413,483 results match your criteria acid levels

Metabolomics study on the Periplocin-induced cardiotoxicity and the compatibility of Periplocin and Panax notoginseng saponins in reducing cardiotoxicity in rats by GC-MS.

J Sep Sci 2021 May 7. Epub 2021 May 7.

State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

Periplocin, as one of the components of cardiac glycosides in Cortex Periplocae, exhibited cardiotonic effects. Orally ingesting periplocin in high doses or over prolonged periods would cause serious adverse reactions, especially cardiotoxicity, which limits the applications of periplocin in clinical therapy. It has been reported that panax notoginseng saponins could be used in compatibility with periplocin, to reduce the cardiotoxicity of periplocin. Read More

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Transfer Learning to CCSD(T): Accurate Anharmonic Frequencies from Machine Learning Models.

J Chem Theory Comput 2021 May 7. Epub 2021 May 7.

Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.

The calculation of the anharmonic modes of small- to medium-sized molecules for assigning experimentally measured frequencies to the corresponding type of molecular motions is computationally challenging at sufficiently high levels of quantum chemical theory. Here, a practical and affordable way to calculate coupled-cluster quality anharmonic frequencies using second-order vibrational perturbation theory (VPT2) from machine-learned models is presented. The approach, referenced as "NN + VPT2", uses a high-dimensional neural network (PhysNet) to learn potential energy surfaces (PESs) at different levels of theory from which harmonic and VPT2 frequencies can be efficiently determined. Read More

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Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction.

Brain Pathol 2021 May 7:e12968. Epub 2021 May 7.

Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan.

Intrauterine growth restriction (IUGR) is a leading cause of perinatal mortality and morbidity, and IUGR survivors are at increased risk of neurodevelopmental deficits. No effective interventions are currently available to improve the structure and function of the IUGR brain before birth. This study investigated the protective effects of low-intensity pulsed ultrasound (LIPUS) on postnatal neurodevelopmental outcomes and brain injury using a rat model of IUGR induced by maternal exposure to dexamethasone (DEX). Read More

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Transplantation of tauroursodeoxycholic acid-inducing M2-phenotype macrophages promotes an anti-neuroinflammatory effect and functional recovery after spinal cord injury in rats.

Cell Prolif 2021 May 7:e13050. Epub 2021 May 7.

Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si, Korea.

Objectives: In this study, we study the transplantation of tauroursodeoxycholic acid (TUDCA)-induced M2-phenotype (M2) macrophages and their ability to promote anti-neuroinflammatory effects and functional recovery in a spinal cord injury (SCI) model.

Methods: To this end, compared to the granulocyte-macrophage colony-stimulating factor (GM-CSF), we evaluated whether TUDCA effectively differentiates bone marrow-derived macrophages (BMDMs) into M2 macrophages.

Results: The M2 expression markers in the TUDCA-treated BMDM group were increased more than those in the GM-CSF-treated BMDM group. Read More

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Functional milk fat enriched in conjugated linoleic acid prevented liver lipid accumulation induced by a high-fat diet in male rats.

Food Funct 2021 May 7. Epub 2021 May 7.

Cátedra de Bromatología y Nutrición, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina. and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina.

The aim was to investigate the potential effect of functional milk fat (FMF), naturally enriched in conjugated linoleic acid, on the prevention of liver lipid accumulation and some biochemical mechanisms involved in the liver triacylglycerol (TAG) regulation in high-fat (HF) fed rats. Male Wistar rats were fed (60 days) with S7 (soybean oil, 7%) or HF diets: S30 (soybean oil, 30%), MF30 (soybean oil, 3% + milk fat -MF-, 27%) or FMF30 (soybean oil, 3% + FMF, 27%). Nutritional parameters, hepatic fatty acid (FA) composition, liver and serum TAG levels, hepatic TAG secretion rate (TAG-SR), lipoprotein lipase (LPL) activity in adipose tissue and muscle, activities and/or mRNA levels of lipogenic and β-oxidative enzymes, and mRNA levels of transcription factors and FA transport proteins were assessed. Read More

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Exogenously-supplied trehalose inhibits the growth of wheat seedlings under high temperature by affecting plant hormone levels and cell cycle processes.

Plant Signal Behav 2021 May 7:1907043. Epub 2021 May 7.

Institute of Plant Stress Biology, State Key Laboratory of Cotton Biology, Department of Biology, Henan University, Kaifeng, China.

High temperature reduces the yield of crops, and exogenous trehalose can improve the stress resistance of plants. However, the mechanism by which trehalose causes phenotypic changes in plants is still unknown. Here we investigated the effects of exogenously supplied trehalose (1. Read More

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Trace elements and omega-3 fatty acids of black sea (Bulgaria) bivalve species , and . Human health risk.

Nat Prod Res 2021 May 7:1-8. Epub 2021 May 7.

Department of Veterinary Sciences, University of Messina, Messina, Italy.

The study aimed to evaluate trace elements (Cd, Cr, Cu, Fe, Ni, Pb and Zn) concentrations and fatty acids of three Black Sea bivalve species - and as well as human health risk and benefit-risk ratio based on n-3 LC-PUFA vs. toxic/essential elements. The results showed variations in the element concentrations among the analysed species. Read More

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Low serum lycopene, and adequate α-tocopherol levels in patients with psoriasis: A cross-sectional study.

Nutr Health 2021 May 7:2601060211014127. Epub 2021 May 7.

Departament of Preventive Medicine, Universidade Federal de São Paulo, Brazil.

Background: Psoriasis is a chronic, immune-mediated skin disease. It affects skin and joints, characterized by abnormal hyperproliferation of keratinocytes. The worldwide prevalence of psoriasis ranges from 2% to 4%. Read More

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Changes in brown adipose tissue lipid mediator signatures with aging, obesity, and DHA supplementation in female mice.

FASEB J 2021 Jun;35(6):e21592

Center for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.

Brown adipose tissue (BAT) dysfunction in aging and obesity has been related to chronic unresolved inflammation, which could be mediated by an impaired production of specialized proresolving lipid mediators (SPMs), such as Lipoxins-LXs, Resolvins-Rvs, Protectins-PDs, and Maresins-MaRs. Our aim was to characterize the changes in BAT SPMs signatures and their association with BAT dysfunction during aging, especially under obesogenic conditions, and their modulation by a docosahexaenoic acid (DHA)-rich diet. Lipidomic, functional, and molecular studies were performed in BAT of 2- and 18-month-old lean (CT) female mice and in 18-month-old diet-induced obese (DIO) mice fed with a high-fat diet (HFD), or a DHA-enriched HFD. Read More

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Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals.

Int Arch Occup Environ Health 2021 May 6. Epub 2021 May 6.

Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah, Qassim, Saudi Arabia.

Objectives: The present study aimed to evaluate the effects of waste anaesthetic gases on cytokines and oxidative stress of hospital health team members following exposure to waste anaesthetic gases (WAGs).

Subjects And Methods: In total, 180 participants took part in this study; 60 of these were healthy male controls and the 120 participants in the intervention group were staff who work in the operating room. This latter group comprises six occupational subgroups (1) surgeons, (2) surgical assistants, (3) anaesthesiologists (4) anaesthesiology assistants, (5) nurses and (6) janitors. Read More

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Social isolation of goats: significance of visual contact with conspecifics on behavioral and physiological responses.

J Anim Sci 2021 May 7. Epub 2021 May 7.

Agricultural Research Station, Fort Valley State University, Fort Valley, GA 31030, USA.

Social isolation can increase distress in goats, particularly when they cannot maintain visual contact with conspecifics. This experiment was conducted to determine the behavioral and physiological responses in goats during isolation with or without visual contact with conspecifics. Male Spanish goats (uncastrated, 8-mo old, average weight 29. Read More

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Multicellular "hotspots" harbor high-grade potential in lower-grade gliomas.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab026. Epub 2021 Feb 8.

Department of Basic and Clinical Neuroscience, King's College London, London, UK.

Background: Lower-grade gliomas may be indolent for many years before developing malignant behavior. The mechanisms underlying malignant progression remain unclear.

Methods: We collected blocks of live human brain tissue donated by people undergoing glioma resection. Read More

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February 2021

Expression of miR-93-5p as a Potential Predictor of the Severity of Chronic Thromboembolic Pulmonary Hypertension.

Biomed Res Int 2021 17;2021:6634417. Epub 2021 Apr 17.

Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.

Background: MicroRNAs (miRNAs) play an important role in the pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH). However, the potential correlation between miRNA expression and the severity of CTEPH remains unclear. Our previous study indicated that miRNAs hsa-let-7b-3p, hsa-miR-17-5p, hsa-miR-106b-5p, hsa-miR-3202, hsa-miR-665, and hsa-miR-93-5p are closely involved in CTEPH. Read More

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Evaluation potential of PGPR to protect tomato against wilt and promote plant growth.

PeerJ 2021 16;9:e11194. Epub 2021 Apr 16.

Laboratory of Plant Functional Genomics, School of Applied Biosciences, Kyungpook National University, Daegu, South Korea.

Soilborne fungal diseases are most common among vegetable crops and have major implications for crop yield and productivity. Eco-friendly sustainable agriculture practices that can overcome biotic and abiotic stresses are of prime importance. In this study, we evaluated the ability of plant growth-promoting rhizobacterium (PGPR) strain SRB02 to control the effects of tomato wilt disease caused by f. Read More

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Ketogenic Diet Suppressed T-Regulatory Cells and Promoted Cardiac Fibrosis via Reducing Mitochondria-Associated Membranes and Inhibiting Mitochondrial Function.

Oxid Med Cell Longev 2021 19;2021:5512322. Epub 2021 Apr 19.

Department of Cardiovascular surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Ketogenic diet (KD) is popular in diabetic patients but its cardiac safety and efficiency on the heart are unknown. The aim of the present study is to determine the effects and the underlined mechanisms of KD on cardiac function in diabetic cardiomyopathy (DCM). We used db/db mice to model DCM, and different diets (regular or KD) were used. Read More

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Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.

Front Pharmacol 2021 20;12:645879. Epub 2021 Apr 20.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout. Berberine (BBR), its characteristic ingredient, has also been shown to be effective in alleviating monosodium urate crystals-triggered gout inflammation and . Dihydroberberine (DHB) is a hydrogenated derivative of BBR that showed improved efficacy on many metabolic disorders. Read More

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Is the Mitochondrial Function of Keloid Fibroblasts Affected by Cytoglobin?

Malays J Med Sci 2021 Apr 21;28(2):39-47. Epub 2021 Apr 21.

Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Background: A keloid is a benign skin tumour characterised by excessive proliferation of fibroblasts, a process that requires a sufficient amount of energy. The energy needs are associated with adequate oxygen (O) flow and well-functioning mitochondria. It is known that cytoglobin (CYGB) has a function in O distribution. Read More

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Mesorhizobium ciceri as biological tool for improving physiological, biochemical and antioxidant state of Cicer aritienum (L.) under fungicide stress.

Sci Rep 2021 May 6;11(1):9655. Epub 2021 May 6.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

Fungicides among agrochemicals are consistently used in high throughput agricultural practices to protect plants from damaging impact of phytopathogens and hence to optimize crop production. However, the negative impact of fungicides on composition and functions of soil microbiota, plants and via food chain, on human health is a matter of grave concern. Considering such agrochemical threats, the present study was undertaken to know that how fungicide-tolerant symbiotic bacterium, Mesorhizobium ciceri affects the Cicer arietinum crop while growing in kitazin (KITZ) stressed soils under greenhouse conditions. Read More

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Metabolomic and phenotypic implications of the application of fertilization products containing microcontaminants in lettuce (Lactuca sativa).

Sci Rep 2021 May 6;11(1):9701. Epub 2021 May 6.

Department of Environmental Chemistry, Institute of Environmental, Assessment and Water Research (IDAEA), Spanish National Research Council (CSIC), c/Jordi Girona, 18-26, 08034, Barcelona, Spain.

Cultivation practice using organic amendments is plausible to ensure global food security. However, plant abiotic stress due to the presence of metals and organic microcontaminants (OMCs) in fertilization products cannot be overlooked. In this study, we monitored lettuce metabolism and phenotypic response following the application of either sewage sludge (SS), the organic fraction of municipal solid waste, swine manure (SM), chemical fertilizers (CF), or no amendment (C) in a greenhouse facility. Read More

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ATHB2 is a negative regulator of germination in Arabidopsis thaliana seeds.

Sci Rep 2021 May 6;11(1):9688. Epub 2021 May 6.

Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura (IFEVA), Facultad de Agronomía, Universidad de Buenos Aires, Av. San Martín 4453, C1417DSE, Buenos Aires, Argentina.

The germination timing of seeds is of the utmost adaptive importance for plant populations. Light is one of the best characterized factors promoting seed germination in several species. The germination is also finely regulated by changes in hormones levels, mainly those of gibberellin (GA) and abscisic acid (ABA). Read More

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Clinical characteristics of tumor lysis syndrome in childhood acute lymphoblastic leukemia.

Sci Rep 2021 May 6;11(1):9656. Epub 2021 May 6.

Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Tumor lysis syndrome (TLS) is a common and fatal complication of childhood hematologic malignancies, especially acute lymphoblastic leukemia (ALL). The clinical features, therapeutic regimens, and outcomes of TLS have not been comprehensively analyzed in Chinese children with ALL. A total of 5537 children with ALL were recruited from the Chinese Children's Cancer Group, including 79 diagnosed with TLS. Read More

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Metformin perturbs pancreatic differentiation from human embryonic stem cells.

Diabetes 2021 May 6. Epub 2021 May 6.

Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore

Metformin is becoming a popular treatment before and during pregnancy but current literature on exposure to metformin lacks long-term clinical trials and mechanistic studies. Current literature on the effects of metformin on mature pancreatic β cells highlighted its dual, opposing, protective or inhibitory, effects depending on metabolic environments. However, the impact of metformin on developing human pancreatic β cells remains unknown. Read More

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Association of 45-bp ins/del polymorphism of uncoupling protein 2 (UCP2) and susceptibility to nonalcoholic fatty liver and type 2 diabetes mellitus in North-west of Iran.

BMC Res Notes 2021 May 6;14(1):169. Epub 2021 May 6.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: Uncoupling protein 2 (UCP2) plays a crucial role in energy homeostasis via insulin secretion regulation, free fatty acid concentrations, and lipid metabolism. This study aimed to investigate the association of 45-bp ins/del polymorphism of UCP2 with susceptibility to NAFLD (Non-Alcoholic Fatty Liver Disease) and T2DM (Type 2 Diabetes Mellitus). DNA was extracted from the white blood cells of the subjects, and the gene polymorphism was determined using polymerase chain reaction (PCR). Read More

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TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae.

BMC Biol 2021 May 6;19(1):95. Epub 2021 May 6.

Bioinformatics Institute, 30 Biopolis Street, Singapore, 138671, Singapore.

Background: Target of Rapamycin Complex 1 (TORC1) is a highly conserved eukaryotic protein complex that couples the presence of growth factors and nutrients in the environment with cellular proliferation. TORC1 is primarily implicated in linking amino acid levels with cellular growth in yeast and mammals. Although glucose deprivation has been shown to cause TORC1 inactivation in yeast, the precise role of TORC1 in glucose signaling and the underlying mechanisms remain unclear. Read More

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The protective role of serum uric acid against premature membrane rupture in gestational diabetes: a cross-sectional study.

BMC Endocr Disord 2021 May 6;21(1):95. Epub 2021 May 6.

Department of Endocrinology and Metabolism, Institute/University/Hospital: Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, No. 105 Jiefang Road, Jinan City, 250013, Shandong Province, China.

Background: Uric acid has strong antioxidant activity, whereas its oxidative damage is closely related to many diseases. We assessed the association between serum uric acid (SUA) levels and premature rupture of membranes (PROM) in pregnant women with gestational diabetes (GDM) in China.

Methods: In this cross-sectional study, a total of 456 pregnant women were enrolled. Read More

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Probiotic red quinoa drinks for celiacs and lactose intolerant people: study of functional, physicochemical and probiotic properties during fermentation and gastrointestinal digestion.

Int J Food Sci Nutr 2021 May 6:1-11. Epub 2021 May 6.

Physiology Department, University of Murcia, Murcia, Spain.

The consumption of probiotic foods is rather limited for many sectors of the population (vegans, lactose intolerant and celiacs). Therefore, it is necessary to offer functional alternatives for these sectors. Different red quinoa drinks were fermented with (QLPBB) and (QBLBB) at different times. Read More

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Cadmium-induced oxidative stress and transcriptome changes in the wolf spider Pirata subpiraticus.

Sci Total Environ 2021 Apr 27;785:147364. Epub 2021 Apr 27.

College of Resources and Environment, Hunan Agricultural University, Changsha 410128, Hunan, China; Hunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake Area, Changsha 410128, Hunan, China.

Spiders are believed to have enormous potential for indicating heavy metal pollution in ecosystems. The diversity of influencing factors caused significant differences in the toxicities of cadmium (Cd) on spiders. There is limited understanding of the underlying mechanism and response to acute Cd exposure at different concentrations and different poisoning times. Read More

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Characterization of a novel carboxylesterase with catalytic activity toward di(2-ethylhexyl) phthalate from a soil metagenomic library.

Sci Total Environ 2021 Apr 21;785:147260. Epub 2021 Apr 21.

Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address:

A novel carboxylesterase gene estyz5 was isolated from a soil metagenomic library. The recombinant enzyme EstYZ5 is 298 amino acids in length with a predicted molecular weight of 32 kDa. Sequence alignment and phylogenetic analysis revealed that EstYZ5 belongs to the hormone-sensitive lipase (HSL) family with a deduced catalytic triad of Ser144-Glu238-His268. Read More

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Mapping the daily nitrous acid (HONO) concentrations across China during 2006-2017 through ensemble machine-learning algorithm.

Sci Total Environ 2021 Apr 24;785:147325. Epub 2021 Apr 24.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China; State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex, Beijing 100084, China. Electronic address:

Nitrous acid (HONO) is a major source of the hydroxyl radical (OH) and plays a key role in atmospheric photochemistry. The lack of spatially resolved HONO concentration information results in large knowledge gaps of HONO and its role in atmospheric chemistry and air pollution in China. In this work, an ensemble machine learning model comprising of random forest, gradient boosting, and back propagation neural network was proposed, for the first time, to estimate the long-term (2006-2017) daily HONO concentrations across China in 0. Read More

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Exposure estimates of phthalates and DINCH from foods and personal care products in comparison with biomonitoring data in 24-hour urine from the Norwegian EuroMix biomonitoring study.

Environ Int 2021 May 3;155:106598. Epub 2021 May 3.

Norwegian Institute of Public Health, Division of Infection Control and Environmental Health, 0403 Oslo, Norway. Electronic address:

Phthalates are diesters of phthalic acid and have been widely used as plasticizers in polyvinyl chloride (PVC) plastics. Phthalates are also used as excipients in pharmaceuticals and personal care products (PCPs). Phthalates can migrate from the plastic into the air, water and food, and humans can be exposed via multiple pathways such as dermal, oral and inhalation. Read More

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