861,182 results match your criteria activities

Multi-task fMRI data classification via group-wise hybrid temporal and spatial sparse representations.

eNeuro 2022 May 20. Epub 2022 May 20.

School of Computer Science and Communication Engineering, Jiangsu University, China.

Task-based functional magnetic resonance imaging (tfMRI) has been widely used to induce functional brain activities corresponding to various cognitive tasks. A relatively under-explored question is whether there exist fundamental differences in fMRI signal composition patterns that can effectively classify the task states of tfMRI data, furthermore, whether there exist key functional components in characterizing the diverse tfMRI signals. Recently, fMRI signal composition patterns of multiple tasks have been investigated via deep learning models, where relatively large populations of fMRI datasets are indispensable and the neurological meaning of their results is elusive. Read More

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Case Study: Improving Energy Status in a Wheelchair Athlete With Suppressed Resting Energy Expenditure.

Int J Sports Physiol Perform 2022 May 23:1-4. Epub 2022 May 23.

Department of Sport and Health Sciences, Technical University of Munich, Munich,Germany.

Purpose: Wheelchair athletes experience a reduction in fat-free mass due to the underlying condition and/or muscle disuse. This leads to a lower resting energy expenditure (REE), as well as a lower energy expenditure during exercise or daily activities. Traditional markers of low energy availability (LEA), including amenorrhea and low bone mineral density, are often inconclusive in wheelchair athletes. Read More

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Pulling back the curtain: The hidden functions of receptor tyrosine kinases in development.

Curr Top Dev Biol 2022 28;149:123-152. Epub 2022 Feb 28.

Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

Receptor tyrosine kinases (RTKs) are a conserved superfamily of transmembrane growth factor receptors that drive numerous cellular processes during development and in the adult. Upon activation, multiple adaptors and signaling effector proteins are recruited to binding site motifs located within the intracellular domain of the RTK. These RTK-effector interactions drive subsequent intracellular signaling cascades involved in canonical RTK signaling. Read More

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February 2022

[Ru(η--cymene)(N^O 8-hydroxyquinoline)(PTA)] complexes as rising stars in medicinal chemistry: synthesis, properties, biomolecular interactions, anti-tumor activity toward human brain carcinomas, and biodistribution and toxicity in a zebrafish model.

Dalton Trans 2022 May 24. Epub 2022 May 24.

Department of Chemistry, School of advanced sciences, Vellore Institute of Technology, Vellore-632014, Tamilnadu, India.

Herein, we have introduced a class of half-sandwich [Ru(η--cymene)(N^O 8-hydroxyquinoline)(PTA)] complexes for brain cancer therapy. Among all the complexes, [RuL3PTA] and [RuL4PTA] exhibited excellent cytotoxicity profiles against T98G, LN229, and U87MG cancer cells. Notably, the antiproliferative activities of the relevant complexes were also supported by neurosphere, DNA intercalation, agarose gel electrophoresis, and time-dependent ROS detection assay studies. Read More

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Multi-staged management of a mangled, exploded hand crush injury with long-term outcome: the critical link between surgery and therapy.

BMJ Case Rep 2022 May 20;15(5). Epub 2022 May 20.

Plastic and Reconstructive Surgery, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.

A 38-year-old right-hand dominant man sustained a severe, work-related left-hand crushing injury. A multi-staged approach to salvage was employed in conjunction with aggressive hand therapy involvement for a successful, functional outcome. Now at approximately 5 years postinjury, the patient can perform daily activities, coaches sports and has returned to and maintained his full-time work position. Read More

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Persisting breathlessness and activities reduced or ceased: a population study in older men.

BMJ Open Respir Res 2022 May;9(1)

Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund University, Lund, Sweden.

Introduction: Breathlessness is debilitating and increases in prevalence with age, with people progressively reducing their everyday activities to 'self-manage' it. This study aimed to evaluate the impact of breathlessness on function in terms of activities that have been reduced or ceased ('compromised') in older men.

Methods: A cross-sectional postal survey of Swedish 73-year-old man in the VAScular and Chronic Obstructive Lung disease study self-reporting on demographics, breathlessness (modified Medical Research Council (mMRC) scale, Dyspnoea-12, Multidimensional Dyspnea Scale) and its duration, anxiety/depression (Hospital Anxiety and Depression Scale), performance status (WHO Performance Status), everyday activities reduced/ceased and exertion. Read More

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Enzymatic Characterization of In Vitro Activity of RNA Methyltransferase PCIF1 on DNA.

Biochemistry 2022 May 23. Epub 2022 May 23.

Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.

PCIF1 and FTO are a pair of human mRNA cap-specific modification enzymes that have opposing activities. PCIF1 adds a methyl group to the N6-position of 2'-methyladenosine (A), generating N6, 2'-dimethyladenosine (mA), when A is the cap-proximal nucleotide. FTO removes the N6-methyl group from mA. Read More

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Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids.

Eur J Pharm Biopharm 2022 May 20. Epub 2022 May 20.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, United Kingdom. Electronic address:

Drug solubility in intestinal fluid is a key parameter controlling absorption after the administration of a solid oral dosage form. To measure solubility in vitro simulated intestinal fluids have been developed, but there are multiple recipes and the optimum is unknown. This situation creates difficulties during drug discovery and development research. Read More

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ANTIMALARIAL activities and alkaloids from Crinum jagus (Thomps) DANDY.

J Ethnopharmacol 2022 May 20:115359. Epub 2022 May 20.

Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, 220005 Osun State, Nigeria. Electronic address:

Ethnopharmacological Relevance: Locally, among the Yoruba speaking people of South Western, Nigeria, the bulb of Crinum jagus (CJ), known as "ogede odo" is used to treat malaria and as an anthelmintic among other uses.

Aims Of This Study: Study aimed at identifying the purified active fractions and constituents of this fraction in an antiplasmodial activity-guided process.

Materials And Methods: Antiplasmodial activity-guided fractionation of the bulb and leaf extracts of CJ was investigated against chloroquine-sensitive (NK 65) Plasmodium berghei using 4-day suppressive and prophylactic methods. Read More

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Association of reduced local activities in the default mode and sensorimotor networks with clinical characteristics in first-diagnosed of schizophrenia.

Neuroscience 2022 May 20. Epub 2022 May 20.

Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China. Electronic address:

The neurodevelopmental hypothesis states that schizophrenia is a brain disease. Exploring abnormal brain activities can improve understanding of the neural pathologic mechanism of clinical characteristics and determine subjective biomarkers to differentiate patients with schizophrenia from healthy controls. We collected clinical characteristics (i. Read More

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A redox-dependent thiol-switch and a Ca binding site within the hinge region hierarchically depend on each other in α7β1 integrin regulation.

Free Radic Biol Med 2022 May 20. Epub 2022 May 20.

University of Münster, Institute of Physiological Chemistry and Pathobiochemistry, Waldeyerstr. 15, 48149, Münster, Germany. Electronic address:

Integrin-mediated cell contacts with the extracellular matrix (ECM) are essential for cellular adhesion, force transmission, and migration. Several effectors, such as divalent cations and redox-active compounds, regulate ligand binding activities of integrins and influence their cellular functions. To study the role of the Ca binding site within the hinge region of the integrin α7 subunit, we genetically abrogated it in the α7hiΔCa mutant. Read More

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Chemical structure and nanomechanics relevant electrochemistry of solid-phase humic acid along a typical forest-river-paddy landscape section in eastern China and its environmental implications.

Sci Total Environ 2022 May 20:156147. Epub 2022 May 20.

College of Environment, Zhejiang University of Technology, Hangzhou 310014, China; Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, Hangzhou 310014, China. Electronic address:

Solid-phase humic acid (HA) plays a critical role in global carbon cycle and redox biogeochemistry of topsoil, because of its unique physicochemical properties, including electrochemical property. In this study, topsoil HA along a typical forest-river-paddy landscape section in eastern China was investigated in the aspects of electrochemical property, chemical structure and nanomechanics, and their relationship. Nano-size HA particles were extracted from topsoil of paddy soil (PS-HA), forest soil (FS-HA) and riverside sediment (RS-HA). Read More

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Reducing MCPA herbicide pollution at catchment scale using an agri-environmental scheme.

Sci Total Environ 2022 May 20:156080. Epub 2022 May 20.

Agri-Environment Branch, Agri-Food and Biosciences Institute, Belfast, UK.

In river catchments used as drinking water sources, high pesticide concentrations in abstracted waters require an expensive treatment step prior to supply. The acid herbicide 2-methyl-4-chlorophenoxyacetic acid (MCPA) is particularly problematic as it is highly mobile in the soil-water environment following application. Here, an agri-environmental scheme (AES) was introduced to a large-scale catchment (384 km) to potentially reduce the burden of pesticides in the water treatment process. Read More

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Toxic effects of fludioxonil on the growth, photosynthetic activity, oxidative stress, cell morphology, apoptosis, and metabolism of Chlorella vulgaris.

Sci Total Environ 2022 May 20:156069. Epub 2022 May 20.

College of Plant Protection, Shandong Agricultural University, Tai'an 271018, PR China. Electronic address:

Fludioxonil is widely used in the control of crop diseases because of its broad spectrum and high activity, but its presence is now common in waterways proximate to treated areas. This study examined the toxic effects and mechanisms of fludioxonil on the microalgal taxa Chlorella vulgaris. The results showed that fludioxonil limited the growth of C. Read More

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Carbon exchange characteristics and their environmental effects in the northern forest ecosystem of the Greater Khingan Mountains in China.

Sci Total Environ 2022 May 20:156056. Epub 2022 May 20.

Department of Forest Management, College of Forestry, Inner Mongolia Agricultural University, Hohhot 010019, China.

Measurement and analysis of CO concentration at the ecosystem scale is the basis for studying ecosystem feedback to global climate change, and it is particularly useful for understanding the processes and mechanisms of ecosystem C exchange. Through observation of CO concentration at different heights, this study examined whether a CO lake phenomenon exists in the Larix gmelinii ecosystem of the Greater Khingan Mountains (China), and how it might be changed and what might represent its driving factors if such a phenomenon were found to exist. Plants and soils were sampled regularly to determine δC and to quantify the proportion of C released by each component of the ecosystem. Read More

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Xanthones from the stems of Calophyllum membranaceum Gardn. et Champ. And their anti-inflammatory activity.

Phytochemistry 2022 May 20:113246. Epub 2022 May 20.

College of Pharmacy, Guilin Medical University, Guilin, 541004, People's Republic of China. Electronic address:

Eighteen undescribed xanthones, including six pairs of xanthone enantiomers, three xanthones, and three xanthone glycosides, together with one pair of known xanthone enantiomers and 12 known xanthones, were isolated from the stems of Calophyllum membranaceum Gardn. et Champ. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of the enantiomers was determined by using experimental and calculated electronic circular dichroism data. Read More

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Altered retinal structure and function in Spinocerebellar ataxia type 3.

Neurobiol Dis 2022 May 20:105774. Epub 2022 May 20.

Department of Neurology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by expansion of a polyglutamine (polyQ)-encoding CAG repeat in the ATXN3 gene. Because the ATXN3 protein regulates photoreceptor ciliogenesis and phagocytosis, we aimed to explore whether expanded polyQ ATXN3 impacts retinal function and integrity in SCA3 patients and transgenic mice. We evaluated the retinal structure and function in five patients with SCA3 and in a transgenic mouse model of this disease (YACMJD84. Read More

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Marine macroalgae in a circular economy context: A comprehensive analysis focused on residual biomass.

Biotechnol Adv 2022 May 20:107987. Epub 2022 May 20.

Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), Department of Metallurgical and Materials Engineering, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal; Associate Laboratory in Chemical Engineering (ALiCE), Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal. Electronic address:

The accumulation of Marine Macroalgal Waste (MMW) - drifted marine macroalgae - is a growing phenomenon. The lack of appropriate management protocols for this residual biomass leaves it mostly unmanaged or disposed of in landfills. Such inappropriate solutions lead to negative environmental impacts, health concerns and coastal degradation, representing an opportunity to develop the bioeconomy. Read More

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Comparison of Visual Motor Integration, Participation and Hand Skills in Children with and Without Type 1 Diabetes.

Percept Mot Skills 2022 May 23:315125221101008. Epub 2022 May 23.

Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey.

Our aim in this study was to compare hand skills, visual-motor integration ability, and participation in daily living activities of children with and without Type 1 diabetes (T1DM). In this prospective cross-sectional study, we included 44 children withT1DM (17 males, 27 females; aged 8-12 years) and a control group of 45 healthy age-matched children without T1DM (22 males, 23 females). We compared group scores on the Jebsen-Taylor Hand Function Test (JTHFT), the Beery-Buktenica Developmental Visual Motor Integration Test (Beery VMI), and on the Participation and Environment Measure - Children and Youth (PEM-CY). Read More

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Survey Results of Speech-Language Pathologists Working With Cognitive-Communication Disorders: Improving Practices for Mild Cognitive Impairment and Early-Stage Dementia From Alzheimer's Disease.

Am J Speech Lang Pathol 2022 May 23:1-19. Epub 2022 May 23.

Department of Communication Sciences & Disorders, University of Delaware, Newark.

Purpose: As the incidence of Alzheimer's disease (AD) continues to rise, there is a need for interventions that focus on risk reduction and early disease management. Speech-language pathologists (SLPs) can contribute to risk reduction efforts and deliver cognitive interventions; however, the nature and frequency of current clinical practice in those areas is unclear. Therefore, the purpose of this study was to conduct an exploratory survey of the cognitive-communication practices and needs of SLPs for adults with mild cognitive impairment (MCI) and early-stage dementia from AD, to inform future research and clinical training efforts. Read More

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Moxibustion plus Acupuncture for the Treatment of PostStroke Shoulder Pain: A Randomized Controlled Pilot Study.

Complement Med Res 2022 May 23. Epub 2022 May 23.

Background: In China, 45% of stroke patients suffer from poststroke shoulder pain, which brings about many obstacles to further rehabilitation. To date, there have been a few studies evaluating the effects of acupuncture or massage in treating poststroke shoulder pain, and good effects have been shown. However, better clinical treatments are still needed. Read More

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Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with l-phenylalanine or l-proline.

Bioorg Chem 2022 May 11;126:105865. Epub 2022 May 11.

State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China. Electronic address:

Extensive research effort has been put in pentacyclic triterpenoids due to their numerous biological activities. However, their poor water solubility and low oral bioavailability limit their antitumor effects in vivo. To address these issues, 37 triterpenoid acid derivatives linked to l-phenylalanine or l-proline were designed and synthesized in this study. Read More

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Quality of life and social vulnerability of older adults in the urban community: A cross-sectional study.

Geriatr Nurs 2022 May 19;46:46-51. Epub 2022 May 19.

Department of Nursing, University of Brasília (UnB), Brasília, DF, Brazil. Electronic address:

We aimed to investigate the association between social vulnerability and the quality of life of older adults. A cross-sectional study was conducted with 805 older adults. Quality of life was measured using the WHOQOL-BREF and WHOQOLOLD instruments. Read More

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Protective mechanism of selenium on mercuric chloride-induced testis injury in chicken via p38 MAPK/ATF2/iNOS signaling pathway.

Theriogenology 2022 May 14;187:188-194. Epub 2022 May 14.

College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province, 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province, 271018, China; Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province, 271018, China. Electronic address:

Mercuric chloride (HgCl) is a well-known toxic heavy metal contaminant, which causes male reproductive function defects. Selenium (Se) has been recognized as an effective antioxidant against heavy metals-induced male reproductive toxicity. The aim of present study was to explore the potentially protective mechanism of Se on HgCl-induced testis injury in chicken. Read More

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Di-(2-ethylhexyl) phthalate exacerbated the toxicity of polystyrene nanoplastics through histological damage and intestinal microbiota dysbiosis in freshwater Micropterus salmoides.

Water Res 2022 May 16;219:118608. Epub 2022 May 16.

College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; Institute of Eco-Environmental Research, Guangxi Academy of Sciences, Nanning, 530007, China; Southern Marine Science and Engineering Guangdong Laboratory, Zhuhai 528478, China. Electronic address:

Organic pollutants such as di-(2-ethylhexyl) phthalate (DEHP) interact with nanoplastics (NPs) and change their bioavailability and toxicity to aquatic organisms. This study aims to assess the ecotoxicological impacts of NPs in the presence and absence of DEHP on juvenile largemouth bass (LMB) Micropterus salmoides. Therefore, LMB was fed with diets containing various concentrations (0, 2, 10, and 40 mg/g) of polystyrene nanoplastics (PSNPs) by the weight of diets. Read More

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A multi-tracer approach to disentangle anthropogenic emissions from natural processes in the St. Lawrence River and Estuary.

Water Res 2022 May 14;219:118588. Epub 2022 May 14.

School of the Environment, Trent University, Peterborough, Canada.

The ability to differentiate anthropogenic signatures from natural processes in complex hydrological systems is critical for environmental regulation perspectives, especially to curb pollution and implement effective water management strategies. Here, we report variations in the concentrations of 57 chemical variables, including nutrients, major, trace and ultra-trace elements, as well as the concentrations of Escherichia coli in different water masses along the St. Lawrence River-Estuary continuum. Read More

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Selection and validation of reference genes for quantitative real-time PCR normalization in Psoralea corylifolia (Babchi) under various abiotic stress.

J Plant Physiol 2022 May 16;274:153722. Epub 2022 May 16.

College of Horticulture, Hunan Agricultural University, Changsha, 410128, China. Electronic address:

Psoralea corylifolia L. is a popular herb and has long been used in traditional Ayurvedic and Chinese medicine owing to its extensive pharmacological activities, especially in the treatment of various shin diseases. To date, the systematic evaluation and selection of the optimum reference genes for gene expression analysis of P. Read More

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Analysis of the reasons for the outbreak of Yellow Sea green tide in 2021 based on long-term multi-source data.

Mar Environ Res 2022 May 17;178:105649. Epub 2022 May 17.

Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai Shandong, 264003, PR China; University of Chinese Academy of Sciences, Beijing, 100049, China.

The green tide disaster is the result of human activities changing the natural environment conditions. What changes have occurred in the environmental factors that affect the green tide outbreak over a long period, and what is the impact of this change on the green tide outbreak? To further understand the outbreak mechanism of green tide, in this study, we used the Google Earth Engine (GEE) platform to extract and analyze the green tide from 2007 to 2021, analyze the long-term trend of various influencing factors (sea surface temperature (SST), sea surface salinity (SSS), photosynthetically available radiation (PAR), precipitation, eutrophication, "nori" aquaculture) in the past 30 years, and explore the impact of each factor on the outbreak of green tide. We found that: 1) SST, seawater eutrophication, and "nori" aquaculture worked together to promote the large-scale outbreak of green tide in 2007; 2) In the context of eutrophication is not effectively controlled, elevated SST, SSS, and PAR will be more conducive to the germination of green tide algae and promote green tide to form a floating state on the sea surface earlier, after that, once there is a year with abundant precipitation, the green tide will break out on a large scale, which is exactly the case in 2021. Read More

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Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities.

Eur J Med Chem 2022 May 18;238:114467. Epub 2022 May 18.

Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China; School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, Henan, 450001, China. Electronic address:

Novel coumarin-indole derivatives were designed, synthesized and evaluated as tubulin polymerization inhibitors targeting the colchicine binding site. Among these compounds, compound MY-413 displayed the most potent inhibitory activities against gastric cancer cell line MGC-803 with an IC value of 0.011 μM. Read More

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Design, synthesis, and in vitro protective effect evaluation of α-carboline derivatives against HO-induced cardiomyocyte injury.

Eur J Med Chem 2022 May 19;238:114469. Epub 2022 May 19.

Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Regenerative Medicine of Guizhou Province, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, 550004, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang, 550004, PR China; School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, 550025, PR China. Electronic address:

As one of the most important features of myocardial ischemia reperfusion (MI/R) injury, the overproduction of reactive oxygen species (ROS) overwhelms the intrinsic antioxidant and impairs the function of mitochondria and, finally, leads to cardiomyocyte death. To improve the damage of cardiomyocyte caused by oxidative stress, a series of α-carboline derivatives were designed and synthesized in this study. The biological studies revealed that most of the α-carbolines exhibited obvious protective activities against HO-induced cardiomyocyte injury. Read More

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