915,525 results match your criteria ache


A Collaborative Partnership between the Multicenter Handoff Collaborative and an Electronic Health Record Vendor.

Appl Clin Inform 2021 May 28;12(3):647-654. Epub 2021 Jul 28.

Department of Anesthesiology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.

Objectives:  The operating room is a specialized, complex environment with many factors that can impede effective communication during transitions of care between anesthesia clinicians. We postulated that an efficient, accessible, standardized tool for intraoperative handoffs built into standard workflow would improve communication and handoff safety. Most institutions now use an electronic health record (EHR) system for patient care and have independently designed intraoperative handoff tools, but these home-grown tools are not scalable to other organizations and lack vendor-supported features. Read More

View Article and Full-Text PDF

Drug-induced Myopathies.

Z Orthop Unfall 2021 Jul 28. Epub 2021 Jul 28.

Professional Association for Orthopaedic and Trauma Surgery (BVOU), Berlin, Germany.

Differential diagnosis of muscle pain and weakness is extensive, including neurological, vertebral, arthrogenic, vascular, traumatic, immunological, endocrine, genetic and infectious aetiologies, as well as medication or toxin-related causes. Muscles are highly sensitive to a large number of drugs, especially with high doses. Although many drug classes can cause toxic myopathy, a significant number of cases are caused by lipid-lowering drugs, long-term use of corticosteroids, and, most often, alcohol misuse. Read More

View Article and Full-Text PDF

Implementing Virtual Case-Based Learning in Dental Interprofessional Education.

Pain Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Oral Surgery, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114.

View Article and Full-Text PDF

Pain location is associated with fracture type in acute osteoporotic thoracolumbar vertebral fracture: a prospective observation study.

Pain Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Spine Surgery, Honghui Hospital of Xi'an Jiaotong University Health Science Center.

Objective: This study investigated the relationship between pain location and fracture type in the patients with acute osteoporotic vertebral fracture (OVF).

Design: A prospective observation study.

Subject: A total of 306 patients with acute OVF were included. Read More

View Article and Full-Text PDF

Efficacy and Safety of Awake CT-guided Percutaneous Balloon Compression of Trigeminal Ganglion for Trigeminal Neuralgia.

Pain Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, 94305, USA.

Objectives: To describe the method and clinical efficacy of awake CT-guided percutaneous balloon compression (PBC) as a treatment for trigeminal neuralgia (TN).

Design: In this case-series, TN patients were treated with awake CT-guided PBC and followed for treatment efficacy and complications for 12 months.

Setting: A single-center study. Read More

View Article and Full-Text PDF

Can imaging help unravel pain in psoriatic arthritis?

Rheumatology (Oxford) 2021 Jul 28. Epub 2021 Jul 28.

Division of Rheumatology, Dept. of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

View Article and Full-Text PDF

Ready Patient One: the role of therapeutic virtual reality in the future management of chronic pain.

Rheumatology (Oxford) 2021 Jul 28. Epub 2021 Jul 28.

Musculoskeletal Epidemiology Centre, University of East Anglia, Norwich, UK.

View Article and Full-Text PDF

Anesthesiology payment methods: US perspective.

Int Anesthesiol Clin 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, New York Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois Department of Anesthesiology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

View Article and Full-Text PDF

Successful Outcomes and Return to Sport After Arthroscopic Bankart Repair in National Collegiate Athletic Association and National Football League Football Players.

Clin J Sport Med 2021 Jul 27. Epub 2021 Jul 27.

Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington; Department of Orthopedics and Sports Medicine, Seattle Children's, Seattle, Washington; Medical College of Georgia, Augusta, Georgia; Orlin & Cohen Orthopedic Group, Woodbury, New York; and The Andrews Research and Education Foundation, Gulf Breeze, Florida.

Objective: To characterize recurrent instability, return to sport (RTS), and patient-reported outcomes (PROs) after arthroscopic Bankart repair for acute traumatic anterior shoulder instability in National Collegiate Athletic Association (NCAA) and National Football League (NFL) football players.

Design: Case series.

Setting: Orthopaedic and sports medicine clinic. Read More

View Article and Full-Text PDF

Distal Gracilis Tear in an Equestrian: A Case Report.

Am J Phys Med Rehabil 2021 Jul 27. Epub 2021 Jul 27.

Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA.

Abstract: A 61-year-old female equestrian presented after two weeks of left medial thigh pain which developed suddenly while exiting a car. She denied any history of recent trauma or falls. On examination she was found to have tenderness at the left distal medial thigh with a palpable region of decreased tissue volume at the gracilis myotendinous junction. Read More

View Article and Full-Text PDF

Cognitive Behavioral Therapy for Sleep Disturbance and Fatigue Following Acquired Brain Injury: Predictors of Treatment Response.

J Head Trauma Rehabil 2021 Jul 26. Epub 2021 Jul 26.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia (Drs Ymer, McKay, Wong, Grima, and Ponsford); Monash Epworth Rehabilitation Research Centre, Melbourne, Australia (Drs Ymer, McKay, Wong, Frencham, Grima, Nguyen, and Ponsford and Ms Tran); Department of Psychology, Epworth Rehabilitation, Melbourne, Australia (Drs Ymer, McKay, and Nguyen); and School of Psychology and Public Health, La Trobe University, Melbourne, Australia (Dr Wong).

Objective: To identify factors associated with treatment response to cognitive behavioral therapy for sleep disturbance and fatigue (CBT-SF) after acquired brain injury (ABI).

Setting: Community dwelling.

Participants: Thirty participants with a traumatic brain injury or stroke randomized to receive CBT-SF in a parent randomized controlled trial. Read More

View Article and Full-Text PDF

Escalating morphine dosage fails to elicit conditioned analgesia in a preclinical chronic neuropathic pain model.

Behav Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

School of Medical Sciences (Neuroscience) and the Brain and Mind Centre, The University of Sydney, New South Wales, Australia.

Many people with chronic pain escalate their opioid dosage to counteract tolerance effects. A treatment regimen consisting of placebos admixed with opioids has been suggested as a possible therapeutic option that could reduce the harm of long-term opioid use. However, the analgesic efficacy of such a regimen requires further investigation before widespread adoption. Read More

View Article and Full-Text PDF

Orexin-2 receptor antagonism in the cornu ammonis 1 region of hippocampus prevented the antinociceptive responses induced by chemical stimulation of the lateral hypothalamus in the animal model of persistent pain.

Behav Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad university Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran Department of Physiology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr Department of Biology, Payame Noor University (PNU) Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.

Orexins are excitatory neuropeptides, mainly produced by neurons located in the lateral hypothalamus, which project to many brain areas. The orexinergic system plays a fundamental role in arousal, sleep/wakefulness, feeding, energy homeostasis, motivation, reward, stress and pain modulation. As a prominent part of the limbic system, the hippocampus has been involved in formalin-induced nociception modulation. Read More

View Article and Full-Text PDF

Spinal Ninjurin2 contributes to the neuropathic pain via NF-κB-mediated neuroinflammation in the spared sciatic nerve injury rats.

Int Immunopharmacol 2021 Jul 25;99:107918. Epub 2021 Jul 25.

Department of Pain Management, the First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China. Electronic address:

Object: Ninjurin2 (nerve injury induced protein 2, NINJ2) is a molecule which mediates cell-to-cell and cell-to-extracellular matrix interactions in the nervous system. Clinical study shows NINJ2 is associated with the development of postherpetic neuralgia. However, it is lack of direct evidence that NINJ2 participated in neuropathic pain. Read More

View Article and Full-Text PDF

Safety and Reactogenicity of the ChAdOx1 (AZD1222) COVID-19 vaccine in Vaccinee in Saudi Arabia.

Int J Infect Dis 2021 Jul 25. Epub 2021 Jul 25.

Specialty Internal Medicine and Quality Department, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN (USA); Infectious Disease Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Introduction: The Kingdom of Saudi Arabia was one of the first countries to implement a COVID-19 vaccination program. Here, we estimated the safety and reactogenicity of the ChAdOx1-S vaccine as administered to adults after the first dose.

Methods: This is a cross-sectional study and included 1592 randomly selected vaccinees from April to May, 2021. Read More

View Article and Full-Text PDF

Infusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: Chemical, toxicological and bioactivities characterization.

J Ethnopharmacol 2021 Jul 25:114455. Epub 2021 Jul 25.

REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, 228 4050-313 Porto, Portugal.

Ethnopharmacological Relevance: Salvia chudaei Batt. & Trab. from Algeria is traditionally used to relieve several dysfunctions, including inflammatory and pain-related situations. Read More

View Article and Full-Text PDF

Accommodative response to ocular surface pain.

Clin Exp Optom 2021 Jul 28:1-7. Epub 2021 Jul 28.

School of Optometry and Vision Science, University of Waterloo, Waterloo, Canada.

Clinical Relevance: The discovery of an accommodative response to ocular surface stimulation could inform clinicians and patients that optical effects may occur due to ocular discomfort and perhaps an assessment of the accommodative system after carrying out interventions impacting the ocular surface, may be warranted.

Background: There have been no previous reports evaluating the effect of noxious stimulation on accommodation. Here, the accommodative response of healthy participants after the application of noxious corneal stimulation is characterised. Read More

View Article and Full-Text PDF

RIP3-mediated necroptosis increases neuropathic pain via microglia activation: necrostatin-1 has therapeutic potential.

FEBS Open Bio 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, Zhejiang, 315040, China.

Neuropathic pain (NP) is a clinical symptom that accompanies many diseases. We investigated the effect of receptor-interacting protein kinase 3 (RIP3)-regulated necroptosis on NP, and explore its relationship with microglia, in order to provide a theoretical basis for further research and provide new insights into the treatment of NP. In this study, the spared nerve injury (SNI) model was used along with intervention with necrostatin and the inhibitor of necroptosis necrostatin-1 (Nec-1). Read More

View Article and Full-Text PDF

4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy for chronic prostatitis.

Prostate 2021 Jul 28. Epub 2021 Jul 28.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, China.

Background: Hyaluronan (HA), an extracellular matrix component, accumulates in most chronic inflammatory tissues. Here, we studied the impact of HA on the pathogenesis of chronic prostatitis.

Materials And Methods: First, we sorted demographic characteristics and peripheral blood serum samples from patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) to assess the relationship between the levels of HA in peripheral blood serum and the severity of inflammation in patients. Read More

View Article and Full-Text PDF

Improvement in Hidradenitis Suppurativa and Quality of Life in Patients Treated With Adalimumab: Real-World Results From the HARMONY Study.

J Eur Acad Dermatol Venereol 2021 Jul 28. Epub 2021 Jul 28.

AbbVie Biopharmaceuticals Ltd, Hod Hasharon, Israel.

Background: Hidradenitis suppurativa (HS), a chronic, recurrent, debilitating skin disease, is characterized by painful, inflammatory, subcutaneous lesions of the axilla, inguinal, and anogenital regions. Overall prevalence of HS is ~1%, and impact of disease on patient quality of life (QoL) and healthcare resource utilization (HRU) is high.

Objectives: To estimate the real-world effectiveness of adalimumab (Humira ) treatment in patients with moderate to severe HS on disease severity, pain, QoL, work productivity, and HRU. Read More

View Article and Full-Text PDF

Time to achieve delivery of nutrition targets is associated with clinical outcomes in critically ill children.

Am J Clin Nutr 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Background: Optimal nutrition in critically ill children involves a complex interplay between the doses, route, and timing of macronutrient delivery.

Objectives: We aimed to examine the association between the time to achieve delivery of 60% of the prescribed energy and protein targets and clinical outcomes in mechanically ventilated children.

Methods: We conducted a prospective, observational cohort study of mechanically ventilated children admitted to pediatric intensive care units (PICUs) worldwide. Read More

View Article and Full-Text PDF

Association of sleep quality and psychological aspects with reports of bruxism and TMD in Brazilian dentists during the COVID-19 pandemic.

J Appl Oral Sci 2021 23;29:e20201089. Epub 2021 Jul 23.

Universidade de São Paulo, Bauru Orofacial Pain Group, Bauru, SP, Brasil.

Background: Dentists are exposed to contamination by SARS-CoV-2 due to dental interventions, leading to a state of alert and potential risk of negative impact in mental health and sleep quality, associated with Temporomandibular Disorder (TMD) and bruxism.

Objective: to evaluate the psychosocial status, sleep quality, symptoms of TMD, and bruxism in Brazilian dentists (DSs) during the COVID-19 pandemic.

Methodology: The sample (n=641 DSs) was divided into three groups (quarantined DSs; DSs in outpatient care; and frontline professionals), which answered an electronic form containing the TMD Pain Screening Questionnaire (Diagnostic Criteria for Temporomandibular Disorders - DC/TMD), the Pittsburgh Sleep Quality Index (PSQI), the Depression, Anxiety and Stress Scale (DASS-21), and the sleep and awake bruxism questionnaire. Read More

View Article and Full-Text PDF

Pain and removal force associated with bracket debonding: a clinical study.

J Appl Oral Sci 2021 23;29:e20200879. Epub 2021 Jul 23.

Nihon University School of Dentistry, Department of Orthodontics, Chiyoda-ku, Tokyo, Japan.

Objective: Pain is a problem during bracket removal, and more comfortable treatment is needed. This study examined the association of pain with the removal force required for ceramic brackets, compared with metal and plastic brackets, to determine which removal method resulted in less pain and discomfort.

Methodology: 81 subjects (mean age, 25. Read More

View Article and Full-Text PDF

Ocular manifestations of Chikungunya fever in the chronic phase.

Arq Bras Oftalmol 2021 Jul 14. Epub 2021 Jul 14.

Department of Ophthalmology, Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil.

Purpose: To identify ocular manifestations in patients with Chikungunya fever in the chronic phase and describe their sociodemographic profile.

Methods: Patients with serologic confirmation of Chikungunya infection were included in this transverse study. All subjects underwent a comprehensive ophthalmologic evaluation, including specific lacrimal function tests (tear break-up time test, Schirmer test, and lissamine green). Read More

View Article and Full-Text PDF

Music-based therapy in rehabilitation of people with multiple sclerosis: a systematic review of clinical trials.

Arq Neuropsiquiatr 2021 Jun;79(6):527-535

Universidade Estadual do Centro-Oeste, Departamento de Fisioterapia, Guarapuava PR, Brazil.

Background: Multiple sclerosis (MS) is a major cause of chronic neurological disability in young adults. An increasing number of controlled studies have assessed the potential rehabilitative effects of new drug-free treatments, complementary to the standard care, including music-based therapy (MBT).

Objective: To analyze the evidence for the effectiveness of MBT within the therapeutic approaches to individuals diagnosed with MS. Read More

View Article and Full-Text PDF

Associations between early postoperative pain outcome measures and late functional outcomes in patients after knee arthroplasty.

PLoS One 2021 28;16(7):e0253147. Epub 2021 Jul 28.

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Introduction/aim: Early rehabilitation, return to daily life activities and function are the ultimate goals of perioperative care. It is unclear which pain-related patient-reported outcome measures (PROM) mirror treatment effects or are related with early and late functional outcomes.

Methods: We examined associations between two approaches of pain management (scheduled vs 'on demand') and PROMs on post-operative days one and five (POD1, 5) with function on POD5 and 3 months after surgery in patients undergoing Total Knee Arthroplasty (TKA) in a single centre. Read More

View Article and Full-Text PDF

Alternatives to Traditional Pedicle Screws for Posterior Fixation of the Degenerative Lumbar Spine.

JBJS Rev 2021 Jul 28;9(7). Epub 2021 Jul 28.

San Francisco Orthopaedic Residency Program, St. Mary's Medical Center, San Francisco, California.

Background: Traditional pedicle screws are currently the gold standard to achieve stable 3-column fixation of the degenerative lumbar spine. However, there are cases in which pedicle screw fixation may not be ideal. Due to their starting point lateral to the pars interarticularis, pedicle screws require a relatively wide dissection along with a medialized trajectory directed toward the centrally located neural elements and prevertebral vasculature. Read More

View Article and Full-Text PDF

FDG PET/CT in Sacroiliac IgG4 Disease.

Clin Nucl Med 2021 Jul 26. Epub 2021 Jul 26.

From the Departments of Nuclear Medicine Radiology, Royal Free London Hospital, London, United Kingdom.

Abstract: A 68-year-old woman with abdominal pain and a raised C-reactive protein was investigated with a CT of the abdomen. CT showed an irregular soft tissue mass anterior to the aorta, which was thought to be neoplastic. The patient underwent 18F-FDG PET/CT, which demonstrated hypermetabolic activity in this mass, as well as further foci of hypermetabolic activity in head and neck, sacroiliac joints, and pelvic floor muscles. Read More

View Article and Full-Text PDF

A Rare Collecting Duct Carcinoma With Widespread Metastasis Visualized by 18F-FDG PET/CT.

Clin Nucl Med 2021 Jul 23. Epub 2021 Jul 23.

From the Departments of Pulmonary and Critical Care Medicine Nuclear Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.

Abstract: Collecting duct carcinoma is a rare and highly aggressive renal tumor with a poor prognosis. The presence of metastasis is common at collecting duct carcinoma diagnosis, but widespread metastases involving multiple soft tissues are extremely unusual. Here, we describe a 65-year-old man presenting with fever and lower leg pain as the first and main manifestations. Read More

View Article and Full-Text PDF

Anterior Atlas Fracture After C1 Laminectomy Which Was Successfully Treated by Brace Therapy: A Case Report.

JBJS Case Connect 2021 Jul 28;11(3). Epub 2021 Jul 28.

Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Case: We report a case of a 67-year-old male patient who underwent a C1 laminectomy with laminoplasty at C2-3 because of cervical ossification of the posterior longitudinal ligament. At 6 weeks after surgery, neck pain occurred after minor trauma without neurological deterioration. Computed tomography (CT) demonstrated C1 anterior atlas fracture with a 3-mm gap. Read More

View Article and Full-Text PDF