37,662 results match your criteria ace inhibitors

Cd immobilization and soil quality under Fe-modified biochar in weakly alkaline soil.

Chemosphere 2021 Apr 29;280:130606. Epub 2021 Apr 29.

Rural Energy & Environment Agency, MARA, Beijing, 100125, China. Electronic address:

Cost-effective and environment-friendly implementation techniques are critical to the success of remediation in large-scale cadmium (Cd) contaminated agricultural soil. Field experiments were conducted to investigate the effect of Fe-modified biochar on Cd bioavailability in soils and uptake by maize (Zea mays L.), soil aggregate distribution and stability, and microbial community composition in weakly alkaline Cd-contaminated soil. Read More

View Article and Full-Text PDF

Association between Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphism with the risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of 53 Studies.

Gene 2021 May 5:145696. Epub 2021 May 5.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Background And Aims: Hemorrhagic stroke (HS) results in significant mortality and disability worldwide. Angiotensin Convertase Enzyme (ACE) is responsible for blood pressure regulation and vascular homeostasis. Our objective was to conduct a comprehensive meta-analysis for ascertaining the association of ACE I/D polymorphism with HS since a number of studies depicted inconclusive evidence. Read More

View Article and Full-Text PDF

ACE-2 down-regulation may act as a transient molecular disease causing RAAS dysregulation and tissue damage in the microcirculatory environment among COVID-19 patients.

Am J Pathol 2021 May 5. Epub 2021 May 5.

Department of Pathology, Faculty of Medicine, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil.

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological agent of COVID-19 (coronavirus disease 2019) and the cause of the current pandemic, produces multiform manifestations throughout the body, causing indiscriminate damage to multiple organ systems, particularly the lungs, heart, brain, kidney, and vasculature. The aim of this review is to provide a new look at the data already available for COVID-19, exploring it as a transient molecular disease that causes negative regulation of ACE-2 (angiotensin-converting enzyme 2) and, consequently, deregulates the renin-angiotensin-aldosterone system (RAAS), promoting important changes in the microcirculatory environment. In addition, the authors seek to demonstrate how these microcirculatory changes may be responsible for the wide variety of injury mechanisms observed in different organs in this disease. Read More

View Article and Full-Text PDF

Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.

Br J Clin Pharmacol 2021 May 7. Epub 2021 May 7.

College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109.

Background And Objective: Enalapril is a prodrug and needs to be activated by carboxylesterase 1 (CES1). A previous in vitro study demonstrated the CES1 genetic variant, G143E (rs71647871), significantly impaired enalapril activation. Two previous clinical studies examined the impact of G143E on single-dose enalapril PK (10 mg); however, the results were inconclusive. Read More

View Article and Full-Text PDF

Use of expedited post-operative protocol for children undergoing appendicostomy reduces length of hospitalization.

J Pediatr Surg 2021 Apr 5. Epub 2021 Apr 5.

Division of Pediatric Surgery, Department of Surgery, University of Utah School of Medicine, 100 N. Mario Ceppechi Drive, Suite 3800, Salt Lake City, UT 84113, United States.

Background: An appendicostomy (ACE) is a surgical option for antegrade enemas in children with severe constipation and/or fecal incontinence who have failed medical management.  In 2019, we initiated an expedited post-operative protocol and sought to examine our short-term outcomes compared with our historical cohort.

Methods: A retrospective review was performed of all children undergoing ACE between 2017 and 2020. Read More

View Article and Full-Text PDF

Potential mechanism of plus semen vaccariae granules in the treatment of diabetes mellitus-induced erectile dysfunction in rats utilizing combined experimental model and network pharmacology.

Pharm Biol 2021 Dec;59(1):547-556

Andrology Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Context: Blume (Amaranthaceae) (ABR) and semen vaccariae (SV) are used commonly in the clinical treatment of erectile dysfunction in males with diabetes mellitus (DMED) to strengthen the kidney and promote blood circulation, and often achieve good curative effects.

Objective: Explore mechanistic details of ABR + SV treatment against DMED.

Materials And Methods: Prediction of key targets by network pharmacology. Read More

View Article and Full-Text PDF
December 2021

Identification of genes involved in neuronal cell death and recovery over time in rat axotomy and neurorrhaphy models through RNA sequencing.

Mol Cell Neurosci 2021 May 4:103628. Epub 2021 May 4.

Regeneration Medicine Research Center, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Electronic address:

Facial nerves are frequently injured during cosmetic or other types of facial surgery. However, information on the genes involved in the damage and recovery of the facial nerves is limited. Here, we aimed to identify the genes affected by facial nerve injury and repair using next-generation sequencing. Read More

View Article and Full-Text PDF

Non-additive effects of foundation species determine the response of aquatic ecosystems to nutrient perturbation.

Ecology 2021 May 7:e03371. Epub 2021 May 7.

Department of Aquatic Ecology, Seestr. 79, 6047 Kastanienbaum, Switzerland.

Eutrophication is a persistent threat to aquatic ecosystems worldwide. Foundation species, namely those that play a central role in the structuring of communities and functioning of ecosystems, are likely important for the resilience of aquatic ecosystems in the face of disturbance. However, little is known about how interactions among such species influence ecosystem responses to nutrient perturbation. Read More

View Article and Full-Text PDF

Perceived risk profile and treatment optimization in heart failure: an analysis from BIOlogy Study to TAilored Treatment in chronic heart failure.

Clin Cardiol 2021 May 7. Epub 2021 May 7.

Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Inserm U1116, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France.

Background: Achieving target doses of angiotensin-converting-enzyme inhibitor/angiotensin-receptor blockers (ACEi/ARB) and beta-blockers in heart failure with reduced ejection fraction (HFrEF) is often underperformed. In BIOlogy Study to TAilored Treatment in chronic heart failure (BIOSTAT-CHF) study, many patients were not up-titrated for which no clear reason was reported. Therefore, we hypothesized that perceived-risk profile might influence treatment optimization. Read More

View Article and Full-Text PDF

Associations Between Adverse Childhood Experiences and Trauma Among Young People Who Offend: A Systematic Literature Review.

Trauma Violence Abuse 2021 May 7:15248380211013132. Epub 2021 May 7.

University of Melbourne, Melbourne, Victoria, Australia.

This systematic review synthesized current knowledge about the prevalence of adverse childhood experiences (ACEs) among young people known to have offended and examined evidence of associations between ACEs, trauma symptoms, and offending behavior. A systematic search of English-language, peer-reviewed studies published from the year 2000 onwards was conducted. A final pool of 124 studies that reported quantitative data were included in the review. Read More

View Article and Full-Text PDF

Association of angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea in a Chinese population: A meta-analysis.

J Renin Angiotensin Aldosterone Syst 2020 Apr-Jun;21(2):1470320320934716. Epub 2020 Jun 17.

Department of Respiratory and Critical Care Medicine, ShenZhen Hospital of Southern Medical University, PR China.

Introduction: Many studies have investigated the association between angiotensin-converting enzyme () gene insertion/deletion (I/D) polymorphism and susceptibility to obstructive sleep apnoea (OSA). However, few have confirmed the relationship between ACE and OSA in the Chinese population. We performed a meta-analysis of studies relating the I/D polymorphism to the risk of OSA in a Chinese population. Read More

View Article and Full-Text PDF

Effect of medical treatment on heart failure incidence in patients with a systemic right ventricle.

Heart 2021 May 6. Epub 2021 May 6.

Adult Congenital Heart Centre, National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK.

Background: To date, clinical trials have been underpowered to demonstrate a benefit from ACE inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) in preventing systemic right ventricle (sRV) failure and disease progression in patients with transposition of the great arteries (TGA). This observational study aimed to estimate the effect of ACEi and ARB on heart failure (HF) incidence and mortality in a large population of patients with an sRV.

Methods: Data on all patients with an sRV under active follow-up at two tertiary centres between January 2007 and September 2018 were studied. Read More

View Article and Full-Text PDF

Adverse childhood experiences and adult self-harm in a female forensic population.

BJPsych Bull 2021 May 7:1-5. Epub 2021 May 7.

South London and Maudsley NHS Foundation Trust, UK.

Aims And Method: This study aimed to investigate the prevalence of adverse childhood experiences (ACEs) among patients in a female forensic psychiatric in-patient medium-secure unit, and to analyse the link between ACEs, adulthood self-harm and associated comorbidities and risk factors. The study used a cross-sectional design, with data gathered from the anonymised electronic health records of patients.

Results: It was found that there was a high prevalence of both ACEs and self-harm among this patient group, and that there was a relationship between the two; those with more ACEs were more likely to have self-harmed during adulthood. Read More

View Article and Full-Text PDF

Covid-19 Clinical Course and Blood Groups: Turkish Population-Based Study.

Turk J Med Sci 2021 May 7. Epub 2021 May 7.

Background/aim: SARS-CoV-2 enters the cell through the binding of the S glycoprotein on the surface of the virus to the angiotensin-converting enzyme 2 (ACE-2) in the host cells and also SARS-CoV S protein binding to ACE-2 was inhibited by anti-A antibodies. The aim of the study was to investigate the relationship between blood groups and the course of COVID-19 in Turkey.

Materials And Methods: Laboratory confirmed COVID-19 patients aged 18 and over (n=39. Read More

View Article and Full-Text PDF

Mentoring from the diverse lens of epidemiologists reveals a dynamic and mutually rewarding relationship.

Ann Epidemiol 2021 May 3. Epub 2021 May 3.

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia SC.

View Article and Full-Text PDF

ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors.

Clin Chim Acta 2021 May 3. Epub 2021 May 3.

Czech Technical University, Faculty of Biomedical Engineering, Sítná 3105, Kladno, Czech Republic; Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague, Czech Republic.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread from China in 2019/2020 to all continents. Significant geographical and ethnic differences were described, and host genetic background seems to be important for the resistance to and mortality of COVID-19. Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4646994) is one of the candidates with the potential to affect infection symptoms and mortality. Read More

View Article and Full-Text PDF

Psychometric properties of Addenbrooke's Cognitive Examination III (ACE-III): An item response theory approach.

PLoS One 2021 6;16(5):e0251137. Epub 2021 May 6.

Departamento de Ingeniería en Sistemas y Ciencias de la Computación, Universidad Católica del Norte, Antofagasta, Chile.

The Addenbrooke's Cognitive Examination III is one of the most widely used tests to assess cognitive impairment. Although previous studies have shown adequate levels of diagnostic utility to detect severe impairment, it has not shown sensitivity to detect mild decline. The aim of this study was to evaluate the psychometric properties of Addenbrooke's Cognitive Examination III in a large sample of elderly people through Item Response Theory, due to the lack of studies using this approach. Read More

View Article and Full-Text PDF

Usefulness of the Monti-Malone procedure as a reconstruction of the antegrade continence enema procedure: a case report.

Surg Case Rep 2021 May 6;7(1):112. Epub 2021 May 6.

Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, Niigata, Japan.

Background: The antegrade continence enema (ACE) procedure is effective for severe constipation in patients with spina bifida and can improve quality of life (QOL). The Monti-Malone procedure (MM), which is a method of creating an enema tract from the colon, has been reported as an alternative to the ACE procedure when the appendix cannot be used. We report the usefulness of MM as a reconstruction of the antegrade continence enema procedure. Read More

View Article and Full-Text PDF

Use of -Lactalbumin and Caseinoglycomacropeptide as Biopeptide Precursors and as Functional Additives in Milk Beverages Fermented by .

Int J Food Sci 2021 13;2021:8822161. Epub 2021 Apr 13.

Department of Biotechnology, Microbiology and Human Nutrition, Faculty of Food Science and Biotechnology, University of Life Sciences in Lublin, 8 Skromna Street, 20-704 Lublin, Poland.

The objective of this investigation was to verify whether biologically active peptides (BAPs) could be obtained from water solutions of -lactalbumin (-la) and caseinoglycomacropeptide (CGMP) through an application of the new strains. Also, the aim of this research was to determine the influence of addition of the analyzed protein preparations to milk subjected to fermentation by tested bacterial strains on the physicochemical properties of obtained milk beverages. The results indicate that CGMP is a more preferable source for the production of BAPs by the test bacteria than -la. Read More

View Article and Full-Text PDF

The role of sex and gender in the selection of Alzheimer patients for clinical trial pre-screening.

Alzheimers Res Ther 2021 May 5;13(1):95. Epub 2021 May 5.

Research Center and Memory Clinic. Fundació ACE. Institut Català de Neurociències Aplicades. Universitat Internacional de Catalunya, Gran Vía de Carles III, 85 BIS, 08028, Barcelona, Spain.

Background: Alzheimer disease (AD) is a progressive neurodegenerative disorder affecting the elderly with a prevalence of 7.1% in women and 3.3% in men. Read More

View Article and Full-Text PDF

Impact of the use of pressurized liquids on the extraction and functionality of proteins and bioactives from brewer's spent grain.

Food Chem 2021 Apr 28;359:129874. Epub 2021 Apr 28.

Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871 Alcalá de Henares (Madrid), Spain; Instituto de Investigación Química "Andrés M. del Rio" (IQAR), Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871 Alcalá de Henares (Madrid), Spain. Electronic address:

A green methodology based on pressurized liquids (PLE) to extract proteins and obtain highly active extracts from brewer's spent grain (BSG) is proposed. Box-Behnken experimental design was employed to study the effect of extraction parameters on the protein content (PC), the total phenolic content (TPC), and the antioxidant activity of extracts. Results were compared with those obtained by conventional alkaline extraction assisted with ultrasounds (UAE). Read More

View Article and Full-Text PDF

Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study.

Arch Microbiol 2021 May 5. Epub 2021 May 5.

Faculty of Science, Department of Chemistry, Karadeniz Technical University, 61080, Trabzon, Turkey.

The angiotensin-converting enzyme (ACE)-related carboxypeptidase, ACE-II, is a type I integral membrane protein of 805 amino acids that contains 1 HEXXH-E zinc binding consensus sequence. ACE-II has been implicated in the regulation of heart function and also as a functional receptor for the coronavirus that causes the severe acute respiratory syndrome (SARS). In this study, the potential of some flavonoids presents in propolis to bind to ACE-II receptors was calculated with in silico. Read More

View Article and Full-Text PDF

Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2): A Review on Pathophysiology, Diagnosis and Investigational Therapeutics.

Curr Med Chem 2021 May 3. Epub 2021 May 3.

University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, Hradec Kralove. Czech Republic.

There is a new public health crisis threatening the world with the emergence and spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was later named as a novel Coronavirus disease or COVID-19. It was then declared a pandemic by the World Health Organization on March 11, 2020. Read More

View Article and Full-Text PDF

Novel Umami Peptide IPIPATKT with Dual Dipeptidyl Peptidase-IV and Angiotensin I-Converting Enzyme Inhibitory Activities.

J Agric Food Chem 2021 May 5. Epub 2021 May 5.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315211, Zhejiang, China.

A novel umami peptide, IPIPATKT, showed excellent dual dipeptidyl peptidase-IV (DPP-IV) and angiotensin I-converting enzyme (ACE) inhibitory activities, the IC values were 64 and 265 μM, respectively. Molecular docking displayed that IPIPATKT was docked into the S1 and S2 pockets of ACE, and it was close to the active site pocket of DPP-IV. The insulin-resistant-HepG2 (IR-HepG2) cell model and human umbilical vein endothelial cell (HUVEC) model showed that the peptide significantly increased the content of glucose, the activities of hexokinase, pyruvate kinase, and the concentration of nitric oxide ( < 0. Read More

View Article and Full-Text PDF

Immunoallergic disorders in the elderly.

Eur Ann Allergy Clin Immunol 2021 May 5. Epub 2021 May 5.

Department of Immunoallergology, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

Summary: Although allergic diseases have become increasingly prevalent in the elderly, there are few data on this population. Through a retrospective analysis of the electronic medical records of patients aged 65 years and above followed in our Immunoallergology Unit, we aimed to characterize the immunoallergic diseases of the elderly. The most common disorders were respiratory diseases (n = 185; 50%), mucocutaneous diseases (n = 113; 31%), drug allergy (n = 31; 8%), food allergy (n = 9; 2%), and anaphylaxis (n = 9; 2%). Read More

View Article and Full-Text PDF

Vehicle emissions-exposure alters expression of systemic and tissue-specific components of the renin-angiotensin system and promotes outcomes associated with cardiovascular disease and obesity in wild-type C57BL/6 male mice.

Toxicol Rep 2021 15;8:846-862. Epub 2021 Apr 15.

Advanced Environmental Research Institute, Department of Biological Sciences, University of North Texas, Denton, TX, 76201, USA.

Exposure to air pollution from traffic-generated sources is known to contribute to the etiology of inflammatory diseases, including cardiovascular disease (CVD) and obesity; however, the signaling pathways involved are still under investigation. Dysregulation of the renin-angiotensin system (RAS) can contribute to CVD and alter lipid storage and inflammation in adipose tissue. Our previous exposure studies revealed that traffic-generated emissions increase RAS signaling, further exacerbated by a high-fat diet. Read More

View Article and Full-Text PDF

polymorphism predicts response to oxaliplatin-based adjuvant chemotherapy in patients with colon cancer.

Am J Cancer Res 2021 15;11(4):1522-1539. Epub 2021 Apr 15.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs Beijing 100021, China.

Response to oxaliplatin-based adjuvant chemotherapy varies among patients with stage II and III colon cancer; however, genetic alterations associated with this response remain incompletely characterized. A three-stage analytical framework, including the discovery, validation, and replication stages, was designed to explore genetic alterations modulating response to oxaliplatin-based chemotherapy in adjuvant setting among patients with stage II and III colon cancer receiving complete resection of tumor. Except for several somatic mutated genes, such as and , showing less definitive associations with response to oxaliplatin-based adjuvant chemotherapy, we found stable associations of rs6891545C > A polymorphism in gene, a key component of DNA damage response system, with the response across all three stages. Read More

View Article and Full-Text PDF

Saliva and its potential in covid-19 cannot be ignored: a point of view.

Infect Control Hosp Epidemiol 2021 May 4:1-5. Epub 2021 May 4.

Associate professor, Conservative dentistry and endodontics, ESIC dental college, Rohini, Guru Gobind Singh Indraprastha

It has been demonstrated that salivary gland duct cells have similar receptors as ACE2-positive cells/keratin epithelial cells of the lung which have high potential to be infected by SARS-CoV 2 virus. The aerosols carrying virus have penetration into the healthy human body and lungs via inhalation through nose or mouth. Read More

View Article and Full-Text PDF

Predictors of fatal outcomes of hospitalized COVID-19 patients with pre-existing hypertension in China.

Clin Respir J 2021 May 3. Epub 2021 May 3.

State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: Coronavirus disease 2019 (COVID-19) is an emerging, rapidly evolving pandemic, hypertension is one of the most common co-existing chronic conditions and a risk factor for mortality. Nearly one third of the adult population are hypertensive worldwide, it is urgent to identify the factors that determine the clinical course and outcomes of COVID-19 patients with hypertension.

Methods And Results: 148 COVID-19 patients with pre-existing hypertension with clarified outcomes (discharge or deceased) from a national cohort in China were included in this study, of whom 103 were discharged and 45 died in hospital. Read More

View Article and Full-Text PDF