4,282 results match your criteria acquisition theoretical

Computational Traditional Chinese Medicine diagnosis: A literature survey.

Comput Biol Med 2021 Mar 28;133:104358. Epub 2021 Mar 28.

The PAMI Research Group, Department of Computer and Information Science, Faculty of Science and Technology, University of Macau, Macau SAR, People's Republic of China. Electronic address:

Background And Objective: Traditional Chinese Medicine (TCM) diagnosis is based on the theoretical principles and knowledge, where it is steeped in thousands of years of history to diagnose various types of diseases and syndromes. It can be generally divided into four main diagnostic approaches: 1. Inspection, 2. Read More

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An Evaluation of Alcohol Sensitivity in the Context of the Acquired Preparedness Model.

Addict Res Theory 2020 23;28(4):335-344. Epub 2019 Aug 23.

Department of Psychology, University of Toronto, Toronto, Canada.

Background: The acquired preparedness model (APM) posits that relationships between impulsivity-related traits and alcohol use are partly mediated by the biased acquisition of positive alcohol expectancies. Additionally, alcohol administration studies implicate associations between impulsivity-related traits and sensitivity to acute alcohol effects, suggesting that impulsivity-expectancy associations could be partly explained by individual differences in alcohol response. The present study assessed a theoretical extension of the APM by testing the prediction that self-reported sensitivity to alcohol would partly mediate impulsivity-expectancy relationships, and that the addition of alcohol sensitivity variables would account for increased variance in drinking quantity and problems relative to the traditional APM. Read More

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The role of activity, scan duration and patient's body mass index in the optimization of FDG imaging protocols on a TOF-PET/CT scanner.

EJNMMI Phys 2021 Apr 6;8(1):35. Epub 2021 Apr 6.

Radiology Department, Azienda Ospedaliero-Universitaria Maggiore della Carità, C.so Mazzini 18, 28100, Novara, Italy.

Background: Time-of-flight (TOF) PET technology determines a reduction in the noise and improves the reconstructed image quality in low count acquisitions, such as in overweight patients, allowing a reduction of administered activity and/or imaging time. However, international guidelines and recommendations on the F-fluoro-2-deoxyglucose (FDG) activity administration scheme are old or only partially account for TOF technology and advanced reconstruction modalities. The aim of this study was to optimize FDG whole-body studies on a TOF-PET/CT scanner by using a multivariate approach to quantify how physical figures of merit related to image quality change with acquisition/reconstruction/patient-dependent parameters in a phantom experiment. Read More

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Infants' neural speech discrimination predicts individual differences in grammar ability at 6 years of age and their risk of developing speech-language disorders.

Dev Cogn Neurosci 2021 Mar 31;48:100949. Epub 2021 Mar 31.

Department of Otolaryngology and Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.

The 'sensitive period' for phonetic learning posits that between 6 and 12 months of age, infants' discrimination of native and nonnative speech sounds diverge. Individual differences in this dynamic processing of speech have been shown to predict later language acquisition up to 30 months of age, using parental surveys. Yet, it is unclear whether infant speech discrimination could predict longer-term language outcome and risk for developmental speech-language disorders, which affect up to 16 % of the population. Read More

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Untargeted In Silico Compound Classification-A Novel Metabolomics Method to Assess the Chemodiversity in Bryophytes.

Int J Mol Sci 2021 Mar 23;22(6). Epub 2021 Mar 23.

Bioinformatics & Scientific Data, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany.

In plant ecology, biochemical analyses of bryophytes and vascular plants are often conducted on dried herbarium specimen as species typically grow in distant and inaccessible locations. Here, we present an automated in silico compound classification framework to annotate metabolites using an untargeted data independent acquisition (DIA)-LC/MS-QToF-sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH) ecometabolomics analytical method. We perform a comparative investigation of the chemical diversity at the global level and the composition of metabolite families in ten different species of bryophytes using fresh samples collected on-site and dried specimen stored in a herbarium for half a year. Read More

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Discovery of Screening Biomarkers for Major Depressive Disorder in Remission by Proteomic Approach.

Diagnostics (Basel) 2021 Mar 17;11(3). Epub 2021 Mar 17.

Department of Biomedical Laboratory Science, College of Health Science, Eulji University, Uijeongbu 11759, Korea.

Major depressive disorder (MDD) is a common disorder involving depressive mood and decreased motivation. Due to its high heterogeneity, novel biomarkers are required to diagnose MDD. In this study, a proteomic method was used to identify a new MDD biomarker. Read More

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An Unambiguous Synchronization Scheme for GNSS BOC Signals Based on Reconstructed Correlation Function.

Sensors (Basel) 2021 Mar 11;21(6). Epub 2021 Mar 11.

Guangxi Key Laboratory of Precision Navigation Technology and Application, Guilin University of Electronic Technology, Guilin 541004, China.

Binary offset carrier (BOC) modulation is a new modulation method that has been gradually applied to the Global Satellite Navigation System (GNSS) in recent years. However, due to the multi-peaks in its auto-correlation function (ACF), it will incur a false lock and generate synchronization ambiguous potentially. In this paper, an unambiguous synchronization method based on a reconstructed correlation function is proposed to solve the ambiguity problem. Read More

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Achyranthes bidentata polypeptide k enhances the survival, growth and axonal regeneration of spinal cord motor neurons in vitro.

Neuroreport 2021 Apr;32(6):518-524

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.

Achyranthes bidentata polypeptide k (ABPPk), a powerful active component from a traditional Chinese medicinal herb-Achyranthes bidentata Bl., has exhibited promising neuroprotective activity due to its multiple-targeting capability. However, the effect of ABPPk on the survival, growth and axonal regeneration of spinal cord motor neurons remains unclear. Read More

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Basic life support training programme in schools by school nurses: How long and how often to train?

Medicine (Baltimore) 2021 Apr;100(13):e24819

Unidad de Radiología Vascular Intervencionista, Complejo Asistencial Universitario de León (CAULE), Gerencia Regional de Salud de Castilla y León (SACYL), Leon, Spain.

Background: Cardiopulmonary resuscitation (CPR) training in schools, despite being legislated in Spain, is not established as such within the subjects that children are taught in schools.

Objective: to evaluate the acquisition of CPR skills by 11-year-old children after a brief theoretical-practical teaching programme taught by nurses at school.

Methods: 62 students were assessed in a quasi-experimental study on 2 cohorts (51. Read More

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Rapid Development of Improved Data-Dependent Acquisition Strategies.

Anal Chem 2021 Mar 30. Epub 2021 Mar 30.

School of Computing Science, University of Glasgow, Glasgow G12 8QQ, United Kingdom.

Tandem mass spectrometry (LC-MS/MS) is widely used to identify unknown ions in untargeted metabolomics. Data-dependent acquisition (DDA) chooses which ions to fragment based upon intensities observed in MS1 survey scans and typically only fragments a small subset of the ions present. Despite this inefficiency, relatively little work has addressed the development of new DDA methods, partly due to the high overhead associated with running the many extracts necessary to optimize approaches in busy MS facilities. Read More

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Efficient gradient waveform measurements with variable-prephasing.

J Magn Reson 2021 Feb 20;327:106945. Epub 2021 Feb 20.

Biomedical Engineering, Vanderbilt University, United States; Institute of Imaging Science, Vanderbilt University, United States.

Accurate measurement of gradient waveform errors can often improve image quality in sequences with time varying readout and excitation waveforms. Self-encoding or offset-slice sequences are commonly used to measure gradient waveforms. However, the self-encoding method requires a long scan time, while the offset-slice method is often low precision, requiring the thickness of the excited slice to be small compared to the maximal k-space encoded by the test waveform. Read More

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February 2021

An early cell shape transition drives evolutionary expansion of the human forebrain.

Cell 2021 Mar 19. Epub 2021 Mar 19.

MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

The human brain has undergone rapid expansion since humans diverged from other great apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use cerebral organoids derived from human, gorilla, and chimpanzee cells to study developmental mechanisms driving evolutionary brain expansion. We find that neuroepithelial differentiation is a protracted process in apes, involving a previously unrecognized transition state characterized by a change in cell shape. Read More

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Detecting and identifying Schistosoma infections in snails and aquatic habitats: A systematic review.

PLoS Negl Trop Dis 2021 Mar 24;15(3):e0009175. Epub 2021 Mar 24.

Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM, United States of America.

Background: We were tasked by the World Health Organization (WHO) to address the following question: What techniques should be used to diagnose Schistosoma infections in snails and in the water in potential transmission sites? Our goal was to review and evaluate the available literature and provide recommendations and insights for the development of WHO's Guidelines Development Group for schistosomiasis control and elimination.

Methodology: We searched several databases using strings of search terms, searched bibliographies of pertinent papers, and contacted investigators who have made contributions to this field. Our search covered from 1970 to Sept 2020. Read More

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Game-Based Learning Outcomes Among Physiotherapy Students: Comparative Study.

JMIR Serious Games 2021 Mar 24;9(1):e26007. Epub 2021 Mar 24.

Department of Nursing, Physical Therapy and Medicine, University of Almeria, Almeria, Spain.

Background: University teaching methods are changing, and in response to a classical teacher-centered approach, new methods continue to strengthen knowledge acquisition by involving students more actively in their learning, thus achieving greater motivation and commitment.

Objective: This study aimed to analyze the degree of satisfaction of physiotherapy students who used a board game-based approach, as well as to compare the difference between traditional and gamification teaching methods and their influence on the final evaluation of these students.

Methods: A comparative study was conducted. Read More

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Honey proteomic signatures for the identification of honey adulterated with syrup, producing country, and nectar source using SWATH-MS approach.

Food Chem 2021 Mar 15;354:129590. Epub 2021 Mar 15.

Institute of Molecular Biology, National Chung Hsing University, Taichung 40227, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung 40447, Taiwan; Advanced Plant Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan; Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan; Rong Hsing Research Center For Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan. Electronic address:

Honey is widely consumed by humans, due to its multiple applications as a food constituent and its therapeutic effects. This study reports on the discrimination of honey products from different geographical and botanical sources, as well as honey products containing distinct forms of syrup used in honey adulteration. Sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS)-based proteomic analysis combined with chemometrics was successfully applied in identifying characteristic proteins that can be used as biomarkers of the original source of honey. Read More

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Using a novel paradigm to examine observational fear-learning across development.

Depress Anxiety 2021 Mar 23. Epub 2021 Mar 23.

School of Psychological Sciences and the Integrated Brain and Behavior Research Center, University of Haifa, Haifa, Israel.

Background: Fear-learning through observing others begins early in life. Yet, most observational fear-learning research has focused on adults. The current study used a novel developmentally appropriate observational fear conditioning paradigm to examine differences in observational fear-learning among children, adolescents, and adults. Read More

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Vulnerability and resiliency implications of and linked : Acknowledging Zigler's contributions to child well-being.

Dev Psychopathol 2021 Mar 23:1-16. Epub 2021 Mar 23.

Department of Comparative Human Development, University of Chicago, Chicago, IL, USA.

Edward Zigler's groundbreaking research on child development resulted in the historic Head Start program. It is useful to examine the theoretical implications of his work by applying a human development theoretical perspective. Phenomenological variant of ecological systems theory (PVEST) is a strengths-based theoretical framework that engages the variability of resource access and coping strategies that promote positive identity development for diverse children. Read More

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Shmuel P Reis

Harefuah 2021 Mar;160(3):175-180

The Center for Medical Education, Hebrew University/Hadassah Faculty of Medicine, Jerusalem, Israel.

Introduction: The Israeli state accords the status of "specialist", after an authorization by the Israeli Medical Association (IMA) Scientific Council and Ministry of Health (MOH), to physicians who fulfilled the requirements for the title in the 56 recognized specialties in the country. An "expert" and "specialist" are synonyms in Hebrew. However, there is no doubt that these two terms are not identical. Read More

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Uncertainty in collocated mobile measurements of air quality.

Atmos Environ X 2020 Oct;7

Independent Consultant, Henderson, NV, 89052, USA.

Mobile mapping of air pollution has the potential to provide pollutant concentration data at unprecedented spatial scales. Characterizing instrument performance in the mobile context is challenging, but necessary to analyze and interpret the resulting data. We used robust statistical methods to assess mobile platform performance using data collected with the Aclima Inc. Read More

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October 2020

Combining label-free and label-based accurate quantifications with SWATH-MS: Comparison with SRM and PRM for the evaluation of bovine muscle type effects.

Proteomics 2021 Mar 18:e2000214. Epub 2021 Mar 18.

Laboratoire de Spectrométrie de Masse BioOrganique, IPHC UMR7178, CNRS, Université de Strasbourg, Strasbourg, France.

Mass spectrometry has proven to be a valuable tool for the accurate quantification of proteins. In this study, the performances of three targeted approaches, namely selected reaction monitoring (SRM), parallel reaction monitoring (PRM) and sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS), to accurately quantify ten potential biomarkers of beef meat tenderness or marbling in a cohort of 64 muscle samples were evaluated. So as to get the most benefit out of the complete MS2 maps that are acquired in SWATH-MS, an original label-free quantification method to estimate protein amounts using an I-spline regression model was developed. Read More

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Progress in the Theory of X-ray Spectroscopy: From Quantum Chemistry to Machine Learning and Ultrafast Dynamics.

J Phys Chem A 2021 Mar 17. Epub 2021 Mar 17.

Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, U.K.

The development of high-brilliance third- and fourth-generation light sources such as synchrotrons and X-ray free-electron lasers (XFELs), the emergence of laboratory-based X-ray spectrometers, and instrumental and methodological advances in X-ray absorption (XAS) and (non)resonant emission (XES and RXES/RIXS) spectroscopies have had far-reaching effects across the natural sciences. However, new kinds of experiments, and their ever-higher resolution and data acquisition rates, have brought acutely into focus the challenge of accurately, quickly, and cost-effectively analyzing the data; a far-from-trivial task that demands detailed theoretical calculations that are capable of capturing satisfactorily the underlying physics. The past decade has seen significant advances in the theory of core-hole spectroscopies for this purpose, driven by all of the developments above and-crucially-a surge in demand. Read More

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Laser acquisition experimental demonstration for space gravitational wave detection missions.

Opt Express 2021 Mar;29(5):6368-6383

The laser acquisition-pointing technique is one of the most important techniques for space gravitational wave detection missions, like the Taiji program and the LISA (Laser Interferometer Space Antenna) program. The laser acquisition system suppresses the laser deviation angle to 1 µrad at the receiving aperture. Corresponding to 80 times of telescope magnification, the acquisition accuracy should reach 80 µrad at the acquisition camera. Read More

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Correcting for Non-stationarity in BOLD-fMRI Connectivity Analyses.

Front Neurosci 2021 24;15:574979. Epub 2021 Feb 24.

Department of Biomedical Engineering, University of Melbourne, Melbourne, VIC, Australia.

In this work fMRI BOLD datasets are shown to contain slice-dependent non-stationarities. A model containing slice-dependent, non-stationary signal power is proposed to address time-varying signal power during BOLD data acquisition. The impact of non-stationary power on functional MRI connectivity is analytically derived, establishing that pairwise connectivity estimates are scaled by a function of the time-varying signal power, with magnitude upper bound by 1, and that the variance of sample correlation is increased, thereby inducing spurious connectivity. Read More

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February 2021

Antifungal polycyclic tetramate macrolactam HSAF is a novel oxidative stress modulator in .

Appl Environ Microbiol 2021 Mar 12. Epub 2021 Mar 12.

Departments of Chemistry, University of Nebraska-Lincoln, NE 68588, USA

Polycyclic tetramate macrolactams (PoTeM) are a fast-growing family of antibiotic natural products found in phylogenetically diverse microorganisms. Surprisingly, none of the PoTeM had been investigated for potential physiological functions in their producers. Here, we used HSAF (heat-stable antifungal factor), an antifungal PoTeM from , as a model to show that PoTeM forms complexes with iron ion, with a of 2. Read More

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Attitudes of Australian Patients Undergoing Treatment for Upper Gastrointestinal Cancers to Different Models of Nutrition Care Delivery: Qualitative Investigation.

JMIR Form Res 2021 Mar 12;5(3):e23979. Epub 2021 Mar 12.

School of Primary and Allied Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.

Background: Adults diagnosed with cancers of the stomach, esophagus, and pancreas are at high risk of malnutrition. In many hospital-based health care settings, there is a lack of systems in place to provide the early and intensive nutritional support that is required by these high-risk cancer patients. Our research team conducted a 3-arm parallel randomized controlled trial to test the provision of an early and intensive nutrition intervention to patients with upper gastrointestinal cancers using a synchronous telephone-based delivery approach versus an asynchronous mobile app-based approach delivered using an iPad compared with a control group to address this issue. Read More

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Discovery and validation of PZP as a novel serum biomarker for screening lung adenocarcinoma in type 2 diabetes mellitus patients.

Cancer Cell Int 2021 Mar 10;21(1):162. Epub 2021 Mar 10.

Department of Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi, 214023, China.

Background: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of suffering from various malignancies. This study aimed to identify specific biomarkers that can detect lung adenocarcinoma (LAC) in T2DM patients for the early diagnosis of LAC.

Methods: The clinical information of hospitalized T2DM patients diagnosed with various cancers was collected by reviewing medical records in Wuxi People's Hospital Affiliated to Nanjing Medical University from January 1, 2015, to June 30, 2020. Read More

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Binary Classifier for Computing Posterior Error Probabilities in MetaMorpheus.

J Proteome Res 2021 Apr 8;20(4):1997-2004. Epub 2021 Mar 8.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

MetaMorpheus is a free, open-source software program for the identification of peptides and proteoforms from data-dependent acquisition tandem MS experiments. There is inherent uncertainty in these assignments for several reasons, including the limited overlap between experimental and theoretical peaks, the / uncertainty, and noise peaks or peaks from coisolated peptides that produce false matches. False discovery rates provide only a set-wise approximation for incorrect spectrum matches. Read More

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Is justice grounded? How expertise shapes conceptual representation of institutional concepts.

Psychol Res 2021 Mar 7. Epub 2021 Mar 7.

Department of Philosophy and Communication, University of Bologna, Via Azzo Gardino, 23, 40122, Bologna, Italy.

Using abstract concepts is a hallmark of human cognition. While multiple kinds of abstract concepts exist, they so far have been conceived as a unitary kind in opposition to concrete ones. Here, we focus on Institutional concepts, like justice or norm, investigating their fine-grained differences with respect to other kinds of abstract and concrete concepts, and exploring whether their representation varies according to individual proficiency. Read More

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Discovery and Identification of Arsenolipids Using a Precursor-Finder Strategy and Data-Independent Mass Spectrometry.

Environ Sci Technol 2021 Mar 5;55(6):3836-3844. Epub 2021 Mar 5.

Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, 10-102 Clinical Sciences Building, Edmonton, Alberta T6G 2G3, Canada.

Arsenolipids are a class of lipid-soluble arsenic species. They are present in seafoods and show high potentials of cytotoxicity and neurotoxicity. Hindered by traditional low-throughput analytical techniques, the characterization of arsenolipids is far from complete. Read More

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