3,142,337 results match your criteria acid tba

Protection of Beta Boswellic Acid against Streptozotocin-induced Alzheimer's Model by Reduction of Tau Phosphorylation Level and Enhancement of Reelin Expression.

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

Laboratory of Neuro-organic Chemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.

Alzheimer's disease is a growing general health concern with huge implications for individuals and society. Beta boswellic acid, a major compound of the plant, has long been used for the treatment of various inflammatory diseases. The exact mechanism of beta boswellic acid action in Alzheimer's disease pathogenesis remains unclear. Read More

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Reactive oxygen species-responsive nanoplatforms for nucleic acid-based gene therapy of cancer and inflammatory diseases.

Biomed Mater 2021 Jun 11. Epub 2021 Jun 11.

China Pharmaceutical University, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, P. R. China, Nanjing, Jiangsu, 210009, CHINA.

Nucleic acid-based gene therapy has recently made important progress toward clinical implementation, and holds tremendous promise for the treatment of some life-threatening diseases, such as cancer and inflammation. However, the on-demand delivery of nucleic acid therapeutics in target cells remains highly challenging. The development of delivery systems responsive to specific pathological cues of diseases is expected to offer promising alternatives for overcoming this problem. Read More

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Increased pro-inflammatory cytokines in ovary and effect of γ-linolenic acid on adipose tissue inflammation in a polycystic ovary syndrome model.

J Reprod Immunol 2021 Jun 5;146:103345. Epub 2021 Jun 5.

Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India. Electronic address:

Polycystic Ovary Syndrome (PCOS), a major endocrine disorder, affects the reproductive function of a woman, along with an association with metabolic conditions like insulin resistance and inflammation. The inflammatory nature of PCOS is much debated over, owing to numerous cases of elevation in cytokine levels. Studies have shown the beneficiary effect of Gamma-Linolenic acid (GLA) in reducing inflammation related to many conditions such as atopic dermatitis, rheumatoid arthritis, arterial disease, obesity, and even PCOS. Read More

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ADP-ribosylation of DNA and RNA.

DNA Repair (Amst) 2021 Jun 3;105:103144. Epub 2021 Jun 3.

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom. Electronic address:

ADP-ribosylation is a chemical modification of macromolecules found across all domains of life and known to regulate a variety of cellular processes. Notably, it has a well-established role in the DNA damage response. While it was historically known as a post-translational modification of proteins, recent studies have shown that nucleic acids can also serve as substrates of reversible ADP-ribosylation. Read More

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Controlled assembly of nitrogen-doped iron carbide nanoparticles on reduced graphene oxide for electrochemical reduction of carbon dioxide to syngas.

J Colloid Interface Sci 2021 May 29;601:877-885. Epub 2021 May 29.

College of Chemistry and Environmental Science, Inner Mongolia Key Laboratory of Green Catalysis and Inner Mongolia Collaborative Innovation Center for Water Environment Safety, Inner Mongolia Normal University, Hohhot 010022, China. Electronic address:

The electrocatalytic CO reduction reaction (CORR) decreases the amount of greenhouse gas in the atmosphere while enabling a closed carbon cycle. Herein, iron oleate was used as a precursor to produce oleic acid-coated triiron tetraoxide nanoparticles ([email protected] NPs) by pyrolysis, which was then assembled with reduced graphene oxide (rGO) and doped with dicyandiamide as a nitrogen source to obtain nitrogen-doped iron carbide nanoparticles assembled on rGO (N-FeC/rGO NPs). The catalyst prepared by nitrogen doping at 800 °C with an [email protected] NPs to rGO weight ratio of 20:1 showed good activity and stability for the CORR. Read More

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Effect of dietary hempseed cake on milk performance and haemato-chemicals in lactating Alpine dairy goats.

Animal 2021 Jun 8;15(7):100255. Epub 2021 Jun 8.

Department for Animal Production and Biotechnology, Faculty of Agrobiotechnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, V. Preloga 1, 31000 Osijek, Croatia.

Owing to the high concentrations of crude protein and beneficial fatty acids, hempseed cake could be a high-quality feedstuff for ruminants. The aim of the present study was to evaluate the effects of hempseed cake on milk production and quality, as well as haemato-chemical parameters in Alpine goats. In total, 28 French Alpine dairy goats were evaluated over 45 days. Read More

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Interaction of CP levels in maternal and nursery diets, and its effect on performance, protein digestibility, and serum urea levels in piglets.

Animal 2021 Jun 8;15(7):100266. Epub 2021 Jun 8.

Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), 9090 Melle, Belgium; Department of Nutrition, Genetics and Ethology, Ghent University, Merelbeke, Belgium. Electronic address:

Reduced protein levels in nursery diets have been associated with a lower risk of postweaning diarrhea, but the interaction with CP levels in maternal diet on the performance of the offspring remains unclear. The objective of this study was to determine the effect of protein content in sow gestation and piglet nursery diets on the performance of the piglets until slaughter. This was studied in a 2 × 2 factorial trial (35 sows, 209 piglets), with higher or lower (H or L) dietary CP in sow diets (168 vs 122 g CP/kg) during late gestation. Read More

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MOF-enzyme hybrid nanosystem decorated 3D hollow fiber membranes for in-situ blood separation and biosensing array.

Biosens Bioelectron 2021 Jun 5;190:113413. Epub 2021 Jun 5.

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China. Electronic address:

Modified metal-organic frameworks (MOFs) doping with enzymes exhibit high enzyme stability and catalytic performance, which is a research hotspot in the field of enzyme-based sensing. Although the MOF-enzyme constitutes a 3D structure in the nanoscale, the macroscopic assembly configuration still stays in 1D or 2D structures, limiting sensing applications towards complex biological targets. Herein, the MOF-enzyme hybrid nanosystem was assembled into 3D porous conductive supports via a controllable physical embedding method, displaying high enzymatic loading, stability and cascade catalytic performance. Read More

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Starch-fatty acid complexes improve the gel properties and enhance the fatty acid content of Nemipterus virgatus surimi under high-temperature treatment.

Food Chem 2021 May 30;362:130253. Epub 2021 May 30.

College of Food Science and Technology, Bohai University, National & Local Joint Engineering Research Center of Storage, Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products, Jinzhou, Liaoning 121013, China.

The effect of high amylose corn starch (HAS)-fatty acid complexes on the gel properties, protein secondary structure, microstructure, fatty acid content, and sensory properties of surimi under high-temperature treatment were investigated. The formation of HAS-fatty acid complexes increased melting temperature and decreased average particle size of HAS. The addition of HAS-fatty acid complexes significantly improved the breaking force, deformation and whiteness of surimi gels. Read More

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A valproic acid-modified platinum diimine complex as potential photosensitizer for photodynamic therapy.

J Inorg Biochem 2021 Jun 5;222:111508. Epub 2021 Jun 5.

Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, China. Electronic address:

Histone deacetylase inhibitors have often been used in combination treatment of various types of cancers due to their non-genotoxic epigenetic potential. Valproic acid (VPA) is a well-known histone deacetylase inhibitor. Conjugate of VPA with a phtoactive platinum diimine complex through an ester bond has been fabricated to potentiate the photocytotoxicity of the photosensitizer. Read More

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Ultrasmall MoS nanodots-wrapped perfluorohexane nanodroplets for dual-modal imaging and enhanced photothermal therapy.

Colloids Surf B Biointerfaces 2021 May 27;205:111880. Epub 2021 May 27.

Department of Ultrasonography, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China. Electronic address:

Development of a multifunctional nanotherapeutic agent with high contrast-enhanced dual-modal imaging and photothermal therapy (PTT) efficacy is of great interest. Combination of ultrasound (US) and computed tomography (CT) imaging offers high spatial resolution images, showing great potential in medical imaging. Herein, the semiconducting perfluorohexane (PFH) nanodroplets, MoS-PFH-PLLAs, are developed by stabilizing PFH droplets with the coating shell of poly (lactic-co-glycolic acid) (PLLA) and encapsulating the droplets with photoabsorbers of ultrasmall molybdenum disulfide (MoS) nanodots. Read More

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Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction.

Environ Int 2021 Jun 8;155:106666. Epub 2021 Jun 8.

Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, United States.

Background: Air pollution exposure has been linked with diminished fertility. Identifying the metabolic changes induced by periconception air pollution exposure among women could enhance our understanding of the potential biological pathways underlying air pollution's reproductive toxicity.

Objective: To identify serum metabolites associated with periconception air pollution exposure and evaluate the extent to which these metabolites mediate the association between air pollution and live birth. Read More

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Interaction of selected terpenoids with two SARS-CoV-2 key therapeutic targets: An in silico study through molecular docking and dynamics simulations.

Comput Biol Med 2021 Jun 8;134:104538. Epub 2021 Jun 8.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Messina, Italy.

The outbreak of COVID-19 disease caused by SARS-CoV-2, along with the lack of targeted medicaments, forced the scientific world to search for new antiviral formulations. In the current emergent situation, drug repurposing of well-known traditional and/or approved drugs could be the most effective strategy. Herein, through computational approaches, we aimed to screen 14 natural compounds from limonoids and terpenoids class for their ability to inhibit the key therapeutic target proteins of SARS-CoV-2. Read More

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Peroxidasin promotes diabetic vascular endothelial dysfunction induced by advanced glycation end products via NOX2/HOCl/Akt/eNOS pathway.

Redox Biol 2021 Jun 6;45:102031. Epub 2021 Jun 6.

Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, 41008, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address:

Reactive oxygen species (ROS) derived from NADPH oxidases (NOX) plays an essential role in advanced glycation end products (AGEs)-induced diabetic vascular endothelial dysfunction. Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (HO) to hypochlorous acid (HOCl). This present study aimed to elucidate the role of PXDN in promoting vascular endothelial dysfunction induced by AGEs in diabetes mellitus. Read More

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Genetic and pathogenic characterization of a novel recombinant avian infectious bronchitis virus derived from GI-1, GI-13, GI-28, and GI-19 strains in Southwestern China.

Poult Sci 2021 Apr 29;100(7):101210. Epub 2021 Apr 29.

Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province; Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science Sichuan University, Chengdu 610064, China. Electronic address:

Avian infectious bronchitis (IB), caused by avian infectious bronchitis virus (IBV), is an acute and highly contagious disease that is extremely harmful to the poultry industry throughout the world. The cross-using of different attenuated live vaccine strains has led to the occurrence of diverse IBV serotypes. In this study, we isolated an IBV strain from a chicken farm in southwest China and designated it CK/CH/SCMY/160315. Read More

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Distribution and molecular characterization of avian infectious bronchitis virus in southern China.

Poult Sci 2021 Mar 27;100(7):101169. Epub 2021 Mar 27.

Guangdong Provincial Animal Virus Vector Vaccine Engineering Technology Research Center, College of Animal Science, South China Agricultural University, Guangzhou, 510642, P.R. China; Key Laboratory of Healthy Animal Husbandry and Environmental Control of Guangdong Province, Guangzhou, 510642, Guangdong, P.R. China. Electronic address:

Avian infectious bronchitis virus (IBV) is causing considerable economic losses in the world poultry industry. The main difficulty of prevention and control of IB disease is the numerous genotypes and serotypes. The genetic analysis of IBV was mainly based on the S1 gene which played an important role in infectivity. Read More

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Molecular characterization of decreased susceptibility to ceftriaxone and genotyping of Neisseria gonorrheae isolates in New Delhi, India.

Diagn Microbiol Infect Dis 2021 May 11;101(1):115423. Epub 2021 May 11.

Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi, India.

Data on genetic characteristics of Neisseria gonorrhoeae isolates exhibiting decreased susceptibility to extended-spectrum cephalosporins in India is deficient. In this study, we have sequenced penA, porB, mtrR and ponA and bla genes in 70 clinical isolates of NG with varying ceftriaxone MICs. Amongst these, 22 (31. Read More

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Evaluation of the Cepheid Xpert SA Nasal Complete for direct detection of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in nasal swabs from pediatric patients.

Diagn Microbiol Infect Dis 2021 May 4;101(1):115417. Epub 2021 May 4.

Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital; Department of Pathology, The Ohio State University, Columbus, OH; Department of Pediatrics, The Ohio State University, Columbus, OH. Electronic address:

Nasal carriers of Staphylococcus aureus (SA) are at increased risk for health-care associated infections with this organism. Timely detection of SA and Methicillin-resistant SA (MRSA) and subsequent decolonization are important components of infection control. While performance of nucleic acid amplification-based tests for detection of SA/MRSA in adults has been well-described, limited data are available in children. Read More

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Synergistic effects of plant growth promoting rhizobacteria and silicon dioxide nano-particles for amelioration of drought stress in wheat.

Plant Physiol Biochem 2021 Jun 4;166:160-176. Epub 2021 Jun 4.

Department of Botany, S.P. College, Srinagar, Jammu, and Kashmir, India.

Drought tolerant plant growth-promoting rhizobacteria (PGPR) can confer drought tolerance in plants, when inoculated, and this effect can be more pronounced by their combined application with silicon oxide nanoparticles (SiO NPs). In this research, drought-tolerant and plant growth-promoting rhizobacterial strains were isolated from the rhizospheric soil of wheat plants growing in the arid region of Pakistan. Out of 30 isolated strains, three rhizobacterial strains were selected based on their drought tolerance, higher phytohormones (indole acetic acid (IAA), abscisic acid (ABA), and cytokinin (CK), and osmolyte (proline and sugar) production ability. Read More

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Impacts of water level fluctuations on mercury concentrations in hydropower reservoirs: A microcosm experiment.

Ecotoxicol Environ Saf 2021 Jun 8;220:112354. Epub 2021 Jun 8.

Department of Physical & Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario M1C 1A4, Canada. Electronic address:

Hydropower generation, a renewable source of electricity, has been linked to elevated methylmercury (MeHg) concentrations in impoundments and aquatic biota. This study investigates the impact of water level fluctuations (WLF) on MeHg concentrations in water, sediment, and fish. Using a set of controlled microcosm experiments emulating the drawdown/refill dynamics and subsequent sediment exposure to air experienced in reservoirs, we demonstrate that less frequent WLFs, and/or increased exposure of sediment to air, can lead to elevated MeHg concentrations in sediment, and total mercury (THg) and MeHg concentrations in water. Read More

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Synthesis and structure-activity relationship of new chalcone linked 5-phenyl-3-isoxazolecarboxylic acid methyl esters potentially active against drug resistant Mycobacterium tuberculosis.

Eur J Med Chem 2021 Jun 2;222:113580. Epub 2021 Jun 2.

Department of Pharmaceutical Technology and Process Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, 500037, Telangana, India. Electronic address:

In search of novel therapeutic agents active against emerging drug-resistant Mycobacterium tuberculosis and to counter the long treatment protocol of existing drugs, herein we present synthesis and biological evaluation of a new series of 5-phenyl-3-isoxazolecarboxylic acid methyl ester-chalcone hybrids. Among 35 synthesized compounds, 32 analogues displayed potent in-vitro activity against Mycobacterium tuberculosis H37Rv with MIC 0.12-16 μg/mL. Read More

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Expression of the Vitreoscilla hemoglobin gene in Nannochloropsis oceanica regulates intracellular oxygen balance under high-light.

J Photochem Photobiol B 2021 Jun 4;221:112237. Epub 2021 Jun 4.

Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Engineering Laboratory of Single Cell Oil, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, China,; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China. Electronic address:

Nannochloropsis oceanica is widely used as a model photosynthetic chassis to produce fatty acids and carotenoid pigments. However, intense light typically causes excessive generation of reactive oxygen species (ROS) and photorespiration in microalgal cells, which results in decreased cell growth rate and unsaturated fatty acid content. In this study, the Vitreoscilla hemoglobin gene (vgb) was introduced into N. Read More

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Tetrabromobisphenol A (TBBPA) anaerobic biodegradation occurs during acidogenesis.

Chemosphere 2021 May 26;282:130995. Epub 2021 May 26.

Laboratory of Biological Processes, Center for Research, Development and Innovation in Environmental Engineering, São Carlos School of Engineering, University of São Paulo (USP), 1100, João Dagnone Ave., Santa Angelina, Zip Code, 13563-120, São Carlos, SP, Brazil. Electronic address:

This is the first study to bring evidence on the anaerobic biodegradation of TBBPA occurring during acidogenesis in domestic sewage at environmentally relevant concentrations by complex microbial communities. This was accomplished by continuously operating two anaerobic structured bed reactors (ASTBR) for over 100 days under acidogenic (Acidogenic Reactor, AR) and multistep methanogenic (Methanogenic Reactor, MR) conditions. In the AR, the temporal carbohydrates consumption and the acetic acid production were strongly correlated with TBBPA removal by the Pearson's test. Read More

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Nano-activated carbon derived from date palm coir waste for efficient sequestration of noxious 2,4-dichlorophenoxyacetic acid herbicide.

Chemosphere 2021 Jun 5;282:131103. Epub 2021 Jun 5.

Department of Chemical Engineering, Khalifa University, P.O. Box 127788, Abu Dhabi, United Arab Emirates. Electronic address:

Alarming water contamination rates by toxic herbicides have drawn attention to treat these pollutants using efficient, easy, and economic techniques. In this work, date-palm coir (DPC) waste-based nano-activated carbon (DPC-AC) was successfully prepared and examined for adsorptive removal of toxic 2,4-dichlorophenoxyacetic acid (2,4-DPA) herbicide from synthetic wastewater. The DPC-AC was synthesized via a single-step carbonization-KOH activation approach. Read More

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Extent of bioleaching and bioavailability reduction of potentially toxic heavy metals from sewage sludge through pH-controlled fermentation.

Water Res 2021 May 27;201:117303. Epub 2021 May 27.

Department of Environmental Engineering, Marmara University, Goztepe, Istanbul 34722, Turkey. Electronic address:

Utilization of anaerobically stabilized sewage sludge on arable lands serve as a renewable alternative to chemical fertilizers as it enables recycling of valuable nutrients to food chain. However, probable presence of heavy metals in sewage sludge restricts the use of stabilized sludge on lands. In this study, a novel approach based on pH-controlled fermentation and anaerobic metal bioleaching was developed to reduce ecotoxicity potential of fermented sludge prior to its land application. Read More

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Bio-electrochemically extracted nitrogen from residual resources for microbial protein production.

Bioresour Technol 2021 Jun 8;337:125353. Epub 2021 Jun 8.

Biomass Energy and Environmental Engineering Research Center, Beijing University of Chemical Technology, Beijing 100029, China; College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:

Upcycling of nutrients from residual resources for producing microbial protein (MP) is an attractive method to valorize residues. In this study, we investigated bio-electrochemical methods to recover ammonia-N, for further production of MP. Reject water and digestate were used for ammonia-N recovery in microbial fuel cell (MFC) system. Read More

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Conjugated linoleic acid improves meiotic spindle morphology and developmental competence of heat-stressed bovine oocyte.

Theriogenology 2021 May 27;172:67-72. Epub 2021 May 27.

Pasargad Institute for Advanced Innovative Solutions (PIAIS), Khatam University, Tehran 1991633356, Iran.

This study was conducted to elucidate the effects of introducing conjugated linoleic acid (CLA) on meiotic spindle organization of heat stressed (HS) matured oocytes and the resulting blastocysts DNA methylation as well as the expression of the genes involved in DNA methylation (DNMT3a, DNMT3b and DNMT1). Immature bovine oocytes were cultured at 41 °C for the first 12 h and 38.5 °C for the second 12 h of maturation time in the presence of 0 and 50 μM of CLA (HS and HS + CLA groups, respectively). Read More

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Combination curettage and modified ALA-PDT for multiple basal cell carcinomas of the face and head.

Photodiagnosis Photodyn Ther 2021 Jun 8:102393. Epub 2021 Jun 8.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, China. Electronic address:

Basal cell carcinoma (BCC) is a common non-melanoma skin malignancy arising in sun exposure area. Patient with multiple BCCs has a high-risk factor for recurrence and is very difficult to be treated with current methods. 5-aminolaevulinic acid-photodynamic therapy (ALA-PDT) is proved to treat superficial type of BCCs with superior efficacy and an excellent cosmetic result, but deep tumor is limited. Read More

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Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b.

J Sport Health Sci 2021 Jun 8. Epub 2021 Jun 8.

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China; Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China. Electronic address:

Background: Exercise is beneficial for muscle atrophy. Peroxisome proliferator-activated receptor gamma (PPARγ) and microRNA-29b (miR-29b) have been reported to be responsible for angiotensin Ⅱ (AngⅡ)-induced muscle atrophy. However, it is unclear whether exercise can protect AngⅡ-induced muscle atrophy by targeting PPARγ/miR-29b. Read More

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Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice.

Mol Metab 2021 Jun 8:101269. Epub 2021 Jun 8.

Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Objective: Throughout the last decade, interest has intensified in intermittent fasting, ketogenic diets, and exogenous ketone therapies as prospective health-promoting, therapeutic, and performance-enhancing agents. However, the regulatory roles of ketogenesis and ketone metabolism on liver homeostasis remain unclear. Therefore, we sought to develop a better understanding of the metabolic consequences of hepatic ketone body metabolism by focusing on the redox-dependent interconversion of acetoacetate (AcAc) and D-β-hydroxybutyrate (D-βOHB). Read More

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