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Definition of competence standards for optical diagnosis of diminutive colorectal polyps: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.

Endoscopy 2021 Dec 6. Epub 2021 Dec 6.

Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, location AMC, University of Amsterdam, Amsterdam, The Netherlands.

BACKGROUND : The European Society of Gastrointestinal Endoscopy (ESGE) has developed a core curriculum for high quality optical diagnosis training for practice across Europe. The development of easy-to-measure competence standards for optical diagnosis can optimize clinical decision-making in endoscopy. This manuscript represents an official Position Statement of the ESGE aiming to define simple, safe, and easy-to-measure competence standards for endoscopists and artificial intelligence systems performing optical diagnosis of diminutive colorectal polyps (1 - 5 mm). Read More

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December 2021

Implantable brain-computer interface for neuroprosthetic-enabled volitional hand grasp restoration in spinal cord injury.

Brain Commun 2021 21;3(4):fcab248. Epub 2021 Oct 21.

Department of Neurological Surgery, University of Miami, Miami, FL 33136, USA.

Loss of hand function after cervical spinal cord injury severely impairs functional independence. We describe a method for restoring volitional control of hand grasp in one 21-year-old male subject with complete cervical quadriplegia (C5 American Spinal Injury Association Impairment Scale A) using a portable fully implanted brain-computer interface within the home environment. The brain-computer interface consists of subdural surface electrodes placed over the dominant-hand motor cortex and connects to a transmitter implanted subcutaneously below the clavicle, which allows continuous reading of the electrocorticographic activity. Read More

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October 2021

Motion Intent Recognition in Intelligent Lower Limb Prosthesis Using One-Dimensional Dual-Tree Complex Wavelet Transforms.

Comput Intell Neurosci 2021 24;2021:5631730. Epub 2021 Nov 24.

School of Mathematics and Computer, Tongling University, Tongling 244061, China.

The motion intent recognition via lower limb prosthesis can be regarded as a kind of short-term action recognition, where the major issue is to explore the gait instantaneous conversion (known as transitional pattern) between each two adjacent different steady states of gait mode. Traditional intent recognition methods usually employ a set of statistical features to classify the transitional patterns. However, the statistical features of the short-term signals via the instantaneous conversion are empirically unstable, which may degrade the classification accuracy. Read More

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November 2021

Non-invasive Metabolomic Profiling of Embryo Culture Medium Using Raman Spectroscopy With Deep Learning Model Predicts the Blastocyst Development Potential of Embryos.

Front Physiol 2021 19;12:777259. Epub 2021 Nov 19.

National Health Commission (NHC) Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China.

This study aimed to establish a non-invasive predicting model via Raman spectroscopy for evaluating the blastocyst development potential of day 3 high-quality cleavage stage embryos. Raman spectroscopy was used to detect the metabolic spectrum of spent day 3 (D3) embryo culture medium, and a classification model based on deep learning was established to differentiate between embryos that could develop into blastocysts (blastula) and that could not (non-blastula). The full-spectrum data for 80 blastula and 48 non-blastula samples with known blastocyst development potential from 34 patients were collected for this study. Read More

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November 2021

[A preliminary investigation on a deep learning convolutional neural networks based pulmonary tuberculosis CT diagnostic model].

Zhonghua Jie He He Hu Xi Za Zhi 2021 May;44(5):450-455

Department of Radiology, Beijing Chest Hospital Affiliated to Capital Medical University, Beijing 101149, China.

To evaluate the clinical value of a pulmonary tuberculosis CT diagnostic model based on deep learning convolutional neural networks (CNN). From March 2017 to March 2018,a total of 1 764 patients with positive sputum for tuberculous bacterium and had received high-resolution chest CT scan in radiology department of Hebei province chest hospital were enrolled. Among them, 937 were male, and 827 were female, aging from 17-73 years (average 38. Read More

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The value of lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyte ratio in differentiating pneumonia from upper respiratory tract infection (URTI) in children: a cross-sectional study.

BMC Pediatr 2021 Dec 3;21(1):545. Epub 2021 Dec 3.

Department of health management, Hangzhou Normal University, Zhejiang, 310000, Hangzhou, China.

Backgrounds: Early and accurate diagnosis of pediatric pneumonia in primary health care can reduce the chance of long-term respiratory diseases, related hospitalizations and mortality while lowering medical costs. The aim of this study was to assess the value of blood biomarkers, clinical symptoms and their combination in assisting discrimination of pneumonia from upper respiratory tract infection (URTI) in children.

Methods: Both univariate and multivariate logistic regressions were used to build the pneumonia screening model based on a retrospective cohort, comprised of 5211 children (age ≤ 18 years). Read More

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December 2021

Direct and Sensitive Determination of Antimony in Water by Hydrogen-Doped Solution Anode Glow Discharge-Optical Emission Spectrometry Without Hydride Generation.

Anal Chem 2021 Dec 3. Epub 2021 Dec 3.

State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China.

In the present work, a novel, simple, and sensitive method for the direct determination of trace Sb in water samples was developed based on hydrogen-doped solution anode glow discharge-optical emission spectrometry (SAGD-OES). It was found that the vapor generation and excitation of Sb occurred simultaneously in the SAGD, contributing to the significant improvement in the sensitivity of Sb as compared with normal pure He-operated SAGD or solution cathode glow discharge. Besides, the proposed hydrogen-doped SAGD-OES could be operated even at pH = 14, which could reduce the interference of coexisting ions as many metal ions could be precipitated and removed. Read More

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December 2021

The validity of ultrasound-derived equation models to predict whole-body muscle mass: A systematic review.

Clin Nutr ESPEN 2021 Dec 11;46:133-141. Epub 2021 Sep 11.

Vrije Universiteit Brussel, Faculty of Physical Education and Physiotherapy, Department Physiotherapy and Human Anatomy, Research Unit Experimental Anatomy, Laarbeeklaan 103, 1090, Brussels, Belgium.

Background & Aims: Sarcopenia is defined as the age-related loss in muscle quantity and quality which is associated with physical disability. The assessment of muscle quantity plays a role in the diagnosis of sarcopenia. However, the methods used for this assessment have many disadvantages in daily practice and research, like high costs, exposure to radiation, not being portable, or doubtful reliability. Read More

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December 2021

Ensemble learning for the early prediction of neonatal jaundice with genetic features.

BMC Med Inform Decis Mak 2021 Dec 1;21(1):338. Epub 2021 Dec 1.

School of Management, Fudan University, Shanghai, China.

Background: Neonatal jaundice may cause severe neurological damage if poorly evaluated and diagnosed when high bilirubin occurs. The study explored how to effectively integrate high-dimensional genetic features into predicting neonatal jaundice.

Methods: This study recruited 984 neonates from the Suzhou Municipal Central Hospital in China, and applied an ensemble learning approach to enhance the prediction of high-dimensional genetic features and clinical risk factors (CRF) for physiological neonatal jaundice of full-term newborns within 1-week after birth. Read More

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December 2021

The effect of mobile camera selection on the capacity to predict water turbidity.

Water Sci Technol 2021 Nov;84(10-11):2749-2759

Departamento de matemáticas, Universidad Nacional de Colombia, Carrera 45 N° 26-85, Bogotá, Colombia E-mail:

Recently, cameras of mobile have phones emerged as an alternative for quantifying water turbidity. Most of these studies lack a strategy to determine the water turbidity for new samples, focusing mainly on one particular device. Nevertheless, widespread use of these approaches requires a predictive capacity on out-of-the-sample images acquired in devices of different capabilities. Read More

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November 2021

Ultrasound Pressure Estimation for Diagnosing Portal Hypertension in Patients Undergoing Dialysis for Chronic Kidney Disease.

J Ultrasound Med 2021 Dec 1. Epub 2021 Dec 1.

Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.

Objectives: Hepatic venous pressure gradient (HVPG) is considered the standard in quantifying portal hypertension, but can be unreliable in dialysis patients. A noninvasive ultrasound technique, subharmonic-aided pressure estimation (SHAPE), may be a valuable surrogate of these pressure estimates. This study compared SHAPE and HVPG with pathology findings for fibrosis in dialysis patients. Read More

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December 2021

Potemkin Protections: Assessing Provider Directory Accuracy and Timely Access for Four Specialties in California.

J Health Polit Policy Law 2021 Nov 29. Epub 2021 Nov 29.

Pennsylvania State University.

Context: Accurate provider directories and whether consumers can schedule timely appointments are crucial determinants of health access and outcomes. We assessed whether consumers can rely on provider directories to find in-network primary care providers, cardiologists, endocrinologists, and gastroenterologists for 2018 and 2019 for all managed care plans in California and whether they can access these providers in a timely manner.

Method: We used large, random, and representative surveys of provider directories for all managed care plans in California for four specialties obtained from the California Department of Managed Health Care with a total of 657,012 observations (290,711 for 2018 and 475,524 for 2019). Read More

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November 2021

predictions of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models.

Xenobiotica 2021 Nov 30:1-19. Epub 2021 Nov 30.

Department of Pharmaceutical Biosciences and Science for Life Laboratory, Uppsala University, Box 591, Uppsala, 75124 Sweden.

Volume of distribution at steady state (V) is an important pharmacokinetic endpoint. In this study we apply machine learning and conformal prediction for human V prediction, and make a head-to-head comparison with rat-to-man scaling, allometric scaling and the Rodgers-Lukova method on combined and data, using a test set of 105 compounds with experimentally observed V.The mean prediction error and % with <2-fold prediction error for our method were 2. Read More

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November 2021

Correlation between TCM Syndromes and Type 2 Diabetic Comorbidities Based on Fully Connected Neural Network Prediction Model.

Evid Based Complement Alternat Med 2021 20;2021:6095476. Epub 2021 Nov 20.

Data Center of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

Objective: To predict the major comorbidities of type 2 diabetes based on the distribution characteristics of syndromes, and to explore the relationship between TCM syndromes and comorbidities of type 2 diabetes.

Methods: Based on the electronic medical record data of 3413 outpatient visits from 995 type 2 diabetes patients with comorbidities, descriptive statistical methods were used to analyze the basic characteristics of the population, the distribution characteristics of comorbidities, and TCM syndromes. A neural network model for the prediction of type 2 diabetic comorbidities based on TCM syndromes was constructed. Read More

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November 2021

Cross-Modal Retrieval between C NMR Spectra and Structures for Compound Identification Using Deep Contrastive Learning.

Anal Chem 2021 Nov 29. Epub 2021 Nov 29.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences. Beijing 100050, China.

Library matching using carbon-13 nuclear magnetic resonance (C NMR) spectra has been a popular method adopted in compound identification systems. However, the usability of existing approaches has been restricted as enlarging a library containing both a chemical structure and spectrum is a costly and time-consuming process. Therefore, we propose a fundamentally different, novel approach to match C NMR spectra directly against a molecular structure library. Read More

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November 2021

[Evaluation value of sequential organ failure assessment score for predicting the prognosis of patients with acute respiratory distress syndrome due to severe pneumonia].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Sep;33(9):1057-1062

Department of Emergency, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China. Corresponding author: Yang Lishan, Email:

Objective: To explore the evaluation value of sequential organ failure assessment (SOFA) score at different time points in the prognosis of patients with severe pneumonia combined with acute respiratory distress syndrome (ARDS).

Methods: A retrospective cohort study method was conducted, including patients with severe pneumonia and ARDS admitted to the emergency intensive care unit (ICU) of General Hospital of Ningxia Medical University from January 2015 to December 2019. General clinical data such as gender, age, and the SOFA scores at 1, 2, 3, and 7 days after admission were recorded. Read More

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September 2021

Diagnostic Accuracy of Intraoperative Intact Parathyroid Hormone Monitoring for Surgical Outcomes of Secondary Hyperparathyroidism.

Med Sci Monit 2021 Nov 28;27:e932556. Epub 2021 Nov 28.

Department of Hepatobiliary and Gland Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China (mainland).

BACKGROUND Intraoperative intact parathyroid hormone (IO-iPTH) monitoring has not reached a consensus in predicting surgical outcomes of secondary hyperparathyroidism. Here, we explore the predictive effect of IO-iPTH monitoring on surgical outcomes of secondary hyperparathyroidism as a potentially effective standard. MATERIAL AND METHODS We enrolled 119 patients who underwent total parathyroidectomy with autotransplantation from January 2016 to August 2019. Read More

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November 2021

Polygenic risk scores across the extended psychosis spectrum.

Transl Psychiatry 2021 Nov 26;11(1):600. Epub 2021 Nov 26.

Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.

As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the additive effects of multiple common genetic variants hold the potential to predict complex diseases and index severity gradients. PRSs for schizophrenia (SZ) and bipolar disorder (BD) were computed using Bayesian regression and continuous shrinkage priors based on the latest SZ and BD genome-wide association studies (Psychiatric Genomics Consortium, third release). Read More

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November 2021

Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years.

Nutrients 2021 Nov 18;13(11). Epub 2021 Nov 18.

Gastroenterology Unit, Modena University Hospital, 41124 Modena, Italy.

(1) Background: Changes in the clinical presentation of celiac disease (CD) in children have been reported. The guidelines of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) allow esophagogastroduodenoscopy (EGD) with biopsies to be avoided under specific circumstances. We aimed to assess the clinical picture of pediatric CD patients at diagnosis and to validate ESPGHAN non-biopsy criteria. Read More

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November 2021

Efficient Surrogate Modeling and Design Optimization of Compact Integrated On-Chip Inductors Based on Multi-Fidelity EM Simulation Models.

Authors:
Piotr Kurgan

Micromachines (Basel) 2021 Oct 30;12(11). Epub 2021 Oct 30.

Department of Microelectronic Systems, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland.

High-performance and small-size on-chip inductors play a critical role in contemporary radio-frequency integrated circuits. This work presents a reliable surrogate modeling technique combining low-fidelity EM simulation models, response surface approximations based on kriging interpolation, and space mapping technology. The reported method is useful for the development of broadband and highly accurate data-driven models of integrated inductors within a practical timeframe, especially in terms of the computational expense of training data acquisition. Read More

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October 2021

Safety Issues in Buckling of Steel Structures by Improving Accuracy of Historical Methods.

Int J Environ Res Public Health 2021 11 22;18(22). Epub 2021 Nov 22.

Engineering Department, Pontificia Universidad Católica del Perú, San Miguel, Lima 15088, Peru.

Buckling of structural elements is a phenomenon that has great consequences on the bearing capacity of structures. Historically, there have been serious buckling-related structural accidents that have resulted in loss of human lives and high material costs. In this article, an attempt is made to perform a historical analysis of the diverse models that experts have been using in designing and calculating compression buckling of simple metallic elements in the last 275 years. Read More

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November 2021

High-Throughput and Accurate Determination of Transgene Copy Number and Zygosity in Transgenic Maize: From DNA Extraction to Data Analysis.

Int J Mol Sci 2021 Nov 19;22(22). Epub 2021 Nov 19.

Center for Crop Functional Genomics and Molecular Breeding, China Agricultural University, Beijing 100193, China.

It is vital to develop high-throughput methods to determine transgene copy numbers initially and zygosity during subsequent breeding. In this study, the target sequence of the previously reported endogenous reference gene was analyzed using 633 maize inbred lines, and two SNPs were observed. These SNPs significantly increased the PCR efficiency, while the newly developed gene assay (hmg-taq-F2/R2) excluding these SNPs reduced the efficiency into normal ranges. Read More

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November 2021

Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus.

Diagnostics (Basel) 2021 Nov 21;11(11). Epub 2021 Nov 21.

Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland.

The purpose of the study was to determine the influence of lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) values on the prognosis in patients with renal cell carcinoma (RCC) and venous tumor thrombus. The respective data of 91 patients treated with radical surgery in the years 2012-2021 in 2 tertiary referral urological centers were retrieved from local medical databases. Mean calculated 3-year overall survival (OS) reached 70% (mean follow-up 35. Read More

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November 2021

Bird Species Identification Using Spectrogram Based on Multi-Channel Fusion of DCNNs.

Entropy (Basel) 2021 Nov 13;23(11). Epub 2021 Nov 13.

School of Technology, Beijing Forestry University, Beijing 100083, China.

Deep convolutional neural networks (DCNNs) have achieved breakthrough performance on bird species identification using a spectrogram of bird vocalization. Aiming at the imbalance of the bird vocalization dataset, a single feature identification model (SFIM) with residual blocks and modified, weighted, cross-entropy function was proposed. To further improve the identification accuracy, two multi-channel fusion methods were built with three SFIMs. Read More

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November 2021

Automatic differentiation of thyroid scintigram by deep convolutional neural network: a dual center study.

BMC Med Imaging 2021 11 25;21(1):179. Epub 2021 Nov 25.

Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, No.37 Guo Xue Alley, Chengdu, 610041, People's Republic of China.

Background: Tc-pertechnetate thyroid scintigraphy is a valid complementary avenue for evaluating thyroid disease in the clinic, the image feature of thyroid scintigram is relatively simple but the interpretation still has a moderate consistency among physicians. Thus, we aimed to develop an artificial intelligence (AI) system to automatically classify the four patterns of thyroid scintigram.

Methods: We collected 3087 thyroid scintigrams from center 1 to construct the training dataset (n = 2468) and internal validating dataset (n = 619), and another 302 cases from center 2 as external validating datasets. Read More

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November 2021

Use of a Bayesian Network Model to predict psychiatric illness in individuals with 'at risk mental states' from a general population cohort.

Neurosci Lett 2021 Nov 22:136358. Epub 2021 Nov 22.

Laboratorio de Neurociencias (LIM 27), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBION), Conselho Nacional de Desenvolvimento Cientifico e Tecnológico, Brazil.

The 'at risk mental state' (ARMS) paradigm has been introduced in psychiatry to study prodromal phases of schizophrenia. With time it was seen that the ARMS state can also precede mental disorders other than schizophrenia, such as depression and anxiety. However, several problems hamper the paradigm's use in preventative medicine, such as varying transition rates across studies, the use of non-naturalistic samples, and the multifactorial nature of psychiatric disorders. Read More

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November 2021

Novel colorimetric membranes based on polylactic acid-grafted-citrated methacrylated urethane (PLA-CMU) to monitor cod freshness.

Int J Biol Macromol 2021 Nov 22. Epub 2021 Nov 22.

College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology (TUST), Tianjin 300457, PR China. Electronic address:

Halochromic agent is easy to fall off from the surface of colorimetric membranes during fish freshness monitoring, which would decay the test accuracy. In order to increase its anchoring, citrated methacrylated urethane (CMU) synthesized by using tributyl citrate, β-hydroxyethyl methacrylate and diphenyl-methane-diisocyanate as a halochromic agent was grafted on polylactic acid (PLA). The CMU grafted PLA (PLA-CMU) together with tetrabutylammonium chloride (TBAC) prepared colorimetric membranes via electrospinning. Read More

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November 2021

The diagnostic accuracy of MRI in determining the relations between paraclinoid aneurysms and the cavernous sinus.

Neuroradiology 2021 Nov 25. Epub 2021 Nov 25.

Departamento de Neurologia, Divisão de Neurocirugia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Purpose: The location of paraclinoid aneurysms is determinant for evaluation of its intradural compartment and risk of SAH after rupture. Advanced MRI techniques have provided clear visualization of the distal dural ring (DDR) to determine whether an aneurysm is intracavernous, transitional or intradural for decision-making. We analyzed the diagnostic accuracy of MRI in predicting whether a paraclinoid aneurysm is intracavernous, transitional or intradural. Read More

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November 2021

Automatic Electrodiagnosis of Carpal Tunnel Syndrome Using Machine Learning.

Bioengineering (Basel) 2021 Nov 10;8(11). Epub 2021 Nov 10.

Department of Computer Science and Engineering, School of Engineering, University of Ioannina, 45110 Ioannina, Greece.

Recent literature has revealed a long discussion about the importance and necessity of nerve conduction studies in carpal tunnel syndrome management. The purpose of this study was to investigate the possibility of automatic detection, based on electrodiagnostic features, for the median nerve mononeuropathy and decision making about carpal tunnel syndrome. The study included 38 volunteers, examined prospectively. Read More

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November 2021

Combining sinus plain film and sinus ultrasound as a screening tool for maxillary fungal sinusitis.

J Chin Med Assoc 2021 Nov 22. Epub 2021 Nov 22.

Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC School of Medicine, National Yang Ming Chiao Tung University, Taiwan, ROC Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, Taipei, Taiwan, ROC Department of Otolaryngology, University of California, Irvine, Orange, CA, USA Department of Otolaryngology, Cheng Hsin Hospital, Taipei, Taiwan, ROC.

Background: Early identification of fungal sinusitis remains a challenge. Previously, we observed a high false negative rate of using A-mode ultrasound to diagnose maxillary fungal sinusitis. This study aims to assess the accuracy of the diagnosis of fungal maxillary sinusitis using sinus plain film and ultrasound. Read More

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November 2021