117,129 results match your criteria activation enhanced


The effect of amisulpride, olanzapine, quetiapine, and aripiprazole single administration on c-Fos expression in vasopressinergic and oxytocinergic neurons of the rat hypothalamic paraventricular nucleus.

Neuropeptides 2021 Apr 14;87:102148. Epub 2021 Apr 14.

Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska Cesta 9, 84505 Bratislava, Slovakia.

Antipsychotics, including amisulpride (AMI), quetiapine (QUE), aripiprazole (ARI), and olanzapine (OLA), are used to treat mental illnesses associated with psychotic symptoms. The effect of these drugs on c-Fos expression in vasopressinergic (AVP) and oxytocinergic (OXY) neurons was studied in the hypothalamic paraventricular nucleus (PVN) of rats. The presence of c-Fos in AVP and OXY perikarya was investigated in seven PVN cells segregations: the anterior (Ant), dorsal cup (Dc), wing-shaped (Wi), periventricular zone (Pe), circle-shaped core (Co) and shell of core (Sh), and the posterior (pPVN) after an acute treatment with AMI-20 mg/kg, QUE-15 mg/kg, ARI-10 mg/kg, and OLA-5 mg/kg/bw in rats. Read More

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Protective effects of glutamine against soy saponins-induced enteritis, tight junction disruption, oxidative damage and autophagy in the intestine of Scophthalmus maximus L.

Fish Shellfish Immunol 2021 Apr 19. Epub 2021 Apr 19.

Marine College, Shandong University, Weihai, Shandong, 264209, China. Electronic address:

Soy saponins, as thermo-stable anti-nutrients in soybean meal (SBM), are the primary causal agents of SBM-induced enteritis, which represents a well-documented pathologic alternation involving the distal intestines of various farmed fish. Our previous work showed that soy saponins might lead to SBM-induced enteritis, destroy tight junction structure and induce oxidative damage in juvenile turbot. Glutamine, as a conditionally essential amino acid, is an important substrate utilized for the growth of intestinal epithelial cells. Read More

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A comprehensive review on time-tested anticancer drug doxorubicin.

Life Sci 2021 Apr 19:119527. Epub 2021 Apr 19.

Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, 603 203 Chengalpattu District, Tamil Nadu, India. Electronic address:

Doxorubicin or Adriamycin, is one of the most widely used chemotherapeutic drug for treating a myriad of cancers. It induces cell death through multiple intracellular targets: reactive oxygen species generation, DNA-adduct formation, topoisomerase II inhibition, histone eviction, Ca and iron hemostasis regulation, and ceramide overproduction. Moreover, doxorubicin-treated dying cells undergo cellular modifications that enable neighboring dendritic cell activation and enhanced presentation of tumor antigen. Read More

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The thrombin receptor modulates astroglia-neuron trophic coupling and neural repair after spinal cord injury.

Glia 2021 Apr 22. Epub 2021 Apr 22.

Department of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Rochester, Minnesota, USA.

Excessive activation of the thrombin receptor, protease activated receptor 1 (PAR1) is implicated in diverse neuropathologies from neurodegenerative conditions to neurotrauma. PAR1 knockout mice show improved outcomes after experimental spinal cord injury (SCI), however information regarding the underpinning cellular and molecular mechanisms is lacking. Here we demonstrate that genetic blockade of PAR1 in female mice results in improvements in sensorimotor co-ordination after thoracic spinal cord lateral compression injury. Read More

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PcG Proteins MSI1 and BMI1 Function Upstream of miR156 to Regulate Aerial Tuber Formation in Potato1[OPEN].

Plant Physiol 2020 Jan;182(1):185-203

Biology Division, Indian Institute of Science Education and Research, Pune 411008, Maharashtra, India.

Polycomb Repressive Complexes (PRC1 and PRC2) regulate developmental transitions in plants. AtBMI1, a PRC1 member, represses micro RNA156 (miR156) to trigger the onset of adult phase in Arabidopsis (Arabidopsis thaliana). miR156 overexpression (OE) reduces below-ground tuber yield, but stimulates aerial tubers in potato (Solanum tuberosum ssp andigena) under short-day (SD) photoperiodic conditions. Read More

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January 2020

Enhanced Antitumor Immune Responses via a Self-Assembled Carrier-Free Nanovaccine.

Nano Lett 2021 Apr 22. Epub 2021 Apr 22.

The Tianjin Key Laboratory of Biomaterials, Institute of Biomedical Engineering, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin 300192, China.

Nanovaccines have emerged as promising agents for cancer immunotherapy. However, insufficient antitumor immunity caused by inefficient antigen/adjuvant loading and complicated preparation processes are the major obstacles that limit their clinical application. Herein, two adjuvants, monophosphatidyl A (MPLA) and CpG ODN, with antigens were designed into a nanovaccine to overcome the above obstacles. Read More

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Pr-Doping Motivating the Phase Transformation of the BaFeO- Perovskite as a High-Performance Solid Oxide Fuel Cell Cathode.

ACS Appl Mater Interfaces 2021 Apr 22. Epub 2021 Apr 22.

Beijing Key Laboratory for Chemical Power Source and Green Catalysis, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China.

Intermediate temperature solid oxide fuel cells (IT-SOFCs) have been extensively studied due to high efficiency, cleanliness, and fuel flexibility. To develop highly active and stable IT-SOFCs for the practical application, preparing an efficient cathode is necessary to address the challenges such as poor catalytic activity and CO poisoning. Herein, an efficient optimized strategy for designing a high-performance cathode is demonstrated. Read More

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Oxiracetam Mediates Neuroprotection Through the Regulation of Microglia Under Hypoxia-Ischemia Neonatal Brain Injury in Mice.

Mol Neurobiol 2021 Apr 22. Epub 2021 Apr 22.

Department of Histology and Embryology, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, 44# Wenhua Xi Road, Jinan, 250012, Shandong, People's Republic of China.

In neonatal hypoxic-ischemic brain damage (HIBD), in addition to damage caused by hypoxia and ischemia, over-activation of inflammation leads to further deterioration of the condition, thus greatly shortening the optimal treatment time window. Ischemic penumbra, the edematous area encompassing the infarct core, is characterized by typical activation of microglia and overt inflammation, and prone to incorporate into the infarct core gradually after ischemia onset. If treated in time, the cells located in the penumbra can survive, thereby impeding the expansion of the infarction. Read More

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Mask-Guided Convolutional Neural Network for Breast Tumor Prognostic Outcome Prediction on 3D DCE-MR Images.

J Digit Imaging 2021 Apr 22. Epub 2021 Apr 22.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

In this proof-of-concept work, we have developed a 3D-CNN architecture that is guided by the tumor mask for classifying several patient-outcomes in breast cancer from the respective 3D dynamic contrast-enhanced MRI (DCE-MRI) images. The tumor masks on DCE-MRI images were generated using pre- and post-contrast images and validated by experienced radiologists. We show that our proposed mask-guided classification has a higher accuracy than that from either the full image without tumor masks (including background) or the masked voxels only. Read More

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Ouabain-induced activation of phospholipase C zeta and its contributions to bovine sperm capacitation.

Cell Tissue Res 2021 Apr 22. Epub 2021 Apr 22.

Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, CAL, T2N 4N1, Canada.

The sperm-derived oocyte activating factor, phospholipase C zeta (PLC ζ), is the only PLC isoform reported in cattle. The objectives were to (1) localize PLC ζ in fresh and capacitated bovine sperm and (2) investigate the activation of PLC ζ during bull sperm capacitation and contributions of PLC activity to this process. We confirmed interaction of testis-specific isoform of Na/K-ATPase (ATP1A4) with PLC ζ (immunolocalization and immunoprecipitation) and tyrosine phosphorylation (immunoprecipitation) of PLC ζ (a post-translational protein modification commonly involved in activation of PLC in somatic cells) during capacitation. Read More

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Uniform decoration of UiO-66-NH nanooctahedra on TiO electrospun nanofibers for enhancing photocatalytic H production based on multi-step interfacial charge transfer.

Dalton Trans 2021 Apr 22. Epub 2021 Apr 22.

Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission, Key Laboratory of Photosensitive Materials and Devices of Liaoning Province, School of Physics and Materials Engineering, Dalian Nationalities University, 18 Liaohe West Road, Dalian 116600, P. R. China..

Metal-organic framework (MOF) materials have been extensively incorporated with inorganic semiconductor photocatalysts to improve their photocatalytic activity through an efficient charge transfer process across their heterointerface. In this work, octahedral UiO-66-NH2 MOFs with edge-lengths of 110-330 nm are uniformly decorated on the surface of TiO2 electrospun nanofibers by a traditional solvothermal method combined with activation pretreatment. Before the solvothermal growth of UiO-66-NH2, the TiO2 electrospun nanofibers were activated in NaOH solution to etch the TiO2 surface for allowing the exposure of lattice oxygen. Read More

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Neuroendocrine responses to a psychosocial stress test for larger groups of participants: comparison of two test exposures.

Endocr Regul 2020 Nov 24;54(4):255-259. Epub 2020 Nov 24.

Institute of Experimental Endocrinology of the Biomedical Research Center, Slovak Academy of Science,Bratislava, Slovakia.

Individual stress tests characterized by social evaluative threat and uncontrollability are known to elicit strong neuroendocrine responses. We tested whether a psychosocial stressor submitted to a larger group of participants (up to 60) may elicit comparable stress responses. A total of 59 adult subjects (33 women, 26 men) participated in the study, whereas 24 of them suffered from allergy and 35 were healthy. Read More

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November 2020

LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies.

Neoplasma 2021 Apr 23. Epub 2021 Apr 23.

Department of Pathology, Guangyuan Central Hospital, Guangyuan, Sichuan, China.

Gastric cancer is a common malignancy in the alimentary system. The laminin subunit gamma 1 (LAMC1) is an important oncogene in human cancers. However, how and whether LAMC1 takes part in gastric cancer progression is largely uncertain. Read More

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One's Interoception Affects the Representation of Seeing Others' Pain: A Randomized Controlled qEEG Study.

Pain Res Manag 2021 3;2021:5585060. Epub 2021 Apr 3.

International Research Center for Cognitive Applied Neuroscience (IrcCAN), Catholic University of the Sacred Heart, Milan, Italy.

Objective: This research demonstrates that interoceptive attentiveness (IA) can modulate cortical oscillations related to the emotional and cognitive representations of observing pain in others.

Methods: Twenty participants were required to observe painful/nonpainful stimuli in an individual versus the interactive condition during the recording of the electroencephalogram. The sample was divided into experimental (EXP) and control (CTR) groups, and the EXP group was explicitly required to direct the attention on its interoceptive correlates while observing the stimuli. Read More

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IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.

Exp Ther Med 2021 Jun 8;21(6):593. Epub 2021 Apr 8.

Department of Emergency Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.

Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is a secreted protein that can bind to IGF2 and has been reported to promote inflammation. The data from the ENCORI database have predicted that IGF2BP2 can bind caspase 4, which mediates pyroptosis and promotes airway inflammation and lipopolysaccharide (LPS)-induced lung injury. The present study investigated whether IGF2BP2 can regulate LPS-induced lung cell inflammation by targeting caspase 4. Read More

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Actin-Like Protein 8 Promotes the Progression of Triple-Negative Breast Cancer via Activating PI3K/AKT/mTOR Pathway.

Onco Targets Ther 2021 12;14:2463-2473. Epub 2021 Apr 12.

Breast and Thyroid Surgery, Dongying People's Hospital, Dongying, Shandong, 257091, People's Republic of China.

Objective: The purpose of this study was to investigate the function of actin-like protein 8 (ACTL8) on triple-negative breast cancer (TNBC) and its potential mechanisms.

Methods: In our study, ACTL8 expression and the prognostic values of ACTL8 were evaluated via the dataset from the Cancer Genome Atlas (TCGA). At the same time, the expression of ACTL8 in TNBC cells was measured by Western blot and qRT-PCR. Read More

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Cyclooxygenase-2 Inhibitor Parecoxib Was Disclosed as a PPAR-γ Agonist by and Assay.

Biomol Ther (Seoul) 2021 Apr 22. Epub 2021 Apr 22.

College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.

In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib to the ligand-binding domain of PPAR-γ showed high binding affinity and relevant binding conformation compared with the PPAR-γ ligand/antidiabetic drug rosiglitazone. Per the docking result, parecoxib showed the best PPAR-γ transactivation in Ac2F rat liver cells. Read More

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Antibody-Dependent Enhancement and the Critical Pattern of COVID-19: Possibilities and Considerations.

Med Princ Pract 2021 Apr 21. Epub 2021 Apr 21.

Coronavirus disease 2019 (COVID-19), a pandemic infection with profound effects on human society, has been emerged recently and rigorously challenged our ability to control viral infections. Although at the beginning of the COVID-19 outbreak, the epidemic seems controllable in Southern Iran, the disease presents a critical pattern as of May 2020. After a few months of COVID-19 emergence, in a twisted turn of events, the severity and mortality of COVID-19 increased dramatically. Read More

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Enhanced organics degradation by three-dimensional (3D) electrochemical activation of persulfate using sulfur-doped carbon particle electrode: The role of thiophene sulfur functional group and specific capacitance.

J Hazard Mater 2021 Apr 6;416:125810. Epub 2021 Apr 6.

State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:

For further enhancing the electrochemical oxidation performance, sulfur-doped carbon particle electrode was employed in the three-dimensional (3D) electro-assisted activation of persulfate process (ACS/PS/EC). Herein, an in situ S-doped activated carbon (ACS) was prepared and applied as the particle electrode as well as catalyst in ACS/PS/EC system. Several carbon particle electrodes with different annealing temperature were prepared and characterized via EA, BET, XPS and Raman spectra. Read More

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Iron enhances the binding rates and translational efficiency of iron responsive elements (IREs) mRNA with initiation factor eIF4F.

PLoS One 2021 21;16(4):e0250374. Epub 2021 Apr 21.

Department of Sciences, John Jay College of Criminal Justice, The City University of New York, New York, NY, United States of America.

Interaction of iron responsive elements (IRE) mRNA with the translational machinery is an early step critical in the initiation of protein synthesis. To investigate the binding specificity of IRE mRNA for eIF4F, kinetic rates for the eIF4F·IRE RNA interactions were determined and correlated with the translational efficiency. The observed rate of eIF4F·FRT IRE RNA interactions was 2-fold greater as compared to eIF4F·ACO2 IRE RNA binding. Read More

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Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers.

Am J Physiol Cell Physiol 2021 Apr 21. Epub 2021 Apr 21.

Division of Bioengineering, Graduate School of Engineering Science, Osaka University, Japan.

Cells adapt to applied cyclic stretch (CS) to circumvent chronic activation of proinflammatory signaling. Currently, the molecular mechanism of the selective disassembly of actin stress fibers (SFs) in the stretch direction, which occurs at the early stage of the cellular response to CS, remains controversial. Here we suggest that the mechanosensitive behavior of myosin II, a major cross-linker of SFs, primarily contributes to the directional disassembly of the actomyosin complex SFs in bovine vascular smooth muscle cells and human U2OS osteosarcoma cells. Read More

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How the Morphology of NiO-Decorated CeO Nanostructures Affects Catalytic Properties in CO Methanation.

Langmuir 2021 Apr 21. Epub 2021 Apr 21.

Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Effects of morphology and exposed crystal planes of NiO-decorated CeO (NiCeO) nanostructured catalysts on activity during CO methanation were examined, using nanorod (NR), nanocube (NC), and nanooctahedron (NO) structures. The NiCeO nanorods (NiCeO-NR) showed superior activity to NiCeO-NC and NiCeO-NO along with excellent selectivity for CH. This material also demonstrated exceptional durability, with no significant loss of catalytic activity or structural change after use. Read More

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Hormesis-Inducing Essential Oil Nanodelivery System Protects Plants against Broad Host-Range Necrotrophs.

ACS Nano 2021 Apr 21. Epub 2021 Apr 21.

Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, Indiana 47907, United States.

, a broad host-range necrotrophic (BHN) phytopathogen, establishes compatible interactions with hosts by deploying multigene infection strategies, rendering simply inherited resistance ineffective to fight off this pathogen. Since essential oils (EOs) serve as intermediators during phytobiome communication, we hypothesize that they have the potential to enhance the quantitative disease resistance against BHN by eliciting the adaptive stress response (hormesis) in plants. However, using EOs is challenging due to their poor solubility in water. Read More

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Assessment of arrhythmia mechanism and burden of the infarcted ventricles following remuscularization with pluripotent stem cell-derived cardiomyocyte patches using patient-derived models.

Cardiovasc Res 2021 Apr 21. Epub 2021 Apr 21.

Department of Biomedical Engineering, Johns Hopkins University, 3400 N Charles Street, 208 Hackerman, Baltimore, MD, 21218, USA.

Aims: Direct remuscularization with pluripotent stem cell-derived cardiomyocytes (PSC-CMs) seeks to address the onset of heart failure post-myocardial infarction (MI) by treating the persistent muscle deficiency that underlies it. However, direct remuscularization with PSC-CMs could potentially be arrhythmogenic. We investigated two possible mechanisms of arrhythmogenesis-focal vs reentrant-arising from direct remuscularization with PSC-CM patches in two personalized, human ventricular computer models of post-MI. Read More

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Wogonoside attenuates the articular cartilage injury and the infiltration of Th1/Th2-type cytokines in papain-induced osteoarthritis in rat model via inhibiting the NF-κB and ERK1/2 activation.

Immunopharmacol Immunotoxicol 2021 Apr 21:1-10. Epub 2021 Apr 21.

Department of Rheumatology, The Affiliated Huai'an NO.1 People's Hospital of Nanjing Medical University, Huai'an, China.

Objects: Osteoarthritis is the most common joint disease and a major cause of functional limitation and pain in adults. This study aims to investigate the effect of wogonoside (WOG) on the progression of knee osteoarthritis (KOA) in model rats.

Materials And Methods: Rats KOA models were established and treated with different doses of WOG (10 mg/kg, 20 mg/kg and 30 mg/kg). Read More

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A multidrug resistance-associated protein inhibitor is a potential enhancer of the benzyl isothiocyanate-induced apoptosis induction in human colorectal cancer cells.

J Biochem Mol Toxicol 2021 Apr 21:e22791. Epub 2021 Apr 21.

Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan.

The increasing drug efflux through the ATP-binding cassette (ABC) transporters is the most plausible mechanism that mediates resistance to the anticancer phytochemicals, such as benzyl isothiocyanate (BITC), as well as chemotherapy drugs. To identify a potential component to overcome this resistance by combinatory utilization, we focused on multidrug resistance-associated proteins (MRPs) pumping various drug metabolites with glutathione as well as the organic anions. The pharmacological treatment of an MRP inhibitor, MK571, significantly potentiated the BITC-induced antiproliferation, coincided with the enhanced accumulation of BITC and glutathione in human colorectal cancer HCT-116 cells. Read More

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Long non‑coding RNA BANCR promotes proliferation, invasion and migration in esophageal squamous cell carcinoma cells via the Raf/MEK/ERK signaling pathway.

Mol Med Rep 2021 Jun 21;23(6). Epub 2021 Apr 21.

Department of Gastroenterology and Hepatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.

Esophageal squamous cell carcinoma (ESCC) is a major histological type of esophageal cancer, identified as a leading cause of tumor‑associated death worldwide. In addition, long non‑coding RNA (lncRNA) BRAF‑activated non‑coding RNA (BANCR) expression is increased in the plasma of patients with ESCC, which can be reversed by tumor resection. Thus, the aim of the present study was to investigate the underlying mechanism of BANCR in ESCC progression. Read More

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CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation.

Cell Death Differ 2021 Apr 20. Epub 2021 Apr 20.

Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Chemokines are important regulators of the immune system, inducing specific cellular responses by binding to receptors on immune cells. In SLE patients, decreased expression of CCL2 on mesenchymal stem cells (MSC) prevents inhibition of B-cell proliferation, causing the characteristic autoimmune phenotype. Nevertheless, the intrinsic role of CCL2 on B-cell autoimmunity is unknown. Read More

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Dimer Asymmetry and Light Activation Mechanism in Blue-Light Sensor Histidine Kinase.

mBio 2021 Apr 20;12(2). Epub 2021 Apr 20.

Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina

The ability to sense and respond to environmental cues is essential for adaptation and survival in living organisms. In bacteria, this process is accomplished by multidomain sensor histidine kinases that undergo autophosphorylation in response to specific stimuli, thereby triggering downstream signaling cascades. However, the molecular mechanism of allosteric activation is not fully understood in these important sensor proteins. Read More

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J Pharmacol Exp Ther 2021 Apr 20. Epub 2021 Apr 20.

Department of Medicine/ Rheumatology, Medical University of South Carolina, United States.

Aging is a progressive, multifactorial degenerative process in which deleterious changes occur in the biochemistry and function of organs. We showed that angiotensin II (AngII)-induced pathologies in the heart and kidney of young, 3-month-old mice are suppressed by the caveolin-1 scaffolding domain (CSD) peptide. Because AngII mediates many aging-associated changes, we explored whether CSD could reverse preexisting pathologies and improve organ function in aged mice. Read More

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