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The critical role of natural history museums in advancing eDNA for biodiversity studies: a case study with Amazonian fishes.

Sci Rep 2021 Sep 13;11(1):18159. Epub 2021 Sep 13.

Natural History Museum and Institute, Chuo-ku, Chiba, 260-8682, Japan.

Ichthyological surveys have traditionally been conducted using whole-specimen, capture-based sampling with varied but conventional fishing gear. Recently, environmental DNA (eDNA) metabarcoding has emerged as a complementary, and possible alternative, approach to whole-specimen methodologies. In the tropics, where much of the diversity remains undescribed, vast reaches continue unexplored, and anthropogenic activities are constant threats; there have been few eDNA attempts for ichthyological inventories. Read More

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September 2021

Clinical prediction models for hospital falls: a scoping review protocol.

BMJ Open 2021 Sep 13;11(9):e051047. Epub 2021 Sep 13.

Australian Centre for Health Services Innovation and Centre for Healthcare Translation, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

Introduction: Falls remain one of the most prevalent adverse events in hospitals and are associated with substantial negative health impacts and costs. Approaches to assess patients' fall risk have been implemented in hospitals internationally, ranging from brief screening questions to multifactorial risk assessments and complex prediction models, despite a lack of clear evidence of effect in reducing falls in acute hospital environments. The increasing digitisation of hospital systems provides new opportunities to understand and predict falls using routinely recorded data, with potential to integrate fall prediction models into real-time or near-real-time computerised decision support for clinical teams seeking to mitigate fall risk. Read More

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September 2021

Fruits for Seizures? A Systematic Review on the Potential Anti- Convulsant Effects of Fruits and its Phytochemicals.

Curr Neuropharmacol 2021 Sep 13. Epub 2021 Sep 13.

Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor. Malaysia.

Epilepsy is a devastating neurological disorder. Current anti-convulsant drugs are only effective in about 70% of patients, while the rest remain drug-resistant. Thus, alternative methods have been explored to control seizures in these drug-resistant patients. Read More

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September 2021

An integrated assessment on the warming effects of urbanization and agriculture in highly developed urban agglomerations of China.

Sci Total Environ 2021 Sep 6;804:150119. Epub 2021 Sep 6.

Jiangsu Key Laboratory of Agricultural Meteorology/College of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, China.

Urbanization and agriculture, the two major and concurrent land use activities, can dramatically alter land surface temperature (LST) through multiple biophysical processes. However, previous studies mainly focused on the warming effects of urbanization in large cities and/or urban core areas that may greatly underestimate the land use impacts on regional climate. Using natural forest as a reference, we assessed the LST changes of both urbanization and agriculture in the three most developed urban agglomerations of China (Jing-Jin-Ji, JJJ; Yangtze River Delta, YRD; Pearl River Delta, PRD) according to satellite observations. Read More

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September 2021

Convenient Tuning of the Elasticity of Self-Assembled Nano-Sized Triterpenoids to Regulate Their Biological Activities.

ACS Appl Mater Interfaces 2021 Sep 13. Epub 2021 Sep 13.

Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fuzhou University, Fuzhou 350108, China.

The impact of the mechanical properties of nanomedicines on their biological functions remains elusive due to the difficulty in tuning the elasticity of the vehicles without changing chemistry. Herein, we report the fabrication of elasticity-tunable self-assembled oleanolic acid (OA) nanoconstructs in an antiparallel zigzag manner and develop rigid nanoparticles (OA-NP) and flexible nanogels (OA-NG) as model systems to decipher the elasticity-biofunction relationship. OA-NG demonstrate less endocytosis and enhanced lysosome escape with deformation compared to OA-NP. Read More

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September 2021

Pain Experience after Dental Implant Placement Compared to Tooth Extraction.

Alaa W AlQutub

Int J Dent 2021 31;2021:4134932. Epub 2021 Aug 31.

Oral and Maxillofacial Surgery Department, Um AlQura University, Faculty of Dentistry, Makkah 24225, Saudi Arabia.

Background: A patients' main concern when visiting the dentist is the pain experience during the procedure and postoperatively. Patients who are undergoing dental surgical procedures in particular may experience more concerns and higher level of anxiety and stress that can affect their psychology and decision-making ability. A thorough discussion with the patients about the planned surgical procedure and the expected postsurgical pain and discomfort level is crucial to reduce their fear and stress. Read More

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Occurrence of Multiple, Extensive and Pan Drug-Resistant and Carbapenemase Production from Presumptive Isolates Stored in a Biobank at Ethiopian Public Health Institute.

Infect Drug Resist 2021 4;14:3609-3618. Epub 2021 Sep 4.

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Purpose: is a common cause of nosocomial infections with associated morbidity and mortality because the organism is unresponsive to commonly available antimicrobials. This study was undertaken to determine the multiple drug-resistant (MDR), extensive drug-resistant (XDR) and pan drug-resistant (PDR) phenotype of and its carbapenemase production rate from presumptive isolates stored in the biobank at the Ethiopian Public Health Institute (EPHI).

Methods: A cross-sectional study was conducted at the EPHI laboratory, Addis Ababa, Ethiopia from March to June 2021. Read More

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September 2021

Study of metabolomics in selenium deprived Przewalski's Gazelles ().

Br J Nutr 2021 Sep 13:1-29. Epub 2021 Sep 13.

College of Life Science, Southwest University of Science and Technology, Mianyang, Sichuan 621010, China.

To understand why P. przewalskii does not show the same white myopathy as sheep in Se-deficient regions, and to provide reference for feeding nutrition level of artificial population and selection of wild reintroduction areas in the later period, a Se-deficient model was established. The mineral elements content, physiological and biochemical parameters in blood, and serum metabonomics were determined. Read More

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September 2021

Celastrol attenuates chronic constrictive injury-induced neuropathic pain and inhibits the TLR4/NF-κB signaling pathway in the spinal cord.

J Nat Med 2021 Sep 12. Epub 2021 Sep 12.

Department of Neonatology, The First People's Hospital of Jingmen, Jingmen, Hubei, China.

Tripterygium wilfordii Hook F. is a well-known but poisonous traditional Chinese medicine used for treating a wide variety of inflammatory and autoimmune disorders. Celastrol, a quinone methyl triterpenoid compound and a representative component of T. Read More

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September 2021

Minimal clinically important difference of modified dynamic gait index in people with neurological disorders.

Gait Posture 2021 Aug 28;90:210-214. Epub 2021 Aug 28.

IRCSS Fondazione Don Carlo Gnocchi, Via Capecelatro, 66-20148, Milano, Italy.

Background: The minimal clinically important difference (MCID) of modified Dynamic Gait Index (mDGI) has not yet been determined for People with Neurological Disorders (PwND).

Research Question: To establish the MCID of the mDGI to determine clinically meaningful improvement in balance and gait in PwND.

Methods: In this longitudinal study from a randomised clinical trial, 55 participants both in and outpatients with neurological disorders, received fifteen 40-minute rehabilitation sessions. Read More

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Development of eye-hand coordination in typically developing children and adolescents assessed using a reach-to-grasp sequencing task.

Hum Mov Sci 2021 Sep 9;80:102868. Epub 2021 Sep 9.

School of Optometry and Vision Science, University of Waterloo, 200 University Ave W, Waterloo ON N2L 3G1, Canada.

Eye-hand coordination is required to accurately perform daily activities that involve reaching, grasping and manipulating objects. Studies using aiming, grasping or sequencing tasks have shown a stereotypical temporal coupling pattern where the eyes are directed to the object in advance of the hand movement, which may facilitate the planning and execution required for reaching. While the temporal coordination between the ocular and manual systems has been extensively investigated in adults, relatively little is known about the typical development of eye-hand coordination. Read More

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September 2021

Demonstration of an aggregated biomarker response approach to assess the impact of point and diffuse contaminant sources in feral fish in a small river case study.

Sci Total Environ 2021 Sep 1;804:150020. Epub 2021 Sep 1.

Department for Evolutionary Ecology and Environmental Toxicology, Goethe University, Max-von-Laue Straße 13, 60438 Frankfurt am Main, Germany; LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG), 60325 Frankfurt am Main, Germany. Electronic address:

The assessment of the exposure of aquatic wildlife to complex environmental mixtures of chemicals originating from both point and diffuse sources and evaluating the potential impact thereof constitutes a significant step towards mitigating toxic pressure and the improvement of ecological status. In the current proof-of-concept study, we demonstrate the potential of a novel Aggregated Biomarker Response (ABR) approach involving a comprehensive set of biomarkers to identify complex exposure and impacts on wild brown trout (Salmo trutta fario). Our scenario used a small lowland river in Germany (Holtemme river in the Elbe river catchment) impacted by two wastewater treatment plants (WWTP) and diffuse agricultural runoff as a case study. Read More

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September 2021

History, phytochemistry, experimental pharmacology and clinical uses of honey: A comprehensive review with special reference to Unani medicine.

J Ethnopharmacol 2021 Sep 8;282:114614. Epub 2021 Sep 8.

HAK Institute for Literary and Historical Research in Unani Medicine, CCRUM, Jamia Millia Islamia Campus, New Delhi, India. Electronic address:

Ethnopharmacological Relevance: Honey is one of the most popular functional foods, speculated to be in use since the advent of human civilization. Its health-protective activity is endorsed by many religions and traditional medicines. In Unani medicine, honey is prescribed for many health conditions as wound-healing, anti-inflammatory, anti-diabetic, etc. Read More

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September 2021

Dysmenorrhea among Nursing Staff in a Tertiary Care Center: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Aug 12;59(240):760-762. Epub 2021 Aug 12.

Department of Obstetrics and Gynecology, Kathmandu Medical College and Teaching Hospital, Kathmandu, Nepal.

Introduction: Menstrual disorders are problems faced by women in their reproductive period, which affects their day-to-day activities and the quality of life and sometimes can be an indicator of serious pathology. There are various types of menstrual disorders with dysmenorrhea being the commonest and most distressing. Health, sense of wellbeing and quality of life can be improved because of early detection and treatment for these disorders. Read More

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Combined evaluation of aminotransferases improves risk stratification for overall and cause-specific mortality in older patients.

Aging Clin Exp Res 2021 Sep 10. Epub 2021 Sep 10.

Clinical Medicine and Hepatology Unit, Campus Bio-Medico University, Rome, Italy.

Background: Recent studies identified low levels of alanine aminotransferase (ALT) as strong predictors of mortality in older people.

Aims: Here we verified if the combined evaluation of aminotransferases may improve risk stratification for adverse outcomes in older patients.

Methods: Data are from 761 participants aged more than 65 years from a prospective population-based database (InCHIANTI study), without known baseline chronic liver disease or malignancies. Read More

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September 2021

Absolute Antioxidant Activity of Five Phenol-Rich Essential Oils.

Molecules 2021 Aug 29;26(17). Epub 2021 Aug 29.

Department of Chemistry "G. Ciamician", University of Bologna, Via S. Giacomo 11, 40126 Bologna, Italy.

Essential oils (EOs) have promising antioxidant activities which are gaining interest as natural alternatives to synthetic antioxidants in the food and cosmetic industries. However, quantitative data on chain-breaking activity and on the kinetics of peroxyl radical trapping are missing. Five phenol-rich EOs were analyzed by GC-MS and studied by oxygen-uptake kinetics in inhibited controlled autoxidations of reference substrates (cumene and squalene). Read More

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The anthropometric assessment of body composition and nutritional status in children aged 2-15 years: A cross-sectional study from three districts in Bangladesh.

PLoS One 2021 9;16(9):e0257055. Epub 2021 Sep 9.

Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.

Background: Early life nutrition plays a critical role in the development of better health and nutrition in adulthood. However, assessing the nutritional status of Bangladeshi children and adolescents through measurement of body composition using skinfold thickness is barely studied. The current study aims to determine children's body composition and nutritional status, and contributing factors among children aged 2 to 15 years in the northern part of Bangladesh. Read More

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September 2021

Anti-inflammatory and antioxidant activities of chemical constituents from the flower buds of .

Nat Prod Res 2021 Sep 9:1-12. Epub 2021 Sep 9.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.

Five new glycosides including mimenghuasu A and B (-), isolinarin (), cyclocitralosides A and B (), along with forty-seven known compounds were isolated from the flower buds of . These structures were elucidated by extensive spectroscopic analysis (UV, IR, 1 D, 2 D NMR, and MS spectra). The anti-inflammatory activities of the isolated compounds were determined by enzyme-linked immunosorbent assay (ELISA) on the expression of TNF- (LPS-activated RAW264. Read More

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September 2021

Improving the quality of malaria diagnosis in southern Africa through the development of a regional malaria slide bank.

Malar J 2021 Sep 8;20(1):365. Epub 2021 Sep 8.

Centre for Emerging Zoonotic and Parasitic Infections, National Institute for Communicable Diseases, Johannesburg, South Africa.

Background: A malaria slide bank (MSB) is a useful asset for any malaria microscopy testing laboratory to have access to. However, it is not feasible for every country to have its own MSB. If countries are able to pool their resources, a regional MSB is a viable solution. Read More

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September 2021

Effects of acute arsenic exposure in two different populations of amphipods from North Patagonia Argentina.

J Toxicol Environ Health A 2021 Sep 8:1-18. Epub 2021 Sep 8.

Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas, PROBIEN, (CONICET- UNCo), , Neuquén, Argentina.

Arsenic (As) is a toxic metalloid present in high levels in diverse regions of Argentina. The aim of this study was to determine acute As-mediated toxicity in two different populations of autochthonous amphipods from a reference site (LB) and an agricultural one (FO) within North Patagonia Argentina. Previously, both populations exhibited significant differences in pesticide susceptibility. Read More

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September 2021

Microbial biomass and activity dynamics in restored lands in a metal contaminated region.

Ecotoxicology 2021 Sep 8. Epub 2021 Sep 8.

Department of Biology, Laurentian University, Sudbury, Ontario, P3E 2C6, Canada.

Soil microbial communities are important for biogeochemical processes, along with the cycling of nutrients in an ecosystem. Their enzymatic activities are key indicators of their responses to stress. The objective of this research was to assess the effect of land reclamation on microbial biomass and activities in soils impacted by metal contamination. Read More

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September 2021

[Assessment on ecological integrity of typical lakes, reservoirs and wetlands in Tianjin, China].

Ying Yong Sheng Tai Xue Bao 2020 Aug;31(8):2767-2774

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

The ecological health assessment of lakes, reservoirs and wetlands can provide decision-making basis for ecosystem restoration and management. We selected 20 typical lakes, reservoirs and wetlands sampling points in Tianjin, based on physical, chemical, and biological community indicators data (zooplankton, phytoplankton, benthos, fish, large aquatic plants, riparian plants) obtained during the survey from August to September 2018. We constructed an index of ecological integrity (IEI) including physical integrity, chemical integrity, and biological integrity to evaluate their ecological health. Read More

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Natural immunomodulating substances used for alleviating food allergy.

Crit Rev Food Sci Nutr 2021 Sep 8:1-19. Epub 2021 Sep 8.

Key Laboratory of Glycobiology and Glycoengineering of Xi'an, College of Food Science and Technology, Northwest University, Xi'an, China.

Food allergy is a serious health problem affecting more than 10% of the human population worldwide. Medical treatments for food allergy remain limited because immune therapy is risky and costly, and anti-allergic drugs have many harmful side effects and can cause drug dependence. In this paper, we review natural bioactive substances capable of alleviating food allergy. Read More

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September 2021

DNA-based taxonomy of a mangrove-associated community of fishes in Southeast Asia.

Sci Rep 2021 Sep 7;11(1):17800. Epub 2021 Sep 7.

Centre for Global Sustainability Studies (CGSS), Level 5, Hamzah Sendut Library, Universiti Sains Malaysia, 11800, Penang, Malaysia.

The Merbok Estuary comprises one of the largest remaining mangrove forests in Peninsular Malaysia. Its value is significant as it provides important services to local and global communities. It also offers a unique opportunity to study the structure and functioning of mangrove ecosystems. Read More

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September 2021

From first to second wave: follow-up of the prospective COVID-19 cohort (KoCo19) in Munich (Germany).

BMC Infect Dis 2021 Sep 8;21(1):925. Epub 2021 Sep 8.

Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.

Background: In the 2nd year of the COVID-19 pandemic, knowledge about the dynamics of the infection in the general population is still limited. Such information is essential for health planners, as many of those infected show no or only mild symptoms and thus, escape the surveillance system. We therefore aimed to describe the course of the pandemic in the Munich general population living in private households from April 2020 to January 2021. Read More

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September 2021

Degradation of low-concentration perfluorooctanoic acid via a microbial-based synergistic method: assessment of the feasibility and functional microorganisms.

J Hazard Mater 2021 08 20;416:125857. Epub 2021 Apr 20.

Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:

Perfluorooctanoic acid (PFOA) is persistent in the environment. The activities of microorganisms alone are insufficient for the decomposition of PFOA, but microorganisms can contribute positively to the degradation of PFOA in synergistic systems. Herein, a synergistic system combining photocatalytic decay with microbial degradation of the transformation products was applied to degrade 500. Read More

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Bisabolane-type sesquiterpenoids: Structural diversity and biological activity.

Phytochemistry 2021 Sep 4;192:112927. Epub 2021 Sep 4.

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Bisabolane-type sesquiterpenoids, a class of monocyclic sesquiterpenoids, are widely distributed in nature and have a variety of biological activities. To provide a reference for the further research and development of these compounds, the phytochemical and biological properties of natural bisabolane-type sesquiterpenoids (356 compounds in total) isolated between 1985 and 2020 from 24 families, primarily Compositae, Zingiberaceae, Aspergillaceae, Halichondriidae, and Aplysiidae were reviewed. In vitro and in vivo studies have indicated that antibacterial, anti-inflammatory, and cytotoxic effects are the most commonly reported pharmacological properties of bisabolane-type sesquiterpenoids. Read More

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September 2021

Do humans take good care of their offspring as animals do…! The Lavreotiki and Lavrion 'sagas', Hellenic Republic-Part 1: Historical outline and mapping of lead contamination.

Environ Geochem Health 2021 Sep 7. Epub 2021 Sep 7.

Institute of Geology and Mineral Exploration, Athens, Hellas.

The Lavreotiki-Lavrion area, situated in the south-eastern tip of mainland Hellas, has one of the longest mining, ore beneficiation and smelting legacies worldwide. With a history of over 5000 years of argentiferous Pb-Zn ore exploitation, Lavrion is a place that shaped human civilisation by being a major wealth producing centre of the ancient world but also represents one of the few significant industrial developments of the modern Hellenic Republic, since the second part of the 19th century. The long history of mining, ore beneficiation and smelting activities produced a vast amount of potentially toxic wastes. Read More

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September 2021

Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects.

Front Pharmacol 2021 17;12:707491. Epub 2021 Aug 17.

Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, Chengdu, China.

Pulmonary fibrosis is a fatal chronic progressive respiratory disease, characterized by continuous scarring of the lung parenchyma, leading to respiratory failure and death. The incidence of PF has increased over time. There are drugs, yet, there are some limitations. Read More

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Influencing factors of Barthel index scores among the community-dwelling elderly in Hong Kong: a random intercept model.

BMC Geriatr 2021 09 6;21(1):484. Epub 2021 Sep 6.

School of Data Science, City University of Hong Kong, Hong Kong, China.

Background: Barthel Index (BI) is one of the most widely utilized tools for assessing functional independence in activities of daily living. Most existing BI studies used populations with specific diseases (e.g. Read More

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September 2021