23,479 results match your criteria activities bone


Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.

Background: Elevated plasma homocysteine has been found to be associated with an increased risk of osteoporosis, especially hip and vertebral fractures. The plasma concentration of homocysteine is dependent on the activities of several B vitamin-dependent enzymes, such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and cystathionine β-synthase (CBS).

Objectives: We investigated whether genetic variants in some of the genes involved in 1 carbon metabolism modify the association of B vitamin-related measures with bone mineral density (BMD) and strength. Read More

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A comparative study on fabrication techniques of gelable bone matrix derived from porcine tibia.

J Biomed Mater Res B Appl Biomater 2021 May 8. Epub 2021 May 8.

Joint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Recently, several types of native tissues have been enzymatically digested to prepare hydrogels that have natural-mimic extracellular matrix (ECM) proteins, architecture, and biologic activities. However, the residual detergents and salts remaining in the hydrogel may cause some undesirable effects on compatibility, functionality, and bioactivity of the material. In this study, we enzymatically digested the demineralized and decellularized bone matrix (DDBM) and adopted two common methods that included dialysis against distilled water and acetone precipitation for sample desalting. Read More

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Optimal Load for Managing Low-Risk Tibial and Metatarsal Bone Stress Injuries in Runners: The Science Behind the Clinical Reasoning.

J Orthop Sports Phys Ther 2021 May 7:1-28. Epub 2021 May 7.

School of Physical Therapy and Health Sciences, University of Montana, Missoula, MT.

Background: Low-risk bone stress injuries (BSIs) of the tibia and metatarsal diaphysis account for >50% of BSIs in runners. They interrupt training and are managed using non-invasive approaches. The desire by all involved is for a speedy, but safe return to running. Read More

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Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR.

J Cell Mol Med 2021 May 7. Epub 2021 May 7.

Department of Orthopedics, Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Osteosarcoma (OS) is the most common primary malignant bone tumour in adolescence. Lately, light-emitting diodes (LED)-based therapy has emerged as a new promising approach for several diseases. However, it remains unknown in human OS. Read More

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infection after anterior cruciate ligament reconstruction: A case report.

World J Orthop 2021 Apr 18;12(4):246-253. Epub 2021 Apr 18.

Department of Orthopaedic Surgery, University Hospital Centre of Saint-Etienne, Saint-Etienne 42000, France.

Background: Infections after anterior cruciate ligament reconstruction (ACLR) are rare. No cases of infection have been described to our knowledge.

Case Summary: We describe a rare case of infection in a 23-year-old patient following an ACLR. Read More

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Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging.

Front Physiol 2021 20;12:673404. Epub 2021 Apr 20.

Departamento de Biología Celular y Molecular, Center for Aging and Regeneration (CARE-ChileUC), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Normal skeletal muscle functions are affected following trauma, chronic diseases, inherited neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of life of the affected patients. The maladaptive accumulation of fibrous intramuscular connective tissue and fat are hallmarks of multiple pathologies where chronic damage and inflammation are not resolved, leading to progressive muscle replacement and tissue degeneration. Muscle-resident fibro-adipogenic progenitors are adaptable stromal cells with multilineage potential. Read More

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A 115,000-year-old expedient bone technology at Lingjing, Henan, China.

PLoS One 2021 6;16(5):e0250156. Epub 2021 May 6.

CNRS UMR5199 -PACEA, Université de Bordeaux, France.

Activities attested since at least 2.6 Myr, such as stone knapping, marrow extraction, and woodworking may have allowed early hominins to recognize the technological potential of discarded skeletal remains and equipped them with a transferable skillset fit for the marginal modification and utilization of bone flakes. Identifying precisely when and where expedient bone tools were used in prehistory nonetheless remains a challenging task owing to the multiple natural and anthropogenic processes that can mimic deliberately knapped bones. Read More

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Hospital solution for COVID-19 isolation facility.

Am J Disaster Med 2021 Winter;16(1):35-41

Hospital Management, Rambam Health Care Campus, Haifa, Israel; The Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. ORCID: https://orcid.org/0000-0003-3172-7619.

Objective: In response to the coronavirus disease 2019 (COVID-19) pandemic, the Israeli government strategy initially focused on containment. The Ministry of Health mandated isolation of COVID-19 patients in hospitals and instructed healthcare institutions to make necessary arrangements. As the second Israeli hospital to establish a COVID-19 department, this article describes our experience in its rapid establishment, while maintaining normal medical center activities. Read More

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Non-union after Fracture of the Anterior Tibial Spine in a 6-Year-old Child: A Case Report.

J Orthop Case Rep 2020 May-Jun;10(3):27-31

Department of Orthopaedics, Orthopaedics and Traumatology Service, Centro Hospitalar de Vila Nova de Gaia/Espinho, Gaia, Portugal.

Introduction: Fractures of the tibial spines occur in 3/100,000 children per year and are rare in children under 8 years. Non-union after avulsion fracture of the tibial spine is even rarer, especially under 8 years, with only few cases described in the literature.

Case Presentation: A 6-year-old boy with went to the emergency department after suffering trauma in his left knee. Read More

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Edible Bird's Nest: The Functional Values of the Prized Animal-Based Bioproduct From Southeast Asia-A Review.

Front Pharmacol 2021 19;12:626233. Epub 2021 Apr 19.

School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, Johor, Malaysia.

Edible Bird's Nest (EBN) is the most prized health delicacy among the Chinese population in the world. Although some scientific characterization and its bioactivities have been studied and researched, no lights have been shed on its actual composition or mechanism. The aim of this review paper is to address the advances of EBN as a therapeutic animal bioproduct, challenges and future perspectives of research involving EBN. Read More

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Improved osteogenesis and angiogenesis of theranostic ions doped calcium phosphates (CaPs) by a simple surface treatment process: A state-of-the-art study.

Mater Sci Eng C Mater Biol Appl 2021 May 29;124:112082. Epub 2021 Mar 29.

Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad (FUM), Azadi Sq., Mashhad 917794-8564, Iran.

Surface treatment of biomaterials could enable reliable and quick cellular responses and accelerate the healing of the host tissue. Here, a series of calcium phosphates (CaPs) were surface treated by hydrogen peroxide (HO) and the treatment effects were physicochemically and biologically evaluated. For this aim, as-synthesized CaPs doped with strontium (Sr), iron (Fe), silicon (Si), and titanium (Ti) ions were sonicated in HO media. Read More

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Bifunctional hydrogel for potential vascularized bone tissue regeneration.

Mater Sci Eng C Mater Biol Appl 2021 May 24;124:112075. Epub 2021 Mar 24.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, United States; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, United States. Electronic address:

Most of the synthetic polymer-based hydrogels lack the intrinsic properties needed for tissue engineering applications. Here, we describe a biomimetic approach to induce the mineralization and vascularization of poly(ethylene glycol) (PEG)-based hydrogel to template the osteogenic activities. The strategy involves the covalent functionalization of oligo[poly(ethylene glycol) fumarate] (OPF) with phosphate groups and subsequent treatment of phosphorylated-OPF (Pi-OPF) hydrogels with alkaline phosphatase enzyme (ALP) and calcium. Read More

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Effect of lumbar spinal stenosis on bone mineral density in osteoporosis patients treated with ibandronate.

BMC Musculoskelet Disord 2021 May 4;22(1):412. Epub 2021 May 4.

Department of Orthopedic Surgery, Eunpyeong St. Mary's Hospital, College of Medicine, the Catholic University of Korea, 1021, Tongil-Ro, Eunpyeong-gu, 03312, Seoul, Republic of Korea.

Background: Lumbar spinal stenosis (LSS) can cause various neurological symptoms and reduce the daily activity of patients. Many studies have shown that free physical activities and exercise can improve bone mineral density (BMD) in patients with osteoporosis. However, the effect of LSS on BMD has not been reported. Read More

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In Search of a Role for Extracellular Purine Enzymes in Bone Function.

Biomolecules 2021 Apr 30;11(5). Epub 2021 Apr 30.

Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.

Bone is one of the major tissues that undergoes continuous remodeling throughout life, thus ensuring both organic body growth during development and protection of internal organs as well as repair of trauma during adulthood. Many endogenous substances contribute to bone homeostasis, including purines. Their role has increasingly emerged in recent decades as compounds which, by interacting with specific receptors, can help determine adequate responses of bone cells to physiological or pathological stimuli. Read More

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Zinc Sulfate Stimulates Osteogenic Phenotypes in Periosteum-Derived Cells and Co-Cultures of Periosteum-Derived Cells and THP-1 Cells.

Life (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Department of Oral and Maxillofacial Surgery, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju 52727, Korea.

Coupling between osteoblast-mediated bone formation and osteoclast-mediated bone resorption maintains both mechanical integrity and mineral homeostasis. Zinc is required for the formation, mineralization, growth, and maintenance of bones. We examined the effects of zinc sulfate on osteoblastic differentiation of human periosteum-derived cells (hPDCs) and osteoclastic differentiation of THP-1 cells. Read More

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Aloperine improves osteoporosis in ovariectomized mice by inhibiting RANKL-induced NF-κB, ERK and JNK approaches.

Int Immunopharmacol 2021 May 1;97:107720. Epub 2021 May 1.

Department of Spinal Surgery, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421000, China. Electronic address:

Presently, postmenopausal osteoporosis mainly caused by excessive activation of in vivo osteoclasts has become a global public health burden. Natural compounds have gradually become the potential drugs for the treatment of postmenopausal osteoporosis. Aloperine is a new alkaloid extracted from the leaves and seeds of sophora bean. Read More

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Additively Manufactured Gradient Porous Ti-6Al-4V Hip Replacement Implants Embedded with Cell-Laden Gelatin Methacryloyl Hydrogels.

ACS Appl Mater Interfaces 2021 May 4. Epub 2021 May 4.

Mechanical and Mechatronics Engineering Department, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada.

Laser additive manufacturing has led to a paradigm shift in the design of next-generation customized porous implants aiming to integrate better with the surrounding bone. However, conflicting design criteria have limited the development of fully functional porous implants; increasing porosity improves body fluid/cell-laden prepolymer permeability at the expense of compromising mechanical stability. Here, functionally gradient porosity implants and scaffolds designed based on interconnected triply periodic minimal surfaces (TPMS) are demonstrated. Read More

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Titanium dioxide nanotubes as drug carriers for infection control and osteogenesis of bone implants.

Drug Deliv Transl Res 2021 May 3. Epub 2021 May 3.

Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE), and Xi'an Institute of Biomedical Materials & Engineering (IBME), Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, China.

Titanium implants have been widely used as one of the most effective treatments of bone defects. However, the lack of osteogenesis and bacteria-resistant activities result in high infection and loosening rates of titanium implants. Anodic oxidation could easily construct titanium dioxide nanotubes (TNTs) array on the surface of titanium, and the rough surface of TNTs is beneficial to the growth of osteoblast-related cells on the surface. Read More

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Experience and impact of crystal pyrophosphate deposition (CPPD) from a patient and caregiver perspective: A qualitative exploration from the OMERACT CPPD working group.

Semin Arthritis Rheum 2021 Apr 21. Epub 2021 Apr 21.

Academic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.

Objective: To explore the lived experience of people with calcium pyrophosphate deposition (CPPD) disease and the impact of this condition on their daily lives.

Methods: Patients with CPPD and their caregivers were invited to take part in a one-to-one (patient only) or paired (patient and caregiver) semi-structured interview. Interviews covered patients' diagnosis and treatment experiences, and the impact of CPPD on their daily lives. Read More

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Ethnopharmacology, chemodiversity, and bioactivity of Cephalotaxus medicinal plants.

Chin J Nat Med 2021 May;19(5):321-338

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Cephalotaxus is the only genus of Cephalotaxaceae family, and its natural resources are declining due to habitat fragmentation, excessive exploitation and destruction. In many areas of China, folk herbal doctors traditionally use Cephalotaxus plants to treat innominate swollen poison, many of which are cancer. Not only among Han people, but also among minority ethnic groups, Cephalotaxus is used to treat various diseases, e. Read More

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Galangin suppresses RANKL-induced osteoclastogenesis via inhibiting MAPK and NF-κB signalling pathways.

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing, China.

Osteoclasts play a critical role in osteoporosis; thus, inhibiting osteoclastogenesis is a therapeutic strategy for osteoporosis. Galangin, a natural bioflavonoid extracted from a traditional Chinese herb, possesses a variety of biological activities, including anti-inflammation and anti-oxidation. However, its effects on osteoporosis have not been elucidated. Read More

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Alleviative Effects of Exercise on Bone Remodeling in Fluorosis Mice.

Biol Trace Elem Res 2021 May 3. Epub 2021 May 3.

Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Veterinary Medicine, Shanxi Agricultural University, 030801, Taigu, Shanxi, China.

Fluorine is widely present in nature in the form of fluoride. Prolonged high-dose fluoride exposure can cause skeletal fluorosis, resulting in osteosclerosis, osteoporosis or osteomalacia. It has been proved that exercise is one of the important factors affecting the health of the bone and promoting bone formation. Read More

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Rethinking Greulich and Pyle: A Deep Learning Approach to Pediatric Bone Age Assessment Using Pediatric Trauma Hand Radiographs.

Radiol Artif Intell 2020 Jul 29;2(4):e190198. Epub 2020 Jul 29.

Department of Diagnostic Imaging, Rhode Island Hospital/Hasbro Children's Hospital, The Warren Alpert Medical School of Brown University, 593 Eddy St, Providence, RI 02903 (I.P., D.W.S., R.S.A.); Department of Diagnostic Imaging and Lifespan Biostatistics Core, Rhode Island Hospital, Providence, RI (G.L.B.); Department of Radiology, Columbia University Medical Center, New York, NY (S.M., C.R.); and Department of Emergency Medicine, University of Florida Shands Hospital, Gainesville, Fla (D.M.).

Purpose: To develop a deep learning approach to bone age assessment based on a training set of developmentally normal pediatric hand radiographs and to compare this approach with automated and manual bone age assessment methods based on Greulich and Pyle (GP).

Methods: In this retrospective study, a convolutional neural network (trauma hand radiograph-trained deep learning bone age assessment method [TDL-BAAM]) was trained on 15 129 frontal view pediatric trauma hand radiographs obtained between December 14, 2009, and May 31, 2017, from Children's Hospital of New York, to predict chronological age. A total of 214 trauma hand radiographs from Hasbro Children's Hospital were used as an independent test set. Read More

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Convolutional Neural Networks for Automatic Risser Stage Assessment.

Radiol Artif Intell 2020 May 27;2(3):e180063. Epub 2020 May 27.

Department of Software and IT Engineering, Ecole de Technologie Supérieure, 1100 rue Notre-Dame Ouest, Montréal, QC, Canada H3C 1K3 (H.K., L.D.); Division of Orthopedics, Sainte-Justine Hospital, Montréal, Canada (J.J., C.B., I.N., O.C., S.P., G.G., H.L.); and Department of Surgery, Université de Montréal, Montréal, Canada (M.L.N., S.P., G.G., H.L.).

Purpose: To develop an automatic method for the assessment of the Risser stage using deep learning that could be used in the management panel of adolescent idiopathic scoliosis (AIS).

Materials And Methods: In this institutional review board approved-study, a total of 1830 posteroanterior radiographs of patients with AIS (age range, 10-18 years, 70% female) were collected retrospectively and graded manually by six trained readers using the United States Risser staging system. Each radiograph was preprocessed and cropped to include the entire pelvic region. Read More

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Accelerated Bone Regeneration by Adrenomedullin 2 Through Improving the Coupling of Osteogenesis and Angiogenesis via β-Catenin Signaling.

Front Cell Dev Biol 2021 14;9:649277. Epub 2021 Apr 14.

Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Both osteogenic differentiation and the pro-angiogenic potential of bone marrow mesenchymal stem cells (BMSCs) contribute to bone regeneration during distraction osteogenesis (DO). Adrenomedullin 2 (ADM2), an endogenous bioactive peptide belonging to the calcitonin gene-related peptide family, exhibits various biological activities associated with the inhibition of inflammation and the attenuation of ischemic-hypoxic injury. However, the effects and underlying mechanisms of ADM2 in osteogenic differentiation and the pro-angiogenic potential of BMSCs, along with bone regeneration, remain poorly understood. Read More

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Total Knee Replacement: Subject-Specific Modeling, Finite Element Analysis, and Evaluation of Dynamic Activities.

Front Bioeng Biotechnol 2021 16;9:648356. Epub 2021 Apr 16.

Department of Electrical and Computer Engineering, University of Patras, Patras, Greece.

This study presents a semi-automatic framework to create subject-specific total knee replacement finite element models, which can be used to analyze locomotion patterns and evaluate knee dynamics. In recent years, much scientific attention was attracted to pre-clinical optimization of customized total knee replacement operations through computational modeling to minimize post-operational adverse effects. However, the time-consuming and laborious process of developing a subject-specific finite element model poses an obstacle to the latter. Read More

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Clinical presentation, diagnosis and management of aerodigestive tract foreign bodies in the adult population: Part 1.

SA J Radiol 2021 23;25(1):2022. Epub 2021 Mar 23.

Department of Radiology & Diagnostic Imaging, Faculty of Medicine and Dentistry, University of Alberta Hospital, Edmonton, Canada.

In the adult population, foreign bodies may be accidentally or intentionally ingested or even inserted into a body cavity. The majority of accidentally ingested foreign bodies pass through the alimentary tract without any complications and rarely require intervention. Accidentally ingested foreign bodies are usually fish bones, bones of other animals, and dentures. Read More

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A Simple Bone Cyst of the Acromion: Case Report.

Rev Bras Ortop (Sao Paulo) 2021 Apr 22;56(2):263-267. Epub 2020 Sep 22.

Departamento de Ortopedia e Traumatologia, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ancara, Turquia.

Simple bone cysts rarely occur in the scapula, and, to our knowledge, they have not been reported in the acromion. In the present report, we present the case of a 24-year-old female patient who was successfully treated by curettage and grafting using xenografting. No recurrence findings were observed during the follow-up six months postoperatively, the patient had recovered full range of motion, and she was able to perform all routine activities satisfactorily. Read More

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