J Nucl Med 2021 Mar 19. Epub 2021 Mar 19.
Department of Nuclear Medicine, University Medical Center Freiburg, Freiburg, Germany, Division of Radiopharmaceutical Development, German Cancer Consortium, partner site Freiburg, Freiburg, Germany and German Cancer Research Center, Heidelberg, Germany, Germany.
The evolution of peptidomimetic hybrid molecules for preoperative imaging and guided surgery targeting the prostate-specific membrane antigen (PSMA) significantly progressed over the past years and some approaches are currently evaluated for further clinical translation. However, accumulation in non-malignant tissue such as kidney, bladder, spleen or liver might limit tumor-to-background contrast for precise lesion delineation particularly in a surgical setting. To overcome these limitations a rational linker design aims at the development of a second generation of PSMA-11 based hybrid molecules with enhanced pharmacokinetic profile and improved imaging contrasts. Read More