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The accuracy of patient-reported weight prior to total joint arthroplasty and arthroscopy of the lower extremity.

Arch Orthop Trauma Surg 2021 Jul 31. Epub 2021 Jul 31.

Department of Orthopaedic Surgery, Center for Hip Preservation, Orthopaedic and Rheumatologic Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Mail code A41, Cleveland, OH, 44195, USA.

Purpose: The accuracy of preoperative patient-reported weight was never evaluated in patients undergoing lower extremity procedures. The purpose of this study was to: (1) compare the disparity between patient-reported and measured weights in patients undergoing lower extremity total joint arthroplasty (LE-TJA) and arthroscopy; and (2) investigate the association between patient-specific factors (patient age, BMI, zip code, and psychiatric comorbidities) and the accuracy of patient-reported weight.

Methods: Preoperative self-reported weights were retrospectively compared to measured weights in 400 LE-TJA and 85 control arthroscopy patients. Read More

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Simultaneous LC-MS/MS bioanalysis of alkaloids, terpenoids, and flavonoids in rat plasma through salting-out-assisted liquid-liquid extraction after oral administration of extract from Tetradium ruticarpum and Glycyrrhiza uralensis: a sample preparation strategy to broaden analyte coverage of herbal medicines.

Anal Bioanal Chem 2021 Jul 31. Epub 2021 Jul 31.

Institute of Chinese Materia Medica, The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.

Herbal medicines have historically been practiced in combinatorial way, which achieves therapeutic efficacy by integrative effects of multi-components. Thus, the accurate and precise measurement of multi bioactive components in matrices is inalienable to understanding the metabolism and disposition of herbal medicines. In this study, aiming to provide a strategy that improves analyte coverage, evaluation of six protocols employing sample pretreatment methods- protein precipitation (PPT), liquid-liquid extraction (LLE), sugaring-out-assisted liquid-liquid extraction (SULLE), and salting-out-assisted liquid-liquid extraction (SALLE)- was performed by LC-MS/MS using rat plasma and a mixture of alkaloid (evodiamine, rutaecarpine, dehydroevodiamine), terpenoid (limonin, rutaevin, obacunone), and flavonoid (liquiritin, isoliquiritin, liquiritigenin) standards isolated from Tetradium ruticarpum and Glycyrrhiza uralensis. Read More

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CellCall: integrating paired ligand-receptor and transcription factor activities for cell-cell communication.

Nucleic Acids Res 2021 Jul 31. Epub 2021 Jul 31.

State Key Laboratory of Organ Failure Research, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

With the dramatic development of single-cell RNA sequencing (scRNA-seq) technologies, the systematic decoding of cell-cell communication has received great research interest. To date, several in-silico methods have been developed, but most of them lack the ability to predict the communication pathways connecting the insides and outsides of cells. Here, we developed CellCall, a toolkit to infer inter- and intracellular communication pathways by integrating paired ligand-receptor and transcription factor (TF) activity. Read More

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Comparison of Conventional Methods for Bowel Length Measurement in Laparoscopic Surgery to a Novel Computer-Assisted 3D Measurement System.

Obes Surg 2021 Jul 30. Epub 2021 Jul 30.

Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.

Purpose: Accurate laparoscopic bowel length measurement (LBLM), which is used primarily in metabolic surgery, remains a challenge. This study aims to three conventional methods for LBLM, namely using visual judgment (VJ), instrument markings (IM), or premeasured tape (PT) to a novel computer-assisted 3D measurement system (BMS).

Materials And Methods: LBLM methods were compared using a 3D laparoscope on bowel phantoms regarding accuracy (relative error in percent, %), time in seconds (s), and number of bowel grasps. Read More

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Predicting non-state terrorism worldwide.

Sci Adv 2021 Jul 30;7(31). Epub 2021 Jul 30.

School of Public Health, Imperial College London, London, UK.

Several thousand people die every year worldwide because of terrorist attacks perpetrated by non-state actors. In this context, reliable and accurate short-term predictions of non-state terrorism at the local level are key for policy makers to target preventative measures. Using only publicly available data, we show that predictive models that include structural and procedural predictors can accurately predict the occurrence of non-state terrorism locally and a week ahead in regions affected by a relatively high prevalence of terrorism. Read More

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Review: Multiplexed profiling of biomarkers in extracellular vesicles for cancer diagnosis and therapy monitoring.

Anal Chim Acta 2021 Aug 15;1175:338633. Epub 2021 May 15.

Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. Electronic address:

Extracellular vesicles (EVs) are nanoscale vesicles secreted by normal and pathological cells. The types and levels of surface proteins and internal nucleic acids in EVs are closely related to their original cells, tumor occurrence, and development. Thus, the sensitive and accurate detection of EV biomarkers is a reliable approach for noninvasive disease diagnosis and treatment response monitoring. Read More

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Primary synovial sarcoma of thyroid gland: A case report and review of literature.

Int J Surg Case Rep 2021 Jul 26;85:106245. Epub 2021 Jul 26.

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction And Importance: Synovial cell sarcoma (SS) is an extremely rare mesenchymal malignancy, representing nearly 10% of all soft-tissue sarcomas. These high-grade soft tissue sarcomas commonly arise in the para-articular regions of lower extremities. However, 15% of Synovial sarcomas has been described at Unusual locations, including head, neck, and trunk. Read More

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Assessment reliability of cervical spine parameters on full-body radiographs apply to asymptomatic and spinal deformities subjects.

Orthop Traumatol Surg Res 2021 Jul 27:103026. Epub 2021 Jul 27.

Faculty of Medicine, University of Saint-Joseph in Beirut, Lebanon. Electronic address:

Background: Cervical spinal alignment is usually assessed on full-body radiographs allowing for the concomitant evaluation of possible compensatory mechanisms that may occur at any level in the setting of postural malalignment.

Hypothesis: Cervical parameters measured on full-body radiographs are reliable.

Patients & Methods: A total of 70 subjects were included and divided in 3 groups: asymptomatic adults (N=21), adolescents with idiopathic scoliosis (N=20), and adults with spinal deformity (N=29), for whom full-body low-dose biplanar radiographs were obtained. Read More

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Two-level moderated mediation models with single-level data and new measures of effect sizes.

Behav Res Methods 2021 Jul 29. Epub 2021 Jul 29.

Center for Studies of Psychological Application / School of Psychology, South China Normal University, No.55, West of Zhongshan Avenue, Tianhe District, Guangzhou, 510631, People's Republic of China.

This article proposes a two-level moderated mediation (2moME) model with single level data, and develops measures to quantify the moderated mediation (moME) effect sizes for both the conventional moME model and the 2moME model. A Bayesian approach is developed to estimate and test moME effects and the corresponding effect sizes (ES). Monte Carlo results indicate that (1) the 2moME model yields more accurate estimates of the parameters than the conventional moME model; (2) the 95% credibility interval following the 2moME model covers the moME effects and the ESs more accurately than that following the conventional moME model; and (3) statistical tests for the existence of the moME effects with the 2moME model are more reliable in controlling type I errors than those with the conventional moME model, especially under heteroscedasticity conditions. Read More

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Deep Unsupervised Hashing for Large-Scale Cross-Modal Retrieval Using Knowledge Distillation Model.

Comput Intell Neurosci 2021 17;2021:5107034. Epub 2021 Jul 17.

College of Computer and Information Science, Chongqing Normal University, Chongqing 401331, China.

Cross-modal hashing encodes heterogeneous multimedia data into compact binary code to achieve fast and flexible retrieval across different modalities. Due to its low storage cost and high retrieval efficiency, it has received widespread attention. Supervised deep hashing significantly improves search performance and usually yields more accurate results, but requires a lot of manual annotation of the data. Read More

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Cold-Injection Molded Gentamicin-Impregnated Polymethyl Methacrylate Implants for Cranioplasty.

Oper Neurosurg (Hagerstown) 2021 Jul 29. Epub 2021 Jul 29.

Department of Clinical Neuroscience, Salmaniya Medical Complex, Ministry of Health, Manama, Kingdom of Bahrain.

Background: Cranioplasty can be carried out using either fresh, frozen autologous bone or synthetic substitutes. Ordering artificial 3 dimensional (3D) implants is challenging and time consuming depending on geographical location. In this article, we share our experience using a streamlined process of producing 3D computer-assisted design (CAD) implants using commercially available 3D printers and silicone molds that can be easily replicated with consistent results and are associated with good outcomes. Read More

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Silver enriched silver phosphate microcubes as an efficient recyclable SERS substrate for the detection of heavy metal ions.

J Colloid Interface Sci 2021 Jul 20;605:173-181. Epub 2021 Jul 20.

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Zhongxiao East Road, Da'an District, 106 Taipei City, Taiwan; Precision Analysis and Materials Research Centre, National Taipei University of Technology, No. 1, Section 3, Zhongxiao East Road, Da'an District, 106 Taipei City, Taiwan. Electronic address:

A rapid, cost-effective and accurate detection of heavy metal ions is crucial for human health monitoring and environmental protection. Surface-enhanced Raman spectroscopy (SERS) has become a reliable method due to its outstanding performance for the identification of contaminants. In this paper, silver phosphate microcubes (AgPO) were fabricated using two different precipitation methods for ultrasensitive SERS detection of heavy metal ions. Read More

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Triplanar ensemble U-Net model for white matter hyperintensities segmentation on MR images.

Med Image Anal 2021 Jul 18;73:102184. Epub 2021 Jul 18.

Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford, UK.

White matter hyperintensities (WMHs) have been associated with various cerebrovascular and neurodegenerative diseases. Reliable quantification of WMHs is essential for understanding their clinical impact in normal and pathological populations. Automated segmentation of WMHs is highly challenging due to heterogeneity in WMH characteristics between deep and periventricular white matter, presence of artefacts and differences in the pathology and demographics of populations. Read More

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Prevalence of gout in the adult general population in Spain: estimating the proportion of undiagnosed cases.

Joint Bone Spine 2021 Jul 26:105257. Epub 2021 Jul 26.

Rheumatology, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain.

Objective: To estimate the prevalence of gout in Spain.

Methods: Cross-sectional, population-based study of people aged 20 years or older. First, randomly selected individuals were contacted by telephone and rheumatic disease screening questionnaires were conducted. Read More

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How do young men want to receive information about fertility? Young men's attitudes towards a fertility campaign targeting men in Copenhagen, Denmark.

Hum Reprod Open 2021 27;2021(3):hoab027. Epub 2021 Jul 27.

Department of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen K, Denmark.

Study Question: What are young men's attitudes towards the Danish fertility campaign 'How's your sperm?' and how do they want to receive fertility information in the future?

Summary Answer: The young men found that the campaign had limited impact because it was not relevant to their current life situation and they believed general fertility awareness should be a mandatory part of education, while more targeted information would be helpful through web-based venues when it was more relevant to their lives (e.g. when ready to have children). Read More

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Predicting Age From Behavioral Test Performance for Screening Early Onset of Cognitive Decline.

Front Aging Neurosci 2021 12;13:661514. Epub 2021 Jul 12.

INSERM, COMETE, GIP CYCERON, Normandie University, UNICAEN, Caen, Research Unit: Aging, Health and Diseases, Caen, France.

Neuronal reactions and cognitive processes slow down during aging. The onset, rate, and extent of changes vary considerably from individual to individual. Assessing the changes throughout the lifespan is a challenging task. Read More

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Positive Multifocal PSMA PET/CT in a Patient With Prostate Cancer and Follicular Lymphoma.

Clin Nucl Med 2021 Jul 26. Epub 2021 Jul 26.

From the Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National, Institutes of Health, Bethesda, MD Department of Nuclear Medicine, University Hospital Düsseldorf, Düsseldorf Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center Translational Lung Research Center Heidelberg, German Center for Lung Research National Center for Tumor Diseases, Heidelberg, Germany.

Abstract: Prostate-specific membrane antigen (PSMA) PET/CT is a highly reliable nuclear tracer for diagnostic imaging of prostate cancer. However, PSMA is also expressed by some nonprostatic tissues such as benign tumors, inflammatory processes, and malignant neoplasms. This case presents a patient with prostate cancer and follicular lymphoma undergoing PSMA PET/CT. Read More

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Sequence-specific capture of oligonucleotide probes (SCOPE): A simple and rapid microbial rRNA quantification method using molecular weight cut-off membrane.

Appl Environ Microbiol 2021 Jul 28:AEM0116721. Epub 2021 Jul 28.

Department of Civil and Environmental Engineering, Tohoku University, 6-6-06, Aza-Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan.

A method named sequence-specific capture of oligonucleotide probes (SCOPE) was developed for quantification of microbial rRNA molecules in a multiplex manner. In this method, molecular weight cut-off membrane (MWCOM) was used for the separation of fluorescent-labeled oligonucleotide probes hybridized with rRNA from free unhybridized probes. To demonstrate proof-of-concept, probes targeting bacteria or archaea at different taxonomic levels were prepared and were hybridized with rRNAs. Read More

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Simulated Raman spectra of bulk and low-dimensional phosphorus allotropes.

Phys Chem Chem Phys 2021 Jul 28. Epub 2021 Jul 28.

Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia.

We present a comprehensive theoretical and experimental Raman spectroscopic comparative study of bulk Phosphorus allotropes (white, black, Hittorf's, fibrous) and their monolayer equivalents, demonstrating that the application of the Placzek approximation to density functional theory calculated frequencies allows reliable and accurate reproduction of the bulk spectra at a relatively low computational cost. As well as accurate frequencies, peak intensities are also reproduced with reasonable accuracy. Having established the viability of the method we apply it to other less well characterised phosphorus forms such as isolated P4 cages and the planar blue-phosphorus phase. Read More

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Rapid Detection of PBP2a in Staphylococci from Shortly Incubated Subcultures of Positive Blood Cultures by an Immunochromatographic Assay.

Microbiol Spectr 2021 Jul 28:e0046221. Epub 2021 Jul 28.

University of Zurichgrid.7400.3, Institute of Medical Microbiology, Zurich, Switzerland.

Staphylococcus aureus, as well as coagulase-negative staphylococci (CoNS), can cause a wide range of human infections both in nosocomial and community settings. Βeta-lactams are the antibiotics of choice for the treatment of bloodstream infections (BSI) caused by these microorganisms. Resistance to virtually all β-lactams (also referred to as methicillin resistance) primarily results from the production of an alternative penicillin-binding protein (PBP2a) encoded by the gene. Read More

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[Application value of liquid crystal digital display goniometer in total hip arthroplasty].

Zhongguo Gu Shang 2021 Jul;34(7):597-600

Department of Orthopaedics, the People's Hospital of Jingjiang, Jingjiang 214500, Jiangsu, China.

Objective: To investigate the application value of liquid crystal digital display goniometer in total hip arthroplasty.

Methods: From January 2018 to December 2019, 83 patients underwent primary total hip arthroplasty, including 28 males and 55 females, aged 42 to 81 (70.4±7. Read More

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Geometric accuracy of magnetic resonance imaging-derived virtual 3-dimensional bone surface models of the mandible in comparison to computed tomography and cone beam computed tomography: A porcine cadaver study.

Clin Implant Dent Relat Res 2021 Jul 27. Epub 2021 Jul 27.

Department of Diagnostic and Interventional Neuroradiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.

Background: Providing accurate 3-dimensional virtual bone surface models is a prerequisite for virtual surgical planning and additive manufacturing in craniomaxillofacial surgery. For this purpose, magnetic resonance imaging (MRI) may be a radiation-free alternative to computed tomography (CT) and cone beam computed tomography (CBCT).

Purpose: The aim of this study was to assess the geometric accuracy of 3-dimensional T1-weighted MRI-derived virtual bone surface models of the mandible in comparison to CT and CBCT. Read More

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Accuracy and precision of pulse oximeter at different sensor locations in patients with heart failure.

Multidiscip Respir Med 2021 Jan 6;16(1):742. Epub 2021 Jul 6.

Department of Chest Diseases and Tuberculosis.

Background: Despite its wide use in clinical practice, few studies have assessed the role of pulse oximetry in patients with heart failure. We aimed to evaluate the accuracy and precision of the pulse oximeter in patients with heart failure and to determine this accuracy at three different sensor locations.

Methods: Comparison of pulse oximetry reading (SpO) with arterial oxygen saturation (SaO) was reported in 3 groups of patients with heart failure (HF); those with ejection fraction (EF) >40%, those with EF <40%, and those with acute HF (AHF) with ST and non-ST segment elevation acute myocardial infarction (STEMI and non-STEMI). Read More

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January 2021

Environmental and political implications of underestimated cropland burning in Ukraine.

Environ Res Lett 2021 Jun 21;16(6):064019. Epub 2021 May 21.

Department of Space Information Technologies and Systems, Space Research Institute NAS Ukraine & SSA Ukraine, Kyiv 03680, Ukraine.

Open burning is illegal in Ukraine, yet Ukraine has, on average, 300 times more fire activity per year (2001-2019) than most European countries. In 2016 and 2017, 47% of Ukraine was identified as cultivated area, with a total of 70% of land area dedicated to agricultural use. Over 57% of all active fires in Ukraine detected using space-borne Visible Infrared Imaging Radiometer Suite (VIIRS) during 2016 and 2017 were associated with pre-planting field clearing and post-harvest crop residue removal, meaning that the majority of these fires are preventable. Read More

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Establishment of a non-squamous cell carcinoma of the larynx nomogram prognostic model and prognosis analysis.

Auris Nasus Larynx 2021 Jul 25. Epub 2021 Jul 25.

Department of Otolaryngology-Head and Neck Surgery,The Second Affiliated Hospital of Harbin Medical University, Haerbin,China. Electronic address:

Objective: We aimed to compare the prognosis of laryngeal squamous cell carcinoma (LSCC) and nSCCs of the larynx.Then we established a nomogram for nSCCs of the larynx.

Methods: Prognosis between the 529 pairs nSCCs of the larynx patients and LSCC patients were compared after propensity score matching (PSM). Read More

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CDK19 as a diagnostic marker for high-grade prostatic intraepithelial neoplasia.

Hum Pathol 2021 Jul 24. Epub 2021 Jul 24.

Institute of Pathology, University Hospital Schleswig-Holstein, Luebeck, Germany; Institute of Pathology, Research Center Borstel, Leibniz Lung Center, Borstel, Germany. Electronic address:

High-grade prostatic intraepithelial neoplasia (HGPIN) is a facultative precursor lesion of prostate cancer (PCa). Multifocal HGPIN in needle biopsies in the absence of PCa indicates a higher risk of cancer detection in subsequent biopsies. Therefore, a reliable diagnosis of HGPIN is of high clinical relevance guiding the management of patients with cancer-negative biopsies. Read More

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Localization of Cementoenamel Junction in Intraoral Ultrasonographs with Machine Learning.

J Dent 2021 Jul 24:103752. Epub 2021 Jul 24.

Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, Canada; Department of Biomedical Engineering, University of Alberta, Edmonton, Canada; School of Dentistry, University of Alberta, Edmonton, Canada. Electronic address:

Objective: Our goal was to automatically identify the cementoenamel junction (CEJ) location in ultrasound images using deep convolution neural networks (CNNs).

Methods: Three CNNs were evaluated using 1400 images and data augmentation. The training and validation were performed by an experienced nonclinical rater with 1000 and 200 images, respectively. Read More

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[Determination of furan in canned foods and packaged beverages by headspace gas chromatography-mass spectrometry].

Wei Sheng Yan Jiu 2021 Jul;50(4):641-645

Beijing Center for Disease Prevention and Control, Beijing Center for Prevention Medicine Research, Beijing 100013, China.

Objective: A headspace gas chromatography-mass spectrometry(HS-GC-MS) method for the analysis of furan in canned foods and packaged beverages was established.

Methods: The furan was extracted from the samples by headspace method. D_4-furan was used as internal standard and separated on a HP-Plot Q(30 m×0. Read More

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Highly sensitive analytical method for the accurate determination of 5-methyltetrahydrofolic acid monoglutamate in various volumes of human plasma using isotope dilution ultra-high performance liquid chromatography-mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 24;1179:122725. Epub 2021 Apr 24.

Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science, Yuseong, Daejeon 34113, Republic of Korea.

One predominant and bioactive folate vitamer circulating in the blood is 5-methyltetrahydrofolate (5-Me-THF). In this study, a method for the accurate determination of 5-Me-THF in human plasma samples of various volumes was established using isotope dilution ultra-high performance liquid chromatography-mass spectrometry (ID-UPLC-MS). For this purpose, 500 μL of homogeneous human plasma was initially employed, and the 5-Me-THF and the C-5-Me-THF standard solutions prepared using 1% ascorbic acid in water gave the calibration solution and spiking sample. Read More

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Developmental validation of a multiplex proteomic assay for the identification of forensically relevant biological fluids.

Forensic Sci Int 2021 Jul 17;326:110908. Epub 2021 Jul 17.

The Center for Forensic Science Research & Education, Willow Grove, PA 19090, USA. Electronic address:

The aim of this study was to validate a multiplex proteomic assay for the identification of high-specificity protein biomarkers by multiple reaction monitoring mass spectrometry on a triple quadrupole mass spectrometer for the accurate, reliable, and confirmatory identification of bodily fluids commonly encountered in a forensic context. This includes the identification of peripheral blood, semen, saliva, urine, and vaginal/menstrual fluid. The assay is able to efficiently identify pure or mixed stains through the identification of target peptide fragments originating from tissue-specific proteins including: uromodulin from urine; prostatic acid phosphatase, prostate specific antigen and semenogelin-II for semen; statherin, submaxillary gland androgen-regulated protein 3B and amylase for saliva; cornulin, martrigel-induced gene C4 protein, suprabasin and neutrophil gelatinase-associated lipocalin for vaginal/menstrual fluid; and alpha-1 antitrypsin, hemopexin, and hemoglobin subunit beta for peripheral blood. Read More

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