5,777 results match your criteria accelerated stability


High Dietary Intervention of Lauric Triglyceride Might be Harmful to Its Improvement of Cholesterol Metabolism in Obese Rats.

J Agric Food Chem 2021 Apr 12. Epub 2021 Apr 12.

Jiangxi Province Key Laboratory of Edible and Medicinal Resources Exploitation, School of Resource and Environmental and Chemical Engineering, Nanchang University, Nanchang 330031, China.

Hypercholesterolemia is often considered to be a major risk factor for atherosclerosis, and medium-chain fatty acids have been found to reduce the total cholesterol (TC) level and maintain low-density lipoprotein cholesterol (LDL-c) stability. However, we unexpectedly found that the levels of TC and LDL-c were increased in obese rats treated with high-dose lauric triglycerides (LT). The study aimed to investigate the effect and mechanism of LT on cholesterol metabolism in obese rats. Read More

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Modeling the Conditional Fragmentation-Induced Microplastic Distribution.

Environ Sci Technol 2021 Apr 11. Epub 2021 Apr 11.

School of Environment, Tsinghua University, Beijing 100084, China.

Microplastics (MPs) are drawing increasing attention from the international community due to their potential threats to the ecosystem and human health. Although their occurrence and spatial distribution have been extensively studied in recent years, the relationship between their abundance and sizes remains unclear. Moreover, the underlying mechanisms dominating their size distribution have rarely been explored. Read More

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Integrating column leaching experiments and geochemical modelling to predict the long-term alkaline stability during erosion process for gypsum amended bauxite residue.

J Environ Manage 2021 Apr 7;289:112479. Epub 2021 Apr 7.

School of Metallurgy and Environment, Central South University, Changsha, 410083, China. Electronic address:

Gypsum amendment is widely used to resolve alkalinity issues and implement sustainable management for bauxite residue disposal areas (BRDAs). Amended BRDAs under natural conditions suffer from long-term erosion processes. Nevertheless, the effect of erosion on amendment efficacy is rarely assessed. Read More

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Identification and characterization of new impurities in zopiclone tablets by LC-QTOF-MS.

J Pharm Biomed Anal 2021 Apr 1;199:114056. Epub 2021 Apr 1.

China National Narcotics Control Commission-China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, China; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Zopiclone, a non-benzodiazepine hypnotic, is the first-line treatment for insomnia. The quality and stability of zopiclone tablets directly affects its efficacy and safety. However, the impurity investigation in zopiclone tablets remain incomplete. Read More

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Extemporaneous printing of diclofenac orodispersible films for pediatrics.

Drug Dev Ind Pharm 2021 Apr 7:1-9. Epub 2021 Apr 7.

Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy.

Objective: The possible application of a hot-melt ram extrusion printing to the preparation of diclofenac orodispersible films (ODF) made of maltodextrin was studied focusing the attention on the effects of taste-masking agents (i.e. namely mint, licorice-mint, and sucralose) and an opacifier (titanium dioxide [TiO]). Read More

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and evaluation of taste-masked orodispersible tablets of fluoxetine hydrochloride for the treatment of depression.

Drug Dev Ind Pharm 2021 Apr 7:1-9. Epub 2021 Apr 7.

Faculty of Pharmacy, Pharmaceutics and Industrial Pharmacy Department, Al-Azhar University, Nasr City, Egypt.

Aim: Fluoxetine (FLX) has become the first-line drug in the pharmacotherapy of patients with depression. However, it has a strong unpleasant bitter taste, leading to the failure to complete the therapy. In this study, FLX is formulated into orodispersible tablets (ODTs) characterized by a fast release with an acceptable taste. Read More

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The modulation of PD-L1 induced by the oncogenic HBXIP for breast cancer growth.

Acta Pharmacol Sin 2021 Apr 6. Epub 2021 Apr 6.

State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin, 300071, China.

Programmed death ligand-1 (PD-L1)/PD-1 checkpoint extensively serves as a central mediator of immunosuppression. A tumor-promoting role for abundant PD-L1 in several cancers is revealed. However, the importance of PD-L1 and how the PD-L1 expression is controlled in breast cancer remains obscure. Read More

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Azelaic Acid/Expanded Graphite Composites with High Latent Heat Storage Capacity and Thermal Conductivity at Medium Temperature.

ACS Omega 2021 Mar 16;6(12):8469-8476. Epub 2021 Mar 16.

Research Institute of Clean Manufacturing System, Korea Institute of Industrial Technology, 89 Yangdaegiro-gil, Ipjang-myeon, Cheonan 31056, South Korea.

A novel azelaic acid/expanded graphite (AA/EG) phase change composite (PCC) was fabricated as a shape-stabilized phase change material (PCM) for latent heat storage at medium temperatures. The composite exhibited a low supercooling degree and high heat storage capacity. Despite the impregnation of a high quantity of AA (85 wt %) in the porous network of EG, there was no leakage of liquid AA. Read More

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First-Principles Model to Evaluate Quantitatively the Long-Life Behavior of Cellulose Acetate Polymers.

ACS Omega 2021 Mar 17;6(12):8028-8037. Epub 2021 Mar 17.

CERENA, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.

A deep understanding of the degradation of cellulose diacetate (CDA) polymer is crucial in finding the appropriate long-term stability solution. This work presents an investigation of the reaction mechanism of hydrolysis using electronic density functional theory calculations with the B3LYP/6-31++G** level of theory to determine the energetics of the degradation reactions. This information was coupled with the transition-state theory to establish the kinetics of degradation for both the acid-catalyzed and noncatalyzed degradation pathways. Read More

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Anatomic all-epiphyseal ACL reconstruction with "inside-out" femoral tunnel placement in immature patients yields high return to sport rates and functional outcome scores a minimum of 24 months after reconstruction.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 3. Epub 2021 Apr 3.

Department of Orthopaedic Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA, 15224, USA.

Purpose: To understand if anatomic physeal-sparing ACL reconstruction in the immature host preserves range of motion, permits a return to sports, and avoids limb length discrepancy and accelerated intra-articular degeneration with a cross-sectional radiographic, physical examination and patient-reported outcomes analysis.

Methods: A cross-sectional recall study included 38 patients aged 7-15 who underwent all-epiphyseal ACL reconstruction with hamstring allograft performed by a single surgeon at a large academic medical center. All-epiphyseal reconstructions were performed using a modified Anderson physeal-sparing technique, with the femoral tunnel placed using an "inside-out" technique. Read More

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A Novel Solid Nanocrystals Self-Stabilized Pickering Emulsion Prepared by Spray-Drying with Hydroxypropyl-β-cyclodextrin as Carriers.

Molecules 2021 Mar 23;26(6). Epub 2021 Mar 23.

Macao Polytechnic Institute, School of Health Sciences and Sports, Macao 00853, China.

A drug nanocrystals self-stabilized Pickering emulsion (NSSPE) with a unique composition and microstructure has been proven to significantly increase the bioavailability of poorly soluble drugs. This study aimed to develop a new solid NSSPE of puerarin preserving the original microstructure of NSSPE by spray-drying. A series of water-soluble solid carriers were compared and then Box-Behnken design was used to optimize the parameters of spray-drying. Read More

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Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals.

Pharmaceutics 2021 Mar 20;13(3). Epub 2021 Mar 20.

Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.

The aim of the study was the manufacturing and scale-up of theophylline-nicotinamide (THL-NIC) pharmaceutical cocrystals processed by hot-melt extrusion (HME). The barrel temperature profile, feed rate and screw speed were found to be the critical processing parameters with a residence time of approximately 47 s for the scaled-up batches. Physicochemical characterization using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction of bulk and extruded materials revealed the formation of high purity cocrystals (98. Read More

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Quality Evaluation, Storage Stability, and Sensory Characteristics of Wheat Noodles Incorporated with Isomaltodextrin.

Plants (Basel) 2021 Mar 18;10(3). Epub 2021 Mar 18.

Department of Medicinal Botanical and Health Applications, Da-Yeh University, Dacun, Changhua 51591, Taiwan.

Wheat noodles incorporated with isomaltodextrin were assessed in relation to physicochemical properties (color), microstructure features, biochemical composition (fiber profile), cooking properties, textural attributes, and sensory evaluations during different storage temperatures (25, 4, -20 °C) and periods (0, 3, 6, 9, 12, 15, 18, 21, 24 months). Meanwhile, an accelerated study was also carried out at 40 °C storage conditions for 12 months to evaluate the fiber profile changes. Under different conditions, the overall quality of both raw and cooked noodle samples depended slightly on both the type and amount of added fiber isomaltodextrin, resistant starch (RS), insoluble high-molecular-weight dietary fiber (IHMWDF), and soluble high-molecular-weight dietary fiber (SHMWDF). Read More

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Impact of Surface Properties of Core Material on the Stability of Hot Melt-Coated Multiparticulate Systems.

Pharmaceutics 2021 Mar 10;13(3). Epub 2021 Mar 10.

Department of Pharmaceutical Technology and Biopharmacy, Institute of Pharmaceutical Science, University of Graz, 8010 Graz, Austria.

Hot melt coating (HMC) of an active pharmaceutical ingredient (API) powder with lipid-based excipients is an innovative method for manufacturing patient-convenient dosage forms. However, drug release instability is still its main industrial challenge. The correlation between the unstable pharmaceutical product performance with the solid-state alteration of lipids is currently well-investigated. Read More

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Self-Fluxing Mechanism in Geopolymerization for Low-Sintering Temperature of Ceramic.

Materials (Basel) 2021 Mar 10;14(6). Epub 2021 Mar 10.

Faculty of Bioengineering and Technology, Universiti Malaysia Kelantan (Jeli Campus), Jeli 17600, Kelantan Darul Naim, Malaysia.

Kaolin, theoretically known as having low reactivity during geopolymerization, was used as a source of aluminosilicate materials in this study. Due to this concern, it is challenging to directly produce kaolin geopolymers without pre-treatment. The addition of ground granulated blast furnace slag (GGBS) accelerated the geopolymerization process. Read More

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Estimation of the Vehicle Speed Using Cross-Correlation Algorithms and MEMS Wireless Sensors.

Sensors (Basel) 2021 Mar 2;21(5). Epub 2021 Mar 2.

Department of Civil and Environmental Engineering, Virginia Tech University, Blacksburg, VA 24060, USA.

Traffic information is critical for pavement design, management, and health monitoring. Numerous in-pavement sensors have been developed and installed to collect the traffic volume and loading amplitude. However, limited attention has been paid to the algorithm of vehicle speed estimation. Read More

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Quality-by-Design-Based Development of n-Propyl-Gallate-Loaded Hyaluronic-Acid-Coated Liposomes for Intranasal Administration.

Molecules 2021 Mar 6;26(5). Epub 2021 Mar 6.

Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, H-6720 Szeged, Hungary.

The present study aimed to develop n-propyl gallate (PG)-encapsulated liposomes through a novel direct pouring method using the quality-by-design (QbD) approach. A further aim was to coat liposomes with hyaluronic acid (HA) to improve the stability of the formulation in nasal mucosa. The QbD method was used for the determination of critical quality attributes in the formulation of PG-loaded liposomes coated with HA. Read More

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Stability of Outer Membrane Vesicles-Based Vaccines, Identifying the Most Appropriate Methods to Detect Changes in Vaccine Potency.

Vaccines (Basel) 2021 Mar 6;9(3). Epub 2021 Mar 6.

GSK Vaccines Institute for Global Health (GVGH) S.r.l., Via Fiorentina 1, 53100 Siena, Italy.

Ensuring the stability of vaccines is crucial to successfully performing global immunization programs. Outer Membrane Vesicles (OMV) are receiving great attention as vaccine platforms. OMV are complex molecules and few data have been collected so far on their stability. Read More

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High Salinity and High Temperature Stable Colloidal Silica Nanoparticles with Wettability Alteration Ability for EOR Applications.

Nanomaterials (Basel) 2021 Mar 11;11(3). Epub 2021 Mar 11.

Department of Geoscience and Petroleum, Norwegian University of Science and Technology (NTNU), 7031 Trondheim, Norway.

The stability of nanoparticles at reservoir conditions is a key for a successful application of nanofluids for any oilfield operations, e.g., enhanced oil recovery (EOR). Read More

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Topical tacrolimus nanocapsules eye drops for therapeutic effect enhancement in both anterior and posterior ocular inflammation models.

J Control Release 2021 Mar 30;333:283-297. Epub 2021 Mar 30.

Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel; BioNanoSim Ltd., Jerusalem, Israel. Electronic address:

Tacrolimus has shown efficacy in eye inflammatory diseases. However, due to the drug lability, its formulation into a stable ophthalmic product remains a challenge. Tacrolimus-loaded nanocapsules (NCs) were designed for ocular instillation. Read More

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Characterization of Amorphous Solid Dispersions and Identification of Low Levels of Crystallinity by Transmission Electron Microscopy.

Mol Pharm 2021 Apr 2. Epub 2021 Apr 2.

School of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, U.K.

Amorphous solid dispersions (ASDs) are used to increase the solubility of oral medicines by kinetically stabilizing the more soluble amorphous phase of an active pharmaceutical ingredient with a suitable amorphous polymer. Low levels of a crystalline material in an ASD can negatively impact the desired dissolution properties of the drug. Characterization techniques such as powder X-ray diffraction (pXRD), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR) are often used to detect and measure any crystallinity within ASDs. Read More

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Transdermal Permeation of Caffeine Aided by Ionic Liquids: Potential for Enhanced Treatment of Cellulitis.

AAPS PharmSciTech 2021 Apr 1;22(3):121. Epub 2021 Apr 1.

PhageLab - Laboratory of Biofilms and Bacteriophages, University of Sorocaba, Sorocaba, SP, 18023-000, Brazil.

Ginoid hydrolipodystrophy (HDLG) or "cellulite" involves alteration of the cutaneous relief and occurs in 80-90% of the female population. Several topical treatments are available with the use of substances capable of stimulating lipolysis, such as caffeine. However, the effectiveness of topical therapy is related to the processes of release and permeation of the active in skin cells. Read More

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Stability of freeze-dried products subjected to microcomputed tomography radiation doses.

J Pharm Pharmacol 2021 Mar;73(2):212-220

GILYOS GmbH, Würzburg, Germany.

Objectives: Microcomputed tomography (µCT) is a powerful analytical tool for non-invasive structural analysis. The stability of drug substances and formulations subjected to X-ray radiation may be a concern in the industry. This study examines the effect of X-ray radiation on the stability of freeze-dried pharmaceuticals. Read More

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