37,692 results match your criteria ace

Associations of adverse childhood experiences with stress physiology and insulin resistance in adolescents at risk for adult obesity.

Dev Psychobiol 2021 May 15. Epub 2021 May 15.

Department of Human Development and Family Studies, Colorado State University, Fort Collins, Colorado, USA.

Adverse childhood experiences (ACEs) heighten the risk for adult obesity and cardiometabolic disease, but physiological factors underlying this connection are not well understood. We determined if ACEs were associated with physiological stress response and insulin resistance in adolescents at risk for adult obesity. Participants were 90 adolescents 12. Read More

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Prevalence of liver injury in 445 patients with Corona Virus Disease-19-Single-centre experience from southern India.

Indian J Gastroenterol 2021 May 15. Epub 2021 May 15.

Department of Gastroenterology and Hepatology, MIOT International, 4/112, Mount Poonamalle High Road, Sathya Nagar, Manapakkam, Chennai, 600 089, India.

Background: Abnormal liver function tests (LFT) are common in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vary from 15% to 53%. There are scanty data  from India on the prevalence of liver injury in corona virus disease 2019 (COVID-19) patients.

Methods: We did this retrospective study in a tertiary care hospital, Chennai, India. Read More

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Kidney Function and Outcomes in Patients Hospitalized with Heart Failure.

J Am Coll Cardiol 2021 May 4. Epub 2021 May 4.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: Few contemporary data exist evaluating care patterns and outcomes in HF across the spectrum of kidney function.

Objectives: To characterize differences in quality of care and outcomes in patients hospitalized for HF by degree of kidney dysfunction.

Methods: We evaluated quality metrics among patients hospitalized with HF at 418 sites in the GWTG-HF registry from 2014-2019 by discharge CKD-EPI-derived eGFR. Read More

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Metal pollution of soil, plants, feed and food in the Niger Delta, Nigeria: Health risk assessment through meat and fish consumption.

Environ Res 2021 May 11:111273. Epub 2021 May 11.

African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR); Department of Experimental Pharmacology & Toxicology, Faculty of Pharmacy, University of Port Harcourt, Rivers State, Nigeria.University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria. Electronic address:

This study was aimed at determining mainly the concentrations of As and other metals (Cd, Cu, Hg, Pb, V and Zn) in samples of feed, soil, plants and foods (fish, chicken, goat and cow meat) grown and consumed in six areas of Niger Delta, Nigeria (Choba, Khana, Trans Amadi, Eleme, Uyo and Yenagoa). Principal Component Analysis (PCA) models were used for identifying groups of variables (i.e. Read More

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Comprehensive Understanding of the Relationship between Bioactive Compounds of Black Tea and its Angiotensin Converting Enzyme (ACE) Inhibition and Antioxidant Activity.

Plant Foods Hum Nutr 2021 May 14. Epub 2021 May 14.

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, People's Republic of China.

Long term regular intake of black tea (BT) can lower blood pressure, which is probably due to its antioxidant activity and angiotensin converting enzymes (ACE) inhibitory activity. This study achieves a comprehensive understanding of the relationship between bioactive compounds of BT and its ACE inhibitory activity and antioxidant activity. Phenolic compounds are closely related to antioxidant activity and ACE inhibitory activity. Read More

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Development of effective heparin extraction method from pig by-products and analysis of their bioavailability.

J Anim Sci Technol 2020 Nov 30;62(6):933-947. Epub 2020 Nov 30.

Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Korea.

This study was conducted to develop an effective heparin extraction method by using low-cost and highly effective enzymes from six pig by-products (liver, lung, heart, stomach, small intestine, and large intestine), and analyze their bioavailability. Low-cost and highly effective enzymes (alkaline-AK and papain) and a common enzyme (trypsin) were used for the heparin extraction. The angiotensin I - converting enzyme (ACE) inhibitory activity and the antimicrobial activity of extracted heparin were analyzed to verify their bioavailability. Read More

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November 2020

Relationships between peripheral reactive hyperemia index with coronary plaque burden and prognosis in patients with unstable angina pectoris complicated with type 2 diabetes mellitus.

Ann Transl Med 2021 Apr;9(8):655

Heart Center, Beijing Chaoyang Hospital, Capital Medical University & Beijing Key Laboratory of Hypertension, Beijing, China.

Background: Coronary plaque burden (CPB) is an important prognostic factor in patients with unstable angina pectoris (UAP). Our current study aims to investigate the relationships between peripheral reactive hyperemia index (RHI) with CPB and prognosis in patients with UAP complicated with type 2 diabetes mellitus (T2DM).

Methods: The clinical data of 187 UAP-T2DM patients who were treated in our center from June 2017 to January 2019 were retrospectively collected. Read More

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Making the "C-ACE" for a Culturally-Informed Adverse Childhood Experiences Framework to Understand the Pervasive Mental Health Impact of Racism on Black Youth.

J Child Adolesc Trauma 2021 Jun 11;14(2):233-247. Epub 2020 Aug 11.

National Crime Victims Research and Treatment Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425 USA.

The high prevalence and psychological impact of childhood exposure to potentially traumatic events (PTE) is a major public health concern in the United States. Considerable evidence has demonstrated the significant racial disparities that exist with respect to PTE exposure, indicating that Black youth are particularly burdened by these harmful experiences. Racism may serve a unique role in explaining why Black youth are disproportionately exposed to PTEs, and why mental health disparities are more likely to occur following such experiences. Read More

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Adverse Childhood Experiences, Depression, Resilience, & Spirituality in African-American Adolescents.

J Child Adolesc Trauma 2021 Jun 4;14(2):209-221. Epub 2021 Jan 4.

UTHealth School of Public Health, Houston, TX USA.

Research shows that exposure to adverse childhood experiences (ACEs) is common among adolescents and that exposure to ACEs is associated with an increased risk of depression in adolescents. Furthermore, it is unknown whether resilience and spirituality moderate the association between ACEs and depression in African-American adolescents. Thus, the present study examined the prevalence of ACEs and the association between ACEs and the risk for depression in African-American adolescents and examined whether this association is moderated by resilience and spirituality. Read More

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Radiation Increases Bioavailability of Lisinopril, a Mitigator of Radiation-Induced Toxicities.

Front Pharmacol 2021 27;12:646076. Epub 2021 Apr 27.

Institute for Health and Equity, Division of Biostatistics, Medical College of WI, Milwaukee, WI, United States.

There are no FDA-approved drugs to mitigate the delayed effects of radiation exposure that may occur after a radiological attack or nuclear accident. To date, angiotensin-converting enzyme inhibitors are one of the most successful candidates for mitigation of hematopoietic, lung, kidney, and brain injuries in rodent models and may mitigate delayed radiation injuries after radiotherapy. Rat models of partial body irradiation sparing part of one hind leg (leg-out PBI) have been developed to simultaneously expose multiple organs to high doses of ionizing radiation and avoid lethal hematological toxicity to study the late effects of radiation. Read More

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[Trend of atmosphreic PM_(2. 5) and their components in two districts of Lanzhou City from 2015 to 2019].

Wei Sheng Yan Jiu 2021 Mar;50(2):274-283

Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, China.

Objective: To analyse the variation of the fine particulate matter(PM_(2. 5)) concentration and its chemical composition in two districts of Lanzhou City from 2015 to 2019.

Methods: From January 2015 to December 2019, two sampling points, namely residential district(Chengguan District) and industrial district(Xigu District) were selected in Lanzhou City, to collect PM_(2. Read More

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Role of ACE2 polymorphism in COVID-19: impact of age.

Clin Chem Lab Med 2021 May 13. Epub 2021 May 13.

Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran.

More than 2 million people have died as a result of the COVID-19 outbreak. Angiotensin-converting enzyme 2 (ACE2) is a counter-regulatory enzyme that converts angiotensin-2 to Ang-(1-7) form in the renin-angiotensin system. Several studies have been analyzed the correlation between ACE2 and COVID-19. Read More

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Validation of The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in behavioural variant Frontotemporal Dementia and Alzheimer's Disease.

Int J Geriatr Psychiatry 2021 May 13. Epub 2021 May 13.

Human Cognitive Neuroscience -Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh.

The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) was developed to assess cognitive and behavioural changes in an anterior frontotemporal syndrome (executive functions, language, fluency and behaviour), common in Amyotrophic Lateral Sclerosis (ALS) and also assesses posterior cerebral dysfunction (memory and visuospatial abilities).

Objectives: To validate the ECAS in behavioural variant Frontotemporal Dementia (bvFTD) without ALS, as compared with Alzheimer's Disease (AD), against comprehensive neuropsychological assessment. Compare its sensitivity to that of the Addenbrooke's Cognitive Examination (ACE-III) and investigate behavioural changes in both types of dementia. Read More

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Glycyrrhizin for topical use and prophylaxis of COVID-19: an interesting pharmacological perspective.

J Biol Regul Homeost Agents 2021 Jan-Feb;35(1 Suppl. 2):15-19

Department, University Tor Vergata, Rome, Italy.

COVID-19, the disease caused by the SARS - CoV - 2 pathogen, is currently a pandemic. At the moment there is not an available vaccine, so, scientific community is looking for strategies and drugs to implement prevention and prophylaxis. Several compounds are examined for this purpose. Read More

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Angiotensin receptors and neuropathic pain.

Pain Rep 2021 9;6(1):e869. Epub 2021 Mar 9.

Laboratories of Neuroimmunology, Division of Internal Medicine, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Growing evidence implicates the renin-angiotensin system (RAS) in multiple facets of neuropathic pain (NP). This narrative review focuses primarily on the major bioactive RAS peptide, Angiotensin II (Ang II), and its receptors, namely type 1 (AT1R) and type 2 (AT2R). Both receptors are involved in the development of NP and represent potential therapeutic targets. Read More

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From cellular function to global impact: the vascular perspective on COVID-19.

Can J Surg 2021 05 12;64(3):E289-E297. Epub 2021 May 12.

From the Division of Vascular Surgery, University of Ottawa at The Ottawa Hospital, Ottawa, Ont. (Strauss, Jetty); the Faculty of Medicine, University of Ottawa, Ottawa, Ont. (Strauss, Seo, Carrier, Jetty); the Division of Hematology, Department of Medicine, University of Ottawa, The Ottawa Hospital, Ottawa, Ont. (Carrier); and the Ottawa Hospital Research Institute, Ottawa, Ont. (Carrier).

Since COVID-19 was declared a pandemic a year ago, our understanding of its effects on the vascular system has slowly evolved. At the cellular level, SARS-CoV-2 - the virus that causes COVID-19 - accesses the vascular endothelium through the angiotensin-converting enzyme 2 (ACE-2) receptor and induces proinflammatory and prothrombotic responses. At the clinical level, these pathways lead to thromboembolic events that affect the pulmonary, extracranial, mesenteric, and lower extremity vessels. Read More

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Impact of heart failure drug therapy on rates of gastrointestinal bleeding in LVAD recipients: An INTERMACS analysis.

Int J Artif Organs 2021 May 12:3913988211013366. Epub 2021 May 12.

Division of Cardiology, Department of Medicine, NewYork-Presbyterian Hospital, Columbia University, New York, NY, USA.

Introduction: Gastrointestinal bleeding (GIB) remains a common and vexing complication of left ventricular assist device (LVAD) support. Recent single-center analyses suggest that ACE inhibitors (ACEi)/angiotensin receptor blockers (ARB) and digoxin may prevent GIB in LVAD patients. Here we evaluate the effect of guideline-directed medical therapies (GDMT) for heart failure (HF) on rates of GIB through analysis of the INTERMACS registry database. Read More

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An update on emerging therapeutics to combat COVID-19.

Basic Clin Pharmacol Toxicol 2021 May 11. Epub 2021 May 11.

Division of Veterinary Parasitology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R.S Pura-181102, J & K, India.

Background: The COVID-19 pandemic has demanded effective therapeutic protocol from researchers and clinicians across the world. Currently, a large amount of primary data have been generated from several preclinical studies. At least 300 clinical trials are underway for drug repurposing against COVID-19; the clinician needs objective evidence-based medication to treat COVID-19. Read More

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A systematic review and meta-analysis of angiotensin-converting enzyme inhibitor use and psoriasis incidence.

Sci Rep 2021 May 11;11(1):10037. Epub 2021 May 11.

College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.

Although a considerable volume of data supporting induction or aggravation of psoriasis because of angiotensin-converting enzyme (ACE) inhibitor use exists, it remains insufficient for definitive conclusions. Therefore, we aimed to evaluate the association between ACE inhibitor use and psoriasis incidence through a systematic literature review and meta-analysis. We searched for qualifying studies across PubMed, Web of Science, and Embase. Read More

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Adverse childhood experiences and future self-rated health: a prospective cohort study.

BMC Public Health 2021 May 12;21(1):895. Epub 2021 May 12.

Department of Occupational Medicine, Danish Ramazzini Centre, University Research Clinic, Regional Hospital West Jutland, Gl. Landevej 61, 7400, Herning, Denmark.

Background: Negative life events (re) occurring during childhood is often described as adverse childhood experiences (ACEs) and may have long-lasting negative effects on health. Previous studies on the association between ACEs and self-rated health (SRH) have primarily been focusing on chronic diseases in elderly, non-Scandinavian populations using a cross-sectional design. The aim of the study was to examine the associations between ACEs and SRH in early adulthood and to investigate if disadvantageous health-behavioral strategies explain the association between ACEs and SRH. Read More

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Levels of angiotensin-converting enzyme 1 and 2 in serum and urine of children with Sickle Cell Disease.

J Bras Nefrol 2021 May 3. Epub 2021 May 3.

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Pediatria, Disciplina de Hematologia, São Paulo, SP, Brasil.

Introduction: Sickle cell nephropathy begins in childhood and presents early increases in glomerular filtration, which, over the long term, can lead to chronic renal failure. Several diseases have increased circulating and urinary angiotensin-converting enzyme (ACE) activity, but there is little information about changes in ACEs activity in children with sickle cell disease (SCD).

Objective: We examined circulating and urinary ACE 1 activity in children with SCD. Read More

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Answering the Challenge of COVID-19 Pandemic Through Innovation and Ingenuity.

Adv Exp Med Biol 2021 ;1318:859-873

Department of Surgery, University Campus, St. Luke's University Health Network, Bethlehem, PA, USA.

The novel coronavirus disease 2019 (COVID-19) pandemic has created a maelstrom of challenges affecting virtually every aspect of global healthcare system. Critical hospital capacity issues, depleted ventilator and personal protective equipment stockpiles, severely strained supply chains, profound economic slowdown, and the tremendous human cost all culminated in what is questionably one of the most profound challenges that humanity faced in decades, if not centuries. Effective global response to the current pandemic will require innovation and ingenuity. Read More

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Autoimmune Processes Involved in Organ System Failure Following Infection with SARS-CoV-2.

Adv Exp Med Biol 2021 ;1318:355-368

Biological Safety and Security, Frederick, MD, USA.

During the COVID-19 pandemic associated with high incidence, transmissibility, and mortality, this chapter focuses on three phases of the disease: initial exposure, initiation of the immune response to the agent, and finally, an inflammatory/autoimmune-like presentation with pulmonary, neurological, and renal failure and disseminated intravascular coagulation which occurs in a small proportion of the patients. The elegant demonstration of the site of interaction between the spike (S) protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of COVID-19, and the ACE (angiotensin-converting enzyme) 2 receptor of cells distributed throughout the body has enabled research efforts to develop pharmacological and immune countermeasures to the viral phase of the disease. This chapter rapidly reviews the molecular and structural organization of SARS-CoV-2 and its interaction with ACE2. Read More

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COVID-19 in Patients with Hypertension.

Adv Exp Med Biol 2021 ;1318:243-261

Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Baltimore, MD, USA.

Hypertension has been listed in several case series and retrospective cohorts as a potential risk factor for the incidence and severity of the new coronavirus (SARS-CoV-2)-associated disease (COVID-19). The debate is noteworthy because almost one billion people around the globe are estimated to have hypertensive diseases, according to the Global Burden of Disease study. Considering the SARS-CoV-2's high infectivity rates, a possible interaction between COVID-19 and hypertension is worrisome. Read More

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Lewis pairing and frustration of group 13/15 elements geometrically enforced by (ace)naphthalene, biphenylene and (thio)xanthene backbones.

Chem Soc Rev 2021 May 24;50(9):5777-5805. Epub 2021 Mar 24.

CNRS/Université Paul Sabatier, Laboratoire Hetérochimie Fondamentale et Appliquée (LHFA, UMR 5069), 118 Route de Narbonne, 31062 Cedex 09 Toulouse, France.

The synthesis, structure, and reactivity of mixed group 13/group 15 compounds (E = B, Al, Ga, In, Tl; E = N, P, Sb, Bi) featuring a rigid (ace)naphthalene or (thio)xanthene backbone are discussed in this review. The backbone may either enforce or prevent E→E interactions, resulting in Lewis pairing or frustration. The formation of strong E→E interactions is possible upon peri-substitution of (ace)naphthalenes. Read More

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Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks.

Mol Psychiatry 2021 May 10. Epub 2021 May 10.

Department of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behavior, Nijmegen, The Netherlands.

Activity in the healthy brain relies on a concerted interplay of excitation (E) and inhibition (I) via balanced synaptic communication between glutamatergic and GABAergic neurons. A growing number of studies imply that disruption of this E/I balance is a commonality in many brain disorders; however, obtaining mechanistic insight into these disruptions, with translational value for the patient, has typically been hampered by methodological limitations. Cadherin-13 (CDH13) has been associated with autism and attention-deficit/hyperactivity disorder. Read More

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Case Report: A Rare Presentation of NSAID-Induced Secondary Membranous Nephropathy in a Pediatric Patient.

Front Pediatr 2021 23;9:670575. Epub 2021 Apr 23.

Department of Pathology, Norton Children's and University of Louisville, Louisville, KY, United States.

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults, but it is responsible for <5% of nephrotic syndrome cases in children. MN has primary and secondary forms. Secondary MN is caused by viral infections, autoimmune diseases like lupus, or drugs. Read More

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Maternal, placental and neonatal outcomes after asymptomatic SARS-CoV-2 infection in the first trimester of pregnancy: A case report.

Case Rep Womens Health 2021 Jul 4;31:e00321. Epub 2021 May 4.

Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

The effects of SARS-CoV-2 infection in the first trimester on the pregnant woman and the fetus remain unclear. We describe the complete follow-up of a pregnant woman with asymptomatic SARS-CoV-2 infection in the first trimester. The woman tested positive for SARS-CoV-2 viral RNA in nasopharyngeal swabs in her seventh week of gestation and was admitted to a local hospital for treatment. Read More

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