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Pilot Feasibility Stud 2022 May 21;8(1):106. Epub 2022 May 21.

School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK.

Background: Kidney transplant recipients (KTRs) exhibit unique elevated inflammation, impaired immune function, and increased cardiovascular risk. Although exercise reduces cardiovascular risk, there is limited research on this population, particularly surrounding novel high-intensity interval training (HIIT). The purpose of this pilot study was to determine the feasibility and acceptability of HIIT in KTRs. Read More

BMC Public Health 2022 May 21;22(1):1026. Epub 2022 May 21.

Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa.

Background: Safe Spaces are a feature of combination HIV prevention interventions for adolescent girls and young women (AGYW) in South Africa. We investigated whether AGYW at risk for adverse sexual and reproductive health (SRH) outcomes accessed Safe Spaces that were part of an intervention, as well as their feasibility and acceptability.

Methods: In December 2020 to February 2021, as part of a process evaluation of a combination HIV prevention intervention, we randomly sampled 2160 AGYW intervention beneficiaries aged 15-24 years from 6 of the 12 intervention districts. Read More

J Affect Disord 2022 May 18. Epub 2022 May 18.

Xiangya Nursing School, Central South University, Changsha, China; Oceanwide Health Management Institute, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Background: To explore effectiveness and acceptability of non-pharmacological interventions in mild cognitive impairment (MCI).

Methods: Overview of systematic reviews and network meta-analysis were conducted. Systematic reviews (SRs) were searched via seven databases from June 2015 to June 2020. Read More

Gait Posture 2022 May 11;96:73-80. Epub 2022 May 11.

University of Sydney School of Health Sciences, Faculty of Medicine and Health & Children's Hospital at Westmead, Sydney, Australia; The Children's Hospital at Westmead, Westmead, Australia.

Background: Children with the most common inherited neuropathy, Charcot-Marie-Tooth disease (CMT), are often prescribed ankle-foot orthoses (AFOs) to improve walking ability and prevent falls by reducing foot drop, postural instability, and other gait impairments. These externally worn assistive devices are traditionally custom-made using thermoplastic vacuum forming. This labour-intensive manufacturing process often results in AFOs which are cumbersome due to limited design options, and are associated with low acceptability, discomfort, and suboptimal impact on gait. Read More

Br J Dermatol 2022 May 21. Epub 2022 May 21.

Centre of Evidence Based Dermatology, School of Medicine, University of Nottingham, UK.

Background: Validated outcome measures are needed for vitiligo trials.

Objectives: Assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS).

Methods: We used images of vitiligo before and after treatment, plus outcome data, from the HI-Light Vitiligo trial. Read More

Vopr Pitan 2022 14;91(2):93-98. Epub 2022 Mar 14.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.

Currently, as part of solving the problems of improving the quality and safety of food, research is underway on the introduction of oleogels into foodstuffs to replace solid fats, which contain saturated and trans-isomeric fatty acids. However, such a replacement leads to a change in the organoleptic characteristics of food. of the work was to identify the characteristics that affect the difference in the perception of cookie descriptors baked using hard fat and oleogels. Read More

J Prosthet Dent 2022 May 17. Epub 2022 May 17.

Professor, Department of Oral Implantology, Peking University School and Hospital of Stomatology, Beijing, China. Electronic address:

Statement Of Problem: Computer-aided design and computer-aided manufacturing (CAD-CAM) monolithic restorative materials have become a popular option because of advantages such as convenience and efficiency. However, studies that quantitatively analyzed their color accuracy and bias are lacking.

Purpose: The purpose of this in vitro study was to evaluate the color accuracy and bias of 4 CAD-CAM monolithic restorative materials with different thicknesses by using the CIELab color space. Read More

J Pain Symptom Manage 2022 Jun;63(6):e621-e632

Pulmonary, Critical Care & Sleep Medicine, Cambia Palliative Care Center of Excellence at UW Medicine (R.A.E.), University of Washington, Seattle, Seattle, Washington, USA.

Context: Outcomes after cardiopulmonary resuscitation (CPR) remain poor. We have spent 10 years investigating an "informed assent" (IA) approach to discussing CPR with chronically ill patients/families. IA is a discussion framework whereby patients extremely unlikely to benefit from CPR are informed that unless they disagree, CPR will not be performed because it will not help achieve their goals, thus removing the burden of decision-making from the patient/family, while they retain an opportunity to disagree. Read More

J Affect Disord 2022 May 17. Epub 2022 May 17.

Semel Institute of Neuroscience and Human Behavior, USA; Department of Psychology, University of California, Los Angeles, CA, USA.

Background: Although transdiagnostic forms of cognitive-behavioral therapy (CBT) have been evaluated in depressive and anxiety disorders, few studies have examined their applicability in youth with more severe mood disorders, such as recurrent or persistent major depressive disorder, bipolar disorder, or psychotic spectrum disorders. This study examined the acceptability and initial efficacy of a mobile-enhanced Unified Protocol for Adolescents [UP-A] when including youth with more severe mood disorders or psychotic spectrum disorders.

Methods: We first adapted a mobile app (based on user-centered feedback from adolescents and their parents) to assist participants in reviewing session content, practicing skills learned in previous sessions, and monitoring progress. Read More

J Food Sci 2022 May 20. Epub 2022 May 20.

International Center of Excellence in Seafood Science and Innovation (ICE-SSI), Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Thailand.

Gel properties of threadfin bream surimi gels with squid fin protein hydrolysate (SFPH) at various concentrations (0, 1, 2, 3, and 4%; w/w) were determined. The gel without SFPH (CON) had the highest breaking force (BrF) and deformation (DeF) as compared to those with SFPH (p < 0.05). Read More

Can Assoc Radiol J 2022 May 20:8465371221102631. Epub 2022 May 20.

Department of Radiology, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

To evaluate the image quality of low voltage chest computed tomography with enhancement (CECT) using low-concentration-iodine contrast media (LCCM). From 9 December to 19 December 2019, three different protocols were used for 263 patients undergoing chest CECT. Chest CECT was done using routine (300 mgI/ml contrast media with 100 kVp) protocol (group 1), LCCM (240 mgI/ml contrast media)-100 kVp protocol (group 2) and LCCM-80 kVp protocol (group 3) in 91, 97 and 75 patients, respectively. Read More

Front Nutr 2022 2;9:861383. Epub 2022 May 2.

Centre d'Innovació, Recerca i Transferència en Tecnologia dels Aliments (CIRTTA), XaRTA, TECNIO, MALTA-Consolider, Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Universitat Autònoma de Barcelona (Cerdanyola del Vallès), Barcelona, Spain.

Increasing consumer demand for healthier foods prompts the development of cheeses reduced in salt. The aim of his study was to assess the effect of reducing the level of sodium chloride (NaCl) and their partial substitution by potassium chloride (KCl) on the biochemical, microbiological, and sensorial characteristics and consumer's acceptability of semi-hard and hard lactose-free cow's milk cheeses. To improve the possible lower salty taste or the development of bitter taste, the addition to yeast extract, as a flavor enhancer, was also checked. Read More

Food Sci Nutr 2022 May 11;10(5):1520-1526. Epub 2022 Feb 11.

Department of Food Industries, Faculty of Agriculture Damietta University Damietta Egypt.

The present study aimed at the development of a groundnut-based dehydrated paneer type product which could serve as an instant vegan protein source. In the process of preparing groundnut paneer, a ratio of 1:5 of groundnut to water and 2.0% calcium chloride (CaCl) solution was used for the preparation of groundnut paneer and the product was evaluated for physicochemical, instrumental color, instrumental textural, and sensory characteristics. Read More

Food Sci Nutr 2022 May 19;10(5):1451-1460. Epub 2022 Apr 19.

China-Australia Joint Research Center for Dairy Future Technology Beijing Key Laboratory of Nutrition, Health & Food Safety Beijing Engineering Laboratory for Geriatric Nutrition Food Research COFCO Nutrition & Health Research Institute Beijing China.

Lactic acid bacteria (LAB) play a crucial role in the development of the taste, texture, and aroma of traditional fermented milk products. Five LABs from Kazakh traditionally prepared dairy products showed continuous subculture stability, as well as proper acidification and coagulation ability. They were identified as (1-5, 1-7), (1-19), and (1-12, 1-15). Read More

Palliat Care Soc Pract 2022 13;16:26323524221095102. Epub 2022 May 13.

The University of British Columbia, Okanagan Campus, Kelowna, BC, Canada.

Background: There is an urgent need for community-based interventions that can be scaled up to meet the growing demand for palliative care. The purpose of this study was to scale out a volunteer navigation intervention called Nav-CARE by replicating the program in multiple contexts and evaluating feasibility, acceptability, sustainability, and impact.

Methods: This was a scale-out implementation and mixed-method evaluation study. Read More

J Food Sci 2022 May 19. Epub 2022 May 19.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.

Cooked off-flavor produced by heat treatment greatly limited the acceptability of commercial tomato juice. To screen and identify the cooked off-flavor compounds, gas chromatography-mass spectrometry-olfactometry (GC-MS-O), aroma extract dilution analysis (AEDA), gas chromatography-mass spectrometry (GC-MS), and odor activity value (OAV) calculation were applied simultaneously. The results showed that there were 17 aroma-active compounds in tomato juice samples. Read More

Trials 2022 May 19;23(1):417. Epub 2022 May 19.

Johns Hopkins Bloomberg School of Public Health, Department of Mental Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

Background: In low- and middle-income countries (LMIC), there is a substantial gap in the treatment of mental and behavioral health problems, which is particularly detrimental to adolescents and young adults (AYA). The Common Elements Treatment Approach (CETA) is an evidence-based, flexible, transdiagnostic intervention delivered by lay counselors to address comorbid mental and behavioral health conditions, though its effectiveness has not yet been tested among AYA. This paper describes the protocol for a randomized controlled trial that will test the effectiveness of traditional in-person delivered CETA and a telehealth-adapted version of CETA (T-CETA) in reducing mental and behavioral health problems among AYA in Zambia. Read More

Pilot Feasibility Stud 2022 May 19;8(1):105. Epub 2022 May 19.

University of Greenwich, Old Royal Naval College, Park Row, London, SE10 9LS, UK.

Background: Swallowing difficulties (dysphagia) and community-acquired pneumonia are common in frail older people and maybe addressed through targeted training of the anterior neck musculature that affects the swallow. We have developed a swallowing exercise rehabilitation intervention (CTAR-SwiFt) by adapting a previously established swallowing exercise to ensure patient safety and ease of execution in the frail elderly population. The CTAR-SwiFt intervention consists of a feedback-enabled exercise ball that can be squeezed under the chin, with real-time feedback provided via a mobile application. Read More

BMC Public Health 2022 May 19;22(1):1010. Epub 2022 May 19.

University of California San Francisco, San Francisco, CA, USA.

Background: Distribution of long-lasting insecticide treated nets (LLINs) is the most widely used intervention for the prevention of malaria but recall and social desirability biases may lead to challenges in accurately measuring use of bednets. SmartNet is a remote electronic monitor that provides objective measurements of bednet use over weeks at a time. Assessing local acceptability is important when implementing innovative global health technologies such as SmartNet. Read More

JPEN J Parenter Enteral Nutr 2022 May 19. Epub 2022 May 19.

Intestinal Failure Unit, Salford Care Organisation, Northern Care Alliance, Salford.

Background: While international guidelines support the use of commercially available multi-chamber bags (MCBs), the majority of home parenteral nutrition (HPN) in the UK has been compounded PN, tailored to the patient. However, national capacity limitations in aseptic facilities have necessitated the increased use of MCBs. There are no studies evaluating the appropriateness or benefits of using a 'hybrid' regimen incorporating both MCBs and compounded PN in patients already established on compounded HPN. Read More

BMJ Open 2022 May 19;12(5):e058144. Epub 2022 May 19.

Department of Psychological Medicine, The University of Auckland, Auckland, New Zealand.

Objectives: To evaluate the efficacy and acceptability of 'Whitu: seven ways in seven days', a well-being application (app) for young people.

Design: Prospective randomised controlled trial of Whitu against waitlist control, with 45 participants in each arm.

Participants: 90 New Zealand young people aged 16-30 recruited via a social media advertising campaign. Read More

Transplant Cell Ther 2022 May 16. Epub 2022 May 16.

Department of Hematology, University Hospitals Leuven, Leuven, Belgium; Department of Public Health and Primary Care, ACCENT VV, KU Leuven, Leuven, Belgium. Electronic address:

Hematopoietic stem cell transplantation (HCT) has the potential to cure malignant and nonmalignant diseases but remains associated with a wide range of complications, necessitating dedicated lifelong follow-up. While patients are monitored closely during the peri-HCT period, leaving the hospital setting after HCT introduces new challenges. This scoping review explores the current use of patient-generated eHealth data in the outpatient setting. Read More

Bioresour Technol 2022 May 16:127329. Epub 2022 May 16.

Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou 325035, China; Department of Chemical Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, 43500 Semenyih, Selangor Darul Ehsan, Malaysia. Electronic address:

Microalgae have been a promising alternative source of high-value compounds to replace the non-sustainable fossil fuels resource. The recent research development of algae-based bioproducts has remarkable impact various industries section for its renewability, efficiency, and environmentally friendly crops over those synthetic-made product. However, by utilizing microalgae biomass toward their full potential is still limited due to lack of research funding, social acceptability and challenges in policy implementation. Read More

Contemp Clin Trials 2022 May 16:106794. Epub 2022 May 16.

School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Australia; The George Institute for Global Health, University of New South Wales, Sydney, Australia.

Background: Practice-level quality improvement initiatives using rapidly advancing technology offers a multidimensional approach to reduce cardiovascular disease burden. For the "QUality improvement in primary care to prevent hospitalisations and improve Effectiveness and efficiency of care for people Living with heart disease" (QUEL) cluster randomised controlled trial, a 12-month quality improvement intervention was designed for primary care practices to use data and implement progressive changes using "Plan, Do, Study, Act" cycles within their practices with training in a series of interactive workshops. This protocol aims to describe the systematic methods to conduct a process evaluation of the data-driven intervention within the QUEL study. Read More

Crit Rev Oncol Hematol 2022 May 16:103711. Epub 2022 May 16.

IQVIA, 37 North Wharf Road, London W2 1AF, UK.

Objective: Event-free survival (EFS) is increasingly used as a primary endpoint in trials of haematological malignancies (HMs). A key consideration is whether EFS can reliably predict survival.

Methods: We conducted a review of the scientific literature and health technology assessments to evaluate evidence for EFS-OS surrogacy in HMs and acceptability of EFS by payers. Read More

JMIR Hum Factors 2022 May 19;9(2):e36959. Epub 2022 May 19.

School of Nursing and Midwifery, Faculty of Health, Deakin University, Geelong, Australia.

Background: Advances in digital technology and the use of multimedia platforms to deliver information provide clinicians with a unique opportunity to develop innovative ways to consistently provide high-quality, accessible, and evidence-based information to support patient participation. Introducing new technologies into everyday acute care clinical practice can be difficult.

Objective: The aim of this paper was to provide a description of an implementation strategy and the subsequent evaluation undertaken to examine the contextual factors important to the successful adoption of new technology by nurses in the context of acute postoperative care. Read More

Int J Geriatr Psychiatry 2022 May 4;37(6). Epub 2022 May 4.

School of Health Sciences, University of Nottingham, Nottingham, UK.

Objectives: Digital health interventions enable services to support people living with dementia and Mild Cognitive Impairment (MCI) remotely. This literature review gathers evidence on the effectiveness of digital health interventions on physical, cognitive, behavioural and psychological outcomes, and Activities of Daily Living in people living with dementia and MCI.

Methods/design: Searches, using nine databases, were run in November 2021. Read More

Psychol Serv 2022 May 19. Epub 2022 May 19.

VA Center for Health Equity Research and Promotion.

Reports an error in "Recovering from intimate partner violence through Strengths and Empowerment (RISE): Development, pilot testing, and refinement of a patient-centered brief counseling intervention for women" by Katherine M. Iverson, Sara B. Danitz, Mary Driscoll, Dawne Vogt, Alison B. Read More

JMIR Res Protoc 2022 May 19;11(5):e37659. Epub 2022 May 19.

Center for Translational Behavioral Research, Florida State University, Tallahassee, FL, United States.

Background: Vulnerable adolescents and emerging adults (aged 18-29 years), particularly young transgender women, are among the fastest-growing HIV positive populations worldwide. Thailand has the highest adult HIV seroprevalence in Asia, with a rate of infection among this population of 18%. Widespread technology offers opportunities for innovative mobile health (mHealth) interventions. Read More

JAMA Netw Open 2022 May 2;5(5):e2212939. Epub 2022 May 2.

Department of Pharmaceutical Economics and Policy, Massachusetts College of Pharmacy and Health Sciences, Boston.

Importance: Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia.

Objective: To investigate the comparative effectiveness and acceptability associated with pharmacological treatment options for fibromyalgia.

Data Sources: Searches of PubMed/MEDLINE, Cochrane Library, Embase, and Clinicaltrials. Read More