53,827 results match your criteria acidosis

The catabolic triad: case report of fasting, major cardiac surgery and sodium-glucose co-transporter 2 inhibitors leading to perioperative euglycaemic ketoacidosis.

Interact Cardiovasc Thorac Surg 2021 May 7. Epub 2021 May 7.

Blackrock Clinic, Dublin, Ireland.

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are novel oral hypoglycaemic agents. For patients with diabetes mellitus, without a prior history of myocardial infarction or atherosclerotic disease, SGLT2i have been shown to reduce incident heart failure and worsening renal function. SGLT2i therapy is increasing among patients presenting for cardiac surgery. Read More

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Factors associated with the absence of pharmacological treatment for common modifiable complications in children with chronic kidney disease.

Pediatr Nephrol 2021 May 6. Epub 2021 May 6.

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, MLC: 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229-3039, USA.

Background: Chronic kidney disease (CKD) is associated with many comorbidities requiring complex management. We described treatment patterns for common modifiable CKD complications (high blood pressure, anemia, hyperphosphatemia, and acidosis) according to severity of CKD and examined factors associated with the absence of drug therapy, among participants with a persistent comorbidity, for 1 year in children enrolled in the CKiD study.

Methods: A total of 703 CKiD participants contributed 2849 person-visits over a median 3. Read More

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Hypokalaemic paralysis as the initial clinical presentation of Sjogren's syndrome induced distal renal tubular acidosis.

BMJ Case Rep 2021 May 6;14(5). Epub 2021 May 6.

Intensive Care Medicine, Saint James's Hospital, Dublin, Ireland.

A 41-year-old woman presented by ambulance with a 1-day history of new-onset paralysis and nausea and vomiting ongoing for 48 hours. She had no history of any similar episodes. Biochemical analysis showed profound hypokalaemia with a non-anion gap metabolic acidosis. Read More

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Dietary acid load and lung cancer risk: A case-control study in men.

Cancer Treat Res Commun 2021 Apr 25;28:100382. Epub 2021 Apr 25.

Unit of Thoracic Oncology, National Cancer Institute, Joanicó 3265, Montevideo 11600, Uruguay.

Background: Dysregulation of the endogenous acid-base balance can contribute to inflammation and cancer development if metabolic acidosis is sustained. The epidemiologic evidence on the association between diet-dependent acid load and cancer risk is scarce and inconsistent. We aim to explore the possible role of dietary acid load in lung cancer (LC) risk. Read More

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Temporal inversion of the acid-base equilibrium in newborns: an observational study.

PeerJ 2021 14;9:e11240. Epub 2021 Apr 14.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Background: A considerable fraction of newborn infants experience hypoxia-ischaemia and metabolic acidosis at birth. However, little is known regarding the biological response of newborn infants to the pH drift from the physiological equilibrium. The aim of this study was to investigate the relationship between the pH drift at birth and postnatal acid-base regulation in newborn infants. Read More

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Persistent lactic acidosis in the Mauriac syndrome in type 1 diabetes mellitus.

Proc (Bayl Univ Med Cent) 2021 Jan 11;34(3):382-383. Epub 2021 Jan 11.

Department of Internal Medicine, State University of New York Upstate Medical University, Syracuse, New York.

Mauriac syndrome is an uncommon clinical condition arising in the setting of poorly controlled type 1 diabetes mellitus. Clinical features include hepatomegaly and liver abnormalities indistinguishable from nonalcoholic fatty liver disease. Early diagnosis and management are essential, as Mauriac syndrome is reversible. Read More

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January 2021

Severe amnestic syndrome due to theophylline toxicity.

BMJ Case Rep 2021 May 5;14(5). Epub 2021 May 5.

Neurology, University Hospital Galway, Galway, Ireland.

We report a case of severe amnestic syndrome following theophylline overdose. A woman in her early 30s was admitted to hospital where she developed status epilepticus following an intentional overdose of theophylline and lansoprazole. She developed a profound acidosis and required intubation in the intensive care unit. Read More

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Development of a Multivariable Prediction Model for Citrate Accumulation in Liver Transplant Patients Undergoing Continuous Renal Replacement Therapy with Regional Citrate Anticoagulation.

Blood Purif 2021 May 5:1-11. Epub 2021 May 5.

Surgical Intensive Care Unit, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Introduction: Patients with impaired citrate metabolism may experience citrate accumulation (CA), which causes life-threatening metabolic acidosis and hypocalcemia. CA poses a challenge for clinicians when deciding on the use of regional citrate anticoagulation (RCA) for patients with liver dysfunction. This study aimed to develop a prediction model integrating multiple clinical variables to assess the risk of CA in liver transplant patients. Read More

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Brain MRS correlates with mitochondrial dysfunction biomarkers in MELAS-associated mtDNA mutations.

Ann Clin Transl Neurol 2021 May 5. Epub 2021 May 5.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Functional and Molecular Neuroimaging Unit, Bologna, Italy.

Objective: The purpose of this study was to investigate correlations between brain proton magnetic resonance spectroscopy ( H-MRS) findings with serum biomarkers and heteroplasmy of mitochondrial DNA (mtDNA) mutations. This study enrolled patients carrying mtDNA mutations associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS), and MELAS-Spectrum Syndrome (MSS).

Methods: Consecutive patients carrying mtDNA mutations associated with MELAS and MSS were recruited and their serum concentrations of lactate, alanine, and heteroplasmic mtDNA mutant load were evaluated. Read More

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Degradation of the Endothelial Glycocalyx Contributes to Metabolic Acidosis in Children Following Cardiopulmonary Bypass Surgery.

Pediatr Crit Care Med 2021 May 4. Epub 2021 May 4.

Paediatric Intensive Care, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Department of Women and Children's Health, School of Life Course Sciences, King's College London, St Thomas' Hospital, London, United Kingdom. Thrombosis and Vascular Biology Research Group, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Department of Cardiology, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Institute of Women and Children's Health, King's College London, St Thomas' Hospital, London, United Kingdom. Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, Guy's Hospital, London, United Kingdom. Department of Intensive Care, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Objectives: Cardiopulmonary bypass surgery is complicated by metabolic acidosis, microvascular dysfunction, and capillary leak. The glycocalyx-a layer of proteins and sugars lining the vascular endothelium-is degraded during cardiopulmonary bypass. We aimed to describe the kinetics of glycocalyx degradation during and following cardiopulmonary bypass. Read More

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En kvinne i 50-årene med magesmerter og alvorlig laktacidose.

Tidsskr Nor Laegeforen 2021 Apr 27. Epub 2021 Apr 27.

Background: Pheochromocytoma is referred to as 'the great mimic' with a broad spectrum of presenting symptoms. In the following case, the diagnosis had an unusual presentation as a medical emergency - pheochromocytoma crisis.

Case Presentation: A previously healthy woman in her fifties was admitted due to abdominal pain and dyspnoea. Read More

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Lipid nanoparticles loaded with butamben and designed to improve anesthesia at inflamed tissues.

Biomater Sci 2021 May;9(9):3378-3389

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.

The most frequently used local anesthetics (LA) for local infiltration have an ionizable amine in the range of pH 7.6-8.9. Read More

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Metabolic changes during carbon monoxide poisoning: An experimental study.

J Cell Mol Med 2021 May 5. Epub 2021 May 5.

Department of Anaesthesiology and Intensive Care, Pulmonary Research Center, Aalborg University Hospital, Aalborg, Denmark.

Carbon monoxide (CO) is the leading cause of death by poisoning worldwide. The aim was to explore the effects of mild and severe poisoning on blood gas parameters and metabolites. Eleven pigs were exposed to CO intoxication and had blood collected before and during poisoning. Read More

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NEURO-IMAGE: MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome).

Acta Neurol Belg 2021 May 4. Epub 2021 May 4.

Radiology Department, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200, Bruxelles, Belgium.

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A near miss: subclinical saddle pulmonary embolism diagnosed by handheld ultrasound.

Oxf Med Case Reports 2021 Apr 28;2021(4):omab011. Epub 2021 Apr 28.

Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.

Introduction: Pulmonary embolism (PE) is a life-threatening condition characterized by occlusive disease of the pulmonary vasculature. Point-of-care ultrasound (POCUS) of right ventricular strain patterns have high specificity and low sensitivity for diagnosis. Here, we describe a patient with a saddle PE and low pre-test probability who was diagnosed primarily by handheld POCUS. Read More

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Glargine versus regular insulin protocol in feline diabetic ketoacidosis.

J Vet Emerg Crit Care (San Antonio) 2021 May 4. Epub 2021 May 4.

School of Veterinary Science, The University of Queensland, Australia.

Objectives: To determine whether basal-bolus administration of glargine insulin is a safe and effective alternative treatment compared to the standard continuous rate infusion (CRI) protocol.

Design: Prospective randomized clinical trial.

Setting: University teaching hospital. Read More

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Atypical Reye syndrome: three cases of a problem that pediatricians should consider and remember.

Acta Biomed 2021 Apr 30;92(S1):e2021110. Epub 2021 Apr 30.

Institute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS - Università Cattolica Sacro Cuore, Rome, Italy .

Introduction: Reye syndrome is a rare acquired metabolic disorder appearing almost always during childhood. Its aetiopathogenesis, although controversial, is partially understood. The classical disease is typically anticipated by a viral infection with 3-5 days of well-being before the onset of symptoms, while the biochemical explanation of the clinical picture is a mitochondrial metabolism disorder, which leads to a metabolic failure of different tissues, especially the liver. Read More

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The Heart in Diabetic Ketoacidosis: A Narrative Review Focusing on the Acute Cardiac Effects and Electrocardiographic Abnormalities.

Am J Med Sci 2020 Nov 26. Epub 2020 Nov 26.

Echocardiography Laboratory, Cardiology Service, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

Diabetic ketoacidosis (DKA) is a serious complication of diabetes mellitus. Hyperglycemia, acidosis, and electrolyte imbalances can directly affect the heart by inducing toxicity, impairing myocardial blood flow, autonomic dysfunction, and altering activation and conduction of electrical impulses throughout the heart, increasing the risk of arrhythmias and ischemia. The electrocardiogram is useful in monitoring patients during and after an episode of DKA, as it allows the detection of arrhythmias and guides metabolic correction. Read More

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November 2020

An extremely high blood glucose level in a child with hyperglycemic hyperosmolar state and type 1 diabetes.

J Pediatr Endocrinol Metab 2021 May 3. Epub 2021 May 3.

Department of Emergency Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia.

Objectives: Hyperglycemic hyperosmolar state (HHS) is one of the most severe acute complications of diabetes mellitus (DM) characterized by severe hyperglycemia and hyperosmolality without significant ketosis and acidosis. What is new? Since HHS in the pediatric population is rare and potentially life-threatening, every reported case is very valuable for raising awareness among healthcare professionals.

Case Presentation: A 7-year-old boy with previously diagnosed Joubert syndrome was admitted due to vomiting, polydipsia and polyuria started several days earlier. Read More

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Comparison of ringer's lactate and plasmalyt-a as cardiopulmonary bypass prime for bypass associated acidosis in valve replacement surgeries.

Ann Card Anaesth 2021 Jan-Mar;24(1):36-41

Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Introduction: A wide range of acid base fluctuations are seen during Cardiopulmonary bypass (CPB) and the development of metabolic acidosis is well recognized. We conducted a study tocompare the metabolic effects of Ringer lactate and Plasmalyte-A as CPB prime in causing bypass associated acidosis in valve replacement surgeries.

Methods: We performed a prospective, randomized controlled study on a total of 80 adult patients undergoing CPB for valvular heart surgeries. Read More

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Accidental systematic administration of 1 litre of cardioplegia solution during paediatric cardiac surgery.

Anaesth Rep 2021 Jan-Jun;9(1):76-80. Epub 2021 Apr 27.

Department of Congenital Cardiothoracic Anaesthesia Freeman Hospital Newcastle upon Tyne UK.

Cardioplegia is used to induce cardiac arrest in order to facilitate cardiac surgery in patients supported by cardiopulmonary bypass. It is administered directly into the coronary vessels after the heart has been isolated from the systemic circulation. We describe the case of a 9-year-old boy who mistakenly received 1 l of high strength St Thomas' Harefield cardioplegia solution delivered into the systemic circulation during cardiac surgery. Read More

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Treatment Outcome of Severe Malaria and Associated Factors among Adults Admitted in Arba Minch General Hospital, Southern Nation Nationality and People's Region, Ethiopia.

J Parasitol Res 2021 10;2021:6664070. Epub 2021 Apr 10.

Arba Minch University College of Medicine and Health Science, Ethiopia.

Introduction: Malaria is a protozoan disease transmitted by the bite of infected female mosquitoes. Progression to severe and fatal disease is largely but not entirely confined to infections. Malaria is a major public health problem in Ethiopia despite relatively low malaria prevalence compared to most other malaria-endemic countries in Africa. Read More

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Cardiac Protection by Oral Sodium Thiosulfate in a Rat Model of L-NNA-Induced Heart Disease.

Front Pharmacol 2021 15;12:650968. Epub 2021 Apr 15.

Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, Netherlands.

Hypertension contributes to cardiac damage and remodeling. Despite the availability of renin-angiotensin system inhibitors and other antihypertensive therapies, some patients still develop heart failure. Novel therapeutic approaches are required that are effective and without major adverse effects. Read More

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Comparison of a modified Story approach to traditional evaluation of acid-base disturbances in patients with shock: a cohort study.

J Clin Monit Comput 2021 May 2. Epub 2021 May 2.

Department of Critical Care, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

To compare whether the diagnostic evaluation of metabolic acidosis can be improved by using a modified Story method compared to the traditional evaluation in a population of critically ill patients with shock. This prospective cohort study included shock patients admitted to the ICU of a tertiary hospital in Brazil between May 2018 and November 2019. We collected laboratory data necessary for traditional evaluation and the simplified Stewart's method. Read More

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Acute Myocardial Infarction and Diabetic Ketoacidosis: The Lethal Duo.

J Nepal Health Res Counc 2021 Apr 23;19(1):212-214. Epub 2021 Apr 23.

Department of Cardiology, Shahid Gangalal National Heart Centre, Bansbari, Kathmandu, Nepal.

Diabetes Ketoacidosis in association with acute myocardial infarction is quite frequent but is also associated with higher morbidity and mortality. These two can trigger each other, different hypothesis have been proposed to explain this phenomenon but still it is difficult to know which one appears first. We report a referred case to our centre with acute Myocardial Infarction and diabetic ketoacidosis promptly initiated treatment of diabetic ketoacidosis along with primary PCI. Read More

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Identification of multiple substrate binding sites in SLC4 transporters in the outward-facing conformation: insights into the transport mechanism.

J Biol Chem 2021 Apr 28:100724. Epub 2021 Apr 28.

Department of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, CA 90095, USA. Electronic address:

SLC4 transporters mediate the transmembrane transport of HCO‾, CO‾, and Cl‾ necessary for pH regulation, transepithelial H/base transport and ion homeostasis. Substrate transport with varying stoichiometry and specificity is achieved through an exchange mechanism and/or through coupling of the uptake of anionic substrates to typically co-transported Na. Recently solved outward facing (OF) structures of two SLC4 members (hAE1 and hNBCe1) with different transport modes (Cl‾/HCO‾ exchange vs Na-CO‾ symport) revealed highly-conserved three-dimensional organization of their transmembrane domains. Read More

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Associated factors with umbilical arterial pH after cesarean delivery under spinal anesthesia: a retrospective cohort study.

Braz J Anesthesiol 2021 Apr 28. Epub 2021 Apr 28.

Nara Medical University, Department of Anesthesiology, Kashihara, Japan.

Background: Maximum decrease of blood pressure and number of minutes of hypotension were independently associated with umbilical arterial pH. However, the impact of hypotension considering the duration of it on umbilical arterial pH is unknown.

Methods: Pregnant women aged ≥ 20 years who delivered a baby at full-term via a cesarean delivery under a single-shot spinal anesthesia between January 2017 and March 2019 were included. Read More

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The Spectrum of Maculopathy in Mitochondrial DNA A3243G Mutation: A Case Series of Six Patients.

Klin Monbl Augenheilkd 2021 Apr 30;238(4):414-417. Epub 2021 Apr 30.

Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland.

Background: The mitochondrial DNA (mtDNA) A3243G point mutation encompasses a heterogenous group of disorders including mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), maternally inherited diabetes and deafness (MIDD), and, rarely, chronic progressive external ophthalmoplegia (CPEO). Regardless of the clinical phenotype, a specific retinopathy has been associated with the presence of this mitochondrial DNA mutation. We present six female patients exhibiting retinopathy of the A3243G point mutation at various stages. Read More

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Embryotoxicity and physiological compensation in chicken embryos exposed to crude oil.

Environ Toxicol Chem 2021 Apr 30. Epub 2021 Apr 30.

Developmental Integrative Biology, Department of Biological Sciences, University of North Texas, Denton, Texas, United States of America.

Terrestrial, marine, or aquatic oil spills can directly or indirectly contaminate bird eggs. We hypothesized that chicken embryos exposed to crude oil can physiologically compensate to mitigate the potentially toxic effect of lower doses of oil. Embryos exposed to 0, 1, 3, or 5 µL of oil on embryonic day (d) 4 and d10 were initially analyzed for mortality. Read More

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Amitraz toxicosis in 3 dogs after being in a rice field.

J Vet Emerg Crit Care (San Antonio) 2021 Apr 30. Epub 2021 Apr 30.

California Animal Health and Food Safety Lab, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

Objective: To describe the clinical course and novel biochemical findings in 3 dogs with amitraz toxicosis.

Case Series Summary: Three Labrador Retrievers developed acute onset obtundation to stupor after being in a rice field. On admittance to the hospital, they all displayed bradycardia, hyperglycemia, hyperlactatemia, respiratory acidosis, and metabolic alkalosis. Read More

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