12,072 results match your criteria acid homocysteine


Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis.

Lipids Health Dis 2021 Apr 12;20(1):31. Epub 2021 Apr 12.

Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Background: Hyperhomocysteinemia (HHcy) is associated with various health problems, but less is known about the gender differences in risk factors for high plasma homocysteine (Hcy) levels.

Methods: In this study, a retrospective study was carried out on 14,911 participants (7838 males and 7073 females) aged 16-102 years who underwent routine checkups between January 2012 and December 2017 in the Health Management Department of Xuanwu Hospital, China. Anthropometric measurements, including body mass index (BMI) and waist-to-hip ratio, were collected. Read More

View Article and Full-Text PDF

Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis.

Pharmacol Res 2021 Apr 7:105599. Epub 2021 Apr 7.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Avenue, Chengdu 611137, P.R. China. Electronic address:

Atherosclerosis, a chronic multifactorial disease, is closely related to the development of cardiovascular diseases and is one of the predominant causes of death worldwide. Normal vascular endothelial cells play an important role in maintaining vascular homeostasis and inhibiting atherosclerosis by regulating vascular tension, preventing thrombosis and regulating inflammation. Currently, accumulating evidence has revealed that endothelial cell apoptosis is the first step of atherosclerosis. Read More

View Article and Full-Text PDF

The Impact of Telmisartan on Cardiometabolic Risk Factors in Hypertensive Male Siblings of Women with Polycystic Ovary Syndrome.

J Clin Pharmacol 2021 Apr 10. Epub 2021 Apr 10.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Brothers of women with polycystic ovary syndrome (PCOS) were found to be at increased risk for cardiometabolic disorders. This risk may be exacerbated by concurrent poorly-controlled hypertension. Angiotensin II receptor blockers are the most frequently used anti-hypertensive drugs. Read More

View Article and Full-Text PDF

Syntheses of Water-Soluble Silver(II)-Phthalocyanines toward Optical Sensing for Thiol Detection.

Inorg Chem 2021 Apr 9. Epub 2021 Apr 9.

University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan.

Water-soluble silver(II)-phthalocyanine complexes (AgPcs), tetrakis{4-(-alkylpyridinium)thio}phthalocyaninato silver(II) tetrafluoroborate, [Ag(tRpySpc)](BF), (R = Me and Et), have been synthesized for the first time by quaternization of pyridyl groups of tetrakis(4-pyridylthio)phthalocyaninato silver(II) by using Meerwein reagents and characterized by ESI-MS, elemental analyses, and optical absorption spectroscopy. Although they strongly aggregate in water, the presence of appropriate surfactants, such as polyethyleneglycol-monooleyl ether ( = approximately 50; PEG50) and sodium dodecyl sulfate, effectively disaggregates them to monomeric species. The spectral properties of the AgPcs and their aggregates in aqueous and nonaqueous solutions have been investigated by optical absorption, emission, and magnetic circular dichroism spectroscopy. Read More

View Article and Full-Text PDF

[Cobalamin in the complex treatment and prevention of cognitive impairment].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):132-137

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Cognitive impairment (CI) develops not only in structural damage to the central nervous system, but also in encephalopathies of dysmetabolic and deficiency etiology. Recently, special attention is focused on the appearance of CI due to the deficiency of cobalamin (vitamin B) and folic acid (FA), the change in the level of homocysteine (HC). To detect vitamin B deficiency is possible by examining key biomarkers in serum based on a decrease in the levels of vitamin B and holotranscobalamin, and levels of methylmalonic acid (MMA) and HC. Read More

View Article and Full-Text PDF

A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Am J Clin Nutr 2021 Apr 7. Epub 2021 Apr 7.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.

Background: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. Read More

View Article and Full-Text PDF

Colorimetric detection of homocysteine by a pyridylazo dye-based Cu complex via indicator displacement mechanism.

Anal Biochem 2021 Apr 4:114185. Epub 2021 Apr 4.

Research Institute of Industrial Technology, Toyo University, 2100 Kujirai, Kawagoe, Saitama, 350-8585, Japan.

A BrPAPS based Cu complex has been developed as a colorimetric probe for the selective recognition of homocysteine (Hcy) over cysteine (Cys) and glutathione (GSH) in an aqueous solution via the indicator displacement assay. BrPAPS formed a complex with Cu in a 1:1 ratio (BrPAPS-Cu) accompanied by the color change from yellow to red. Detecting Hcy is based on high affinity of Hcy for Cu. Read More

View Article and Full-Text PDF

The impact of hypotestosteronemia on cardiometabolic effects of atorvastatin in men with hypercholesterolemia: a pilot study.

Coron Artery Dis 2021 Mar 16. Epub 2021 Mar 16.

Department of Internal Medicine and Clinical Pharmacology Department of Pediatrics in Bytom, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.

Background: Hypothyroidism, hyperprolactinemia, macroprolactinemia and low vitamin D status were found to impair pleiotropic effects of hypolipidemic agents. The aim of the current study was to investigate whether cardiometabolic effects of atorvastatin in men are determined by endogenous testosterone.

Methods: We studied three groups of men matched for age, BMI, plasma lipids and blood pressure: 19 untreated subjects with low testosterone levels (group A), 19 normotestosteronemic men receiving testosterone preparations (group B) and 21 untreated men with testosterone levels within the reference range (group C). Read More

View Article and Full-Text PDF

Maternal vitamin B12 deficiency and perinatal outcomes in southern India.

PLoS One 2021 6;16(4):e0248145. Epub 2021 Apr 6.

St. John's Research Institute, Bangalore, Karnataka, India.

Background: Vitamin B12 deficiency during pregnancy has been associated with adverse maternal and infant health outcomes. Few prospective studies have investigated vitamin B12 status early in pregnancy, and its links to infant vitamin B12 status, particularly in India where the burden of vitamin B12 deficiency is estimated to be the highest globally. The objective of this study was to examine the associations of maternal vitamin B12 biomarkers with neonatal vitamin B12 status. Read More

View Article and Full-Text PDF

Anti--homocysteine-protein autoantibodies are associated with impaired cognition.

Alzheimers Dement (N Y) 2021 31;7(1):e12159. Epub 2021 Mar 31.

Department of Biochemistry and Biotechnology Poznań University of Life Sciences Poznań Poland.

Introduction: Elevated homocysteine (Hcy) and related metabolites accelerate Alzheimer's disease. Hcy-lowering B vitamins slow brain atrophy/cognitive decline in mild cognitive impairment (MCI). Modification with Hcy-thiolactone generates auto-immunogenic -Hcy-protein. Read More

View Article and Full-Text PDF

Did Amino Acid Side Chain Reactivity Dictate the Composition and Timing of Aminoacyl-tRNA Synthetase Evolution?

Genes (Basel) 2021 Mar 12;12(3). Epub 2021 Mar 12.

Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.

The twenty amino acids in the standard genetic code were fixed prior to the last universal common ancestor (LUCA). Factors that guided this selection included establishment of pathways for their metabolic synthesis and the concomitant fixation of substrate specificities in the emerging aminoacyl-tRNA synthetases (aaRSs). In this conceptual paper, we propose that the chemical reactivity of some amino acid side chains (e. Read More

View Article and Full-Text PDF

The Effect of Omega-3 Fatty Acids on Thromboxane, Brain-Derived Neurotrophic Factor, Homocysteine, and Vitamin D in Depressive Children and Adolescents: Randomized Controlled Trial.

Nutrients 2021 Mar 27;13(4). Epub 2021 Mar 27.

Department of Paediatric Psychiatry, Faculty of Medicine, The National Institute of Children's Diseases, Comenius University, Limbová 1, 833 40 Bratislava, Slovakia.

In the DEPOXIN project, we have found that a high ratio of omega-6/omega-3 fatty acids (FA) is associated with worsening of depressive symptoms in children and adolescents with depressive disorder (DD) and that the 12-week omega-3 FA supplementation modulates DD symptoms. Here we present our results of the secondary outcomes: the levels of thromboxane (TXB), brain-derived neurotrophic factor (BDNF), homocysteine (HCy) and vitamin D. Fifty-eight patients were randomized into two arms. Read More

View Article and Full-Text PDF

Proteome-Wide Analysis of Protein Lysine -Homocysteinylation in .

J Proteome Res 2021 04 2. Epub 2021 Apr 2.

Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Poznań 60-632, Poland.

Protein -homocysteinylation by a homocysteine (Hcy) metabolite, Hcy-thiolactone, is an emerging post-translational modification (PTM) that occurs in all tested organisms and has been linked to human diseases. The yeast is widely used as a model eukaryotic organism in biomedical research, including studies of protein PTMs. However, patterns of global protein -homocysteinylation in yeast are not known. Read More

View Article and Full-Text PDF

Neuroprotective Roles of the Reverse Transsulfuration Pathway in Alzheimer's Disease.

Authors:
Bindu Diana Paul

Front Aging Neurosci 2021 16;13:659402. Epub 2021 Mar 16.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

The reverse transsulfuration pathway has emerged as a central hub that integrates the metabolism of sulfur-containing amino acids and redox homeostasis. Transsulfuration involves the transfer of sulfur from homocysteine to cysteine. Cysteine serves as the precursor for several sulfur-containing molecules, which play diverse roles in cellular processes. Read More

View Article and Full-Text PDF

Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.

Exp Ther Med 2021 May 16;21(5):483. Epub 2021 Mar 16.

Department of Cardiology, Tianjin Chest Hospital, Tianjin 300211, P.R. China.

Hyperhomocysteinemia (HHcy) can be used as an independent risk factor for predicting cardiovascular disease, stroke and vitamin B12 deficiency. Patients with HHcy have elevated plasma homocysteine (Hcy) concentrations. Enhancing cerebrovascular permeability of substances such as Hcy and brain damage will synergistically increase the symptoms of hypertension, but the specific immune regulation mechanism is still not clear. Read More

View Article and Full-Text PDF

Folic acid alleviates jaundice of phenylhydrazine (PHA)-induced neonatal rats by reducing Lys-homocysteinylation of albumin.

Cell Biol Toxicol 2021 Mar 31. Epub 2021 Mar 31.

Department of Critical Care Medicine, Shanghai Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, 200438, China.

Neonatal jaundice is a common symptom that occurs in neonates during the first month of their life and is generally divided into physiological and pathological subtypes. In serious cases, pathological neonatal jaundice frequently shows complications including seizures, cerebral palsy, and kernicterus. However, due to the unclear pathogenesis of pathological neonatal jaundice, effective drugs for this disease remain unsatisfied. Read More

View Article and Full-Text PDF

Homocysteine and Gliotoxicity.

Neurotox Res 2021 Mar 30. Epub 2021 Mar 30.

Programa de Pós-Graduação em Ciências Biológicas - Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Homocysteine is a sulfur amino acid that does not occur in the diet, but it is an essential intermediate in normal mammalian metabolism of methionine. Hyperhomocysteinemia results from dietary intakes of Met, folate, and vitamin B12 and lifestyle or from the deficiency of specific enzymes, leading to tissue accumulation of this amino acid and/or its metabolites. Severe hyperhomocysteinemic patients can present neurological symptoms and structural brain abnormalities, of which the pathogenesis is poorly understood. Read More

View Article and Full-Text PDF

The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease.

J Obstet Gynaecol Res 2021 Mar 29. Epub 2021 Mar 29.

Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

Due to the spread of the western style diet, which is characterized by high intake of processed food, micronutrients (vitamins and minerals) deficiency is increasing in the Japanese population of all ages and genders. During pregnancy, the elevated demand for micronutrients put pregnant women at even higher risk of micronutrients deficiency. Some micronutrients are relatively famous such that women with reproductive age are recommended to take folic acid supplementation for the prevention of neural tube defect. Read More

View Article and Full-Text PDF

Analysis of Plasma Homocysteine Levels in Patients with Chronic Periodontitis Before and After Nonsurgical Periodontal Therapy Using High-Performance Liquid Chromatography.

Contemp Clin Dent 2020 Jul-Sep;11(3):266-273. Epub 2020 Nov 26.

Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.

Introduction: Homocysteine (Hcy), an inflammatory biomarker, is a sulfur-containing amino acid. Elevated levels of plasma Hcy are evident in various inflammatory conditions and have been described as an independent risk factor for cardiovascular disease. The literature has also stated that a similar association could exist between the chronic periodontitis and plasma-Hcy levels, in otherwise systemically healthy individuals. Read More

View Article and Full-Text PDF
November 2020

Clinical, biochemical, and genetic characterization of acute hepatic porphyrias in a cohort of Argentine patients.

Mol Genet Genomic Med 2021 Mar 25:e1059. Epub 2021 Mar 25.

Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), Hospital de Clínicas José de San Martín, CONICET-UBA, Buenos Aires, Argentina.

Background: Acute Hepatic Porphyrias (AHPs) are characterized by an acute neuroabdominal syndrome including both neuropsychiatric symptoms and neurodegenerative changes. Two main hypotheses explain the pathogenesis of nervous system dysfunction: (a) the ROS generation by autooxidation of 5-aminolevulinic acid accumulated in liver and brain; (b) liver heme deficiency and in neural tissues that generate an oxidative status, a component of the neurodegenerative process.

Methods: We review results obtained from Acute Intermittent Porphyria (AIP) and Variegate Porphyria (VP) families studied at clinical, biochemical, and molecular level at the CIPYP in Argentina. Read More

View Article and Full-Text PDF

A Cross-Sectional Study on the Combined Effect of Body Weight and Coffee Consumption on Serum Levels of Leptin, Vitamin B12, and Folic Acid in Healthy Young Adult Males.

J Multidiscip Healthc 2021 15;14:639-650. Epub 2021 Mar 15.

Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan.

Purpose: Studies on the effect of body weight and coffee consumption on leptin, vitamin B12, and folic acid are scarce and conflicting. This study investigates the effect of body weight and/or coffee consumption rate on the serum levels of these molecules in healthy young adult males.

Patients And Methods: This observational cross-sectional study was carried out at the faculty of pharmacy, Applied Science Private University (ASU), Amman, Jordan, from July to September 2020. Read More

View Article and Full-Text PDF

Homocysteine induced a calcium-mediated disruption of mitochondrial function and dynamics in endothelial cells.

J Biochem Mol Toxicol 2021 Mar 9:e22737. Epub 2021 Mar 9.

Institute of Pharmacology and Toxicology, Zhejiang University, Hangzhou, China.

Homocysteine (Hcy) is a sulfur-containing amino acid that originated in methionine metabolism and the elevated level of Hcy in plasma is considered to be an independent risk factor for cardiovascular diseases (CVD). Endothelial dysfunction plays a major role in the development of CVD, while the potential mechanism of Hcy-induced endothelial dysfunction is still unclear. Here, in Hcy-treated endothelial cells, we observed the destruction of mitochondrial morphology and the decline of mitochondrial membrane potential. Read More

View Article and Full-Text PDF

Effects of Folic Acid Combined with DHA Supplementation on Cognitive Function and Amyloid-β-Related Biomarkers in Older Adults with Mild Cognitive Impairment by a Randomized, Double Blind, Placebo-Controlled Trial.

J Alzheimers Dis 2021 Mar 13. Epub 2021 Mar 13.

Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.

Background: The neuroprotective benefits of combined folic acid and docosahexaenoic acid (DHA) on cognitive function in mild cognitive impairment (MCI) patients are suggested but unconfirmed.

Objective: To explore the effects of 6-month folic acid + DHA on cognitive function in patients with MCI.

Methods: Our randomized controlled trial (trial number ChiCTR-IOR-16008351) was conducted in Tianjin, China. Read More

View Article and Full-Text PDF

Safety of megadose of vitamin D in patients with nephrolithiasis.

Nutrition 2021 Feb 12;87-88:111201. Epub 2021 Feb 12.

Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University, Saint Petersburg, Russia.

Objective: This article describes two patients with renal lithiasis who received a megadose of 25-hydroxy vitamin D (25[OH]D) and had a good outcome.

Methods: The first case reports a 74-year-old man with a long-term history of renal lithiasis and about four episodes of renal crisis. He was treated once with extracorporeal shock wave lithotripsy. Read More

View Article and Full-Text PDF
February 2021

Homocysteine - what is it good for?

Authors:
Joshua W Miller

J Intern Med 2021 Mar 19. Epub 2021 Mar 19.

Dept. of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.

Almost 90 years ago, Vincent du Vigneaud, who would later win the 1955 Nobel prize in chemistry, published the first in vitro synthesis of the sulfur amino acid, homocysteine [1]. Over the next several decades, homocysteine would become recognized as an important intermediate in methionine, folate and one-carbon metabolism. In the 1960s, the pathologist Kilmer McCully proposed the homocysteine theory of atherosclerosis based on observations of thromboembolic disease in young children who suffered from homocystinurias, inborn errors of metabolism that cause extreme increases of homocysteine in the blood and urine [1]. Read More

View Article and Full-Text PDF

Risk factors for incident vertebral fractures in osteoporosis pharmacotherapy: a 2-year, prospective, observational study.

J Bone Miner Metab 2021 Mar 18. Epub 2021 Mar 18.

Japan Osteoporosis Foundation, Tokyo, Japan.

Introduction: To identify predictors for incident fractures in patients on pharmaceutical treatment for osteoporosis by a secondary analysis of the Japanese Osteoporosis Intervention Trial protocol number 4 (JOINT-04), which was a 2-year, randomized, parallel-group, controlled trial of minodronate and raloxifene in women with primary osteoporosis.

Materials And Methods: This was a prospective, observational study using JOINT-04 data, in which biomarkers, such as undercarboxylated osteocalcin (ucOC), N-telopeptide of type 1 collagen, tartrate-resistant acid phosphatase 5b (TRACP-5b), bone alkaline phosphatase, homocysteine, and pentosidine in blood, and physical functions, such as the timed up and go test and one-leg standing test with eyes open (OLST), and the fall risk index, were measured. The relationships of incident morphometric vertebral fractures during the treatment period, as well as prevalent vertebral fractures, and baseline data were analyzed. Read More

View Article and Full-Text PDF