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IL-34 reprograms glycolytic and osteoclastic RA macrophages via Syndecan-1 and M-CSFR.

Arthritis Rheumatol 2021 May 13. Epub 2021 May 13.

Jesse Brown VA Medical Center, Chicago, IL, 60612, USA.

Objective: In RA, IL-34 serum levels are linked with increased disease severity. IL-34 binds to two receptors, M-CSFR and Syndecan-1 (SDC-1), which are co-expressed in RA macrophages (MФs). Expression of both IL-34 and SDC-1 is strikingly elevated in the RA synovium, yet their mechanism of action remains undefined. Read More

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Radiologic findings that aid in the reduction of misdiagnoses of Langerhans cell histiocytosis of the bone: a retrospective study.

World J Surg Oncol 2021 May 10;19(1):146. Epub 2021 May 10.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.

Background: This study aimed to identify the characteristic radiological signs for the diagnosis of Langerhans cell histiocytosis (LCH) of the bone.

Methods: We retrospectively studied 82 cases of LCH with bone lesions confirmed by pathology. Clinical and radiological features of the patients were analyzed. Read More

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ADIPOCYTOKINES LEPTIN AND ADIPONEСTIN AS PREDICTORS OF GENERALIZED PERIODONTITIS ASSOCIATED WITH OBESITY.

Georgian Med News 2021 Mar(312):42-46

Bogomolets National Medical University, Institute of Postgraduate Education, Department of Dentistry, Kyiv, Ukraine.

In recent years, according to the WHO, more than 1,9 billion people over the age of 18 are overweight, of whom more than 650 million are obese, with an annual trend. Studies in recent decades have shown that obese young people with generalized periodontitis have abnormalities in protein, fat and carbohydrate metabolism, which contributes to the early destruction of the periodontal tissue complex and rapid tooth loss. The aim of our study was to examine changes in serum leptin and adiponectin in patients with generalized periodontitis on the background of obesity. Read More

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Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients.

Sci Rep 2021 May 7;11(1):9796. Epub 2021 May 7.

Oral Sciences, Glasgow Dental Hospital and School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.

Periodontitis is characterized by subgingival biofilm dysbiosis, inflammation and tissue destruction. Current treatment involves mechanical biofilm disruption known as non-surgical periodontal therapy (NSPT). This study sought to characterise the impact of treatment on microbial diversity and overall community, and the parallel impact on host inflammation in the oral cavity. Read More

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Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation by scanning electron microscopy based on analysis of 140 patients.

Otolaryngol Pol 2021 Feb;75(3):1-5

Chair Otolaryngology of the Jagiellonian University Collegium Medicum, Cracow, Poland.

Objectives Chronic purulent cholesteatoma of the middle ear, as well as to a lesser extent chronic granulomatous otitis media, lead to destruction of bone structures within the middle ear space. Above process is controlled by the OPG/RANKL/RANK system. Material and methods An analysis of 140 patients operated on due to chronic otitis media was performed. Read More

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February 2021

Release of vascular agonists from liposome-microbubble conjugate by ultrasound-mediated microbubble destruction: effect on vascular function.

Drug Deliv Transl Res 2021 May 3. Epub 2021 May 3.

Centro de Investigación y de Estudios Avanzados del IPN, Unidad-Monterrey, Vía del Conocimiento 201, PIIT, NL, Apodaca, Mexico.

The endothelium is a single cell layer of the vessel wall and a key regulator of blood flow in vascular beds. Local and systemic pathologies have been associated with alterations in endothelial function. However, targeting the endothelium with vasoconstrictor or vasodilator drugs is often accompanied by systemic effects. Read More

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First report of eggplant mottled crinkle virus infecting eggplant in Greece.

Plant Dis 2021 May 2. Epub 2021 May 2.

Benaki Phytopathologiocal Institute, Plant Pathology, S. Delta 8, kifissia, Greece, 14561;

During winter 2020-2021, a severe virus-like disease outbreak was observed in eggplant ( L.) hybrids 'Monarca' (F1) and 'Angela' (F1) growing under protected conditions in Heraklion, Crete, Greece. In three greenhouses, the percentage of infected plants reached 100% leading to crop abandonment. Read More

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Multifunctional Magneto-Plasmonic FeO/Au Nanocomposites: Approaching Magnetophoretically-Enhanced Photothermal Therapy.

Nanomaterials (Basel) 2021 Apr 25;11(5). Epub 2021 Apr 25.

College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

Magneto-plasmonic nanocomposites can possess properties inherent to both individual components (iron oxide and gold nanoparticles) and are reported to demonstrate high potential in targeted drug delivery and therapy. Herein, we report on FeO/Au magneto-plasmonic nanocomposites (MPNC) synthesized with the use of amino acid tryptophan via chemical and photochemical reduction of Au ions in the presence of nanosized magnetite. The magnetic field (MF) induced aggregation was accompanied by an increase in the absorption in the near-infrared (NIR) spectral region, which was demonstrated to provide an enhanced photothermal (PT) effect under NIR laser irradiation (at 808 nm). Read More

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Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response.

Int J Mol Sci 2021 Apr 2;22(7). Epub 2021 Apr 2.

Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8549, Japan.

Periodontal disease is an inflammatory disease caused by pathogenic oral microorganisms that leads to the destruction of alveolar bone and connective tissues around the teeth. Although many studies have shown that periodontal disease is a risk factor for systemic diseases, such as type 2 diabetes and cardiovascular diseases, the relationship between nonalcoholic fatty liver disease (NAFLD) and periodontal disease has not yet been clarified. Thus, the purpose of this review was to reveal the relationship between NAFLD and periodontal disease based on epidemiological studies, basic research, and immunology. Read More

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Angioleiomyoma of the sacrum: a case report and literature review of similar sacral lesions.

Radiol Case Rep 2021 Jun 10;16(6):1428-1432. Epub 2021 Apr 10.

Department of Oncology, Tai'an City Cancer Prevention Hospital, Taian City Shandong, China.

Angioleiomyoma is a solitary smooth muscle cell tumor that originates from the tunical media of arteries and veins. Its origin in the sacrum is rare, only one case has been recorded in the literature to date, but cases with bone destruction are even rarer. We present a 49-year-old woman with lumbosacral pain, unsteady gait and right lower extremity pain for two years, accompanied by radiation pain. Read More

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SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses.

Neural Regen Res 2021 Dec;16(12):2453-2464

Department of Neurosurgery, First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China; Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, Anhui Province, China.

The SOCS1/JAK2/STAT3 axis is strongly associated with tumor growth and progression, and participates in cytokine secretion in many diseases. However, the effects of the SOCS1/JAK2/STAT3 axis in experimental subarachnoid hemorrhage remain to be studied. A subarachnoid hemorrhage model was established in rats by infusing autologous blood into the optic chiasm pool. Read More

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December 2021

Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model.

J Neuroinflammation 2021 Apr 27;18(1):101. Epub 2021 Apr 27.

Department of Neurology, University Clinic Bonn, Campus Venusberg 1, D-53127, Bonn, Germany.

Background: Interleukin 23 is a critical cytokine in the pathogenesis of multiple sclerosis. But the local impact of interleukin 23 on the course of neuroinflammation is still not well defined. To further characterize the effect of interleukin 23 on CNS inflammation, we recently described a transgenic mouse model with astrocyte-specific expression of interleukin 23 (GF-IL23 mice). Read More

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Self-Circulation Oxygen-Hydrogen Peroxide-Oxygen System for Ultrasensitive Cathode Photoelectrochemical Bioassay Using a Stacked Sealed Paper Device.

ACS Appl Mater Interfaces 2021 May 22;13(17):19793-19802. Epub 2021 Apr 22.

School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, P. R. China.

In this work, a self-circulation oxygen-hydrogen peroxide-oxygen (O-HO-O) system with photogenerated electrons as fuel and highly active hemin monomers as operators was engineered for ultrasensitive cathode photoelectrochemical bioassay of microRNA-141 (miRNA-141) using a stacked sealed paper device. During the circulation, the photogenerated electrons from BiVO/CuO photosensitive structures assembled on a reduced graphene oxide paper electrode first reduced the electron acceptors (dissolved O) to HO, which was then catalytically decomposed by hemin monomers to generate O again. The regenerated O continued to be reduced, which made O and HO stuck in the infinite loop of O-HO-O accompanied by the fast consumption of photogenerated electrons, generating an amplified photocurrent signal. Read More

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Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis.

Front Cell Dev Biol 2021 1;9:663037. Epub 2021 Apr 1.

Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, China.

Periodontitis is an immune inflammatory disease that leads to progressive destruction of bone and connective tissue, accompanied by the dysfunction and even loss of periodontal ligament stem cells (PDLSCs). Pyroptosis mediated by gasdermin-D (GSDMD) participates in the pathogenesis of inflammatory diseases. However, whether pyroptosis mediates PDLSC loss, and inflammation triggered by pyroptosis is involved in the pathological progression of periodontitis remain unclear. Read More

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Effect of different copper oxide particles on cell division and related genes of soybean roots.

Plant Physiol Biochem 2021 Jun 5;163:205-214. Epub 2021 Apr 5.

University Key Laboratory of Plant Biotechnology in Shandong Province, College of Life Sciences, Qingdao Agricultural University, Qingdao, 266109, China. Electronic address:

In this study, soybean (Glycine max) seeds were cultured in distilled water. When the roots were about 2 cm, they were separately treated with copper oxide bulk particles (CuO BPs) suspensions and copper oxide nanoparticle (CuO NPs) suspensions in different concentrations (2, 5 and 10 mg L) for 24 h and 48 h. Results showed that different concentrations of CuO BPs suspensions had little effect on the structure and cell division of meristematic zone. Read More

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Exposure-time-dependent subcellular staging of gold nanoparticles deposition and vesicle destruction in mice livers.

Nanomedicine 2021 Apr 20;34:102393. Epub 2021 Apr 20.

Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, PR China; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, PR China. Electronic address:

Several advances in nanomedicine have been accompanied by rising concerns about the bioaccumulation and toxicity of gold nanoparticles (AuNPs). Here, we assessed the in vivo fate of diversely sized AuNPs that were injected into mice as a computed tomography contrast agent and examined with multi-scale analyses across the organ, tissue, cell, and subcellular levels. After focusing on the strong detected accumulation in livers, our data revealed a set of three clear, exposure-time-dependent patterns based on i) AuNPs deposit morphology and ii) readily identifiable phenotypes for AuNP-impacted subcellular vesicles. Read More

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Transcriptomics-based analysis of the mechanism by which Wang-Bi capsule alleviates joint destruction in rats with collagen-induced arthritis.

Chin Med 2021 Apr 12;16(1):31. Epub 2021 Apr 12.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease accompanied with joint destruction that often leads to disability. Wang-Bi capsule (WB), a traditional Chinese medicine-based herbs formula, has exhibited inhibition effect on joint destruction of collagen-induced arthritis (CIA) animal model in our previous study. But its molecular mechanisms are still obscure. Read More

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The positive effect of pregnancy in rheumatoid arthritis and the use of medications for the management of rheumatoid arthritis during pregnancy.

Inflammopharmacology 2021 Apr 12. Epub 2021 Apr 12.

Acharya and BM Reddy College of Pharmacy, Soldevanahalli, Bangalore, Karnataka, India.

Rheumatoid arthritis (RA) is an autoimmune systemic inflammatory disorder that is mostly characterised by progressive symmetrical joint destruction, particularly in the wrist and fingers, while it may also affect additional joints and several organs, such as the skin, heart, blood vessels, and lungs. It is identified by raised anti-rheumatoid factor and anti-cyclic citrullinated peptide antibodies. The chemical mediators involved in the activity of RA are IL-1β, TNF-α, and IL-6. Read More

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Static and Dynamic Behavior of Polymer/Graphite Oxide Nanocomposites before and after Thermal Reduction.

Polymers (Basel) 2021 Mar 25;13(7). Epub 2021 Mar 25.

Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas, N. Plastira 100, 700 13 Heraklion Crete, Greece.

Nanocomposites of hyperbranched polymers with graphitic materials are investigated with respect to their structure and thermal properties as well as the dynamics of the polymer probing the effect of the different intercalated or exfoliated structure. Three generations of hyperbranched polyester polyols are mixed with graphite oxide (GO) and the favorable interactions between the polymers and the solid surfaces lead to intercalated structure. The thermal transitions of the confined chains are suppressed, whereas their dynamics show similarities and differences with the dynamics of the neat polymers. Read More

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Focal Synovial Inflammation Versus Enthesitis Theory in Distal Psoriatic Arthritis: A Pioneer Histopathologic Study.

Am J Dermatopathol 2021 Mar 30. Epub 2021 Mar 30.

Laboratoire Central d'Anatomie Pathologique, Hôpital L. Pasteur, University of Nice, Nice, France; Nail's Dermatology Consultations, Cannes, France.

Abstract: The aim of this analysis was to re-examine the classical concept of distal interphalangeal joint (DIP) psoriatic arthritis (PsA) as an entheseal-driven disease. Two cadaveric fingers with severe psoriatic arthritis were analyzed. Our results demonstrate that inflammation of DIP PsA is multifocal without interconnection between entheses and articular cartilage of the DIP. Read More

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Dysregulation of lncRNAs in Rheumatoid Arthritis: Biomarkers, Pathogenesis and Potential Therapeutic Targets.

Front Pharmacol 2021 12;12:652751. Epub 2021 Mar 12.

Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology, mainly manifested by persistent abnormal proliferation of fibroblast-like synoviocytes (FLSs), inflammation, synovial hyperplasia and cartilage erosion, accompanied by joint swelling and joint destruction. Abnormal expression or function of long noncoding RNAs (lncRNAs) are closely related to human diseases, including cancers, mental diseases, autoimmune diseases and others. The abnormal sequence and spatial structure of lncRNAs, the disorder expression and the abnormal interaction with the binding protein will lead to the change of gene expression in the way of epigenetic modification. Read More

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Single-cell transcriptomics dissects hematopoietic cell destruction and T cell engagement in aplastic anemia.

Blood 2021 Mar 24. Epub 2021 Mar 24.

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Tianjin, China.

Aplastic anemia (AA) is a T cell-mediated autoimmune disorder of the hematopoietic system manifested by severe depletion of the hematopoietic stem and progenitor cells (HSPCs). Nonetheless our understanding of the complex relationship between HSPCs and T cells is still obscure, mainly limited by techniques and the sparsity of HSPCs in the context of bone marrow failure. Here we performed single-cell transcriptome analysis of residual HSPCs and T cells to identify the molecular players from AA patients. Read More

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Artesunate attenuates bone erosion in rheumatoid arthritis by suppressing reactive oxygen species via activating p62/Nrf2 signaling.

Biomed Pharmacother 2021 May 23;137:111382. Epub 2021 Feb 23.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address:

Accumulating studies have indicated that reactive oxygen species (ROS) may be implicated into the destructive pathological events of rheumatoid arthritis (RA). As an effective antioxidant, artesunate (ARS) was reported to exert antiarthritic effects. However, whether ARS attenuates the bone erosion during RA progression by regulating ROS production remains to be defined. Read More

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CTLA-4 (+49A/G) Polymorphism in Type 1 Diabetes Children of Sudanese Population.

Glob Med Genet 2021 Mar 15;8(1):11-18. Epub 2021 Feb 15.

Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Albaha University, Al Bahah, Saudi Arabia.

 Type 1 diabetes mellitus (T1DM) is an organ-specific T cell-mediated autoimmune disease, characterized by destruction of pancreatic islets. Cytotoxic lymphocyte antigen-4 ( ) is a negative regulator of T cell proliferation, thus conferring susceptibility to autoimmunity.  This study aimed to investigate the association of +49A/G (rs231775) polymorphism with a risk of T1DM in Sudanese children. Read More

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Radiological spectrum of metastasis to the oral and maxillofacial region.

Oral Radiol 2021 Mar 20. Epub 2021 Mar 20.

Department of Diagnostics and Radiology, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa.

Objective: Oral and maxillofacial metastasis may be the first indication of an undiscovered malignancy in a significant number of cases. Therefore, the rationale of this article is to highlight the clinical and radiological presentation of metastatic lesions involving the oral and maxillofacial region. This will serve as a reference for clinicians, who may first encounter patients with possible metastatic lesions in this region. Read More

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In Vivo Insulin Peptide Autoantigen Delivery by Mannosylated Sodium Alginate Nanoparticles Delayed but Could Not Prevent the Onset of Type 1 Diabetes in Nonobese Diabetic Mice.

Mol Pharm 2021 04 18;18(4):1806-1818. Epub 2021 Mar 18.

Tianjin Key Laboratory of Biomedical Materials, Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.

Type 1 diabetes (T1D) is an autoimmune subtype of diabetes, mainly caused by the immune attack of self-insulin-producing cells. Immune modulation that delays the onset of T1D is able to reduce diabetic complications and mortality. We have previously reported that mannosylated sodium alginate nanoparticles (MAN-ALG) exhibited excellent dendritic cell targeting and in vivo antigen delivery efficacy. Read More

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Recent Advances of Therapeutic Targets for the Treatment of Periodontal Disease.

Biomol Ther (Seoul) 2021 May;29(3):263-267

Department of Periodontology, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea.

Periodontal disease is primarily associated with bacterial infection such as dental plaque. Dental plaque, an oral biofilm harboring a complex microbial community, can cause various inflammatory reactions in periodontal tissue. In many cases, the local bacterial invasion and host-mediated immune responses lead to severe alveolar bone destruction. Read More

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ST36 Acupuncture Alleviates the Inflammation of Adjuvant-Induced Arthritic Rats by Targeting Monocyte/Macrophage Modulation.

Evid Based Complement Alternat Med 2021 27;2021:9430501. Epub 2021 Feb 27.

Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

Background: Rheumatoid arthritis (RA) is a chronic systemic chronic autoimmune disease characterized by the aggregation of immune cells and secretion of cytokines in the joint synovium, causing hyperblastosis and even bone destruction. Acupuncture has been proven effective in RA treatment. This study aimed to investigate the anti-inflammatory action of acupuncture, specifically, in relation to immune cell interactions and key mediators. Read More

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February 2021

Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders.

Brain 2021 Mar 12. Epub 2021 Mar 12.

Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.

Aquaporin 4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG+NMOSD) is an autoimmune astrocytopathic disease pathologically characterized by the massive destruction and regeneration of astrocytes with diverse types of tissue injury with or without complement deposition. However, it is unknown whether this diversity is derived from differences in pathological processes or temporal changes. Furthermore, unlike for the demyelinating lesions in multiple sclerosis, there has been no staging of astrocytopathy in AQP4-IgG+NMOSD based on astrocyte morphology. Read More

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Gentamicin Induced Microbiome Adaptations Associate With Increased BCAA Levels and Enhance Severity of Influenza Infection.

Front Immunol 2020 23;11:608895. Epub 2021 Feb 23.

Anhui Medical University, Hefei, China.

Involvement of gut microbiota in pulmonary disease by the gut-lung axis has been widely observed. However, the cross-talk messengers between respiratory mucosal immunity and gut microbiota are largely unknown. Using selective pharmacologic destruction of gut microenvironment mouse models, we found gut microbiota displayed significantly lower alpha diversity and relative abundance of bacteria in Gentamicin treated mice. Read More

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February 2021