Free Radic Biol Med 2021 Sep 22. Epub 2021 Sep 22.
Institute of Geriatrics, Affiliated People's Hospital of Nanchang University, Nanchang, Jiangxi, 330006, PR China; Department of Neurology, Affiliated People's Hospital of Nanchang University, Nanchang, Jiangxi, 330006, PR China. Electronic address:
Corneal alkali burn, as one of the most serious ophthalmic emergencies, is difficult to be cured by conservative treatments. It is well known that oxidative stress, inflammation, and neovascularization are the main causes of corneal damage after alkali burn, but its underlying mechanism remains to be elucidated. Here, we reported that the expression and phosphorylation (Ser616) of mitochondrial fission protein Drp1 were up-regulated at day 3 after alkali burn, while mitochondrial fusion protein Mfn2 was down-regulated. Read More