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Gender-linked determinants for utilization of long2 term care in community-dwelling adults 65+ in 3 Germany: Results from the population-based 4 KORA-Age study.

Exp Gerontol 2021 Jul 28:111500. Epub 2021 Jul 28.

Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, Germany; Quality Management and Gender Medicine, München Klinik Schwabing, Kölner Platz 1, 80804 Munich, Germany. Electronic address:

Background: The number of people using long-term care (LTC) is increasing steadily, hence, demand for adequate services is rising. The purpose of this exploratory study was to identify relevant gender-linked determinants for utilization of LTC in community-dwelling older adults.

Methods: We examined 4077 females (52. Read More

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A novel method for linking between a 3D printer and printed objects using toolmark comparison techniques.

J Forensic Sci 2021 Jul 30. Epub 2021 Jul 30.

Questioned Documents Laboratory, Division of Identification and Forensic Science (DIFS), Israel Police, National H.Q., Jerusalem, Israel.

Rapid advances and decreased production costs in 3D printing (3DP) have resulted in its accelerated implementation in criminal activities. Fused Deposition Modeling (FDM (3DP and Polylactic Acid (PLA) filament were chosen for the current research because they are widely used in commodity 3DP, particularly in documented criminal activities. This study shows how specific features of 3DP along with classical toolmark comparison techniques using Stereo-Microscopy and Comparison Microscopy can be used to link between two 3DP objects as well as between a printed object and a suspected 3D printer. Read More

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Effects of hyperbaric oxygen therapy on postoperative recovery after incomplete cervical spinal cord injury.

Spinal Cord 2021 Jul 29. Epub 2021 Jul 29.

People's Liberation Army Hangzhou Sanatorium, Hangzhou, China.

Study Design: A retrospective study of incomplete cervical spinal cord injury (SCI) treated with and without hyperbaric oxygen (HBO) therapy after operation.

Objective: To investigate the effects of hyperbaric oxygen therapy on patients' postoperative recovery after incomplete cervical spinal cord injury.

Setting: Shulan Hangzhou Hospital, Hangzhou, China. Read More

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Beyond the metrics of health research performance in African countries.

BMJ Glob Health 2021 Jul;6(7)

Department of Health Policy, London School of Economics and Political Science, London, UK.

While it is important to be able to evaluate and measure a country's performance in health research (HR), HR systems are complex and multifaceted in nature. As such, attempts at measurement can suffer several limitations which risk leading to inadequate indices or representations. In this study, we critically review common indicators of HR capacity and performance and explore their strengths and limitations. Read More

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Effects of Vegetation Restoration on Soil Enzyme Activity in Copper and Coal Mining Areas.

Environ Manage 2021 Jul 27. Epub 2021 Jul 27.

Forestry Academy of Shandong Province, Jinan, 250014, China.

Mining areas are suffering from serious environmental hazards, such as soil erosion, water pollution as well as land degradation. In this study, two types of mining areas in Anhui Province, China-one a copper mining area and the other a coal mining area-were selected to compare the soil properties under different vegetation restoration conditions, which can be generally classified into reclaimed and non-reclaimed areas. Soil catalase and urease activities and soil chemical properties were chosen to be the main indicators of soil quality. Read More

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Estimating an EQ-5D-3L Value Set for Romania Using Time Trade-Off.

Int J Environ Res Public Health 2021 Jul 11;18(14). Epub 2021 Jul 11.

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4AX, UK.

Objective: To provide health-related quality of life (HRQoL) data to support health technology assessment (HTA) and reimbursement decisions in Romania, by developing a country-specific value set for the EQ-5D-3L questionnaire.

Methods: We used the cTTO method to elicit health state values using a computer-assisted personal interviewing approach. Interviews were standardized following the most recent version of the EQ-VT protocol developed by the EuroQoL Foundation. Read More

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Profile Of Head And Neck Burns During COVID-19 Pandemic.

J Burn Care Res 2021 Jul 23. Epub 2021 Jul 23.

Assistant Professor in Surgery, Emory University School of Medicine, Department of Surgery, Director Burn Outcomes Research, Burn Center, Grady Memorial Hospital, Atlanta, GA.

Coronavirus disease 2019 (COVID- 19) affected daily activities since December 2019. Burn injuries to head and neck can result in cosmetic and functional deformities. The purpose of this study was to characterize patients with burns to head and neck during the pandemic. Read More

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Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors.

Invest New Drugs 2021 Jul 21. Epub 2021 Jul 21.

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

Background The study determined the safety, pharmacokinetics/pharmacodynamics (PK/PD), and recommended Phase II dose of BCT-100 for arginine auxotrophic tumours in a non-Chinese population. Methods This is a Phase I, 3 + 3 dose-escalation, open-label, multi-centre study in two arginine auxotrophic cancers-Malignant Melanoma (MM) and Castration Resistant Prostate Cancer (CRPC). Patients were enrolled to receive weekly intravenous BCT-100. Read More

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Effects of lower extremity constraint-induced movement therapy on gait and balance of chronic hemiparetic patients after stroke: description of a study protocol for a randomized controlled clinical trial.

Trials 2021 Jul 19;22(1):463. Epub 2021 Jul 19.

Neurology/Neuroscience program, Federal University of São Paulo - UNIFESP, Botucatu street, 862 - 5° floor Edifico Ciências Biomédicas, São Paulo, Brazil.

Background: Protocols involving intensive practice have shown positive outcomes. Constraint induced movement therapy (CIT) appears to be one of the best options for better outcomes in upper limb rehabilitation, but we still have little data about lower extremity constraint-induced movement therapy (LE-CIT) and its effects on gait and balance.

Objective: To evaluate the effects of an LE-CIT protocol on gait functionality and balance in chronic hemiparetic patients following a stroke. Read More

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Vilém Dušan Lambl in the Imperial University of Kharkiv (Charkov) (1861-1871): biography outlines.

Cesk Patol 2021 ;57(2):113-119

This article focuses on the biography of the famous Czech pathologist Dušan Lambl (1824-95), especially during his period of life in Kharkiv, Sloboda Ukraine (part of the Russian Empire). At the end of the 1850s, pursued by the authorities of the Austrian Empire as a politically compromised person (being a Czech patriot and slavophile, he took an active part in the so-called Spring of Nations in 1848), Dušan Lambl was forced to seek refuge in the Russian Empire. He put forward his candidacy for the post of professor in the department of anatomy at the School of Medicine of Kharkiv University and was selected for this position. Read More

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Insecticide Residues in Cotton, Sorghum and Fallow Soil from the Nuba Mountains Cotton Corporation of South Kordofan State, Sudan.

J Health Pollut 2021 Jun 17;11(30):210608. Epub 2021 Jun 17.

Department of Biological Environment, Kangwon National University, The Republic of Korea.

Background: Soil is the final depot of most environmental contaminants, including pesticides. Soil may be contaminated by pesticides as a result of direct application or drift during spray activities. Soil contamination with pesticide residues may affect the quality of food crops, animal products, and soil micro-organisms which may in turn negatively affect human health and the environment. Read More

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Types of social networks and starting leisure activities in later life: A longitudinal Japan Gerontological Evaluation Study (JAGES).

PLoS One 2021 15;16(7):e0254828. Epub 2021 Jul 15.

Center for Advanced Intelligence Project, RIKEN, Chuo-ku, Tokyo, Japan.

Considering beneficial effects of leisure activities in later life on well-being and health, we investigated which type of social network among older adults is associated with starting their participation in leisure activities. We used data from a longitudinal Japan Gerontological Evaluation Study (JAGES) conducted in Japan every three years from 2010 to 2016. We extracted types of social networks of older adults who did not participate in leisure activities in 2013 and responded to items related to social networks (n = 3436) relying on latent class analysis to examine changes in leisure activity participation over a three-year period within each latent class while controlling for participants' activity in 2010. Read More

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Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion.

Microb Cell Fact 2021 Jul 14;20(1):134. Epub 2021 Jul 14.

Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.

Monoclonal antibodies, antibody fragments and fusion proteins derived thereof have revolutionized the practice of medicine. Major challenges faced by the biopharmaceutical industry are however high production costs, long processing times and low productivities associated with their production in mammalian cell lines. The yeast Saccharomyces cerevisiae, a well-characterized eukaryotic cell factory possessing the capacity of post-translational modifications, has been industrially exploited as a secretion host for production of a range of products, including pharmaceuticals. Read More

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Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis.

J Nanobiotechnology 2021 Jul 13;19(1):209. Epub 2021 Jul 13.

Medical Science Research Center (MRC), Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, Beijing, 100730, China.

Background: The therapeutic potential of exosomes derived from stem cells has attracted increasing interest recently, because they can exert similar paracrine functions of stem cells and overcome the limitations of stem cells transplantation. Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) have been confirmed to promote osteogenesis and angiogenesis. The magnetic nanoparticles (eg. Read More

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Non-pharmacological interventions for pain management in patients with dementia: A mixed-methods systematic review.

J Clin Nurs 2021 Jul 12. Epub 2021 Jul 12.

Catherine McAuley School of Nursing and Midwifery, University College Cork, Cork, Ireland.

Aims And Objectives: To systematically identify, summarise and compare evidence from studies related to the non-pharmacological interventions used to manage pain in patients with dementia. Secondly, this study aims to provide evidence on the effectiveness of non-pharmacological interventions used to manage pain in patients with dementia.

Background: The number of people diagnosed with dementia is rising rapidly in the context of ageing. Read More

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Clinical expert consensus on standard care of blood glucose for residents in senior care facility in China (2021 edition).

Aging Med (Milton) 2021 Jun 11;4(2):93-108. Epub 2021 Jun 11.

Department of Geriatrics and Geriatric Endocrinology The Second Xiangya Hospital and the Institute of Aging and Geriatrics Central South University National Clinical Research Center for Metabolic Diseases (The Second Xiangya Hospital) Changsha China.

With the demographic changes, more and more elderly people have chosen to spend their retirement life in a senior care facility. The elderly people in senior care facility are commonly suffering from various geriatric syndromes, including declined daily living activities, cognitive dysfunction, frailty, comorbidities, and polypharmacy, which make them vulnerable to adverse effects, like hypoglycemia and fall. Therefore, layered management is necessary for this population with group disparities. Read More

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Pressure injuries and skin tone diversity in undergraduate nurse education: Qualitative perspectives from a mixed methods study.

J Adv Nurs 2021 Jul 10. Epub 2021 Jul 10.

Susan Wakil School of Nursing, University of Sydney Australia, Sydney, NSW, Australia.

Aims: To, firstly, explore student and academic nurse perceptions of classroom content about the assessment and identification of pressure injuries across skin tone diversity and, secondly, to describe the impact of classroom content on student nurse understanding of pressure injury in people with dark skin tones.

Design: Qualitative case study employing focus groups and semi-structured interviews.

Methods: Five higher education institutions in the United Kingdom were purposively chosen. Read More

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Strategies and challenges in Kerala's response to the initial phase of COVID-19 pandemic: a qualitative descriptive study.

BMJ Open 2021 07 9;11(7):e051410. Epub 2021 Jul 9.

Community Medicine, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India

Objective: To understand the structures and strategies that helped Kerala in fighting the COVID-19 pandemic, the challenges faced by the state and how it was tackled.

Design: Qualitative descriptive study using focus group discussions and in-depth interviews.

Setting: State of Kerala, India. Read More

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Religious Leaders' Knowledge of Family Planning and Modern Contraceptive Use and Their Involvement in Family Planning Programmes in Burkina Faso: A Qualitative Study in Dori in the Sahel Region.

Open Access J Contracept 2021 28;12:123-132. Epub 2021 Jun 28.

Département Biomédical et Santé Publique, Institut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso.

Introduction: It is necessary to understand religious leaders' perceptions of modern contraceptive use and their role in influencing fertility behaviour for the successful adoption of family planning, especially in societies where the religious leaders' opinions can have a significant influence on individuals' reproductive decisions. This study, therefore, aimed to assess religious leaders' knowledge of family planning and their involvement in family planning programmes in the Sahel region of Burkina Faso.

Methods: This is a qualitative study comprising in-depth individual interviews with twenty-one religious' leaders in the town of Dori in the Sahel region of Burkina Faso. Read More

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TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis.

Trials 2021 Jul 6;22(1):433. Epub 2021 Jul 6.

Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.

Background: Adaptive model-based dose-finding designs have demonstrated advantages over traditional rule-based designs but have increased statistical complexity but uptake has been slow especially outside of cancer trials. TRAFIC is a multi-centre, early phase trial in rheumatoid arthritis incorporating a model-based design.

Methods: A Bayesian adaptive dose-finding phase I trial rolling into a single-arm, single-stage phase II trial. Read More

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[High-efficiency separation and analysis of monosaccharides in Pueraria polysaccharides by pressurized capillary electrochromatography].

Se Pu 2020 Nov;38(11):1323-1331

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

Pueraria polysaccharides have been proven to possess biological activities such as bacteriostasis, anti-oxidative, anti-tumor, and immunity boosting activities. The variation in the structure, composition, and amount of monosaccharides in these polysaccharides may lead to different spatial structures and biological activities. Therefore, extraction of Pueraria polysaccharides and determination of the monosaccharide composition are of great significance for activity analysis and quality control. Read More

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November 2020

A New Dermal Substitute Containing Polyvinyl Alcohol with Silver Nanoparticles and Collagen with Hyaluronic Acid: In Vitro and In Vivo Approaches.

Antibiotics (Basel) 2021 Jun 19;10(6). Epub 2021 Jun 19.

Faculty of Medical Sciences and Health, Pontifical Catholic University of São Paulo (PUC/SP), São Paulo 18030-070, Brazil.

The experimental use of poly (alcohol-vinyl) (PVA) as a skin curative is increasing widely. However, the use of this hydrogel is challenging due to its favorable properties for microbiota growth. The association with silver nanoparticles (AgNPs) as an antimicrobial agent turns the match for PVA as a dressing, as it focuses on creating a physical barrier to avoid wound dehydration. Read More

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Structural and Energetic Affinity of Annocatacin B with ND1 Subunit of the Human Mitochondrial Respiratory Complex I as a Potential Inhibitor: An In Silico Comparison Study with the Known Inhibitor Rotenone.

Polymers (Basel) 2021 Jun 2;13(11). Epub 2021 Jun 2.

Centro de Investigación en Ingeniería Molecular-CIIM, Universidad Católica de Santa María, Urb. San José s/n-Umacollo, Arequipa 04013, CP, Peru.

ND1 subunit possesses the majority of the inhibitor binding domain of the human mitochondrial respiratory complex I. This is an attractive target for the search for new inhibitors that seek mitochondrial dysfunction. It is known, from in vitro experiments, that some metabolites from called acetogenins have important biological activities, such as anticancer, antiparasitic, and insecticide. Read More

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Growth factor-loaded microspheres in mPEG-polypeptide hydrogel system for articular cartilage repair.

J Biomed Mater Res A 2021 Jun 30. Epub 2021 Jun 30.

Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.

We developed an injectable hydrogel system with a sustained release of TGF-β3 through growth factor-loaded microsphere to mimic the cartilage-like microenvironment. Poly(lactic-co-glycolic acid) (PLGA) microspheres incorporated in three dimensional (3D) scaffolds were chosen because of its regulatory approval, good biodegradability, and acting as carriers with sustained release behavior. We evaluated sustained release of TGF-β3 by PLGA microspheres encapsulated in methoxy poly(ethylene glycol)-poly(alanine) (mPA) hydrogels and the resulting enhanced chondrogenic effects. Read More

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SARS-CoV-2 in eight municipalities of the Colombian tropics: high immunity, clinical and sociodemographic outcomes.

Trans R Soc Trop Med Hyg 2021 Jun 29. Epub 2021 Jun 29.

Instituto de Investigaciones Biológicas del Trópico, Colombia-Universidad de Córdoba, Montería, Colombia.

Background: Serological evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an alternative that allows us to determine the prevalence and dynamics of this infection in populations. The goal of this study was to determine the clinical and sociodemographic dynamics of SARS-CoV-2 infection in a region of the Colombian Caribbean.

Methods: Between July and November 2020, a cross-sectional observational study was carried out in Córdoba, located in northeast Colombia in the Caribbean area. Read More

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Acquisition of novel ball-related skills associated with sports experience.

Sci Rep 2021 Jun 28;11(1):12379. Epub 2021 Jun 28.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan.

Some individuals can quickly acquire novel motor skills, while others take longer. This study aimed to investigate the relationships between neurophysiological state, sports experience, and novel ball-related skill acquisition. We enrolled 28 healthy collegiate participants. Read More

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Shifting From Sectoral to Integrated Surveillance by Changing Collaborative Practices: Application to West Nile Virus Surveillance in a Small Island State of the Caribbean.

Front Public Health 2021 10;9:649190. Epub 2021 Jun 10.

CIRAD, UMR, ASTRE, Petit-Bourg, France.

After spreading in the Americas, West Nile virus was detected in Guadeloupe (French West Indies) for the first time in 2002. Ever since, several organizations have conducted research, serological surveys, and surveillance activities to detect the virus in horses, birds, mosquitoes, and humans. Organizations often carried them out independently, leading to knowledge gaps within the current virus' situation. Read More

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Staphylococcus aureus membrane-damaging activities of four phenolics.

FEMS Microbiol Lett 2021 07;368(13)

Univ Lyon, Université Claude Bernard Lyon 1, ISARA Lyon, BioDyMIA (Bioingénierie et Dynamique Microbienne aux Interfaces Alimentaires), Equipe Mixte d'Accueil n°3733, IUT Lyon 1, technopole Alimentec, rue Henri de Boissieu, F-01000 Bourg en Bresse, France.

The membrane-damaging activities of four phenolics chosen for their bactericidal activity against Staphylococcus aureus CNRZ3 were investigated: 5,7-dihydroxy-4-phenylcoumarin (DHPC), 5,8-dihydroxy-1,4-naphthoquinone (DHNQ), epigallocatechin gallate (EGCG) and isobutyl 4-hydroxybenzoate (IBHB). Staphylococcus aureus CNRZ3 cells, as well as model liposomes mimicking its membrane phospholipids composition, were treated with each phenolic at its minimal bactericidal concentration. Membrane integrity, intracellular pH and intracellular esterase activity were examined by flow cytometric analysis of S. Read More

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Complicated Traumatic Nerve Injury Treated with Tendon Transfers in a Patient with Myotonic Dystrophy: First Case Report.

JBJS Case Connect 2021 06 25;11(2). Epub 2021 Jun 25.

Plastic and Reconstructive Surgery Department, Hospital "Dr. Enrique Garcés," Quito, Ecuador.

Case: We report a right-handed 37-year-old woman, with myotonic dystrophy type 1 (MD1), presenting with a posterior interosseus nerve injury because of a penetrating trauma in the right forearm. The tendon transfer technique was chosen based on tendon response and functionality of the arms during the surgery. The patient has been able return to her daily life activities with proper fine and gross motor control. Read More

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