42 results match your criteria acid-gelatin hydrogel


Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis.

Pharmaceutics 2021 Feb 17;13(2). Epub 2021 Feb 17.

Department of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea.

Polydimethylsiloxane (PDMS) is a biocompatible polymer that has been applied in many fields. However, the surface hydrophobicity of PDMS can limit successful implementation, and this must be reduced by surface modification to improve biocompatibility. In this study, we modified the PDMS surface with a hydrogel and investigated the effect of this on hydrophilicity, bacterial adhesion, cell viability, immune response, and biocompatibility of PDMS. Read More

View Article and Full-Text PDF
February 2021

Injectable conductive hydrogel can reduce pacing threshold and enhance efficacy of cardiac pacemaker.

Theranostics 2021 6;11(8):3948-3960. Epub 2021 Feb 6.

Toronto General Hospital Research Institute, Division of Cardiovascular Surgery, University Health Network, Toronto, Ontario, Canada.

Pacemaker implantation is currently used in patients with symptomatic bradycardia. Since a pacemaker is a lifetime therapeutic device, its energy consumption contributes to battery exhaustion, along with its voltage stimulation resulting in local fibrosis and greater resistance, which are all detrimental to patients. The possible resolution for those clinical issues is an injection of a conductive hydrogel, poly-3-amino-4-methoxybenzoic acid-gelatin (PAMB-G), to reduce the myocardial threshold voltage for pacemaker stimulation. Read More

View Article and Full-Text PDF
February 2021

Additive manufacturing of hydroxyapatite-chitosan-genipin composite scaffolds for bone tissue engineering applications.

Mater Sci Eng C Mater Biol Appl 2021 Feb 17;119:111639. Epub 2020 Oct 17.

Research Unit of Advanced, Composite, Nanomaterials and Nanotechnology, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str., Zografou Campus, 15780 Athens, Greece.

Additive manufacturing holds promise for the fabrication of three-dimensional scaffolds with precise geometry, to serve as substrates for the guided regeneration of natural tissue. In this work, a bioinspired approach is adopted for the synthesis of hybrid hydroxyapatite hydrogels, which were subsequently printed to form 3D scaffolds for bone tissue engineering applications. These hydrogels consist of hydroxyapatite nanocrystals, biomimetically synthesized in the presence of both chitosan and l-arginine. Read More

View Article and Full-Text PDF
February 2021

Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease.

Int J Biol Macromol 2021 Jan 18;167:1598-1612. Epub 2020 Nov 18.

School of Pharmaceutical Science, South-Central University for Nationalities, Wuhan 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, Wuhan 430074, China. Electronic address:

A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific distribution of drugs during long-term treatment. Despite its effectiveness as an anti-inflammatory drug, curcumin (CUR) is limited by its low bioavailability in IBD treatment. Herein, a pH-sensitive composite hyaluronic acid/gelatin (HA/GE) hydrogel drug delivery system containing carboxymethyl chitosan (CC) microspheres loaded with CUR was fabricated for IBD treatment. Read More

View Article and Full-Text PDF
January 2021

Effect of electrical stimulation on chondrogenic differentiation of mesenchymal stem cells cultured in hyaluronic acid - Gelatin injectable hydrogels.

Bioelectrochemistry 2020 Aug 18;134:107536. Epub 2020 Apr 18.

Centre for Biomaterials and Tissue Engineering (CBIT), Universitat Politècnica de València, Valencia, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valencia, Spain.

Electrical stimulation (ES) has provided enhanced chondrogenesis of mesenchymal stem cells (MSCs) cultured in micro-mass without the addition of exogenous growth factors. In this study, we demonstrate for the first time that ES of MSCs encapsulated in an injectable hyaluronic acid (HA) - gelatin (GEL) mixture enhances the chondrogenic potential of the hydrogel. Samples were stimulated for 21 days with 10 mV/cm at 60 kHz, applied for 30 min every 6 h a day. Read More

View Article and Full-Text PDF

A human co-culture cell model incorporating microglia supports glioblastoma growth and migration, and confers resistance to cytotoxics.

FASEB J 2020 01 5;34(1):1710-1727. Epub 2019 Dec 5.

Brain Tumour Research Centre, Institute of Biological and Biomolecular Sciences (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.

Despite the importance of the tumor microenvironment in regulating tumor progression, few in vitro models have been developed to understand the effects of non-neoplastic cells and extracellular matrix (ECM) on drug resistance in glioblastoma (GBM) cells. Using CellTrace-labeled human GBM and microglial (MG) cells, we established a 2D co-culture including various ratios of the two cell types. Viability, proliferation, migration, and drug response assays were carried out to assess the role of MG. Read More

View Article and Full-Text PDF
January 2020

Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons.

Int J Mol Sci 2019 Nov 29;20(23). Epub 2019 Nov 29.

Brain Tumour Research Centre, Institute of Biological and Biomedical Sciences (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK.

The role of astrocytes in the glioblastoma (GBM) microenvironment is poorly understood; particularly with regard to cell invasion and drug resistance. To assess this role of astrocytes in GBMs we established an all human 2D co-culture model and a 3D hyaluronic acid-gelatin based hydrogel model (HyStem™-HP) with different ratios of GBM cells to astrocytes. A contact co-culture of fluorescently labelled GBM cells and astrocytes showed that the latter promotes tumour growth and migration of GBM cells. Read More

View Article and Full-Text PDF
November 2019

Human gingival derived neuronal cells in the optimized caffeic acid hydrogel for hemitransection spinal cord injury model.

J Cell Biochem 2020 03 23;121(3):2077-2088. Epub 2019 Oct 23.

Department of Periodontology and Implantology, Faculty of Dental Sciences and Centre for Regenerative Medicine and Stem Cell Research, Sri Ramachandra Medical College and Research Institute, Chennai, India.

Spinal cord injury induces scar formation causes axonal damage that leads to the degeneration of axonal function. Still, there is no robust conceptual design to regenerate the damaged axon after spinal injury. Therefore, the present study demonstrates that human gingival derived neuronal stem cells (GNSCs) transplants in the injectable caffeic acid bioconjugated hydrogel (CBGH) helps to bridge the cavity and promote the engraftment and repopulation of transplants in the injured spinal tissue. Read More

View Article and Full-Text PDF

Gelatin/Hyaluronic Acid Content in Hydrogels Obtained through Blue Light-Induced Gelation Affects Hydrogel Properties and Adipose Stem Cell Behaviors.

Biomolecules 2019 08 5;9(8). Epub 2019 Aug 5.

Department of Materials Science and Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.

Composite hydrogels of hyaluronic acid and gelatin attract great attention in biomedical fields. In particular, the composite hydrogels obtained through processes that are mild for cells are useful in tissue engineering. In this study, hyaluronic acid/gelatin composite hydrogels obtained through a blue light-induced gelation that is mild for mammalian cells were studied for the effect of the content of each polymer in the precursor solution on gelation, properties of resultant hydrogels, and behaviors of human adipose stem cells laden in the hydrogels. Read More

View Article and Full-Text PDF

In situ injectable hyaluronic acid/gelatin hydrogel for hemorrhage control.

Mater Sci Eng C Mater Biol Appl 2019 May 9;98:628-634. Epub 2019 Jan 9.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.. Electronic address:

Tissue sealants are used for hemorrhage control which is imperative in many surgical procedures. It is a highly challenging task to obtain the ideal tissue sealant. Only a few commercially tissue sealants are available to be used for internal tissue or organ hemorrhage control. Read More

View Article and Full-Text PDF

Human umbilical cord tissue stem cells and neuronal lineages in an injectable caffeic acid-bioconjugated gelatin hydrogel for transplantation.

J Cell Physiol 2019 03 24;234(3):1967-1977. Epub 2018 Aug 24.

Department of Periodontology and Implantology, Faculty of Dental Sciences, Centre for Regenerative Medicine and Stem Cell Research, Sri Ramachandra Medical College and Research Institute, Porur, India.

Present-day scaffolds are useful in cell therapy to a reasonable extent, but in pursuit of improvising the scaffold to improve the outcome, we tested a new injectable caffeic acid-bioconjugated gelatin hydrogel scaffold (CBGH; with tunable stiffness -10%). Two-dimensional (2D) form of human umbilical cord tissue-derived mesenchymal stem cells (HUCMSCs) culture performed based on our previously reported methods and characterized by using multipotent and pluripotent analysis. In addition, neurogenesis was induced in the presence of retinoic acid or neural growth factor or epidermal growth factor categorized by neuronal markers. Read More

View Article and Full-Text PDF

Sustained release of stem cell factor in a double network hydrogel for ex vivo culture of cord blood-derived CD34 cells.

Cell Prolif 2018 Apr 15;51(2):e12407. Epub 2017 Nov 15.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, 200237, China.

Objectives: Stem cell factor (SCF) is considered as a commonly indispensable cytokine for proliferation of haematopoietic stem cells (HSCs), which is used in large dosages during ex vivo culture. The work presented here aimed to reduce the consumption of SCF by sustained release but still support cells proliferation and maintain the multipotency of HSCs.

Materials And Methods: Stem cell factor was physically encapsulated within a hyaluronic acid/gelatin double network (HGDN) hydrogel to achieve a slow release rate. Read More

View Article and Full-Text PDF

Differentiation potential of human adipose stem cells bioprinted with hyaluronic acid/gelatin-based bioink through microextrusion and visible light-initiated crosslinking.

Biopolymers 2018 Feb 15;109(2). Epub 2017 Nov 15.

Department of Materials Science and Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, 560-8531, Japan.

Bioprinting has a great potential to fabricate three-dimensional (3D) functional tissues and organs. In particular, the technique enables fabrication of 3D constructs containing stem cells while maintaining cell proliferation and differentiation abilities, which is believed to be promising in the fields of tissue engineering and regenerative medicine. We aimed to demonstrate the utility of the bioprinting technique to create hydrogel constructs consisting of hyaluronic acid (HA) and gelatin derivatives through irradiation by visible light to fabricate 3D constructs containing human adipose stem cells (hADSCs). Read More

View Article and Full-Text PDF
February 2018

A novel hybrid multichannel biphasic calcium phosphate granule-based composite scaffold for cartilage tissue regeneration.

J Biomater Appl 2018 01 13;32(6):775-787. Epub 2017 Nov 13.

1 Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, 366-1 Ssangyoung-Dong, Cheonan, South Korea.

The objective of the present study was to develop a novel hybrid multichannel biphasic calcium phosphate granule (MCG)-based composite system for cartilage regeneration. First, hyaluronic acid-gelatin (HG) hydrogel was coated onto MCG matrix (MCG-HG). Poly(lactic-co-glycolic acid) (PLGA) microspheres was separately prepared and modified with polydopamine subsequent to BMP-7 loading (B). Read More

View Article and Full-Text PDF
January 2018

Enhanced tissue adhesiveness of injectable gelatin hydrogels through dual catalytic activity of horseradish peroxidase.

Biopolymers 2018 Jan 6;109(1). Epub 2017 Nov 6.

Department of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea.

Development of bioadhesives with tunable mechanical strength, high adhesiveness, biocompatibility, and injectability is greatly desirable in all surgeries to replace or complement the sutures and staples. Herein, the dual catalytic activity of horseradish peroxidase is exploited to in situ form the hydroxyphenyl propionic acid-gelatin/thiolated gelatin (GH/GS) adhesive hydrogels including two alternative crosslinks (phenol-phenol and disulfide bonds) with fast gelation (few seconds - several minutes) and improved physicochemical properties. Their elastic moduli increase from 6. Read More

View Article and Full-Text PDF
January 2018

A hybrid composite system of biphasic calcium phosphate granules loaded with hyaluronic acid-gelatin hydrogel for bone regeneration.

J Biomater Appl 2017 Oct 24;32(4):433-445. Epub 2017 Sep 24.

1 Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Chungnam, Cheonan City, Republic of Korea.

An ideal bone substitute should be made of biocompatible materials that mimic the structure, characteristics, and functions of natural bone. Many researchers have worked on the fabrication of different bone scaffold systems including ceramic-polymer hybrid system. In the present study, we incorporated hyaluronic acid-gelatin hydrogel to micro-channeled biphasic calcium phosphate granules as a carrier to improve cell attachment and proliferation through highly interconnected porous structure. Read More

View Article and Full-Text PDF
October 2017

Synthesis and Characterization of Gelatin-Based Crosslinkers for the Fabrication of Superabsorbent Hydrogels.

Materials (Basel) 2017 Jul 19;10(7). Epub 2017 Jul 19.

Department of Integrative Engineering, Chung-Ang University, Seoul 156756, Korea.

In this work, crosslinkers were prepared by conjugating high- and low-molecular-weight gelatin with different mole ratios of itaconic acid (IA) with double bonds. Then, the gelatin-itaconic acid (gelatin-IA) crosslinkers were compared with the gelatin-methacrylate (gelatin-MA) crosslinkers. The molecular weights and structures of gelatin-MA and gelatin-IA were confirmed using gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR). Read More

View Article and Full-Text PDF

Regulation of adipose-tissue-derived stromal cell orientation and motility in 2D- and 3D-cultures by direct-current electrical field.

Dev Growth Differ 2017 Feb 10;59(2):70-82. Epub 2017 Feb 10.

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.

Cell alignment and motility play a critical role in a variety of cell behaviors, including cytoskeleton reorganization, membrane-protein relocation, nuclear gene expression, and extracellular matrix remodeling. Direct current electric field (EF) in vitro can direct many types of cells to align vertically to EF vector. In this work, we investigated the effects of EF stimulation on rat adipose-tissue-derived stromal cells (ADSCs) in 2D-culture on plastic culture dishes and in 3D-culture on various scaffold materials, including collagen hydrogels, chitosan hydrogels and poly(L-lactic acid)/gelatin electrospinning fibers. Read More

View Article and Full-Text PDF
February 2017

Effect of carbodiimide-derivatized hyaluronic acid gelatin on preventing postsurgical intra-abdominal adhesion formation and promoting healing in a rat model.

J Biomed Mater Res A 2016 May 2;104(5):1175-81. Epub 2016 Feb 2.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.

Adhesions often occur after abdominal surgery. It could cause chronic pelvic pain, intestinal obstruction, and infertility. A hydrogel biomaterial, carbodiimide-derivatized hyaluronic acid gelatin (cd-HA gelatin), has been successfully used to reduce adhesion formation after flexor tendon grafting. Read More

View Article and Full-Text PDF

Highly Compliant Vascular Grafts with Gelatin-Sheathed Coaxially Structured Nanofibers.

Langmuir 2015 Dec 19;31(47):12993-3002. Epub 2015 Nov 19.

Department of Mechanical Engineering, University of Colorado at Boulder , Boulder, Colorado 80309, United States.

We have developed three types of materials composed of polyurethane-gelatin, polycaprolactone-gelatin, or polylactic acid-gelatin nanofibers by coaxially electrospinning the hydrophobic core and gelatin sheath with a ratio of 1:5 at fixed concentrations. Results from attenuated total reflection-Fourier transformed infrared spectroscopy demonstrated the gelatin coating around nanofibers in all of the materials. Transmission electron microscopy images further displayed the core-sheath structures showing the core-to-sheath thickness ratio varied greatly with the highest ratio found in polyurethane-gelatin nanofibers. Read More

View Article and Full-Text PDF
December 2015

Investigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic Acid/Gelatin Microgel-Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration.

Adv Healthc Mater 2016 Jan 26;5(2):255-65. Epub 2015 Oct 26.

Biomechanics Laboratory, Department of Mechanical Engineering, Faculty of Engineering, McGill University, 817 Rue Sherbrooke Ouest, Montreal, QC, H3A 0C3, Canada.

The potential use of a novel scaffold biomaterial consisting of cross-linked hyaluronic acid (HA)-gelatin (Ge) composite microgels is investigated for use in treating vocal fold injury and scarring. Cell adhesion integrins and kinematics of cell motion are investigated in 2D and 3D culture conditions, respectively. Human vocal fold fibroblast (hVFF) cells are seeded on HA-Ge microgels attached to a HA hydrogel thin film. Read More

View Article and Full-Text PDF
January 2016

Dressing with epigallocatechin gallate nanoparticles for wound regeneration.

Wound Repair Regen 2016 03 10;24(2):287-301. Epub 2015 Dec 10.

Department of Materials Science and Engineering, Feng Chia University, Taichung, Taiwan.

Several reagents have been studied to overcome the problems encountered with antiseptic use, such as moderate cutaneous wound cytotoxicity and skin thinning. We successfully prepared a gelatin/chitosan/epigallocatechin gallate nanoparticle incorporated in a poly(γ-glutamic acid)/gelatin hydrogel, which comprised activated carbon fibers with gentamicin, to fabricate a sandwiched dressing to enhance wound regeneration. The inner layer of activated carbon fibers with gentamicin was designed to prevent bacterial infection, and the outer layer of gelatin/chitosan/epigallocatechin gallate nanoparticles incorporated in a poly(γ-glutamic acid)/gelatin hydrogel was designed to prevent inflammation and facilitate reepithelialization. Read More

View Article and Full-Text PDF

Viscoelasticity of hyaluronic acid-gelatin hydrogels for vocal fold tissue engineering.

J Biomed Mater Res B Appl Biomater 2016 Feb 27;104(2):283-90. Epub 2015 Feb 27.

Biomechanics Research Laboratory, Department of Mechanical Engineering, McGill University, Montreal, Quebec, H3A 0C3, Canada.

Crosslinked injectable hyaluronic acid (HA)-gelatin (Ge) hydrogels have remarkable viscoelastic and biological properties for vocal fold tissue engineering. Patient-specific tuning of the viscoelastic properties of this injectable biomaterial could improve tissue regeneration. The frequency-dependent viscoelasticity of crosslinked HA-Ge hydrogels was measured as a function of the concentration of HA, Ge, and crosslinker. Read More

View Article and Full-Text PDF
February 2016

Improved stability and enhanced efficiency to degrade chlorimuron-ethyl by the entrapment of esterase SulE in cross-linked poly (γ-glutamic acid)/gelatin hydrogel.

J Hazard Mater 2015 Apr 28;287:287-95. Epub 2015 Jan 28.

State Key Laboratory of Forest and Soil Ecology, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, China. Electronic address:

Free enzymes often undergo some problems such as easy deactivation, low stability, and less recycling in biodegradation processes, especially in soil condition. A novel esterase SulE, which is responsible for primary degradation of a wide range of sulfonylurea herbicides by methyl or ethyl ester de-esterification, was expressed by strain Hansschlegelia sp. CHL1 and entrapped for the first time in an environment-friendly, biocompatible and biodegradable cross-linked poly (γ-glutamic acid)/gelatin hydrogel (CPE). Read More

View Article and Full-Text PDF

Platelet-rich plasma encapsulation in hyaluronic acid/gelatin-BCP hydrogel for growth factor delivery in BCP sponge scaffold for bone regeneration.

J Biomater Appl 2015 Feb 17;29(7):988-1002. Epub 2014 Sep 17.

Department of Regenerative Medicine, Ssangyong-dong, Chungnam, Republic of Korea Instititue of Tissue Regeneration, College of Medicine, Soonchunhyang University, Ssangyong-dong, Chungnam, Republic of Korea

Microporous calcium phosphate based synthetic bone substitutes are used for bone defect healing. Different growth factor loading has been investigated for enhanced bone regeneration. The platelet is a cellular component of blood which naturally contains a pool of necessary growth factors that mediate initiation, continuation, and completion of cellular mechanism of healing. Read More

View Article and Full-Text PDF
February 2015

An in vivo study of composite microgels based on hyaluronic acid and gelatin for the reconstruction of surgically injured rat vocal folds.

J Speech Lang Hear Res 2014 Apr;57(2):S658-73

PURPOSE The objective of this study was to investigate local injection with a hierarchically microstructured hyaluronic acid-gelatin (HA-Ge) hydrogel for the treatment of acute vocal fold injury using a rat model. METHOD Vocal fold stripping was performed unilaterally in 108 Sprague-Dawley rats. A volume of 25 μl saline (placebo controls), HA-bulk, or HA-Ge hydrogel was injected into the lamina propria (LP) 5 days after surgery. Read More

View Article and Full-Text PDF

Graphene oxide/poly(acrylic acid)/gelatin nanocomposite hydrogel: experimental and numerical validation of hyperelastic model.

Mater Sci Eng C Mater Biol Appl 2014 May 15;38:299-305. Epub 2014 Feb 15.

Biomedical Engineering Department, Maziar University, Noor, Royan 151, Iran.

Owing to excellent thermal and mechanical properties, graphene-based nanomaterials have recently attracted intensive attention for a wide range of applications, including biosensors, bioseparation, drug release vehicle, and tissue engineering. In this study, the effects of graphene oxide nanosheet (GONS) content on the linear (tensile strength and strain) and nonlinear (hyperelastic coefficients) mechanical properties of poly(acrylic acid) (PAA)/gelatin (Gel) hydrogels are evaluated. The GONS with different content (0. Read More

View Article and Full-Text PDF

A combination of biphasic calcium phosphate scaffold with hyaluronic acid-gelatin hydrogel as a new tool for bone regeneration.

Tissue Eng Part A 2014 Jul 21;20(13-14):1993-2004. Epub 2014 Mar 21.

1 Department of Regenerative Medicine, College of Medicine, Soonchunhyang University , Cheonan, South Korea .

A novel bone substitute was fabricated to enhance bone healing by combining ceramic and polymer materials. In this study, Hyaluronic acid (HyA)-Gelatin (Gel) hydrogel was loaded into a biphasic calcium phosphate (BCP) ceramic, and the resulting scaffold, with unique micro- and macroporous orientation, was evaluated for bone regeneration applications. The fabricated scaffold showed high interconnected porosity, with an average compressive strength of 2. Read More

View Article and Full-Text PDF

Entrapment of methyl parathion hydrolase in cross-linked poly(γ-glutamic acid)/gelatin hydrogel.

Biomacromolecules 2014 Feb 21;15(2):690-7. Epub 2014 Jan 21.

Institute of Applied Ecology, Chinese Academy of Sciences , No. 72, Wenhua Road, Shenhe District, Shenyang, Liaoning, China.

Methyl parathion hydrolase (MPH) is an important enzyme in hydrolyzing toxic organophosphorus (OP) compounds. However, MPH is easily deactivated when subjected to extreme environmental conditions and is difficult to recover from the reaction system for reuse, thereby limiting its practical application. To address these shortcomings, we examined the entrapment of MPH in an environment-friendly, biocompatible and biodegradable cross-linked poly(γ-glutamic acid)/gelatin hydrogel. Read More

View Article and Full-Text PDF
February 2014

Production of a composite hyaluronic acid/gelatin blood plasma gel for hydrogel-based adipose tissue engineering applications.

J Biomed Mater Res A 2014 Jul 10;102(7):2220-9. Epub 2013 Aug 10.

Center for Stem Cell and Gene Therapies Research and Practice, Kocaeli University, Izmit Kocaeli, Turkey, 41380.

Standard approaches to soft-tissue reconstruction include autologous adipose tissue transplantation, but most of the transferred adipose tissue is generally reabsorbed in a short time. To overcome this problem, long lasting implantable hydrogel materials that can support tissue regeneration must be produced. The purpose of this study was to evaluate the suitability of composite 3D natural origin scaffolds for reconstructive surgery applications through in vitro tests. Read More

View Article and Full-Text PDF