read More

View Article and Full-Text PDF

Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning.

Neuron 2022 May 12. Epub 2022 May 12.

Neurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, and Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:

Inhibitory neurons (INs) consist of distinct subtypes with unique functions. Previous studies on INs mainly focused on single brain regions, and thus it remains unclear whether the modulation of IN subtypes occurs globally across multiple regions. Here, we monitored the activity of different cortical IN subtypes at both macroscale and microscale in mice learning a lever-press task. Read More

View Article and Full-Text PDF

Age-Dependent Differences of Paraspinal Muscle Endurance and Morphology in Chinese Community Population Without Chronic Low Back Pain.

Global Spine J 2022 May 18:21925682221103507. Epub 2022 May 18.

Department of Orthopaedics, 66482Peking University Third Hospital, Beijing, China.

Study Design: Cross-sectional study.

Objectives: Our aim was to describe age-dependent changes of lumbar paraspinal muscle endurance and morphology in Chinese healthy population. We also explored the relationship between paraspinals endurance and morphology. Read More

View Article and Full-Text PDF

Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1-3 in mesendoderm cell differentiation.

Cell Rep 2022 May;39(7):110818

Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia. Electronic address:

Histone deacetylases (HDACs) are a class of enzymes that control chromatin state and influence cell fate. We evaluated the chromatin accessibility and transcriptome dynamics of zinc-containing HDACs during cell differentiation in vitro coupled with chemical perturbation to identify the role of HDACs in mesendoderm cell fate specification. Single-cell RNA sequencing analyses of HDAC expression during human pluripotent stem cell (hPSC) differentiation in vitro and mouse gastrulation in vivo reveal a unique association of HDAC1 and -3 with mesendoderm gene programs during exit from pluripotency. Read More

View Article and Full-Text PDF

A highland-adaptation mutation of the Epas1 protein increases its stability and disrupts the circadian clock in the plateau pika.

Cell Rep 2022 May;39(7):110816

National Institute of Biological Sciences, Beijing 102206, China; Graduate School of Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100006, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China. Electronic address:

The Qinghai-Tibet Plateau (QTP) harbors hundreds of species well adapted to its extreme conditions, including its low-oxygen (hypoxic) atmosphere. Here, we show that the plateau pika-a keystone mammal of the QTP-lacks robust circadian rhythms. The major form of the plateau pika Epas1 protein includes a 24-residue insert caused by a point mutation at the 5' juncture site of Intron14 and is more stable than other mammalian orthologs. Read More

View Article and Full-Text PDF

Divergent properties and independent regulation of striatal dopamine and GABA co-transmission.

Cell Rep 2022 May;39(7):110823

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 E 19th Ave, Aurora, CO 80045, USA. Electronic address:

Substantia nigra pars compacta (SNc) dopamine neurons play a key role in regulating the activity of striatal circuits within the basal ganglia. In addition to dopamine, these neurons release several other transmitters, including the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). Both dopamine and GABA are loaded into SNc synaptic vesicles by the vesicular monoamine transporter 2 (VMAT2), and co-release of GABA provides strong inhibition to the striatum by directly inhibiting striatal medium spiny projection neurons (MSNs) through activation of GABA receptors. Read More

View Article and Full-Text PDF

Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila.

Cell Rep 2022 May;39(7):110817

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

Drosophila Toll-1 and all mammalian Toll-like receptors regulate innate immunity. However, the functions of the remaining eight Toll-related proteins in Drosophila are not fully understood. Here, we show that Drosophila Toll-9 is necessary and sufficient for a special form of compensatory proliferation after apoptotic cell loss (undead apoptosis-induced proliferation [AiP]). Read More

View Article and Full-Text PDF