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How can human-centered design build a story-based video intervention that addresses vaccine hesitancy and bolsters vaccine confidence in the Philippines? A mixedmethod protocol for project SALUBONG.

BMJ Open 2021 06 9;11(6):e046814. Epub 2021 Jun 9.

Heidelberg Institute of Global Health, Ruprecht Karls Universität Heidelberg, Heidelberg, Germany

Introduction: Since the onset of a dengue vaccine controversy in late 2017, vaccine confidence has plummeted in the Philippines, leading to measles and polio outbreaks in early 2019. This protocol outlines a human-centered design (HCD) approach to co-create and test an intervention that addresses vaccine hesitancy (VH) via narrative and empathy with and among families and healthcare workers. METHODS AND ANALYSIS: 'Salubong' is a Filipino term that means to welcome someone back into one's life, reinforcing notions of family ties and friendships. Read More

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Relationship of transitional regulatory B and regulatory T cells and immunosuppressive drug doses in stable renal transplant recipients.

Immun Inflamm Dis 2021 Jun 8. Epub 2021 Jun 8.

Transplantation Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany.

Objectives: Regulatory B cells (Bregs) and T cells (Tregs) are thought to be involved in the regulation of graft acceptance in renal transplant recipients. However, mechanisms that affect Breg differentiation and interaction with Tregs are rather unclear.

Methods: Using eight-color-fluorescence flow cytometry, Tregs and CD19+ CD24hiCD38hi Bregs were analyzed in whole blood samples of 80 stable kidney transplant recipients, 20 end-stage renal disease (ESRD) patients and 32 healthy controls (HC). Read More

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Perceived Causes of Obstetric Fistula and Predictors of Treatment Seeking among Ugandan Women: Insights from Qualitative Research.

Afr J Reprod Health 2020 Jun;24(2):129-140

Department of Obstetrics, Gynaecology and Reproductive Sciences, University of California, San Francisco, 550 16th Street, San Francisco, USA.

Many obstetric fistula patients remain untreated or present late to treatment despite increasing surgical availability in Uga nda. We explored women's perceptions of the cause of their obstetric fistula and their treatment seeking behaviours, including barriers and facilitators to timely care access. In-depth interviews and focus group discussions were conducted from June-August 2014 among 33 women treated for obstetric fistula at Mulago Hospital, Kampala. Read More

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Acute Exposure to European Viper Bite in Children: Advocating for a Pediatric Approach.

Toxins (Basel) 2021 05 2;13(5). Epub 2021 May 2.

Clinical Trial Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

Viper bite is an uncommon but serious cause of envenoming in Europe, especially in children. Our study aim is to better describe and analyze the clinical course and treatment of viper bite envenoming in a pediatric population. We retrospectively reviewed 24 cases of pediatric viper bites that were admitted to the Pediatric Emergency Department and the Pediatric Intensive Care Unit of the Bambino Gesù Children Hospital in Rome between 2000 and 2020. Read More

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How do urban rainfall-runoff pollution control technologies develop in China? A systematic review based on bibliometric analysis and literature summary.

Sci Total Environ 2021 May 27;789:148045. Epub 2021 May 27.

Skate Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, PR China. Electronic address:

Rapid urbanization in China is driving the need of urban rainfall-runoff pollution control technologies due to adverse impacts on water environment. In this study, literature from China National Knowledge Infrastructure, Web of Science and Scopus in 1995/1/1-2019/5/15 are used to review research hotspots, development process and future directions of urban rainfall-runoff pollution control technologies in China and global world. Temporal evolution of publications showed that source reduction played better growing trend in urban rainfall-runoff pollution control field for both China and global world. Read More

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Minimising missed opportunities to promote and deliver immunization services to middle and older age adults: Can hospital-based programs be a solution?

Vaccine 2021 06 20;39(26):3467-3472. Epub 2021 May 20.

School of Population Health, University of New South Wales, NSW, Australia. Electronic address:

Background: There has been a recent recognized shift towards a whole-of-life or life-course approach to immunisation. However, coverage amongst at-risk adults for recommended vaccines continues to be suboptimal. This study examined the perceptions of middle and older aged Australian adults towards hospital-based immunization programs and their previous exposures to receiving vaccines via tertiary care. Read More

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Both younger and elderly patients in pain are willing to undergo knee replacement despite the COVID-19 pandemic: a study on surgical waiting lists.

Knee Surg Sports Traumatol Arthrosc 2021 May 20. Epub 2021 May 20.

Orthopaedic Surgery and Traumatology Department, Knee Unit, Hospital La Paz, Universidad Autónoma de Madrid, Pº Castellana 261, 28046, Madrid, Spain.

Purpose: To identify factors influencing patient's availability to re-schedule primary total knee replacement (TKR) or revision (RKR) surgery after the lockdown (March-May 2020) during the COVID-19 pandemic.

Methods: A prospective cohort study through a telephone survey was performed in 156 patients (143 for primary and 13 for revision) included in the TKR and RKR surgical waiting list before March 2020. Contact of each patient with COVID-19, stress and anxiety, perceived pain, and function were obtained in the interviews, and also the preference of each patient to have re-scheduled surgery (early or late). Read More

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Less Expectation, Less Pain: Low Wealth Alleviates Sense of Unfairness.

Front Psychol 2021 28;12:571952. Epub 2021 Apr 28.

Accounting Department, Zhejiang Radio and TV Group, Hangzhou, China.

Objective wealth plays an important role in social interaction and economic decision making. Previous studies indicate that objective wealth of others may influence the way we participate in resources allocation. However, the effect of objective wealth on responses to fairness-related resource distribution is far from clear, as are the underlying neural processes. Read More

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Acceptance of a COVID-19 vaccine and associated factors among pregnant women in China: a multi-center cross-sectional study based on health belief model.

Hum Vaccin Immunother 2021 May 14:1-10. Epub 2021 May 14.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

: Vaccine hesitancy has been recognized as an urgent public health issue. We aimed to explore the acceptance of a COVID-19 vaccine and related factors among pregnant women, a vulnerable population for vaccine-preventable diseases. A multi-center cross-sectional study among pregnant women was conducted in five provinces of mainland China from November 13 to 27, 2020. Read More

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Using an electronic health record alert to prompt blood-borne virus testing in primary care.

AIDS 2021 May 10. Epub 2021 May 10.

Centre for Clinical Infection, The James Cook University Hospital, Middlesbrough TS4 3BW, UK Leadgate Medical Centre, Consett, DH8 6DP, UK Department of Psychology, Teesside University, Middlesbrough TS1 3BX, UK.

Background: Late diagnosis of HIV, hepatitis B (HBV) and hepatitis C (HCV) remains relatively common in the UK and many people who present late have missed opportunities for testing in primary care. The objective was to assess the effectiveness and acceptance of a prototype application (BBV_TP1), embedded in a primary care electronic health record (EHR), to increase real-time blood-borne virus (BBV) testing.

Methods: This prospective cohort study assessed BBV_TP1 in 14 general practices in North East England, in comparison to 54 similar practices in 2019. Read More

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Preferences of quality delivery of palliative care among cancer patients in low- and middle-income countries: A review.

Palliat Support Care 2021 May 6:1-8. Epub 2021 May 6.

School of Nursing, Faculty of Health Sciences, National University of Samoa, Toomatagi, Samoa.

Background: All forms of cancer pose a tremendous and increasing problem globally. The prevalence of cancer across the globe is anticipated to double over the next two decades. About 50% of most cancer cases are expected to occur in low- and middle-income countries (LMICs), where there is a greater disproportionate level in mortality. Read More

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Promoting HIV, Hepatitis B Virus, and Hepatitis C Virus Screening Among Migrants With a Language Barrier: Protocol for the Development and Evaluation of an Electronic App (Apidé).

JMIR Res Protoc 2021 May 5;10(5):e22239. Epub 2021 May 5.

Patient-Reported Outcomes Unit (PROQOL), UMR 1123, Université de Paris, INSERM, F-75004, Paris, France.

Background: Late diagnoses of HIV, hepatitis B, and hepatitis C are important public health problems that affect the population at large and migrants in particular. Missed opportunities of HIV and hepatitis screening are numerous, with language differences being a significant barrier to testing. Several studies have shown that migrants who do not speak the language of the health provider are less likely to get tested, due to health providers' reluctance to offer a test and to migrants' reluctance to accept testing. Read More

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Factors Associated With Access to and Timing of Coronavirus Testing Among US Adults After Onset of Febrile Illness.

JAMA Netw Open 2021 05 3;4(5):e218500. Epub 2021 May 3.

Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco.

Importance: Active SARS-CoV-2 (coronavirus) transmission continues in the US. It is unclear whether better access to coronavirus testing and more consistent use of testing could substantially reduce transmission.

Objective: To describe coronavirus testing in persons with new onset of febrile illness and analyze whether there are changes over time and differences by race and ethnicity. Read More

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FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective.

AAPS J 2021 04 30;23(3):60. Epub 2021 Apr 30.

Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, 20903, USA.

The pharmaceutical industry is actively applying quantitative systems pharmacology (QSP) to make internal decisions and guide drug development. To facilitate the eventual development of a common framework for assessing the credibility of QSP models for clinical drug development, scientists from US Food and Drug Administration and the pharmaceutical industry organized a full-day virtual Scientific Exchange on July 1, 2020. An assessment form was used to ensure consistency in the evaluation process. Read More

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hCG is more effective than the GnRH agonist buserelin for inducing the first ovulation of the breeding season in mares.

Equine Vet J 2021 Apr 21. Epub 2021 Apr 21.

Dipartimento di Scienze Veterinarie, Università di Pisa, Pisa, Italy.

Background: Human Chorionic Gonadotropin (hCG) and Gonadotropin Releasing Hormone agonists (GnRHa) are routinely used to induce ovulation in mares. However, GnRHa efficacy in transitional mares has been suggested to be low.

Objectives: The aims of this study were as follows: (a) to compare the efficacy of hCG and GnRHa in inducing the first ovulation of the breeding season and (b) to evaluate the correlation between ovulatory response, uterine oedema and teasing score at the time of treatment during the early or late transitional phase. Read More

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Engineering Strategies for Allogeneic Solid Tissue Acceptance.

Trends Mol Med 2021 Jun 14;27(6):572-587. Epub 2021 Apr 14.

Department of Chemistry, CICECO - Aveiro Institute of Materials, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. Electronic address:

Advances in allogeneic transplantation of solid organs and tissues depend on our understanding of mechanisms that mediate the prevention of graft rejection. For the past decades, clinical practice has established guidelines to prevent allograft rejection, which mostly rely on the intake of nontargeted immunosuppressants as the gold standard. However, such lifelong regimens have been reported to trigger severe morbidities and commonly fail in preventing late allograft loss. Read More

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Acceptance and commitment therapy for late-life treatment-resistant generalised anxiety disorder: a feasibility study.

Age Ageing 2021 Apr 13. Epub 2021 Apr 13.

Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK.

Background: Generalised anxiety disorder (GAD) is the most common anxiety disorder in older people. First-line management includes pharmacological and psychological therapies, but many do not find these effective or acceptable. Little is known about how to manage treatment-resistant generalised anxiety disorder (TR-GAD) in older people. Read More

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Postoperative changes in vertical ground reaction forces, walking barefoot and with ankle-foot orthoses in children with Cerebral Palsy.

Clin Biomech (Bristol, Avon) 2021 Apr 23;84:105336. Epub 2021 Mar 23.

Faculty of Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway; Division of Orthopaedic Surgery, Department of Research, Oslo University Hospital, Oslo, Norway.

Background: Children with cerebral palsy often have problems to support the body centre of mass, seen as increased ratio between excessive vertical ground reaction forces during weight acceptance and decreased forces below bodyweight in late stance. We aimed to examine whether increasing ankle range of motion through surgery and restraining motion with ankle-foot orthoses postoperatively would have impact on the vertical ground reaction force in weight acceptance and late stance.

Methods: Ground reaction forces were recorded from 24 children with bilateral and 32 children with unilateral cerebral palsy, each measured walking barefoot before and after triceps surae lengthening. Read More

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Social Feedback Valence Differentially Modulates the Reward Positivity, P300, and Late Positive Potential.

J Psychophysiol 2020 Oct 23;34(4):255-267. Epub 2019 Oct 23.

Department of Psychology, University of Illinois at Chicago.

Abnormal social or reward processing is associated with several mental disorders. Although most studies examining reward processing have focused on monetary rewards, recent research also has tested neural reactivity to social rewards (e.g. Read More

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October 2020

Management Challenges in Chronic Obstructive Pulmonary Disease in the COVID-19 Pandemic: Telehealth and Virtual Reality.

J Clin Med 2021 Mar 18;10(6). Epub 2021 Mar 18.

Department of Physical Education and Physiotherapy, Opole University of Technology, 45-758 Opole, Poland.

For the treatment of chronic obstructive pulmonary disease (COPD), early diagnosis and unconditionally correct management at the initial stage of the disease are very important when the symptoms are not yet too worrying. In this way, the progress of the disease can be slowed down, as can the occurrence of late, life-threatening symptoms. Pulmonary rehabilitation is an essential component of the management of COPD. Read More

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Electronic medical records and primary care quality: Evidence from Manitoba.

Health Econ 2021 May 10;30(5):1124-1138. Epub 2021 Mar 10.

Department of Economics, University of Manitoba, Winnipeg, Canada.

Improvements in quality of care through supporting decision-making processes and increased efficiency have prompted widespread implementation of electronic medical records (EMRs) in Canada. Using a set of indicators of preventive care, chronic disease management, and hospitalizations due to ambulatory care sensitive conditions (ACSC), this study measures the effect of EMR adoption on quality of primary care measures. Population-based data for the Canadian province of Manitoba are used in a difference-in-differences approach with patient- and time-fixed effects. Read More

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Prokaryotic symbiotic consortia and the origin of nucleated cells: A critical review of Lynn Margulis hypothesis.

Biosystems 2021 Jun 17;204:104408. Epub 2021 Mar 17.

Department of Biochemistry and Molecular Biology, Universitat de València, C. Dr. Moliner 50, 46100, Burjassot, Spain; Institute for Integrative Systems Biology (I(2)SysBio), Universitat de València-CSIC, C. José Beltrán 2, 46980, Paterna, Spain. Electronic address:

The publication in the late 1960s of Lynn Margulis endosymbiotic proposal is a scientific milestone that brought to the fore of evolutionary discussions the issue of the origin of nucleated cells. Although it is true that the times were ripe, the timely publication of Lynn Margulis' original paper was the product of an intellectually bold 29-years old scientist, who based on the critical analysis of the available scientific information produced an all-encompassing, sophisticated narrative scheme on the origin of eukaryotic cells as a result of the evolution of prokaryotic consortia and, in bold intellectual stroke, put it all in the context of planetary evolution. A critical historical reassessment of her original proposal demonstrates that her hypothesis was not a simple archival outline of past schemes, but a renewed historical narrative of prokaryotic evolution and the role of endosymbiosis in the origin of eukaryotes. Read More

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Palliative medicine referrals for hepatocellular carcinoma: a national survey of gastroenterologists.

BMJ Support Palliat Care 2021 Mar 18. Epub 2021 Mar 18.

AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia

Objectives: Palliative care (PC) service involvement for hepatocellular carcinoma (HCC) patients is suboptimal and little is known about the underlying reasons for this. We aimed to study clinicians' experience and attitudes towards PC in HCC.

Methods: A nationwide survey was conducted of consultants/trainees recruited from the Gastroenterological Society of Australia membership directory. Read More

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Effects of antenatal care service utilization on maternal near miss in Gamo Gofa zone, southern Ethiopia: retrospective cohort study.

BMC Pregnancy Childbirth 2021 Mar 16;21(1):209. Epub 2021 Mar 16.

School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Antenatal care (ANC) provides an opportunity to prevent, identify and intervene maternal health problems. Maternal near miss (MNM), as an indicator of maternal health, is increasingly gaining global attention to measure these problems. However, little has been done to measure the effect of ANC on MNM in Ethiopia. Read More

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Aggressiveness in Adopted and Non-Adopted Teens: The Role of Parenting, Attachment Security, and Gender.

Int J Environ Res Public Health 2021 02 19;18(4). Epub 2021 Feb 19.

Faculty of Psychology, University of the Basque Country UPV/EHU, 20018 Donostia-San Sebastián, Spain.

The aim of this study was to examine the relationship among aggressiveness, parenting practices, and attachment security in adolescents, assessing maternal and paternal effects separately. Two different subsamples of adolescents between 12 and 16 years old participated in the study ( = 157): 67 adopted adolescents (61.2% girls) and 90 non-adopted adolescents (56. Read More

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February 2021

Case series of late complications after transcatheter mitral annuloplasty using Cardioband and surgical treatment options.

J Card Surg 2021 Jun 4;36(6):2149-2152. Epub 2021 Mar 4.

Department of Cardiothoracic Surgery, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.

Background: Treatment of functional mitral regurgitation using transcatheter techniques such as the Cardioband annuloplasty device (Edwards Lifesciences) has gained wide acceptance in the recent years. However, complications of such devices are rarely reported.

Methods: Here, we present a case series involving two patients with dislocation of the Cardioband device and discuss the surgical management. Read More

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Challenges faced by parents when seeking diagnosis for children with sensorineural hearing loss.

Int J Pediatr Otorhinolaryngol 2021 Apr 19;143:110656. Epub 2021 Feb 19.

Department of Otorhinolaryngology-Head & Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Introduction: The Joint Committee of Infant Hearing (JCIH) recommended hearing screening by one month of age, diagnosis of hearing loss by three months of age, and intervention initiated by six months of age. In Malaysia however, the age of diagnosis of hearing loss in children is relatively late. This study aimed to identify the challenges faced by parents in seeking a diagnosis of hearing loss for their children. Read More

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Emotion regulation in the face of loss: How detachment, positive reappraisal, and acceptance shape experiences, physiology, and perceptions in late life.

Emotion 2021 Mar 4. Epub 2021 Mar 4.

School of Education and Social Policy, Northwestern University.

How individuals regulate emotions in the face of loss has important consequences for well-being and health, but we know little about which emotion regulation strategies are most effective for older adults for whom loss is ubiquitous. The present laboratory-based study examined effects of three emotion regulation strategies (i.e. Read More

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Impact of faculty interviewers on student matriculation following pharmacy school offer of admission.

Curr Pharm Teach Learn 2021 Mar 29;13(3):288-291. Epub 2020 Oct 29.

Pharmacy Practice, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, United States. Electronic address:

Introduction: Acceptance to pharmacy school relies on data such as grade point average (GPA) and Pharmacy College Admission Test (PCAT) scores in addition to holistic review. The interview is the final step in finding successful applicants. This study sought to identify if faculty interviewers had an impact on prospective students' decisions to accept an offer of admission to our college of pharmacy. Read More

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From the origin of NASH to the future of metabolic fatty liver disease.

Gut 2021 Feb 25. Epub 2021 Feb 25.

Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Wien, Wien, Austria.

Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Understanding the pathological and molecular hallmarks from its first description to definitions of disease entities, classifications and molecular phenotypes is crucial for both appropriate clinical management and research in this complex disease. We provide an overview through almost two hundred years of clinical research from the beginnings as a nebulous disease entity of unknown origin in the 19th century to the most frequent and vigorously investigated liver disease today. Read More

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February 2021