40 results match your criteria acms patients


Less is more: Deprescribing anticholinergic medications in persons with severe mental illness.

Ann Clin Psychiatry 2021 05;33(2):80-92

University of Pittsburgh School of Medicine, UPMC Western Psychiatric Hospital, Pittsburgh, Pennsylvania, USA.

Background: Long-term prescribing of anticholinergic medications (ACM) for antipsychotic-associated extrapyramidal symptoms (EPS) is not recommended, yet is widely prevalent. Adverse effects of ACM include memory impairment, dry mouth, constipation, blurred vision, urinary retention, and tachycardia, which can seriously impact quality of life. This quality improvement deprescription project sought to reduce chronic ACM use in patients with serious mental illness (SMI). Read More

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Long-term impact of early initiation of enzyme replacement therapy in 34 MPS VI patients: A resurvey study.

Mol Genet Metab 2021 05 27;133(1):94-99. Epub 2021 Feb 27.

Serviço de Genética Médica, Universidade Federal da Bahia, Salvador, BA, Brazil.

Patients with mucopolysaccharidosis type VI (MPS VI) present with a wide range of disease severity and clinical manifestations, with significant functional impairment and shortened lifespan. Enzyme replacement therapy (ERT) with galsulfase has been shown to improve clinical and biochemical parameters including patient survival, quality of life and growth. The present study is a resurvey of 34 Brazilian MPS VI patients with rapidly progressive disease (classical phenotype) who initiated ERT with galsulfase under five years of age and had been on ERT until data collection in 2019, with few exceptions (n = 4 patients who died before 2019). Read More

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Inhibiting microRNA-155 attenuates atrial fibrillation by targeting CACNA1C.

J Mol Cell Cardiol 2021 Feb 24;155:58-65. Epub 2021 Feb 24.

Key Laboratory of Interdisciplinary Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; Medical School of University of Chinese Academy of Sciences, Beijing, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China. Electronic address:

Background: Reduction in L-type Ca current (I) density is a hallmark of the electrical remodeling in atrial fibrillation (AF). The expression of miR-155, whose predicted target gene is the α1c subunit of the calcium channel (CACNA1C), was upregulated in atrial cardiomyocytes (aCMs) from patients with paroxysmal AF.The study is to determine miR-155 could target the gene expression of I and contribute to electrical remodeling in AF. Read More

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February 2021

Less is more: Deprescribing anticholinergic medications in persons with severe mental illness.

Ann Clin Psychiatry 2021 Feb 1;33(1):e1-e13. Epub 2021 Feb 1.

UPMC Western Psychiatric Hospital, Pittsburgh, PA 15213 USA. EMAIL:

Background: Long-term prescribing of anticholinergic medications (ACM) for antipsychotic-associated extrapyramidal symptoms (EPS) is not recommended, yet is widely prevalent. Adverse effects of ACM include memory impairment, dry mouth, constipation, blurred vision, urinary retention, and tachycardia, which can seriously impact quality of life. This quality improvement deprescription project sought to reduce chronic ACM use in patients with serious mental illness (SMI). Read More

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February 2021

Clinical evaluation of "componeers" and direct composite veneers using minimally invasive enamel preparation technique: study.

J Indian Prosthodont Soc 2020 Oct-Dec;20(4):424-430. Epub 2020 Oct 8.

Dental Centre, Amritsar, Punjab, India.

Aim: The aim of this study was to evaluate the clinical behavior of prefabricated componeers and direct composite veneering. The objective of the study was to compare the changes in color, surface texture, marginal integrity, and gingival response for componeers and direct composite veneers.

Settings And Study Design: This was an , comparative study. Read More

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October 2020

Posterior latissimus dorsi transfer for massive irreparable posterosuperior rotator cuff tears: does it work in the elderly population? A comparative study between 2 age groups (≤55 vs. ≥75 years old).

J Shoulder Elbow Surg 2021 Mar 7;30(3):641-651. Epub 2020 Jul 7.

Hôpital Ambroise Pare, Shoulder Department, Paris, France.

Hypothesis And/or Background: Management of irreparable posterosuperior rotator cuff tears (RCTs) presents a significant challenge to shoulder surgeons. Previous studies on latissimus dorsi transfer (LDT) have demonstrated good to excellent outcomes in younger patients, but this indication is debatable in the elderly. The main objective of this study was to compare the results of LDT in a group of patients aged ≤55 years vs. Read More

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Microsurgical Transcranial Approach of 112 Paraoptic Meningiomas: A Single-Center Case Series.

Oper Neurosurg (Hagerstown) 2020 Jul 10. Epub 2020 Jul 10.

Department of Neurosurgery, Rothschild Foundation Hospital, Paris, France.

Background: Predictors of visual outcomes after optic nerve decompression are controversial.

Objective: To identify the predictors of poor visual outcomes after surgery of meningiomas responsible of a compressive optic neuropathy.

Methods: We focused on paraoptic meningiomas (POMs), which gathered tuberculum sellae meningiomas (TSMs) and anterior clinoid meningiomas (ACMs) responsible for visual impairment or threatening visual function, that underwent surgery at our institution between January 2009 and December 2015 and analyzed the clinical and radiological findings of our patients. Read More

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Anterior Clinoidal Meningiomas: Meningeal Anatomical Considerations and Surgical Implications.

Front Oncol 2020 25;10:634. Epub 2020 May 25.

Department of Neurosurgery, Changzheng Hospital, Naval Medical University, Shanghai, China.

Surgical removal of anterior clinoidal meningiomas (ACMs) remains a challenge because of its complicated relationship with surrounding meninges, major arteries and cranial nerves. This study aims to define the meningeal structures around the anterior clinoid process (ACP) and its surgical implications. Five dry skulls and 19 cadavers were used in the anatomical study. Read More

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Identification of endogenous 1-aminopyrene as a novel mediator of progressive chronic kidney disease via aryl hydrocarbon receptor activation.

Br J Pharmacol 2020 08 28;177(15):3415-3435. Epub 2020 May 28.

Faculty of Life Science & Medicine, Northwest University, Xi'an, Shaanxi, China.

Background And Purpose: Increasing evidence has indicated that the high risk of cardiovascular disease in chronic kidney disease (CKD) patients cannot be sufficiently explained by classic risk factors.

Experimental Approach: Based on the least absolute shrinkage and selection operator method, we identified significantly altered renal tissue metabolites during progressive CKD in a 5/6 nephrectomized rat model and in CKD patients.

Key Results: Six aryl-containing metabolites (ACMs) were significantly increased from Week 1 to Week 20. Read More

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truncations cause arrhythmogenic right ventricular cardiomyopathy.

J Med Genet 2020 04 10;57(4):254-257. Epub 2020 Jan 10.

Division of Cardiology, Johns Hopkins, Baltimore, Maryland, USA.

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease that affects predominantly the right ventricle and is part of the spectrum of arrythmogenic cardiomyopathies (ACMs). ARVC is a genetic condition; however, a pathogenic gene variant is found in only half of patients.

Objective: Filamin C gene truncations () have recently been identified in dilated cardiomyopathy with ventricular arrhythmia and sudden cardiac death, a phenotype partially overlapping with ARVC and part of the ACM spectrum. Read More

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The use of the gait profile score and gait variable score in individuals with Duchenne Muscular Dystrophy.

J Biomech 2020 01 6;98:109485. Epub 2019 Nov 6.

Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Brazil. Electronic address:

Therapeutic gait interventions for individuals with Duchenne Muscular Dystrophy (DMD) should be based on understanding how movement of the individual is affected and whether different clusters of individuals, determined by clinical severity, differ. Gait indexes have been developed to synthesize the data provided by the three-dimensional (3D) gait analysis such as the Gait Deviation Index (GDI) and the Gait Profile Score (GPS) where the gait variable score (GVS) can be calculated. The objective this study was to evaluate the potential use of the GDI and GPS and MAP using data from 3D gait analysis of DMD patients. Read More

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January 2020

Navigating Barriers to Patient Access and Reimbursement in Mohs Micrographic Surgery.

Dermatol Surg 2020 05;46(5):599-604

All authors are affiliated with the Division of Dermatology, Albert Einstein College of Medicine, Bronx, New York.

Background: Insurance companies have implemented new policies including excessive prior authorization (PA) requirements, high-deductible plans, and complicated billing structures in an effort to curb rising health care costs. Studies investigating the real-time impact on providers and patients are emerging, but few within the field of dermatology have been published.

Objective: To assess the impact of cost-cutting policies on patients and physicians. Read More

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Cytological Correlates of Axillary Nodal Involvement in Invasive Ductal Carcinoma of Breast.

J Cytol 2019 Jul-Sep;36(3):142-145

Department of Laboratory Services, Jehangir Hospital, Pune, Maharashtra, India.

Context: Fine needle aspiration cytology (FNAC) plays an important role in the diagnosis of breast carcinoma. However, its role as a prognostic tool needs to be explored. This can be achieved by studying its correlation with an established prognostic marker such as axillary nodal metastasis. Read More

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Uncertainty quantification of simulated biomechanical stimuli in coronary artery bypass grafts.

Comput Methods Appl Mech Eng 2019 Mar 15;345:402-428. Epub 2018 Nov 15.

Department of Pediatrics (Cardiology), Bioengineering and ICME, Stanford University, Stanford, CA, USA.

Coronary artery bypass graft surgery (CABG) is performed on more than 400,000 patients annually in the U.S. However, saphenous vein grafts (SVGs) implanted during CABG exhibit poor patency compared to arterial grafts, with failure rates up to 40% within 10 years after surgery. Read More

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Impact of breast cancer-related lymphedema on working women.

Support Care Cancer 2020 Jan 13;28(1):79-85. Epub 2019 Apr 13.

Department of Lymphology, Hôpital Cognacq-Jay, 15, rue Eugène-Millon, 75015, Paris, France.

Background: The professional impact of upper limb lymphedema, which affects 15-20% of women after breast cancer treatment, has been poorly evaluated.

Objective: To analyze lymphedema characteristics and global lymphedema- and/or sleeve-attributed impact (mildly inconvenient to severely debilitating) on professional activities, workplace relationships, and workstation ergonomics.

Methods: Patients received a standardized, anonymous, self-administered questionnaire at consultation/hospitalization for treatment in a specialized lymphedema management center. Read More

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January 2020

Mapping whole brain connectivity changes: The potential impact of different surgical resection approaches for temporal lobe epilepsy.

Cortex 2019 04 17;113:1-14. Epub 2018 Nov 17.

Neuroscience and Aphasia Research Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, UK. Electronic address:

In neurosurgery there are several situations that require transgression of the temporal cortex. For example, a subset of patients with temporal lobe epilepsy require surgical resection (most typically, en-bloc anterior temporal lobectomy). This procedure is the gold standard to alleviate seizures but is associated with chronic cognitive deficits. Read More

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Clinical importance of atrial cardiomyopathy.

Int J Cardiol 2019 07 28;287:174-180. Epub 2018 Nov 28.

Working Group of Molecular Electrophysiology, Institute of Clinical Chemistry and Pathobiochemistry, Medical Faculty, Otto von Guericke University Magdeburg, Germany; Department of Cardiology and Intensive Care Medicine, St. Vincenz-Krankenhaus, Paderborn, Germany. Electronic address:

Atrial fibrillation (AF) is the most common cause of thromboembolic complications. The risk of suffering a thromboembolic complication correlates with the CHA2DS2-VASc score identifying patients at increased risk. It is based on patient age, prior thromboembolic events, and clinical comorbidities, but not based on pathophysiological changes in different types of atrial cardiomyopathy (ACM) as classified in the expert consensus on ACM published in 2016. Read More

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Fire Safety in Mohs Micrographic Surgery.

Dermatol Surg 2019 03;45(3):390-397

Both authors are affiliated with the Division of Dermatology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.

Background: Surgical fire is a rare event, but one with potentially devastating patient outcomes.

Objective: This study was conducted to investigate the incidence, risk factors, and outcome of surgical fires experienced by members of the American College of Mohs Surgeons (ACMS).

Methods: An internet survey was developed and sent to ACMS members. Read More

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Correlative Study of Cytological Features in Grading of Invasive Breast Carcinoma.

J Cytol 2018 Jul-Sep;35(3):149-152

Department of Laboratory Services, Jehangir Hospital, Pune, Maharashtra, India.

Context: Fine-needle aspiration cytology (FNAC) is a proven diagnostic technique for establishing the benign or malignant character of breast lesions. Several cytological grading systems have been proposed for grading of carcinoma breast, with results similar to histologic grades.

Aims: This study sought to evaluate the prognostic value of FNAC in invasive ductal carcinoma of breast by correlating it with histological grade. Read More

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The correlation between crizotinib efficacy and molecular heterogeneity by next-generation sequencing in non-small cell lung cancer.

J Thorac Dis 2018 May;10(5):2948-2959

Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.

Background: Non-small cell lung cancer (NSCLC) patients with fusion exhibited various durations of response to crizotinib. Molecular heterogeneity is also one of the factors associated with resistance to crizotinib. This study investigated the relevance of molecular heterogeneity to the clinical efficacy of crizotinib using next-generation sequencing (NGS). Read More

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Study of personality traits, individual coping resources, and their association in HIV-seropositive males.

Ind Psychiatry J 2017 Jan-Jun;26(1):45-51

Department of Psychiatry, ACMS, New Delhi, India.

Background: HIV infection is an unfortunate consequence of a defined set of behaviors. Individuals with continued high-risk behavior either due to personality factors or due to maladaptive coping skills have higher viral loads and morbidity. Research has shown significant interactions between less effective coping styles and personality factors. Read More

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February 2018

Examining the Relevance to Patients of Complications in the American College of Mohs Surgery Registry: Results of a Delphi Consensus Process.

Dermatol Surg 2018 06;44(6):763-767

Department of Dermatology, St. Louis University, St. Louis, Missouri.

Background: Surgical registries are valuable tools for tracking outcomes. Incorporating patient input allows registries to address the interests of this important stakeholder group.

Objective: The aim of this study was to identify a list of "patient-selected complications" and to explore the relevance to patients of previously published physician-identified complications. Read More

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History of Asbestos Ban in Hong Kong.

Int J Environ Res Public Health 2017 10 31;14(11). Epub 2017 Oct 31.

Hong Kong Workers' Health Centre, Room 1429 Beverley Commercial Centre, Tsimshatsui, Hong Kong, China.

As millions of immigrants moved to Hong Kong (HK) from China in the recent decades, large amount of residential housings were built in the early years and a substantial proportion of those buildings used asbestos-containing materials (ACMs). Since the number of new cases of ARDs diagnosed has increased year by year since 1990's, the remarkable increase of incidences had drawn the attention of the public and most importantly the HK government. It became one of the trigger points leading to asbestos ban in HK history. Read More

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October 2017

Anticholinergic use trends in 14,013 patients with schizophrenia from three national surveys on the use of psychotropic medications in China (2002-2012).

Psychiatry Res 2017 11 21;257:132-136. Epub 2017 Jul 21.

Peking University Sixth Hospital (Institute of Mental Health) & National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China. Electronic address:

Our previous study demonstrated that there have been changes in the patterns of prescription antipsychotic use in China over the period from 2002 to 2012. The aim of this study was to evaluate whether time trends were present for the prescription of anticholinergic medications (ACMs) during the observation period. A total of 14,013 patients with schizophrenia treated in 45 psychiatric hospitals/centers nationwide were surveyed in 2002, 2006 and 2012. Read More

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November 2017

Hypofractionated stereotactic radiotherapy (HFSRT) for who grade I anterior clinoid meningiomas (ACM).

Jpn J Radiol 2016 Nov 22;34(11):730-737. Epub 2016 Sep 22.

Department of Radiation Oncology, Gulhane Medical School, Ankara, Turkey.

Purpose: While microsurgical resection plays a central role in the management of ACMs, extensive surgery may be associated with substantial morbidity particularly for tumors in intimate association with critical structures. In this study, we evaluated the use of HFSRT in the management of ACM.

Materials And Methods: A total of 22 patients with ACM were treated using HFSRT. Read More

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November 2016

Beneficial effects of ankle-foot orthosis daytime use on the gait of Duchenne muscular dystrophy patients.

Clin Biomech (Bristol, Avon) 2016 06 22;35:102-10. Epub 2016 Apr 22.

Ribeirao Preto Medical School, University of Sao Paulo, Bandeirantes Av., 3500, 14049-900 Ribeirao Preto, Sao Paulo, Brazil. Electronic address:

Background: Orthosis use prevents muscle contracture and prolongs ambulation in patients with Duchenne muscular dystrophy (DMD). However, its biomechanical effects on gait are unclear. This study assessed the effects of daytime and night-time use of Articulated Ankle Foot Orthosis (AFO) on kinematic, kinetic and spatial/temporal gait parameters of DMD patients. Read More

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Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung adenocarcinoma.

Oncotarget 2015 May;6(14):12783-95

Department of Medicine, Medical Oncology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Cancer molecular heterogeneity might explain the variable response of EGFR mutant lung adenocarcinomas to tyrosine kinase inhibitors (TKIs). We assessed the mutational status of 22 cancer genes by next-generation sequencing (NGS) in poor, intermediate or good responders to first-line gefitinib. Clinical outcome was correlated with Additional Coexisting Mutations (ACMs) and the EGFR Proportion of Mutated Alleles (PMA). Read More

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Full-thickness rotator cuff tears in patients younger than 55 years: clinical outcome of arthroscopic repair in comparison with older patients.

Knee Surg Sports Traumatol Arthrosc 2015 Feb 4;23(2):508-13. Epub 2014 Jun 4.

University of Toronto Orthopaedic Sports Medicine, Toronto, Canada,

Purpose: The purpose of this study was to examine whether younger patients had a similar response to repair of a full-thickness rotator cuff tear (RCT) as older patients.

Methods: A secondary analysis was conducted of prospectively collected data of patients with full-thickness RCTs. Patients were categorized into patients <55 years of age and patients 55 and older. Read More

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February 2015

A clinical study to evaluate the efficacy of intravitreal Anti-VEGF therapy in treating macular edema due to retinal venous occlusions.

Med J Armed Forces India 2013 Jul 23;69(3):260-7. Epub 2013 May 23.

Professor (Microbiology), ACMS, Delhi, India.

Background: A non-randomized, interventional study was carried out various types of retinal venous occlusions with significant macular edema who required an Anti-VEGF injection.

Method: One hundred and one consecutive patients diagnosed as a case of CRVO/HCRVO/BRVO were enrolled in the study provided they had significant macular edema. Atleast three intra-vitreal injections of Anti-VEGFs were given and both the pre and post injections BCVA and CMT on OCT were observed and analyzed. Read More

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Morphological adaptation of muscle collagen and receptor of advanced glycation end product (RAGE) in osteoarthritis patients with 12 weeks of resistance training: influence of anti-inflammatory or glucosamine treatment.

Rheumatol Int 2013 Sep 27;33(9):2215-24. Epub 2013 Feb 27.

Department of Biomechanics, Medicine and Rehabilitation of the Locomotor Apparatus, Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, SP 14049-900, Brazil.

The aim of this study was to investigate the effect of 12-week resistance training on morphological presence of collagen and RAGE (receptor for advanced glycation end products) in skeletal muscle of patients with knee osteoarthritis (OA). Little is known about the influence of exercise on the skeletal muscle matrix that supports joints affected by OA mainly when it is associated with medication taken by OA patients (non-steroid anti-inflammatory drugs (NSAID) and glucosamine). A biopsy was collected from the vastus lateralis muscle in all patients before and after 12-week period of training. Read More

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September 2013