3,130,138 results match your criteria acid

Biocompatible and biodegradable scaffold based on polytrimethylene carbonate-tricalcium phosphate microspheres for tissue engineering.

Colloids Surf B Biointerfaces 2021 Apr 30;204:111808. Epub 2021 Apr 30.

Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, Sichuan, 610041, China. Electronic address:

Biocompatible polymers and drug delivery vehicles have been driving development in bone regeneration. However, most bone scaffolds show poor degradation and proliferation. In this study, a composite microsphere scaffold was prepared using vancomycin hydrochloride(VH)-loaded polytrimethylene carbonate(PTMC) microsphere (PTMC-VH). Read More

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Green surfactant-dendrimer aggreplexes: An ingenious way to launch dual attack on arch-enemy cancer.

Colloids Surf B Biointerfaces 2021 May 5;204:111821. Epub 2021 May 5.

Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali, 160062, Punjab, India. Electronic address:

Combination therapy, which combines anti-cancer drugs with different oligonucleotides, have shown potential in cancer treatment. However, delivering a hydrophobic anti-cancer drug and a hydrophilic oligonucleotide simultaneously is a herculean task. This study takes advantage of interactions between histidine-lauric acid-based green surfactant and poly(amidoamine) dendrimers to achieve this aim. Read More

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Per and polyfluoroalkyl substances (PFAS) at high concentrations in neonatal Australian pinnipeds.

Sci Total Environ 2021 Apr 30;786:147446. Epub 2021 Apr 30.

Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia. Electronic address:

Per and polyfluorinated substances (PFAS) exposure was investigated in Australian pinnipeds. Concentrations of 16 PFAS were measured in the livers of Australian sea lion (Neophoca cinerea), Australian fur seal (Arctocephalus pusillus doriferus) and a long-nosed Fur Seal (Arctocephalus forsteri) pup sampled between 2017 and 2020 from colonies in South Australia and Victoria. Findings reported in this study are the first documented PFAS concentrations in Australian pinnipeds. Read More

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Characterizing the sources, concentrations and resuspension potential of metals and metalloids in the thoracic fraction of urban road dust.

Sci Total Environ 2021 Apr 30;786:147467. Epub 2021 Apr 30.

Exposure and Biomonitoring Division, Environmental Health Science and Research Bureau, HECSB, Health Canada, Ottawa, ON, Canada; Earth and Environmental Sciences Department, University of Ottawa, Ottawa, ON, Canada.

Road dust is a sink and source of metals and metalloids of human health concern. To date, many studies have examined the composition of road dust but there remain critical knowledge gaps on the chemistry of thoracic fractions (< 10 μm) and their patterns of deposition and resuspension. The goal of this study is to characterize the elemental concentrations and sources of thoracic fractions of road dust and their resuspension potential for Toronto, Ontario, Canada. Read More

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Species, fractions, and characterization of phosphorus in sewage sludge: A critical review from the perspective of recovery.

Sci Total Environ 2021 Apr 30;786:147437. Epub 2021 Apr 30.

Department of Civil and Environmental Engineering, Graduate School of Engineering, Tohoku University, 6-6-06 Aza, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan.

Phosphorus recovery from municipal sewage sludge is a promising way to alleviate the shortage of phosphorus resources. However, the recovery efficiency and cost depend greatly on phosphorus species and fractions in different sewage sludges, i.e. Read More

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Influence of the mobile phase composition on hyphenated ultraviolet and charged aerosol detection for the impurity profiling of vigabatrin.

J Pharm Biomed Anal 2021 May 3;201:114110. Epub 2021 May 3.

University of Würzburg, Institute for Pharmacy and Food Chemistry, 97074, Würzburg, Germany. Electronic address:

Recently, charged aerosol detection (CAD), a universal detection technique in liquid chromatography, has been introduced into monographs of the European Pharmacopoeia (Ph. Eur.), which now employs HPLC-UV-CAD for assessing the impurities of the drug vigabatrin. Read More

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Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation.

Biomaterials 2021 May 4;274:120845. Epub 2021 May 4.

Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea; Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea; Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul, 04763, Republic of Korea. Electronic address:

Sepsis is an acute systemic inflammatory disease triggered by bacterial infection leading organ dysfunctions that macrophages are responsible for major triggering of systemic inflammation. Treatment options are limited to antibiotics and drugs to manage the symptoms of sepsis, but there are currently no molecular-targeted therapies. Here, we identified a novel macrophage-preferable delivery peptide, C10, which we conjugated to truncated domains of NLRX1 (leucine-rich repeat region (LRR), and nucleotide binding domain (NBD)) to obtain C10-LRR and C10-NBD. Read More

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Destroying the structure of extracellular polymeric substance to improve the dewatering performance of waste activated sludge by ionic liquid.

Water Res 2021 Apr 17;199:117161. Epub 2021 Apr 17.

Sichuan Base of International Science and Technology Cooperation for Green Chemical Industry, School of Chemical Engineering, Sichuan University, Chengdu, 610065, China. Electronic address:

The disposal and resource utilization of waste activated sludge (WAS) is a big challenge for its high moisture content. Ionic liquid (IL), 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([EMIM][OTf]), was innovatively used as a conditioner to improve the dewatering performance of WAS. The WAS was characterized by flocs size, three-dimensional excitation-emission matrix (3D-EEM), zeta potential, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM) for the investigation of intensification mechanism. Read More

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Evaluation of immunogenicity and protection mediated by Lawsonia intracellularis subunit vaccines.

Vet Immunol Immunopathol 2021 May 7;237:110256. Epub 2021 May 7.

Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address:

Lawsonia intracellularis is an economically important bacterium that causes ileitis in pigs. Current vaccines for L. intracellularis do not allow for differentiation between infected and vaccinated animals (DIVA), which is beneficial for disease tracking and surveillance. Read More

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Pyridine-containing octadentate ligand NE3TA-PY for formation of neutral complex with Lu(III) and Y(III) for radiopharmaceutical applications: Synthesis, DFT calculation, radiolabeling, and in vitro complex stability.

J Inorg Biochem 2021 Apr 24;221:111436. Epub 2021 Apr 24.

Department of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States of America.

Targeted radionuclide therapy is a developing therapeutic modality for cancer and employs a cytotoxic radionuclide bound to a chelating agent and a bioactive molecule with high binding affinity for a specific biomarker in tumors. An optimal chelator is one of the critical components to control therapeutic efficacy and toxicity of targeted radionuclide therapy. We designed a new octadentate ligand NE3TA-PY (7-[2-[(carboxymethyl)(2-pyridylmethyl)amino]ethyl]-1,4,7-triazacyclononane-1,4-diacetic acid) for β-particle-emitting Lu and Y with targeted radionuclide therapy applications. Read More

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Sustainable treatment of bimetallic (Ag-Pd/α-AlO) catalyst waste from naptha cracking process: An innovative waste-to-value recycling of precious metals.

J Environ Manage 2021 May 7;291:112748. Epub 2021 May 7.

Department of Environment and Energy, Jeonbuk National University, Jeonju, Jeonbuk, 54896, Republic of Korea; Department of Mineral Resources and Energy Engineering, Jeonbuk National University, Jeonju, Jeonbuk, 54896, Republic of Korea. Electronic address:

Bimetallic (Ag-Pd/α-AlO) catalysts are essentially applied to naptha-cracking process with a controlled CO emission. After losing the catalytic properties in long run, the landfilling disposal of spent catalysts poses severe stress to the environment and deprivation of precious metals. Therefore, an innovative solvo-chemical recycling approach that involving the solid-liquid and liquid-liquid mass transfer phenomena was studied. Read More

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Acid mine drainage and sewage impacted groundwater treatment by membrane distillation: Organic micropollutant and metal removal and membrane fouling.

J Environ Manage 2021 May 7;291:112708. Epub 2021 May 7.

Strategic Water Infrastructure Laboratory, School of Civil, Mining and Environmental Engineering, University of Wollongong, Wollongong, NSW, 2522, Australia. Electronic address:

Groundwater is the dominant source of freshwater in many countries around the globe, and the deterioration in its quality by contaminants originating from anthropogenic sources raises serious concern. In this study, a scenario where groundwater is contaminated by acid mine drainage (AMD) from mining activities and/or sewage was envisaged, and the performance of a direct contact membrane distillation (DCMD) system was investigated comprehensively for different compositions of the AMD- and sewage-impacted groundwater. Regardless of the composition, MD membrane achieved 98-100% removal of metals and bulk organics, while the removal of the selected micropollutants ranged between 80 and 100%. Read More

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Tatibody, a recombinant antibody with higher internalization potency.

Mol Immunol 2021 May 7;135:320-328. Epub 2021 May 7.

Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Using antibody drug conjugates (ADC) which can exclusively bind to their target cells and upon internalization release their toxic agent, is one of the most effective methods for killing tumor cells. Therefore, increasing the internalization rate is an important factor for tumor treatment in this case. The aim of the present study was to develop a new variant of pertuzumab (an anti-ErbB2 humanized antibody) with higher internalization rate that can be a good candidate for the production of ADC. Read More

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Chlorogenic acid is a positive regulator of MDA5, TLR7 and NF-κB signaling pathways mediated antiviral responses against Gammacoronavirus infection.

Int Immunopharmacol 2021 May 7;96:107671. Epub 2021 May 7.

Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:

Chlorogenic acid (CGA) is a phenolic compound that has been well studied for its antiviral, anti-inflammatory and immune stimulating properties. This research was aimed to focus on the antiviral properties of CGA on infectious bronchitis virus (IBV) in vivo and in vitro for the very first time. The outcome of in vitro experiments validated that, out of five previously reported antiviral components, CGA significantly reduced the relative mRNA expression of IBV-N in CEK cells. Read More

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Release of soil colloids during flow interruption increases the pore-water PFAS concentration in saturated soil.

Environ Pollut 2021 May 4;286:117297. Epub 2021 May 4.

Department of Civil and Environmental Engineering, University of California, Los Angeles, USA. Electronic address:

Groundwater flow through aquifer soils or packed bed systems can fluctuate for various reasons, which could affect the concentration of natural colloids and per- and polyfluoroalkyl substances (PFAS) in the pore water. In such cases, PFAS concentration could either decrease due to matrix diffusion of PFAS or increase by the detachment of colloids carrying PFAS. Yet, the effect of flow fluctuation on PFAS transport or release in porous media has not been examined. Read More

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Integration of environmental metabolomics and physiological approach for evaluation of saline pollution to rice plant.

Environ Pollut 2021 Apr 27;286:117214. Epub 2021 Apr 27.

Henan Province Engineering Research Center for Biomass Value-added Products, School of Forestry, Henan Agricultural University, Zhengzhou, 450002, China.

Salinisation of soil is associated with urban pollution, industrial development and rising sea level. Understanding how high salinity is managed at the plant cellular level is vital to increase sustainable farming output. Previous studies focus on plant stress responses under salinity tolerance. Read More

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Novel luteolin sensor of tannic acid-stabilized copper nanoclusters with blue-emitting fluorescence.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 30;259:119887. Epub 2021 Apr 30.

College of Arts, Taiyuan University of Technology, Jinzhong, 030600, Shanxi, China. Electronic address:

In this work, the fluorescent copper nanoclusters (Cu NCs) were firstly adopted to detect luteolin with excellent performance. The blue-emitting Cu NCs was successfully prepared through a facile one-pot approach by protection of tannic acid (TA) and chemical reduction of ascorbic acid (AA). The water-soluble nanoclusters possessed uniform size and displayed good stability. Read More

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Degradation of sulfamerazine by a novel CuO@C composite derived from Cu-MOFs under air aeration.

Chemosphere 2021 May 4;280:130678. Epub 2021 May 4.

College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, 610066, China; Key Laboratory of Treatment for Special Wastewater of Sichuan Province Higher Education System, Sichuan, Chengdu, 610066, China. Electronic address:

Most metal-organic frameworks (MOFs) are synthesized from carboxylate and metal precursors by hydrothermal process, which will consume a large amount of solvent and carboxylate. To address this issue, a new strategy for Cu-based MOFs was developed, in which the Cu-based MOFs was obtained by using abundant natural polymer (tannic acid) as one of the precursors and using high-energy ball milling to achieve a self-assembly of tannic acid and copper sulfate. Based on this strategy, a novel Cu-based MOFs derivative (CuO@C composite) was synthesized by high-temperature sintering of Cu-based MOFs and used for sulfamerazine (SMR) removal via O activation. Read More

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One-pot pyrolysis of a typical invasive plant into nitrogen-doped biochars for efficient sorption of phthalate esters from aqueous solution.

Chemosphere 2021 May 3;280:130712. Epub 2021 May 3.

Co-Innovation Center for the Sustainable Forestry in Southern China, College of Biology and the Environment, Nanjing Forestry University, Nanjing, 210037, PR China; National Positioning Observation Station of Hung-tse Lake Wetland Ecosystem in Jiangsu Province, Huaian, Jiangsu, 223100, PR China. Electronic address:

Invasive plants pose a significant threat to natural ecosystems because of their high adaptability, rapid propagation and spreading ability in the environment. In this study, a typical aquatic invasive plant, Pistia stratiotes, was chosen as a novel feedstock for the preparation of nitrogen-doped biochars (NBs) for the first time, and the NBs were used as efficient sorbents to remove phthalate esters (PAEs) from aqueous solution. Characterization results showed that NBs possess great pore structure (up to 126. Read More

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Ultra-high mechanical property and multi-layer porous structure of amidoximation ethylene-acrylic acid copolymer balls for efficient and selective uranium adsorption from radioactive wastewater.

Chemosphere 2021 Apr 30;280:130722. Epub 2021 Apr 30.

Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, China; Institute of Advanced Marine Materials, Harbin Engineering University, 150001, China. Electronic address:

Adsorption uranium [U(VI)] from U-containing radioactive wastewater (URW) is a critical strategy for solving the resource shortage and environmental pollution in pace with the sustainable development of nuclear energy. However, the URW universally exhibits acidity and contains co-existing metal ions with high concentration. Herein, the amidoximation ethylene-acrylic acid copolymer balls (EAA-AO) with aciduric and super-high mechanical property were successfully synthesized through grafting diaminomaleonitrile and further treatment of amidoximation. Read More

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Magnetic nanostructured material as heterogeneous catalyst for degradation of AB210 dye in tannery wastewater by electro-Fenton process.

Chemosphere 2021 May 5;280:130675. Epub 2021 May 5.

Chemistry Department, Federal University of Sergipe (UFS), 49100-000, São Cristóvão, SE, Brazil; Institute of Chemistry, UNESP, National Institute of Alternative Technologies for Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactive Materials (INCT-DATREM), P.O. Box 355, 14800-900, Araraquara, SP, Brazil. Electronic address:

Degradation of the Acid Black 210 dye (AB210) in synthetic and industrial effluent samples was performed, for the first time, using a heterogeneous electro-Fenton (EF) process with a CoFeO/NOM magnetic hybrid catalyst (Hb200). The technique was compared with electrochemical oxidation using electrogenerated hydrogen peroxide (AO-HO). The catalyst was synthesized by the sol-gel technique, using water with a high content of natural organic matter (NOM) as an eco-friendly solvent. Read More

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Iodinated disinfection byproduct formation in a MnO/I/EPS system.

Chemosphere 2021 May 4;280:130643. Epub 2021 May 4.

Faculty of Environmental Engineering, University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, Fukuoka, Japan. Electronic address:

Manganese dioxide (MnO) is a Mn deposit widely accumulated in the corrosion layer of pipelines, and iodide (I) is a halogen ion frequently detected in waters. The biofilm dwelling on the corrosion scales often secretes extracellular polymeric substances (EPS) into drinking water. The paper aimed to study the I oxidation by MnO and iodinated disinfection byproducts (I-DBPs) formation with biofilm EPS as a precursor. Read More

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Divergent metabolic responses to sex and reproduction in the sea cucumber Apostichopus japonicus.

Comp Biochem Physiol Part D Genomics Proteomics 2021 May 6;39:100845. Epub 2021 May 6.

Liaoning Key Lab of Germplasm Improvement and Fine Seed Breeding of Marine Aquatic Animals, Liaoning Ocean and Fisheries Science Research Institute, Dalian, Liaoning 116023, PR China. Electronic address:

The sea cucumber Apostichopus japonicus is an economically important marine organism, and its aquaculture has rapidly developed in China. The very large market demand puts forward higher requirements for the economically efficient breeding of sea cucumbers. Sex and the associated reproductive processes have been reported to affect the physiological characteristics of sea cucumbers. Read More

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The blue-light receptor CRY1 interacts with GID1 and DELLA proteins to repress GA signaling during photomorphogenesis in Arabidopsis.

Mol Plant 2021 May 7. Epub 2021 May 7.

College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan Hybrid Rape Engineering and Technology Research enter, Hunan University, Changsha 410082, China; Shenzhen Institute, Hunan University, Shenzhen, 518057, China. Electronic address:

Light is a critical environmental cue that regulates a variety of diverse plant developmental processes. Cryptochrome 1 (CRY1) is the major photoreceptor mediating blue light-dependent photomorphogenic responses, such as inhibition of hypocotyl elongation. Gibberellin (GA) participates in repressing photomorphogenesis and promotes hypocotyl elongation. Read More

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PGI inhibits intestinal epithelial permeability and apoptosis to alleviate colitis.

Cell Mol Gastroenterol Hepatol 2021 May 7. Epub 2021 May 7.

Université de Nantes, Inserm, TENS, The Enteric Nervous System in Gut and Brain Disorders, Institut des Maladies de l'Appareil Digestif, Nantes, F-44093, France. Electronic address:

Background And Aims: Inflammatory bowel diseases (IBD) that encompass both ulcerative colitis and Crohn's disease are a major public health problem with an etiology that has not been fully elucidated. There is a need to improve disease outcomes and preventive measures by developing new effective and lasting treatments. While polyunsaturated fatty acid metabolites play an important role in the pathogenesis of several disorders, their contribution to IBD is yet to be understood. Read More

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High-throughput insertional mutagenesis reveals novel targets for enhancing lipid accumulation in Nannochloropsis oceanica.

Metab Eng 2021 May 7. Epub 2021 May 7.

Wageningen University, Bioprocess Engineering, PO Box 16, 6700 AA, Wageningen, Netherlands.

The microalga Nannochloropsis oceanica is considered a promising platform for the sustainable production of high-value lipids and biofuel feedstocks. However, current lipid yields of N. oceanica are too low for economic feasibility. Read More

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Food reward depends on TLR4 activation in dopaminergic neurons.

Pharmacol Res 2021 May 7:105659. Epub 2021 May 7.

Guangdong Provincial Key Laboratory of Animal Nutrition Control, Guangzhou, Guangdong 510642, China; National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China. Electronic address:

The rising prevalence of obesity and being overweight is a worldwide health concern. Food reward dysregulation is the basic factor for the development of obesity. Dopamine (DA) neurons in the ventral tegmental area (VTA) play a vital role in food reward. Read More

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Taste-induced facial responses in black-handed spider monkeys (Ateles geoffroyi).

Behav Processes 2021 May 7:104417. Epub 2021 May 7.

IFM Biology, Linköping University, SE-581 83, Linköping, Sweden. Electronic address:

Taste-induced facial expressions are thought to reflect the hedonic valence of an animal's gustatory experience. We therefore assessed taste-induced facial responses in six black-handed spider monkeys (Ateles geoffroyi) to water, sucrose, caffeine, citric acid and aspartame, representing the taste qualities sweet, bitter, and sour, respectively. We decided not to include salty-tasting substances as the concentrations of such tastants found in the fruits consumed by spider monkeys are below their taste preference threshold. Read More

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Evaluation of heptelidic acid as a potential inhibitor for tau aggregation-induced Alzheimer's disease and associated neurotoxicity.

Int J Biol Macromol 2021 May 7. Epub 2021 May 7.

Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Electronic address:

Tau is a major component of protein plaques in tauopathies, especially Alzheimer's disease (AD). The purpose of the present study is to explore the inhibitory effects of heptelidic acid as a bioactive compound from fungus T. koningii on tau fibrillization and associated neurotoxicity. Read More

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Enhanced adsorption of acid Blue-25 dye onto chitosan/porous carbon composite modified in 1-allyl-3-methyl imidazolium bromide ionic liquid.

Int J Biol Macromol 2021 May 7. Epub 2021 May 7.

Green Analytical Chemistry Laboratory, School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia. Electronic address:

In this study, chitosan/porous carbon composite (C-PC) modified in 1-Allyl-3-methyl imidazolium bromide [AMIM][Br] under airtight condition was prepared for the removal of Acid Blue-25 dye (AB-25) from aqueous medium. For comparison of adsorption efficiency of C-PC, chitosan-activated carbon composite (C-AC) was also prepared in 1% acetic acid. The adsorbents were characterised using SEM, EDX, XRD, BET, TGA and FTIR. Read More

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