44,965 results match your criteria active components

Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models.

J Ethnopharmacol 2021 Jul 24:114453. Epub 2021 Jul 24.

Department of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Fritillariae thunbergii Bulbus (FT), knowns as "Jeolpaemo ()" in Korean traditional medicine, is a perennial plant belonging to the Liliaceae family and has been used to treat symptoms such as cough, sputum formation, and purulent pneumonia. Owing to its effects of lowering heat, removing sputum, and reducing swelling, the plant has also been used as an external prescription medicine to treat inflammation.

Aim Of The Study: To analyze the anti-inflammatory effects of FT-ethanol extract (FT-Et) and FT-chloroform fraction extract (FT-Cl) on 1-chloro-2,4-dinitrobenzene (DNCB)-induced atopic dermatitis (AD) in vivo and in vitro. Read More

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Can We Afford to Ignore the Biology of Joint Healing and Graft Incorporation After ACL Reconstruction?

Constance R Chu

J Orthop Res 2021 Jul 27. Epub 2021 Jul 27.

Department Orthopaedic Surgery, Stanford University, Stanford, CA.

Anterior cruciate ligament (ACL) reconstruction is successful at restoring stability to return ACL injured patients to high demand work, sports, and recreational activities. The development of post-traumatic osteoarthritis (OA) in roughly half of patients just 10-15 years after ACLR highlight the need to improve clinical care pathways. Graft failure and reinjury rates which further increase OA risk also remain high for younger and more active patients. Read More

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Recent progress on pristine two-dimensional metal-organic frameworks as active components in supercapacitors.

Dalton Trans 2021 Jul 27. Epub 2021 Jul 27.

Department of Materials Science and Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong, SAR 999077, P. R. China. and Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, Hong Kong, SAR 999077, P. R. China.

Two-dimensional (2D) metal-organic frameworks (MOFs) are a new generation of 2D materials that can provide uniform active sites and unique open channels as well as excellent catalytic abilities, interesting magnetic properties, and reasonable electrical conductivities. Thus, these MOFs are uniquely qualified for use in applications in energy-related fields or portable devices because they possess fast charge and discharge ability, high power density, and ultralong cycle life factors. There has been worldwide research interest in 2D conducting MOFs, and numerous techniques and strategies have been developed to synthesize these MOFs and their derivatives. Read More

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Crescents in primary glomerulonephritis: a pattern of injury with dissimilar actors. A pathophysiologic perspective.

Pediatr Nephrol 2021 Jul 27. Epub 2021 Jul 27.

Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74 (1280), Buenos Aires, Argentina.

Cellular crescents are defined as two or more layers of proliferating cells in Bowman's space and are a hallmark of inflammatory active glomerulonephritis and a histologic marker of severe glomerular injury. In general, the percentage of glomeruli that exhibit crescents correlates with the severity of kidney failure and other clinical manifestations of nephritic syndrome. In general, a predominance of active crescents is associated with rapidly progressive glomerulonephritis and a poor outcome. Read More

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Phytochemical analyses of UV active and inactive bioactive compounds present in Polianthes tuberosa (Linn.) flower.

J Sep Sci 2021 Jul 23. Epub 2021 Jul 23.

Department of Chemistry, Jawaharlal Nehru National College of Engineering, Visvesvarayya Technological University, Shivamogga, Karnataka, 577204, India.

Polianthes tuberosa (Linn.) is traditionally considered as an ornamental and medicinal plant worldwide. However, extensive studies on its phytochemical composition are very limited. Read More

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Cesium-Induced Active Sites for C-C Coupling and Ethanol Synthesis from CO Hydrogenation on Cu/ZnO(0001̅) Surfaces.

J Am Chem Soc 2021 Jul 23. Epub 2021 Jul 23.

Chemistry Division, Brookhaven National Laboratory, Upton, New York 11973, United States.

The efficient conversion of carbon dioxide, a major air pollutant, into ethanol or higher alcohols is a big challenge in heterogeneous catalysis, generating great interest in both basic scientific research and commercial applications. Here, we report the facilitated methanol synthesis and the enabled ethanol synthesis from carbon dioxide hydrogenation on a catalyst generated by codepositing Cs and Cu on a ZnO(0001̅) substrate. A combination of catalytic testing, X-ray photoelectron spectroscopy (XPS) measurements, and calculations based on density functional theory (DFT) and kinetic Monte Carlo (KMC) simulation was used. Read More

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Anthocyanin extract from Lycium ruthenicum enhanced production of biomass and polysaccharides during submerged fermentation of Agaricus bitorquis (Quél.) Sacc. Chaidam.

Bioprocess Biosyst Eng 2021 Jul 23. Epub 2021 Jul 23.

College of Agriculture and Animal Husbandry, Qinghai University, No.251 Ningda Road, Xining, 810016, Qinghai, China.

Agaricus bitorquis (Quél.) Sacc. Chaidam (ABSC) is a wild edible fungus uniquely found in the Tibet Plateau. Read More

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Development of a novel denture care agent with highly active enzyme, arazyme.

BMC Oral Health 2021 Jul 22;21(1):365. Epub 2021 Jul 22.

Industrial Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.

Background: The importance of efficient denture deposit removal and oral hygiene has been further underscored by the continuous increase of denture wearers. Denture hygiene management has also become an important aspect associated with denture-induced stomatitis. This study aims to evaluate the denture cleaning effect of arazyme, the metalloprotease produced from the Serratia proteamaculans HY-3. Read More

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A Novel Nanomedicine Ameliorates Acute Inflammatory Bowel Disease by Regulating Macrophages and T-Cells.

Mol Pharm 2021 Jul 26. Epub 2021 Jul 26.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P. R. China.

polysaccharide (RMP), one of the most important active components of , has been attracting increasing interest because of its potent bioactive properties, including anti-inflammatory, antitumor, and antidiabetic effects. Despite the great therapeutic potential of RMP, its inherent properties of low bioavailability and brief biological half-life have limited its applications to the clinic. Thus, RMP was packaged by poly(lactic--glycolic acid) (PLGA) nanoparticles to develop a novel anti-inflammatory nanomedicine (PLGA-RMP) in this study. Read More

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Sclerotium oryzae biocontrol in flooded rice fields with floating microcarrier technology: The effect of chitosan molecular weight.

Pest Manag Sci 2021 Jul 26. Epub 2021 Jul 26.

Grupo de Innovación en Ingeniería de Bioprocesos - Facultad de Bioquímica y Ciencias Biológicas (FBCB) - Universidad Nacional del Litoral (UNL), Ciudad Universitaria (Paraje El Pozo), Santa Fe, Argentina.

Background: Biocontrol strategies are of significant concern for their application in crops. Various green practices have been designed, but almost all of them had delivery constraints. Especially, to design biocontrol strategies against Sclerotium oryzae in flooded rice fields, the active agent should be retained on the plant leaves by spreading application, nevertheless, the direct application onto the water produces the biocontrol agent dilution. Read More

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[Pollution Characteristics and Source Apportionment of Atmospheric VOCs During Ozone Pollution Period in the Main Urban Area of Chongqing].

Huan Jing Ke Xue 2021 Aug;42(8):3595-3603

Key Laboratory for Urban Atmospheric Environment Integrated Observation & Pollution Prevention and Control of Chongqing, Chongqing Research Academy of Eco-Environmental Sciences, Chongqing 401147, China.

In late August 2020, a period of O pollution occurred in the main urban area of Chongqing and lasted for approximately 2 weeks (till early September). Ambient air samples, collected using Summa Canisters and DNPH sampling columns at three observation sites in the main urban area, were used to study the composition, photochemical reaction activity, and source apportionment of volatile organic compounds (VOCs) during the period of O pollution. The results showed that the mean volume fraction of TVOCs in the main urban area of Chongqing during the observation period was 45. Read More

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Green Synthesis of Gold Nano-bioconjugates from Onion Peel Extract and Evaluation of Their Antioxidant, Anti-inflammatory, and Cytotoxic Studies.

ACS Omega 2021 Jul 8;6(28):17811-17823. Epub 2021 Jul 8.

Material Nanochemistry Laboratory, Physical Sciences Division, Institute of Advanced Study in Science and Technology, Paschim Boragaon, Garchuk, Guwahati 781035, India.

Plant secondary metabolites such as flavonoids demonstrate high degrees of antioxidant, anti-inflammatory, and anticancer activities. Among flavonoids, quercetin plays an important role in inflammation by downregulating the level of various cytokines. Thereby, in this work, onion () peel was successfully utilized for the synthesis of gold nano-bioconjugates acting as a natural therapeutic drug. Read More

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Simultaneous Determination of 78 Compounds of Extract by Supercritical CO-Extraction and HPLC-ESI-MS/MS Spectrometry.

Biochem Res Int 2021 6;2021:9957490. Epub 2021 Jul 6.

N. I. Vavilov All-Russian Institute of Plant Genetic Resources, B. Morskaya 42-44, Saint-Petersburg 190000, Russia.

The plant L. of family was extracted using the supercritical CO-extraction method. Several experimental conditions were investigated in the pressure range of 200-500 bar, with the used volume of cosolvent ethanol in the amount of 1% in the liquid phase at a temperature in the range of 31-70°C. Read More

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Network Pharmacology-Based Mechanistic Investigation of Jinshui Huanxian Formula Acting on Idiopathic Pulmonary Fibrosis.

Evid Based Complement Alternat Med 2021 7;2021:8634705. Epub 2021 Jul 7.

Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China.

Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease with high incidence, morbidity, and mortality rates. Jinshui Huanxian formula (JHF) is an empirical formula that targets the pathogenesis of lung-kidney qi deficiency and phlegm-blood stasis in pulmonary fibrosis (PF). The purpose of this study was to explore JHF's potential pharmacological mechanisms in IPF therapy using network intersection analysis. Read More

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A Combined Network Pharmacology and Molecular Docking Approach to Investigate Candidate Active Components and Multitarget Mechanisms of Hemerocallis Flowers on Antidepressant Effect.

Evid Based Complement Alternat Med 2021 30;2021:7127129. Epub 2021 Jun 30.

School of Functional Food and Wine, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.

Objective: The purpose of our research is to systematically explore the multiple mechanisms of Flowers (HF) on depressive disorder (DD).

Methods: The components of HF were searched from the literature. The targets of components were obtained from PharmMapper. Read More

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The Potential Effect of on Polycystic Ovary Syndrome Based on Network Pharmacology and Molecular Docking.

Evid Based Complement Alternat Med 2021 8;2021:5577610. Epub 2021 Jul 8.

Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Background: (RC) showed a significant effect on PCOS, but its mechanism in PCOS remains unclear.

Methods: The components of RC were searched by TCMSP. The Smiles number of the active ingredients was queried through PubChem, and the predicted targets were obtained from the SwissTargetPrediction database. Read More

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Electrophysiological Proxy of Cognitive Reserve Index.

Front Hum Neurosci 2021 8;15:690856. Epub 2021 Jul 8.

Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven, Leuven, Belgium.

Cognitive reserve (CR) postulates that individual differences in task performance can be attributed to differences in the brain's ability to recruit additional networks or adopt alternative cognitive strategies. Variables that are descriptive of lifetime experience such as socioeconomic status, educational attainment, and leisure activity are common proxies of CR. CR is mostly studied using neuroimaging techniques such as functional MRI (fMRI) in which case individuals with a higher CR were observed to activate a smaller brain network compared to individuals with a lower CR, when performing a task equally effectively (higher efficiency), and electroencephalography (EEG) where a particular EEG component (P300) that reflects the attention and working memory load, has been targeted. Read More

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Co-treatment with Ginsenoside 20(S)-Rg3 and Curcumin increases Radiosensitivity of MDA-MB-231 Cancer Cell Line.

Iran J Med Sci 2021 Jul;46(4):291-297

Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Breast cancer is the second most common cancer in women worldwide. Developing drugs increase the radiosensitivity effect of tumoral tissue, while protecting normal tissues has gained much attention. Ginsenoside Rg3, one of the active components of ginseng, has been shown to possess various pharmacological effects and antiproliferation activity on cancer cell lines. Read More

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Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components.

Toxicol Lett 2021 Jul 22. Epub 2021 Jul 22.

Chair of Biological Chemistry, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address:

The phosphotriesterase of the bacterium Brevundimonas diminuta (BdPTE) is a naturally occurring biocatalyst suitable for the hydrolysis of organophosphate (OP) nerve agents as well as pesticides and offers a potential treatment of corresponding intoxications. While BdPTE mutants with improved catalytic efficiencies against several OPs have been described, unexpectedly, less efficient breakdown of an OP was observed upon application in an animal model compared with in vitro studies. Here, we describe detailed inhibition studies with the high-activity BdPTE mutant 10-2-C3(C59M/C227A) by human plasma components, indicating that this enzyme is inhibited by serum albumin. Read More

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Phytonanomaterials as therapeutic agents and drug delivery carriers.

Adv Drug Deliv Rev 2021 Jul 22:113868. Epub 2021 Jul 22.

Department of Neurosurgery, Yale University, New Haven, CT, 06510, US; Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, China. Electronic address:

Medicinal plants have been a major resource for drug discovery. Emerging evidence shows that in addition to pharmacologically active components, medicinal plants also contain phytochemical nanomaterials, or phytonanomaterials, which form nanoparticles for drug delivery. In this review, we examine the evidence supporting the existence of phytonanomaterials. Read More

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Integrating systematic pharmacology-based strategy and experimental validation to explore the synergistic pharmacological mechanisms of Guanxin V in treating ventricular remodeling.

Bioorg Chem 2021 Jul 18;115:105187. Epub 2021 Jul 18.

Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:

Background: Guanxin V (GXV) has been widely used to treat ventricular remodeling (VR) in clinical practice in China. However, the underlying mechanisms are currently still lack.

Methods: A systematic pharmacology-based strategy was utilized for predicting the synergistic pharmacological mechanisms of GXV in VR. Read More

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Timosaponin alleviates oxidative stress in rats with high fat diet-induced obesity via activating Nrf2/HO-1 and inhibiting the NF-κB pathway.

Eur J Pharmacol 2021 Jul 21:174377. Epub 2021 Jul 21.

Department of Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. Electronic address:

Anemarrhena asphodeloides originated from the rhizome of Liliaceae Anemarrhena asphodeloides. One of the active pharmacological components of Anemarrhena asphodeloides is timosaponin (TSA), which reduces blood lipids and shows antioxidation and anti-inflammatory effects, but its mechanism is unclear. The objective of this study was to investigate the effect of TSA on oxidative stress induced by a long-term high-fat diet in obese rats. Read More

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Physical activity behaviours in adolescence: current evidence and opportunities for intervention.

Lancet 2021 Jul 21. Epub 2021 Jul 21.

Population and Public Health Sciences, Pennington Biomedical Research Center, Baton Rouge, LA, USA.

Young people aged 10-24 years constitute 24% of the world's population; investing in their health could yield a triple benefit-eg, today, into adulthood, and for the next generation. However, in physical activity research, this life stage is poorly understood, with the evidence dominated by research in younger adolescents (aged 10-14 years), school settings, and high-income countries. Globally, 80% of adolescents are insufficiently active, and many adolescents engage in 2 h or more daily recreational screen time. Read More

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An integrated giant polyoxometalate complex for photothermally enhanced catalytic oxidation.

Sci Adv 2021 Jul 23;7(30). Epub 2021 Jul 23.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China.

A strategy integrating near infrared (NIR) photothermal and catalytic effects within one active center beyond ultraviolet and visible light is proposed without the combination of separated photothermal transformation components. A giant polyoxomolybdate, which has high NIR photothermal conversion efficiency, is selected as the model catalyst, while a cationic β-cyclodextrin is used to cover its negatively charged surface electrostatically. Under NIR light radiation, the designed catalyst increases catalytic activity of cyclohexene oxidation under O atmosphere in water. Read More

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Mixed Cation Halide Perovskite under Environmental and Physical Stress.

Materials (Basel) 2021 Jul 15;14(14). Epub 2021 Jul 15.

C.H.O.S.E. (Centre for Hybrid and Organic Solar Energy), Department of Electronic Engineering, University of Rome Tor Vergata, 00133 Rome, Italy.

Despite the ideal performance demonstrated by mixed perovskite materials when used as active layers in photovoltaic devices, the factor which still hampers their use in real life remains the poor stability of their physico-chemical and functional properties when submitted to prolonged permanence in atmosphere, exposure to light and/or to moderately high temperature. We used high resolution photoelectron spectroscopy to compare the chemical state of triple cation, double halide Csx(FA0.83MA0. Read More

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An Integrated Compensation Method for the Force Disturbance of a Six-Axis Force Sensor in Complex Manufacturing Scenarios.

Sensors (Basel) 2021 Jul 9;21(14). Epub 2021 Jul 9.

School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

As one of the key components for active compliance control and human-robot collaboration, a six-axis force sensor is often used for a robot to obtain contact forces. However, a significant problem is the distortion between the contact forces and the data conveyed by the six-axis force sensor because of its zero drift, system error, and gravity of robot end-effector. To eliminate the above disturbances, an integrated compensation method is proposed, which uses a deep learning network and the least squares method to realize the zero-point prediction and tool load identification, respectively. Read More

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Do Age-Friendly Rural Communities Affect Quality of Life? A Comparison of Perceptions from Middle-Aged and Older Adults in China.

Int J Environ Res Public Health 2021 Jul 7;18(14). Epub 2021 Jul 7.

Suzhou University, Suzhou 234000, China.

The aging population in rural areas of China faces serious challenges due to urban-rural disparities. In order to improve the active aging of rural older adults, the establishment of age-friendly communities is encouraged. However, globally, the focus is on age-friendly communities in urban areas, not reflecting rural communities. Read More

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Golfers' Interest in Multilevel Sun-Protection Strategies.

Int J Environ Res Public Health 2021 Jul 7;18(14). Epub 2021 Jul 7.

Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA.

Active adults accumulate more ultraviolet (UV) radiation exposure and are at greater risk of skin cancer than inactive adults. Golf is a popular sport that increases UV exposure because it is played outdoors in daylight. This study evaluated adult golfers' interest in multilevel sun-protection strategies and characterized differences in interest as a function of golfer characteristics. Read More

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Validated Simultaneous Gradient Ultra-Performance Liquid Chromatographic Quantification of Some Proton Pump Inhibitor Drug Residues in Saudi Pharmaceutical Industrial Wastewater.

Molecules 2021 Jul 19;26(14). Epub 2021 Jul 19.

Pharmaceutical Chemistry Department, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.

Monitoring and quantification of active pharmaceutical ingredients (APIs) in the environment constitute important and challenging tasks, as they are directly associated with human health. Three commonly used proton pump inhibitors (PPIs), namely, omeprazole sodium (OMP), pantoprazole sodium (PNT), and lansoprazole sodium (LNZ) are well separated and quantified using ultra-performance liquid chromatography (UPLC) in pharmaceutical industrial wastewater. The separation of the studied drugs was performed on a stationary phase with a Waters column (100 × 2. Read More

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Hydroxyapatite Obtained via the Wet Precipitation Method and PVP/PVA Matrix as Components of Polymer-Ceramic Composites for Biomedical Applications.

Molecules 2021 Jul 14;26(14). Epub 2021 Jul 14.

Department of Materials Science, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawła II Av., 31-864 Krakow, Poland.

The aspect of drug delivery is significant in many biomedical subareas including tissue engineering. Many studies are being performed to develop composites with application potential for bone tissue regeneration which at the same provide adequate conditions for osteointegration and deliver the active substance conducive to the healing process. Hydroxyapatite shows a great potential in this field due to its osteoinductive and osteoconductive properties. Read More

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