2 results match your criteria activation mlav

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Impact of Měnglà Virus Proteins on Human and Bat Innate Immune Pathways.

J Virol 2020 06 16;94(13). Epub 2020 Jun 16.

Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA

Měnglà virus (MLAV), identified in bats, is a phylogenetically distinct member of the family Because the filoviruses Ebola virus (EBOV) and Marburg virus (MARV) modulate host innate immunity, MLAV VP35, VP40, and VP24 proteins were compared with their EBOV and MARV homologs for innate immune pathway modulation. In human and cells, MLAV VP35 behaved like EBOV and MARV VP35s, inhibiting virus-induced activation of the interferon beta (IFN-β) promoter and interferon regulatory factor 3 (IRF3) phosphorylation. MLAV VP35 also interacted with PACT, a host protein engaged by EBOV VP35 to inhibit RIG-I signaling. Read More

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Effects of insulin, dexamethasone and phorbol ester on virus production in cultivated DBA/2 mouse leukemia (MLA) cells.

Acta Virol 1983 Nov;27(6):457-62

The in vitro production of intracytoplasmic oncovirus A-particles and of atypical mammary tumor virus (MLAV) from a line of DBA/2 mouse leukemia (MLA) cells were compared in the presence of insulin, dexamethasone and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), which are known to stimulate the synthesis of mouse mammary tumor virus. High amounts of A-particles were recovered from cells cultivated in the presence of dexamethasone (1 microgram/ml) as compared to untreated controls; in contrast, the production of MLAV was suppressed. Insulin and TPA did not show any significant effects. Read More

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November 1983
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