Bioorg Med Chem Lett 2020 12 29;30(24):127651. Epub 2020 Oct 29.
GenoFocus Inc., 65 Techno 1-ro, Gwanpyeong-dong, Yuseong-gu, Daejeon 34014, Republic of Korea; Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 111 Gwahangno, Yuseong, Daejeon 34141, Republic of Korea. Electronic address:
Xanthorrhizol, isolated from the Indonesian Java turmeric Curcuma xanthorrhiza, displays broad-spectrum antibacterial activity. We report herein the evidence that mechanism of action of xanthorrhizol may involve FabI, an enoyl-(ACP) reductase, inhibition. The predicted Y156V substitution in the FabI enzyme promoted xanthorrhizol resistance, while the G93V mutation originally known for triclosan resistance was not effective against xanthorrhizol. Read More