242,441 results match your criteria activities enzymes


Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource, College of Tropical Crops, Hainan University, Haikou, Hainan, 570228, People's Republic of China.

Arsenic (As) is known for its carcinogenic and hepatorenal toxic effects causing serious health problems in human beings. Turmeric (Curcuma longa L.) extracted curcumin (Cur) is a polyphenolic antioxidant which has ability to combat hazardous environmental toxicants. Read More

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Telfairia occidentalis mitigates dextran sodium sulfate-induced ulcerative colitis in rats via suppression of oxidative stress, lipid peroxidation, and inflammation.

J Food Biochem 2021 Jul 31:e13873. Epub 2021 Jul 31.

Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.

Ulcerative colitis (UC), a subcategory of inflammatory bowel diseases, affects more than 2 million people globally. This study sought to investigate the curative ability of aqueous leaf extract of Telfairia occidentalis (ATO) on dextran sodium sulfate (DSS)-mediated colitis in rats. UC was induced by 5% of DSS in drinking water, and the curative ability of ATO was assessed at 200 mg/kg by oral administration for 10 days. Read More

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Targeting redox metabolism of the maize-Azospirillum brasilense interaction exposed to arsenic-affected groundwater.

Physiol Plant 2021 Jul 30. Epub 2021 Jul 30.

Instituto de Investigaciones Agrobiotecnológicas - Consejo Nacional de Investigaciones Científicas y Técnicas (INIAB-CONICET), Departamento de Ciencias Naturales, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto (UNRC), Córdoba, Argentina.

Arsenic in groundwater constitutes an agronomic problem due to its potential accumulation in the food chain. Among the agro-sustainable tools to reduce metal(oid)s toxicity, the use of Plant Growth-Promoting Bacteria (PGPB) becomes important. For that, and based on previous results in which significant differences of As translocation were observed when inoculating maize plants with Az39 or CD Azospirillum strains, we decided to decipher the redox metabolism changes and the antioxidant system response of maize plants inoculated when exposed to a realistic arsenate (As ) dose. Read More

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Effects of FeO nanoparticles on anaerobic digestion enzymes and microbial community of sludge.

Environ Technol 2021 Jul 30:1-26. Epub 2021 Jul 30.

School of Environmental Engineering, Faculty of Environmental and Safety Engineering, Qingdao University of Science and Technology, 53, Zhengzhou Road, Qingdao, Shandong Province 266042, China.

FeO nanoparticles (NPs) have potential effects on the anaerobic digestion of excess sludge. The effects of different concentrations of FeO NPs (0, 100, 200, 400 and 600 mg/L) on enzymes and microorganisms in anaerobic digestion were studied to explore the mechanism of the effect of FeO NPs on anaerobic digestion. The results showed that 100, 200 and 400 mg/L FeO NPs could promote anaerobic digestion, and 200 mg/L FeO NPs had the most obvious promoting effect. Read More

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Prediction of hyaluronic acid target on sucrase-isomaltase (SI) with reverse docking and molecular dynamics simulations for inhibitors binding to SI.

PLoS One 2021 30;16(7):e0255351. Epub 2021 Jul 30.

Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, Changchun, China.

Auricularia cornea (E.) polysaccharide is an important component of A. cornea Ehrenb, a white mutant strain of Auricularia with biological activities, such as enhancement of human immune function and cancer prevention. Read More

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Physiological role of CYP17A1-like in cadmium detoxification and its transcriptional regulation in the Pacific oyster, Crassostrea gigas.

Sci Total Environ 2021 Jul 14;796:149039. Epub 2021 Jul 14.

Key Laboratory of Mariculture, Ministry of Education, College of Fisheries, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. Electronic address:

Cadmium (Cd) is one of the most harmful heavy metals due to its persistence and bioaccumulation through the food chains, posing health risks to human. Oysters can bioaccumulate and tolerate high concentrations of Cd, providing a great model for studying molecular mechanism of Cd detoxification. In a previous study, we identified two CYP genes, CYP17A1-like and CYP2C50, that were potentially involved in Cd detoxification in the Pacific oyster, Crassostrea gigas. Read More

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Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats.

Biomed Pharmacother 2021 Jul 10;141:111908. Epub 2021 Jul 10.

Department of Pharmaceutical Sciences, North South University Bangladesh, Bangladesh. Electronic address:

The present investigation was an attempt to evaluate the hypoglycemic, lipid-lowering, antioxidant and hepatoprotective effects of cumin (Cuminum cyminum family: Apiaceae) supplementation in high fat (HF) diet fed rats. Male Wistar rats were divided into four groups, such as control, control+ cumin, HF and HF+ cumin. Oral glucose tolerance test, plasma lipids, oxidative stress parameters, antioxidant enzymes activities, and liver dysfunction marker enzyme activities were evaluated. Read More

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[Effect of E54 mutation of human secreted phospholipase A2 GIIE on substrate selectivity].

Sheng Wu Gong Cheng Xue Bao 2021 Jul;37(7):2513-2521

Shanxi Key Laboratory of Birth Defect and Cell Regeneration, College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, Shanxi, China.

Human secreted phospholipase A2 GIIE (hGIIE) is involved in inflammation and lipid metabolism due to its ability of hydrolyzing phospholipids. To reveal the mechanism of substrate head-group selectivity, we analyzed the effect of mutation of hGIIE on its activity and selectivity. hGIIE structural analysis showed that E54 might be related to its substrate head-group selectivity. Read More

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Extracellular Nucleotide Metabolism Promotes Neutrophils Extracellular Traps Escape.

Front Cell Infect Microbiol 2021 13;11:678568. Epub 2021 Jul 13.

Medical Microbiology Research Group, CNC-Center for Neurosciences and Cell Biology, Coimbra, Portugal.

Host innate immunity is fundamental to the resistance against and infection, two of the most important agents contributing to human fungal infections. Phagocytic cells, such as neutrophils, constitute the first line of host defense mechanisms, and the release of neutrophil extracellular traps (NETs) represent an important strategy to immobilize and to kill invading microorganisms, arresting the establishment of infection. The purinergic system operates an important role in the homeostasis of immunity and inflammation, and ectophosphatase and ectonucleotidase activities are recognized as essential for survival strategies and infectious potential of several pathogens. Read More

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Computational and Preclinical Evidence of Anti-ischemic Properties of L-Carnitine-Rich Supplement via Stimulation of Anti-inflammatory and Antioxidant Events in Testicular Torsed Rats.

Oxid Med Cell Longev 2021 5;2021:5543340. Epub 2021 Jul 5.

Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, Egypt.

Ischemia-reperfusion injury is a urological emergency condition that could lead to necrosis, testicular damage subfertility, and infertility. The purpose of this study was to identify changes taking place in the rat testis at short-term (4 hr) as well as long-term (7 days) reperfusion following testicular torsion and to evaluate the effects of Proxeed Plus (PP), L-carnitine-rich antioxidant supplement, on preventing these changes using the biochemical parameters and histopathology. Thirty adult male rats were divided into five groups: in groups, 1-4 testicular ischemia was achieved by rotating the left testis 720° clockwise for 4 h and dividing into the sham, torsion/detorsion (T/D), T/D+1000 mg/kg BW PP, and T/D+5000 mg/kg BW PP groups, respectively. Read More

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Effects of Dietary Ferulic Acid on the Intestinal Microbiota and the Associated Changes on the Growth Performance, Serum Cytokine Profile, and Intestinal Morphology in Ducks.

Front Microbiol 2021 13;12:698213. Epub 2021 Jul 13.

College of Animal Science and Technology, Hunan Agriculture University, Changsha, China.

The present study investigated the effects of ferulic acid (FA) on the growth performance, serum cytokine profile, intestinal morphology, and intestinal microbiota in ducks at the growing stage. 300 female ducks at 28 days of age with similar body weights were randomly divided into five groups. Each group contained six replicates of 10 birds. Read More

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Protective Effect of L. Seeds against Paracetamol-Induced Hepatotoxicity in Rats: A Comparison with Vitamin C.

ScientificWorldJournal 2021 6;2021:6618273. Epub 2021 Jul 6.

Biochemistry of Natural Products Team, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco.

L. (date palm) seeds have been mentioned in the Moroccan pharmacopoeia as efficient remedies against a wide range of diseases including hepatic and gastrointestinal disorders and countless infections. The current work was performed to assess the phenolic profile and hepatoprotective potential of two date seed varieties, locally known as and , aqueous extracts against paracetamol- (PCM-) driven liver toxicity in 42 Wistar rats. Read More

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Long-term administration of low-dose selenium nanoparticles with different sizes aggravated atherosclerotic lesions and exhibited toxicity in apolipoprotein E-deficient mice.

Chem Biol Interact 2021 Jul 26:109601. Epub 2021 Jul 26.

Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China; Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Wuhan, 430074, China. Electronic address:

Exploration of long-term in vivo effects of nanomaterials, particularly those with potential biomedical applications, is quite important for better understanding and evaluating their biosafety. Selenium nanoparticles (SeNPs) has been considered as a good candidate in biomedical applications due to its high bioavailability, considerable biological activity, and low toxicity. However, its long-term biological effects and biosafety remain unknown. Read More

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Actinoplanes aureus sp. nov., a novel protease-producing actinobacterium isolated from soil.

Antonie Van Leeuwenhoek 2021 Jul 29. Epub 2021 Jul 29.

Key Laboratory of Agricultural Microbiology of Heilongjiang Province, Northeast Agricultural University, No. 59 Mucai Street, Xiangfang District, Harbin, 150030, People's Republic of China.

A novel protease-producing actinobacterium, designated strain NEAU-A11, was isolated from soil collected from Aohan banner, Chifeng, Inner Mongolia Autonomous Region, China, and characterised using a polyphasic approach. The hydrolytic enzymes, such as proteases, played critical roles in destruction of fungi by degrading the protein linkages to disrupt integrity in the cell wall. This suggested that the isolate could be a good biocontrol candidate against pathogens to control fungal diseases. Read More

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Ligninolytic valorization of agricultural residues by Aspergillus nomius and Trichoderma harzianum isolated from gut and comb of Odontotermes obesus (Termitidae).

Chemosphere 2021 Jun 29;284:131384. Epub 2021 Jun 29.

PG and Research Department of Zoology, Kongunadu Arts and Science College, Coimbatore, 641 029, Tamil Nadu, India. Electronic address:

Fungi produce enzymes that degrade the complex lignin thereby enabling the efficient utilization of plant lignocellulosic biomass in the production of biofuel and cellulose-based products. In the present study, the agricultural residues such as paddy straw, sugarcane bagasse, and coconut husk were used as substrates for the biodegradation by Aspergillus nomius (MN700028) and Trichoderma harzianum (MN700029) isolated from gut of the termite, Odontotermes obesus and fungus comb in the termite mound, respectively. The influence of varying concentrations of different carbon sources, pH, and temperature on ligninolytic enzyme production was examined under laboratory conditions. Read More

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Exposure of earthworm (Eisenia fetida) to rice straw biochar: Ecotoxicity assessments for soil-amended programmes.

Sci Total Environ 2021 Jun 30;794:148802. Epub 2021 Jun 30.

Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.

Increasing attentions of agricultural straw-derived biochar on biological interactions in soil environment have been gained following the benefits obtained from its role of soil conditioner. However, scientific probing on its unintended effects on soil organisms remain largely understudied. In this study, an avoidance test and a 14-day of incubation experiment in earthworm Eisenia fetida were conducted in field soil amended with rice straw-derived biochar (RSB) to evaluate its eco-toxic effect. Read More

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Intercrop mulch affects soil biology and microbial diversity in rainfed transgenic Bt cotton hybrids.

Sci Total Environ 2021 Jul 1;794:148787. Epub 2021 Jul 1.

Division of Crop Production, ICAR-Central Institute for Cotton Research, Nagpur 440010, Maharashtra, India.

Growing live mulch between the wide-row spaced transgenic Bt cotton hybrids is a low-cost option to control weeds compared to the use of plastic mulch. However, nothing is known about their effects on soil biology. Therefore, soil samples were collected from a long-term field study (2014-15 to 2018-19) to investigate the soil biological activities as well as the microbial diversity (soil metagenomic analysis). Read More

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ADP-ribosyltransferases, an update on function and nomenclature.

FEBS J 2021 Jul 29. Epub 2021 Jul 29.

Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway.

ADP-ribosylation, a modification of proteins, nucleic acids and metabolites, confers broad functions, including roles in stress responses elicited for example by DNA damage and viral infection and is involved in intra- and extracellular signaling, chromatin and transcriptional regulation, protein biosynthesis and cell death. ADP-ribosylation is catalyzed by ADP-ribosyltransferases, which transfer ADP-ribose from NAD onto substrates. The modification, which occurs as mono- or poly-ADP-ribosylation, is reversible due to the action of different ADP-ribosylhydrolases. Read More

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Long-Term Lime and Phosphogypsum Amended-Soils Alleviates the Field Drought Effects on Carbon and Antioxidative Metabolism of Maize by Improving Soil Fertility and Root Growth.

Front Plant Sci 2021 12;12:650296. Epub 2021 Jul 12.

Department of Biosystems Engineering, School of Sciences and Engineering, São Paulo State University, Tupã, Brazil.

Long-term surface application of lime (L) and/or phosphogypsum (PG) in no-till (NT) systems can improve plant growth and physiological and biochemical processes. Although numerous studies have examined the effects of L on biomass and plant growth, comprehensive evaluations of the effects of this practice on net CO assimilation, antioxidant enzyme activities and sucrose synthesis are lacking. Accordingly, this study examined the effects of long-term surface applications of L and PG on soil fertility and the resulting impacts on root growth, plant nutrition, photosynthesis, carbon and antioxidant metabolism, and grain yield (GY) of maize established in a dry winter region. Read More

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Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity.

Xenobiotica 2021 Jul 28:1-36. Epub 2021 Jul 28.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Podophyllotoxin (POD) is a natural compound with antiviral and anticancer activities. The purpose of the present study was to determine the metabolic map of POD in vitro and in vivo.Mouse and human liver microsomes were employed to identify POD metabolites in vitro and recombinant drug-metabolizing enzymes were used to identify the mono-oxygenase enzymes involved in POD metabolism. Read More

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Illuminating key microbial players and metabolic processes involved in the remineralization of particulate organic carbon in the ocean's twilight zone by metaproteomics.

Appl Environ Microbiol 2021 Jul 28:AEM0098621. Epub 2021 Jul 28.

State Key Laboratory of Marine Environmental Science/College of the Environment and Ecology, Xiamen University, Xiamen 361005, China.

The twilight zone (from the base of the euphotic zone to the depth of 1000 m) is the major area of particulate organic carbon (POC) remineralization in the ocean, and heterotrophic microbes contribute to more than 70% of the estimated remineralization. However, little is known about the microbial community and metabolic activity directly associated with POC remineralization in this chronically understudied realm. Here, we characterized the microbial community proteomes of POCs collected from the twilight zone of three contrasting sites in the Northwest Pacific Ocean using a metaproteomic approach. Read More

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Effects of tea polyphenols on the activities of antioxidant enzymes and the expression of related gene in the leaves of wheat seedlings under salt stress.

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

School of Life Science, Northwest Normal University, Lanzhou, 730070, Gansu, People's Republic of China.

Longchun 30, a new wheat variety, was used to investigate seedling growth, element absorption, and antioxidant response under 150 mM NaCl and tea polyphenols (TP) (25 and 100 mg L) treatments alone or in combination, thus revealing TP-alleviating mechanism on the salt damage to plants. 150 mM NaCl stress alone inhibited the seedling growth, increased sodium content and reactive oxygen species (ROS) accumulation, but reduced potassium (K) and calcium (Ca) levels at different culture times, thus resulting in the oxidative damage to the leaves. Even though 25 or 100 mg L TP treatment alone led to the significant increases of O and HO generation, TP-treated leaves exhibited the reduction of relative electrical conductivity and no change of malondialdehyde content. Read More

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Design, Synthesis, Antibacterial Activity, and Mechanisms of Novel 1,3,4-Thiadiazole Derivatives Containing an Amide Moiety.

J Agric Food Chem 2021 Jul 28. Epub 2021 Jul 28.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P.R. China.

To discover novel antibacterial agents, a series of novel 1,3,4-thiadiazole derivatives containing an amide moiety were designed and synthesized, and their antibacterial activities were tested. Compound was designed and synthesized according to the CoMFA model. Compound exhibited higher antibacterial activities against pv. Read More

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Small RNAs as a New Platform for Tuning the Biosynthesis of Silver Nanoparticles for Enhanced Material and Functional Properties.

ACS Appl Mater Interfaces 2021 Jul 28. Epub 2021 Jul 28.

McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.

Genetic engineering of nanoparticle biosynthesis in bacteria could help facilitate the production of nanoparticles with enhanced or desired properties. However, this process remains limited due to the lack of mechanistic knowledge regarding specific enzymes and other key biological factors. Herein, we report on the ability of small noncoding RNAs (sRNAs) to affect silver nanoparticle (AgNP) biosynthesis using the supernatant from the bacterium . Read More

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Investigations of the maintenance system of the Konik Polski horse and its effects on fecal microbiota activity during the winter and summer seasons.

Anim Sci J 2021 Dec;92(1):e13603

Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

Gastrointestinal microbiota play a key role in the nutrients digestion and hence maintaining animal health and welfare. The diet offered to the animals in captivity may differ considerably from that on natural pastures. In a stabled maintenance system, horses have a limited choice of habitat and feed. Read More

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December 2021

Structural characteristics and improved in vitro hepatoprotective activities of Maillard reaction products of decapeptide IVTNWDDMEK and ribose.

J Food Sci 2021 Jul 27. Epub 2021 Jul 27.

School of Food Science and Technology, Dalian Polytechnic University, Dalian, P.R. China.

Here, a novel decapeptide IVTNWDDMEK with Maillard reactivity derived from scallop Chlamys farreri mantle was identified. The structural characteristics and in vitro hepatoprotective effects of IVTNWDDMEK conjugated with ribose were further investigated. The changes in decapeptide structures were determined by ultraviolet-visible (UV-vis), Fourier transform infrared (FTIR), and atomic force microscopy (AFM), and the modification sites induced by Maillard reaction of IVTNWDDMEK and ribose were monitored by high performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS). Read More

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Effects of Herbaspirillum sp. p5-19 assisted with alien soil improvement on the phytoremediation of copper tailings by Vetiveria zizanioides L.

Environ Sci Pollut Res Int 2021 Jul 27. Epub 2021 Jul 27.

College of Resources and Environmental Engineering, Anhui University, Hefei, 230601, China.

Microbial assisted phytoremediation and reclamation are both potential contaminated soil remediation technologies, but little is known about the combined application of the two technologies on real contaminated soils. This study investigated the potential of Herbaspirillum sp. p5-19 (p5-19) assisted with alien soil improvement on improving stress tolerance and enhancing the accumulation of Mn, Cu, Zn, and Cd by Vetiveria zizanioides L. Read More

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Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities.

Open Life Sci 2021 16;16(1):719-727. Epub 2021 Jul 16.

Department of Critical Care Medicine, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi Province, 710003, China.

Gastric mucosal injury is caused by an imbalance between the mucosal defense and gastro-irritants, leading to gastroenteritis. Diosgenin is a steroidal sapogenin found in the wild Yam plant that has been reported with several pharmacological properties. The aim of this study is to explore the gastroprotective role of diosgenin on gastric mucosal damage caused by HCl/ethanol in rats. Read More

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Combats Oxidative Stress, Protein and Lipid Dyshomeostasis, Inflammation, Hepatic Injury, and Glomerular Blockage in Rats.

Prev Nutr Food Sci 2021 Jun;26(2):177-185

Department of Biochemistry, College of Health Sciences, School of Basic Medical Sciences, Igbinedion University Okada, Benin City, Edo State 302110, Nigeria.

, better known as 'pepperfruit', is a medicinal plant consumed in West Africa. possesses strong antioxidant properties and contains uvariopsine, an alkaloid which improves bile secretion and liver function. In the present study, the ethanolic extract of fruits was tested for its ability to alleviate pathophysiological conditions bordering on oxidative stress, including protein and lipid dyshomeostasis, inflammation, and hepatic and glomerular injury. Read More

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Evaluating the contribution of osmotic and oxidative stress components on barley growth under salt stress.

AoB Plants 2021 Aug 11;13(4):plab034. Epub 2021 Jun 11.

Laboratory of Plant Molecular Physiology, Center of Biotechnology of Borj Cedria, BP 901, Hammam-Lif 2050, Tunisia.

Salt stress is considered one of the most devastating environmental stresses, affecting barley growth and leading to significant yield loss. Hence, there is considerable interest in investigating the most effective traits that determine barley growth under salt stress. The objective of this study was to elucidate the contribution of osmotic and oxidative stress components in leaves and roots growth under salt stress. Read More

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