Gastroenterology 2021 Apr 2. Epub 2021 Apr 2.
Department of Neurology, Duke University, Durham, NC 27710, USA; Department of Anesthesiology, Duke University, Durham, NC 27710, USA; Department of Neurobiology, Duke University, Durham, NC 27710, USA; Neurology Clinics for Headache, Head-Pain and Trigeminal Sensory Disorders, Duke University, Durham NC 27705, USA; Clinics for Innovative Pain Therapy, Department of Anesthesiology, Duke University, Raleigh NC 27512, USA. Electronic address:
Background & Aims: Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of anti-pruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus.
Methods: Pruritogenicity of LPC, LPA's precursor, was examined in naïve mice, cholestatic mice, and nonhuman primates. Read More